Serine protease HtrA1 expression in human hepatocellular carcinoma

Hepatobiliary and Pancreatic Diseases International

Volumn 9, Issue 5, 2010, Pages 508-512

  Zhu, Feng ^a   Jin, Lei ^a   Luo, Tian Ping ^a   Luo, Guang Hua ^a   Tan, Yan ^a   Qin, Xi Hu ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Apoptosis; Hepatocellular carcinoma; HtrA1; Metastasis; Serine protease

Indexed keywords

SERINE PROTEINASE; SERINE PROTEINASE HTRA1; UNCLASSIFIED DRUG;

AGED; ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER INVASION; CANCER SURVIVAL; CLINICAL ARTICLE; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CELL CARCINOMA; MALE; PROTEIN EXPRESSION;

ADULT; CARCINOMA, HEPATOCELLULAR; DOWN-REGULATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; SERINE ENDOPEPTIDASES; STATISTICS, NONPARAMETRIC; SURVIVAL ANALYSIS;

EID: 78249232657     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Shariff MI, Cox IJ, Gomaa AI, Khan SA, Gedroyc W, Taylor- Robinson SD. Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis and therapeutics. Expert Rev Gastroenterol Hepatol 2009;3:353-367.
2. Lau WY, Lai EC. Hepatocellular carcinoma: current management and recent advances. Hepatobiliary Pancreat Dis Int 2008;7: 237-257.
3. Koorey D. Hepatocellular carcinoma: prevention, detection and treatment in the real world. Intern Med J 2007;37:513-515.
4. Pleguezuelo M, Marelli L, Misseri M, Germani G, Calvaruso V, Xiruochakis E, et al. TACE versus TAE as therapy for hepatocellular carcinoma. Expert Rev Anticancer Ther 2008;8: 1623-1641.
5. Zumbrunn J, Trueb B. Primary structure of a putative serine protease specific for IGF-binding proteins. FEBS Lett 1996;398: 187-192.
6. Clausen T, Southan C, Ehrmann M. The HtrA family of proteases: implications for protein composition and cell fate. Mol Cell 2002;10:443-455.
7. Hu SI, Carozza M, Klein M, Nantermet P, Luk D, Crowl RM. Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage. J Biol Chem 1998;273:34406-34412.
8. Faccio L, Fusco C, Chen A, Martinotti S, Bonventre JV, Zervos AS. Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia. J Biol Chem 2000;275: 2581-2588.
9. Gray CW, Ward RV, Karran E, Turconi S, Rowles A, Viglienghi D, et al. Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. Eur J Biochem 2000;267:5699-5710.
10. Nie GY, Hampton A, Li Y, Findlay JK, Salamonsen LA. Identification and cloning of two isoforms of human hightemperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2. Biochem J 2003;371:39-48.
11. Canfield AE, Hadfield KD, Rock CF, Wylie EC, Wilkinson FL. HtrA1: a novel regulator of physiological and pathological matrix mineralization? Biochem Soc Trans 2007;35:669-671.
12. Chien J, Campioni M, Shridhar V, Baldi A. HtrA serine proteases as potential therapeutic targets in cancer. Curr Cancer Drug Targets 2009;9:451-468.
13. Chien J, Staub J, Hu SI, Erickson-Johnson MR, Couch FJ, Smith DI, et al. A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer. Oncogene 2004;23:1636-1644.
14. Baldi A, De Luca A, Morini M, Battista T, Felsani A, Baldi F, et al. The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells. Oncogene 2002;21:6684-6688.
15. Shridhar V, Sen A, Chien J, Staub J, Avula R, Kovats S, et al. Identification of underexpressed genes in early- and latestage primary ovarian tumors by suppression subtraction hybridization. Cancer Res 2002;62:262-270.
16. Esposito V, Campioni M, De Luca A, Spugnini EP, Baldi F, Cassandro R, et al. Analysis of HtrA1 serine protease expression in human lung cancer. Anticancer Res 2006;26:3455-3459.
17. Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 1954;7:462-503.
18. Yu YP, Landsittel D, Jing L, Nelson J, Ren B, Liu L, et al. Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy. J Clin Oncol 2004;22:2790-2799.
19. Varambally S, Yu J, Laxman B, Rhodes DR, Mehra R, Tomlins SA, et al. Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. Cancer Cell 2005;8:393-406.
20. Segal NH, Pavlidis P, Noble WS, Antonescu CR, Viale A, Wesley UV, et al. Classification of clear-cell sarcoma as a subtype of melanoma by genomic profiling. J Clin Oncol 2003; 21:1775-1781.
21. Zurawa-Janicka D, Kobiela J, Stefaniak T, Wozniak A, Narkiewicz J, Wozniak M, et al. Changes in expression of serine proteases HtrA1 and HtrA2 during estrogen-induced oxidative stress and nephrocarcinogenesis in male Syrian hamster. Acta Biochim Pol 2008;55:9-19.
22. Papa D, Li SA, Li JJ. Comparative genomic hybridization of estrogen-induced ectopic uterine-like stem cell neoplasms in the hamster kidney: nonrandom chromosomal alterations. Mol Carcinog 2003;38:97-105.
23. Oka C, Tsujimoto R, Kajikawa M, Koshiba-Takeuchi K, Ina J, Yano M, et al. HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins. Development 2004;131: 1041-1053.
24. Mazzocca A, Fransvea E, Lavezzari G, Antonaci S, Giannelli G. Inhibition of transforming growth factor beta receptor I kinase blocks hepatocellular carcinoma growth through neoangiogenesis regulation. Hepatology 2009;50:1140-1151.
25. Haurie V, M?ard L, Nicou A, Touriol C, Metzler P, Fernandez J, et al. Adenosine triphosphatase pontin is overexpressed in hepatocellular carcinoma and coregulated with reptin through a new posttranslational mechanism. Hepatology 2009;50:1871-1883.
26. Zhang X, Frank AC, Gille CM, Daucher M, Kabat J, Becker S, et al. Altered regulation of extrinsic apoptosis pathway in HCVinfected HCC cells enhances susceptibility to mapatumumabinduced apoptosis. Hepatol Res 2009;39:1178-1189.
27. Shi YH, Ding ZB, Zhou J, Qiu SJ, Fan J. Prognostic significance of Beclin 1-dependent apoptotic activity in hepatocellular carcinoma. Autophagy 2009;5:380-382.
28. Carmona-Cuenca I, Roncero C, Sancho P, Caja L, Fausto N, Fern?dez M, et al. Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its proapoptotic activity. J Hepatol 2008;49:965-976.