-
1
-
-
0025012050
-
Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression
-
Albelda, S.M., Mette, S.A., Elder, D.E., Stewart, R., Damjanovich, L., Herlyn, M., and Buck, C.A. (1990). Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression. Cancer Res. 50, 6757-6764.
-
(1990)
Cancer Res.
, vol.50
, pp. 6757-6764
-
-
Albelda, S.M.1
Mette, S.A.2
Elder, D.E.3
Stewart, R.4
Damjanovich, L.5
Herlyn, M.6
Buck, C.A.7
-
2
-
-
65749118370
-
Randomized, double-blind, double-dummy, vehicle-controlled study of ingenol mebutate gel 0.025% and 0.05% for actinic keratosis
-
Anderson, L., Schmieder, G.J., Werschler, W.P., Tschen, E.H., Ling, M.R., Stough, D.B., and Katsamas, J. (2009). Randomized, double-blind, double-dummy, vehicle-controlled study of ingenol mebutate gel 0.025% and 0.05% for actinic keratosis. J. Am. Acad. Dermatol. 60, 934-943.
-
(2009)
J. Am. Acad. Dermatol.
, vol.60
, pp. 934-943
-
-
Anderson, L.1
Schmieder, G.J.2
Werschler, W.P.3
Tschen, E.H.4
Ling, M.R.5
Stough, D.B.6
Katsamas, J.7
-
3
-
-
0026808452
-
Growth of human melanocyte cultures supported by 12-O-tetradecanoylphorbol-13-acetate is mediated through protein kinase C activation
-
Arita, Y., O'Driscoll, K.R., and Weinstein, I.B. (1992). Growth of human melanocyte cultures supported by 12-O-tetradecanoylphorbol-13-acetate is mediated through protein kinase C activation. Cancer Res. 52, 4514-4521.
-
(1992)
Cancer Res.
, vol.52
, pp. 4514-4521
-
-
Arita, Y.1
O'Driscoll, K.R.2
Weinstein, I.B.3
-
4
-
-
0028266194
-
Growth inhibition of human melanoma-derived cells by 12-O-tetradecanoyl phorbol 13-acetate
-
Arita, Y., O'Driscoll, K.R., and Weinstein, I.B. (1994). Growth inhibition of human melanoma-derived cells by 12-O-tetradecanoyl phorbol 13-acetate. Int. J. Cancer 56, 229-235.
-
(1994)
Int. J. Cancer
, vol.56
, pp. 229-235
-
-
Arita, Y.1
O'Driscoll, K.R.2
Weinstein, I.B.3
-
5
-
-
34548787911
-
Protein kinase Cε interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer
-
Aziz, M.H., Manoharan, H.T., Church, D.R., Dreckschmidt, N.E., Zhong, W., Oberley, T.D., Wilding, G., and Verma, A.K. (2007a). Protein kinase Cε interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer. Cancer Res. 67, 8828-8838.
-
(2007)
Cancer Res.
, vol.67
, pp. 8828-8838
-
-
Aziz, M.H.1
Manoharan, H.T.2
Church, D.R.3
Dreckschmidt, N.E.4
Zhong, W.5
Oberley, T.D.6
Wilding, G.7
Verma, A.K.8
-
6
-
-
33847019644
-
Protein kinase C ε, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3
-
Aziz, M.H., Manoharan, H.T., and Verma, A.K. (2007b). Protein kinase C ε, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3. Cancer Res. 67, 1385-1394.
-
(2007)
Cancer Res.
, vol.67
, pp. 1385-1394
-
-
Aziz, M.H.1
Manoharan, H.T.2
Verma, A.K.3
-
7
-
-
0035035103
-
Phase II evaluation of bryostatin-1 in metastatic melanoma
-
Bedikian, A.Y., Plager, C., Stewart, J.R., O'Brian, C.A., Herdman, S.K., Ross, M., Papadopoulos, N., Eton, O., Ellerhorst, J., and Smith, T. (2001). Phase II evaluation of bryostatin-1 in metastatic melanoma. Melanoma Res. 11, 183-188.
-
(2001)
Melanoma Res.
, vol.11
, pp. 183-188
-
-
Bedikian, A.Y.1
Plager, C.2
Stewart, J.R.3
O'Brian, C.A.4
Herdman, S.K.5
Ross, M.6
Papadopoulos, N.7
Eton, O.8
Ellerhorst, J.9
Smith, T.10
-
8
-
-
79551571444
-
Transgenic overexpression of PKCepsilon in the mouse prostate induces preneoplastic lesions
-
Benavides, F., Blando, J., Perez, C.J., Garg, R., Conti, C.J., DiGiovanni, J., and Kazanietz, M.G. (2011). Transgenic overexpression of PKCepsilon in the mouse prostate induces preneoplastic lesions. Cell Cycle 10, 268-277.
-
(2011)
Cell Cycle
, vol.10
, pp. 268-277
-
-
Benavides, F.1
Blando, J.2
Perez, C.J.3
Garg, R.4
Conti, C.J.5
DiGiovanni, J.6
Kazanietz, M.G.7
-
9
-
-
17444403210
-
The C2 domain of PKCδ is a phosphotyrosine binding domain
-
Benes, C.H., Wu, N., Elia, A.E., Dharia, T., Cantley, L.C., and Soltoff, S.P. (2005). The C2 domain of PKCδ is a phosphotyrosine binding domain. Cell 121, 271-280.
-
(2005)
Cell
, vol.121
, pp. 271-280
-
-
Benes, C.H.1
Wu, N.2
Elia, A.E.3
Dharia, T.4
Cantley, L.C.5
Soltoff, S.P.6
-
10
-
-
0034601455
-
Molecular classification of cutaneous malignant melanoma by gene expression profiling
-
Bittner, M., Meltzer, P., Chen, Y. et al. (2000). Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature 406, 536-540.
-
(2000)
Nature
, vol.406
, pp. 536-540
-
-
Bittner, M.1
Meltzer, P.2
Chen, Y.3
-
11
-
-
77952241390
-
RNAi-mediated knockdown of protein kinase C-alpha inhibits cell migration in MM-RU human metastatic melanoma cell line
-
Byers, H.R., Boissel, S.J., Tu, C., and Park, H.Y. (2010). RNAi-mediated knockdown of protein kinase C-alpha inhibits cell migration in MM-RU human metastatic melanoma cell line. Melanoma Res. 20, 171-178.
-
(2010)
Melanoma Res.
, vol.20
, pp. 171-178
-
-
Byers, H.R.1
Boissel, S.J.2
Tu, C.3
Park, H.Y.4
-
12
-
-
33748670455
-
Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer
-
Carducci, M.A., Musib, L., Kies, M.S. et al. (2006). Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer. J. Clin. Oncol. 24, 4092-4099.
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 4092-4099
-
-
Carducci, M.A.1
Musib, L.2
Kies, M.S.3
-
13
-
-
77952290430
-
PhosphoMARCKS drives motility of mouse melanoma cells
-
Chen, X., and Rotenberg, S.A. (2010). PhosphoMARCKS drives motility of mouse melanoma cells. Cell Signal. 22, 1097-1103.
-
(2010)
Cell Signal.
, vol.22
, pp. 1097-1103
-
-
Chen, X.1
Rotenberg, S.A.2
-
14
-
-
58149175775
-
Rationally designed peptide regulators of protein kinase C
-
Churchill, E.N., Qvit, N., and Mochly-Rosen, D. (2009). Rationally designed peptide regulators of protein kinase C. Trends Endocrinol. Metab. 20, 25-33.
-
(2009)
Trends Endocrinol. Metab.
, vol.20
, pp. 25-33
-
-
Churchill, E.N.1
Qvit, N.2
Mochly-Rosen, D.3
-
15
-
-
33745699726
-
Protein kinase Cζ mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase
-
Cohen, E.E., Lingen, M.W., Zhu, B., Zhu, H., Straza, M.W., Pierce, C., Martin, L.E., and Rosner, M.R. (2006). Protein kinase Cζ mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase. Cancer Res. 66, 6296-6303.
-
(2006)
Cancer Res.
, vol.66
, pp. 6296-6303
-
-
Cohen, E.E.1
Lingen, M.W.2
Zhu, B.3
Zhu, H.4
Straza, M.W.5
Pierce, C.6
Martin, L.E.7
Rosner, M.R.8
-
16
-
-
33750536856
-
Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-dependent hyperactivation of the mitogen-activated protein kinase pathway
-
Cozzi, S.J., Parsons, P.G., Ogbourne, S.M., Pedley, J., and Boyle, G.M. (2006). Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-dependent hyperactivation of the mitogen-activated protein kinase pathway. Cancer Res. 66, 10083-10091.
-
(2006)
Cancer Res.
, vol.66
, pp. 10083-10091
-
-
Cozzi, S.J.1
Parsons, P.G.2
Ogbourne, S.M.3
Pedley, J.4
Boyle, G.M.5
-
17
-
-
30944435449
-
The proapoptotic tumor suppressor protein kinase C-δ is lost in human squamous cell carcinomas
-
D'Costa, A.M., Robinson, J.K., Maududi, T., Chaturvedi, V., Nickoloff, B.J., and Denning, M.F. (2006). The proapoptotic tumor suppressor protein kinase C-δ is lost in human squamous cell carcinomas. Oncogene 25, 378-386.
-
(2006)
Oncogene
, vol.25
, pp. 378-386
-
-
D'Costa, A.M.1
Robinson, J.K.2
Maududi, T.3
Chaturvedi, V.4
Nickoloff, B.J.5
Denning, M.F.6
-
18
-
-
33645452703
-
Chondrocyte cell death mediated by reactive oxygen species-dependent activation of PKC-βI
-
DelCarlo, M., and Loeser, R.F. (2006). Chondrocyte cell death mediated by reactive oxygen species-dependent activation of PKC-βI. Am. J. Physiol. Cell Physiol. 290, C802-C811.
-
(2006)
Am. J. Physiol. Cell Physiol.
, vol.290
-
-
DelCarlo, M.1
Loeser, R.F.2
-
19
-
-
0027332733
-
Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C δ
-
Denning, M.F., Dlugosz, A.A., Howett, M.K., and Yuspa, S.H. (1993). Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C δ. J. Biol. Chem. 268, 26079-26081.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 26079-26081
-
-
Denning, M.F.1
Dlugosz, A.A.2
Howett, M.K.3
Yuspa, S.H.4
-
20
-
-
0032491318
-
Protein kinase Cδ is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes
-
Denning, M.F., Wang, Y., Nickoloff, B.J., and Wrone-Smith, T. (1998). Protein kinase Cδ is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes. J. Biol. Chem. 273, 29995-30002.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 29995-30002
-
-
Denning, M.F.1
Wang, Y.2
Nickoloff, B.J.3
Wrone-Smith, T.4
-
21
-
-
0036144679
-
Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocyte requires activation of protein kinase C
-
Denning, M.F., Wang, Y., Tibudan, S., Nickoloff, B.J., and Qin, J.Z. (2002). Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocyte requires activation of protein kinase C. Cell Death Differ. 9, 40-52.
-
(2002)
Cell Death Differ.
, vol.9
, pp. 40-52
-
-
Denning, M.F.1
Wang, Y.2
Tibudan, S.3
Nickoloff, B.J.4
Qin, J.Z.5
-
22
-
-
0037110732
-
Nuclear import of PKCδ is required for apoptosis: identification of a novel nuclear import sequence
-
DeVries, T.A., Neville, M.C., and Reyland, M.E. (2002). Nuclear import of PKCδ is required for apoptosis: identification of a novel nuclear import sequence. EMBO J. 21, 6050-6060.
-
(2002)
EMBO J.
, vol.21
, pp. 6050-6060
-
-
DeVries, T.A.1
Neville, M.C.2
Reyland, M.E.3
-
23
-
-
34447131518
-
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition
-
Dissanayake, S.K., Wade, M., Johnson, C.E. et al. (2007). The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J. Biol. Chem. 282, 17259-17271.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 17259-17271
-
-
Dissanayake, S.K.1
Wade, M.2
Johnson, C.E.3
-
24
-
-
57749098673
-
Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation
-
Dissanayake, S.K., Olkhanud, P.B., O'Connell, M.P. et al. (2008). Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation. Cancer Res. 68, 10205-10214.
-
(2008)
Cancer Res.
, vol.68
, pp. 10205-10214
-
-
Dissanayake, S.K.1
Olkhanud, P.B.2
O'Connell, M.P.3
-
25
-
-
0001418906
-
Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin
-
Eisinger, M., and Marko, O. (1982). Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin. Proc. Natl. Acad. Sci. U.S.A. 79, 2018-2022.
-
(1982)
Proc. Natl. Acad. Sci. U.S.A.
, vol.79
, pp. 2018-2022
-
-
Eisinger, M.1
Marko, O.2
-
26
-
-
0020954606
-
Stimulation of growth of human melanocytes by tumor promoters
-
Eisinger, M., Marko, O., and Weinstein, I.B. (1983). Stimulation of growth of human melanocytes by tumor promoters. Carcinogenesis 4, 779-781.
-
(1983)
Carcinogenesis
, vol.4
, pp. 779-781
-
-
Eisinger, M.1
Marko, O.2
Weinstein, I.B.3
-
27
-
-
13344259987
-
Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells
-
Emoto, Y., Manome, Y., Meinhardt, G. et al. (1995). Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells. EMBO J. 14, 6148-6156.
-
(1995)
EMBO J.
, vol.14
, pp. 6148-6156
-
-
Emoto, Y.1
Manome, Y.2
Meinhardt, G.3
-
28
-
-
0038394537
-
Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ
-
Faul, M.M., Gillig, J.R., Jirousek, M.R., Ballas, L.M., Schotten, T., Kahl, A., and Mohr, M. (2003). Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ. Bioorg. Med. Chem. Lett. 13, 1857-1859.
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 1857-1859
-
-
Faul, M.M.1
Gillig, J.R.2
Jirousek, M.R.3
Ballas, L.M.4
Schotten, T.5
Kahl, A.6
Mohr, M.7
-
29
-
-
21244435590
-
Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1
-
Feldman, R.I., Wu, J.M., Polokoff, M.A. et al. (2005). Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J. Biol. Chem. 280, 19867-19874.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 19867-19874
-
-
Feldman, R.I.1
Wu, J.M.2
Polokoff, M.A.3
-
30
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty, K.T., Puzanov, I., Kim, K.B. et al. (2010). Inhibition of mutated, activated BRAF in metastatic melanoma. N. Engl. J. Med. 363, 809-819.
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
-
31
-
-
42449148790
-
The reactive oxygen-driven tumor: relevance to melanoma
-
Fried, L., and Arbiser, J.L. (2008). The reactive oxygen-driven tumor: relevance to melanoma. Pigment Cell Melanoma Res. 21, 117-122.
-
(2008)
Pigment Cell Melanoma Res.
, vol.21
, pp. 117-122
-
-
Fried, L.1
Arbiser, J.L.2
-
32
-
-
21844478747
-
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
-
Garraway, L.A., Widlund, H.R., Rubin, M.A. et al. (2005). Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 436, 117-122.
-
(2005)
Nature
, vol.436
, pp. 117-122
-
-
Garraway, L.A.1
Widlund, H.R.2
Rubin, M.A.3
-
33
-
-
0034902972
-
Loss of expression of protein kinase C β is a common phenomenon in human malignant melanoma: a result of transformation or differentiation?
-
Gilhooly, E.M., Morse-Gaudio, M., Bianchi, L., Reinhart, L., Rose, D.P., Connolly, J.M., Reed, J.A., and Albino, A.P. (2001). Loss of expression of protein kinase C β is a common phenomenon in human malignant melanoma: a result of transformation or differentiation? Melanoma Res. 11, 355-369.
-
(2001)
Melanoma Res.
, vol.11
, pp. 355-369
-
-
Gilhooly, E.M.1
Morse-Gaudio, M.2
Bianchi, L.3
Reinhart, L.4
Rose, D.P.5
Connolly, J.M.6
Reed, J.A.7
Albino, A.P.8
-
34
-
-
12344274453
-
Ingenol 3-angelate induces dual modes of cell death and differentially regulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in melanoma cells
-
Gillespie, S.K., Zhang, X.D., and Hersey, P. (2004). Ingenol 3-angelate induces dual modes of cell death and differentially regulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in melanoma cells. Mol. Cancer Ther. 3, 1651-1658.
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 1651-1658
-
-
Gillespie, S.K.1
Zhang, X.D.2
Hersey, P.3
-
35
-
-
22744447211
-
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis
-
Giorgio, M., Migliaccio, E., Orsini, F. et al. (2005). Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 122, 221-233.
-
(2005)
Cell
, vol.122
, pp. 221-233
-
-
Giorgio, M.1
Migliaccio, E.2
Orsini, F.3
-
36
-
-
0033407483
-
Treatment of patients with metastatic melanoma with bryostatin-1--a phase II study
-
Gonzalez, R., Ebbinghaus, S., Henthorn, T.K., Miller, D., and Kraft, A.S. (1999). Treatment of patients with metastatic melanoma with bryostatin-1--a phase II study. Melanoma Res. 9, 599-606.
-
(1999)
Melanoma Res.
, vol.9
, pp. 599-606
-
-
Gonzalez, R.1
Ebbinghaus, S.2
Henthorn, T.K.3
Miller, D.4
Kraft, A.S.5
-
37
-
-
0042173193
-
Analysis of BRAF and N-RAS mutations in metastatic melanoma tissues
-
Gorden, A., Osman, I., Gai, W., He, D., Huang, W., Davidson, A., Houghton, A.N., Busam, K., and Polsky, D. (2003). Analysis of BRAF and N-RAS mutations in metastatic melanoma tissues. Cancer Res. 63, 3955-3957.
-
(2003)
Cancer Res.
, vol.63
, pp. 3955-3957
-
-
Gorden, A.1
Osman, I.2
Gai, W.3
He, D.4
Huang, W.5
Davidson, A.6
Houghton, A.N.7
Busam, K.8
Polsky, D.9
-
38
-
-
33847417986
-
Overexpression of Akt converts radial growth melanoma to vertical growth melanoma
-
Govindarajan, B., Sligh, J.E., Vincent, B.J. et al. (2007). Overexpression of Akt converts radial growth melanoma to vertical growth melanoma. J. Clin. Invest. 117, 719-729.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 719-729
-
-
Govindarajan, B.1
Sligh, J.E.2
Vincent, B.J.3
-
39
-
-
23844521568
-
The protein kinase Cβ-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
-
Graff, J.R., McNulty, A.M., Hanna, K.R. et al. (2005). The protein kinase Cβ-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res. 65, 7462-7469.
-
(2005)
Cancer Res.
, vol.65
, pp. 7462-7469
-
-
Graff, J.R.1
McNulty, A.M.2
Hanna, K.R.3
-
40
-
-
0030777104
-
Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
-
Guldberg, P., thor, S.P., Birck, A., Ahrenkiel, V., Kirkin, A.F., and Zeuthen, J. (1997). Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res. 57, 3660-3663.
-
(1997)
Cancer Res.
, vol.57
, pp. 3660-3663
-
-
Guldberg, P.1
Thor, S.P.2
Birck, A.3
Ahrenkiel, V.4
Kirkin, A.F.5
Zeuthen, J.6
-
41
-
-
23744432856
-
PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC
-
Hampson, P., Chahal, H., Khanim, F., Hayden, R., Mulder, A., Assi, L.K., Bunce, C.M., and Lord, J.M. (2005). PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. Blood 106, 1362-1368.
-
(2005)
Blood
, vol.106
, pp. 1362-1368
-
-
Hampson, P.1
Chahal, H.2
Khanim, F.3
Hayden, R.4
Mulder, A.5
Assi, L.K.6
Bunce, C.M.7
Lord, J.M.8
-
42
-
-
34248631942
-
Antitumor activity of enzastaurin (LY317615.HCl) against human cancer cell lines and freshly explanted tumors investigated in in-vitro [corrected] soft-agar cloning experiments
-
Hanauske, A.R., Oberschmidt, O., Hanauske-Abel, H., Lahn, M.M., and Eismann, U. (2007). Antitumor activity of enzastaurin (LY317615.HCl) against human cancer cell lines and freshly explanted tumors investigated in in-vitro [corrected] soft-agar cloning experiments. Invest. New Drugs 25, 205-210.
-
(2007)
Invest. New Drugs
, vol.25
, pp. 205-210
-
-
Hanauske, A.R.1
Oberschmidt, O.2
Hanauske-Abel, H.3
Lahn, M.M.4
Eismann, U.5
-
43
-
-
77949685981
-
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
-
Hatzivassiliou, G., Song, K., Yen, I. et al. (2010). RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 464, 431-435.
-
(2010)
Nature
, vol.464
, pp. 431-435
-
-
Hatzivassiliou, G.1
Song, K.2
Yen, I.3
-
44
-
-
0023253596
-
Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin
-
Hennings, H., Blumberg, P.M., Pettit, G.R., Herald, C.L., Shores, R., and Yuspa, S.H. (1987). Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin. Carcinogenesis 8, 1343-1346.
-
(1987)
Carcinogenesis
, vol.8
, pp. 1343-1346
-
-
Hennings, H.1
Blumberg, P.M.2
Pettit, G.R.3
Herald, C.L.4
Shores, R.5
Yuspa, S.H.6
-
45
-
-
0642376906
-
Protein kinase Cζ (PKCζ): activation mechanisms and cellular functions
-
Hirai, T., and Chida, K. (2003). Protein kinase Cζ (PKCζ): activation mechanisms and cellular functions. J. Biochem. 133, 1-7.
-
(2003)
J. Biochem.
, vol.133
, pp. 1-7
-
-
Hirai, T.1
Chida, K.2
-
46
-
-
0035513616
-
Endothelins are involved in regulating the proliferation and differentiation of mouse epidermal melanocytes in serum-free primary culture
-
Hirobe, T. (2001). Endothelins are involved in regulating the proliferation and differentiation of mouse epidermal melanocytes in serum-free primary culture. J. Invest. Dermatol. Symp. Proc. 6, 25-31.
-
(2001)
J. Invest. Dermatol. Symp. Proc.
, vol.6
, pp. 25-31
-
-
Hirobe, T.1
-
47
-
-
3442894137
-
Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas
-
Hoek, K., Rimm, D.L., Williams, K.R. et al. (2004). Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Cancer Res. 64, 5270-5282.
-
(2004)
Cancer Res.
, vol.64
, pp. 5270-5282
-
-
Hoek, K.1
Rimm, D.L.2
Williams, K.R.3
-
48
-
-
76849106075
-
Interaction with AKAP79 modifies the cellular pharmacology of PKC
-
Hoshi, N., Langeberg, L.K., Gould, C.M., Newton, A.C., and Scott, J.D. (2010). Interaction with AKAP79 modifies the cellular pharmacology of PKC. Mol. Cell 37, 541-550.
-
(2010)
Mol. Cell
, vol.37
, pp. 541-550
-
-
Hoshi, N.1
Langeberg, L.K.2
Gould, C.M.3
Newton, A.C.4
Scott, J.D.5
-
49
-
-
0031203749
-
The role of endothelin-1 in epidermal hyperpigmentation and signaling mechanisms of mitogenesis and melanogenesis
-
Imokawa, G., Kobayashi, T., Miyagishi, M., Higashi, K., and Yada, Y. (1997). The role of endothelin-1 in epidermal hyperpigmentation and signaling mechanisms of mitogenesis and melanogenesis. Pigment Cell Res. 10, 218-228.
-
(1997)
Pigment Cell Res.
, vol.10
, pp. 218-228
-
-
Imokawa, G.1
Kobayashi, T.2
Miyagishi, M.3
Higashi, K.4
Yada, Y.5
-
50
-
-
78650309875
-
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
-
Johannessen, C.M., Boehm, J.S., Kim, S.Y. et al. (2010). COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 468, 968-972.
-
(2010)
Nature
, vol.468
, pp. 968-972
-
-
Johannessen, C.M.1
Boehm, J.S.2
Kim, S.Y.3
-
51
-
-
0034025493
-
Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters
-
Kazanietz, M.G. (2000). Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters. Mol. Carcinog. 28, 5-11.
-
(2000)
Mol. Carcinog.
, vol.28
, pp. 5-11
-
-
Kazanietz, M.G.1
-
52
-
-
0027297104
-
Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes
-
Kazanietz, M.G., Areces, L.B., Bahador, A., Mischak, H., Goodnight, J., Mushinski, J.F., and Blumberg, P.M. (1993). Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes. Mol. Pharmacol. 44, 298-307.
-
(1993)
Mol. Pharmacol.
, vol.44
, pp. 298-307
-
-
Kazanietz, M.G.1
Areces, L.B.2
Bahador, A.3
Mischak, H.4
Goodnight, J.5
Mushinski, J.F.6
Blumberg, P.M.7
-
53
-
-
0442329299
-
LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice
-
Keyes, K.A., Mann, L., Sherman, M., Galbreath, E., Schirtzinger, L., Ballard, D., Chen, Y.F., Iversen, P., and Teicher, B.A. (2004). LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice. Cancer Chemother. Pharmacol 53, 133-140.
-
(2004)
Cancer Chemother. Pharmacol
, vol.53
, pp. 133-140
-
-
Keyes, K.A.1
Mann, L.2
Sherman, M.3
Galbreath, E.4
Schirtzinger, L.5
Ballard, D.6
Chen, Y.F.7
Iversen, P.8
Teicher, B.A.9
-
54
-
-
79959731072
-
A novel mouse PKCdelta splice variant, PKCdeltaIX, inhibits etoposide-induced apoptosis
-
Kim, J.D., Seo, K.W., Lee, E.A., Quang, N.N., Cho, H.R., and Kwon, B. (2011). A novel mouse PKCdelta splice variant, PKCdeltaIX, inhibits etoposide-induced apoptosis. Biochem. Biophys. Res. Commun. 410, 177-182.
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.410
, pp. 177-182
-
-
Kim, J.D.1
Seo, K.W.2
Lee, E.A.3
Quang, N.N.4
Cho, H.R.5
Kwon, B.6
-
55
-
-
0029887701
-
Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein
-
Klauck, T.M., Faux, M.C., Labudda, K., Langeberg, L.K., Jaken, S., and Scott, J.D. (1996). Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein. Science 271, 1589-1592.
-
(1996)
Science
, vol.271
, pp. 1589-1592
-
-
Klauck, T.M.1
Faux, M.C.2
Labudda, K.3
Langeberg, L.K.4
Jaken, S.5
Scott, J.D.6
-
56
-
-
84863012289
-
PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria
-
Lau, E., Kluger, H., Varsano, T., Lee, K., Scheffler, I., Rimm, D.L., Ideker, T., and Ronai, Z.A. (2012). PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Cell 148, 543-555.
-
(2012)
Cell
, vol.148
, pp. 543-555
-
-
Lau, E.1
Kluger, H.2
Varsano, T.3
Lee, K.4
Scheffler, I.5
Rimm, D.L.6
Ideker, T.7
Ronai, Z.A.8
-
57
-
-
0029759727
-
Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation
-
Lewis, J.M., Cheresh, D.A., and Schwartz, M.A. (1996). Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation. J. Cell Biol. 134, 1323-1332.
-
(1996)
J. Cell Biol.
, vol.134
, pp. 1323-1332
-
-
Lewis, J.M.1
Cheresh, D.A.2
Schwartz, M.A.3
-
58
-
-
0033233483
-
Protein kinase C δ targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector
-
Li, L., Lorenzo, P.S., Bogi, K., Blumberg, P.M., and Yuspa, S.H. (1999). Protein kinase C δ targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector. Mol. Cell. Biol. 19, 8547-8558.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 8547-8558
-
-
Li, L.1
Lorenzo, P.S.2
Bogi, K.3
Blumberg, P.M.4
Yuspa, S.H.5
-
59
-
-
77953155672
-
The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature
-
Li, L., Shukla, S., Lee, A., Garfield, S.H., Maloney, D.J., Ambudkar, S.V., and Yuspa, S.H. (2010). The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. Cancer Res. 70, 4509-4519.
-
(2010)
Cancer Res.
, vol.70
, pp. 4509-4519
-
-
Li, L.1
Shukla, S.2
Lee, A.3
Garfield, S.H.4
Maloney, D.J.5
Ambudkar, S.V.6
Yuspa, S.H.7
-
60
-
-
23044464191
-
RACK1 mediates activation of JNK by protein kinase C
-
Lopez-Bergami, P., Habelhah, H., Bhoumik, A., Zhang, W., Wang, L.H., and Ronai, Z. (2005). RACK1 mediates activation of JNK by protein kinase C. Mol. Cell 19, 309-320.
-
(2005)
Mol. Cell
, vol.19
, pp. 309-320
-
-
Lopez-Bergami, P.1
Habelhah, H.2
Bhoumik, A.3
Zhang, W.4
Wang, L.H.5
Ronai, Z.6
-
61
-
-
34247606483
-
Rewired ERK-JNK signaling pathways in melanoma
-
Lopez-Bergami, P., Huang, C., Goydos, J.S. et al. (2007). Rewired ERK-JNK signaling pathways in melanoma. Cancer Cell 11, 447-460.
-
(2007)
Cancer Cell
, vol.11
, pp. 447-460
-
-
Lopez-Bergami, P.1
Huang, C.2
Goydos, J.S.3
-
62
-
-
74049109400
-
c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis
-
Lopez-Bergami, P., Kim, H., Dewing, A., Goydos, J., Aaronson, S., and Ronai, Z. (2010). c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis. J. Biol. Chem. 285, 903-913.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 903-913
-
-
Lopez-Bergami, P.1
Kim, H.2
Dewing, A.3
Goydos, J.4
Aaronson, S.5
Ronai, Z.6
-
63
-
-
0027965006
-
Protein kinase C ζ isoform is critical for κB-dependent promoter activation by sphingomyelinase
-
Lozano, J., Berra, E., Municio, M.M., Diaz-Meco, M.T., Dominguez, I., Sanz, L., and Moscat, J. (1994). Protein kinase C ζ isoform is critical for κB-dependent promoter activation by sphingomyelinase. J. Biol. Chem. 269, 19200-19202.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 19200-19202
-
-
Lozano, J.1
Berra, E.2
Municio, M.M.3
Diaz-Meco, M.T.4
Dominguez, I.5
Sanz, L.6
Moscat, J.7
-
64
-
-
77949732137
-
3-phosphoinositide-dependent protein kinase-1 regulates proliferation and survival of cancer cells with an activated mitogen-activated protein kinase pathway
-
Lu, Z., Cox-Hipkin, M.A., Windsor, W.T., and Boyapati, A. (2010). 3-phosphoinositide-dependent protein kinase-1 regulates proliferation and survival of cancer cells with an activated mitogen-activated protein kinase pathway. Mol. Cancer Res. 8, 421-432.
-
(2010)
Mol. Cancer Res.
, vol.8
, pp. 421-432
-
-
Lu, Z.1
Cox-Hipkin, M.A.2
Windsor, W.T.3
Boyapati, A.4
-
65
-
-
34250902930
-
Targeting the protein kinase C family: are we there yet?
-
Mackay, H.J., and Twelves, C.J. (2007). Targeting the protein kinase C family: are we there yet? Nat. Rev. Cancer 7, 554-562.
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 554-562
-
-
Mackay, H.J.1
Twelves, C.J.2
-
66
-
-
33646372468
-
Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates ERK1/2 via PKCε
-
Marin, Y.E., Namkoong, J., Cohen-Solal, K., Shin, S.S., Martino, J.J., Oka, M., and Chen, S. (2006). Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates ERK1/2 via PKCε. Cell. Signal. 18, 1279-1286.
-
(2006)
Cell. Signal.
, vol.18
, pp. 1279-1286
-
-
Marin, Y.E.1
Namkoong, J.2
Cohen-Solal, K.3
Shin, S.S.4
Martino, J.J.5
Oka, M.6
Chen, S.7
-
67
-
-
77956061891
-
The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells
-
Mason, S.A., Cozzi, S.J., Pierce, C.J., Pavey, S.J., Parsons, P.G., and Boyle, G.M. (2009). The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells. Invest. New Drugs 28, 575-586.
-
(2009)
Invest. New Drugs
, vol.28
, pp. 575-586
-
-
Mason, S.A.1
Cozzi, S.J.2
Pierce, C.J.3
Pavey, S.J.4
Parsons, P.G.5
Boyle, G.M.6
-
68
-
-
0035884882
-
Aberrant redox regulation in human metastatic melanoma cells compared to normal melanocytes
-
Meyskens Jr, F.L., McNulty, S.E., Buckmeier, J.A., Tohidian, N.B., Spillane, T.J., Kahlon, R.S., and Gonzalez, R.I. (2001). Aberrant redox regulation in human metastatic melanoma cells compared to normal melanocytes. Free Radic. Biol. Med. 31, 799-808.
-
(2001)
Free Radic. Biol. Med.
, vol.31
, pp. 799-808
-
-
Meyskens Jr., F.L.1
McNulty, S.E.2
Buckmeier, J.A.3
Tohidian, N.B.4
Spillane, T.J.5
Kahlon, R.S.6
Gonzalez, R.I.7
-
69
-
-
35948958991
-
Regulation of docetaxel-induced apoptosis of human melanoma cells by different isoforms of protein kinase C
-
Mhaidat, N.M., Thorne, R.F., Zhang, X.D., and Hersey, P. (2007). Regulation of docetaxel-induced apoptosis of human melanoma cells by different isoforms of protein kinase C. Mol. Cancer Res. 5, 1073-1081.
-
(2007)
Mol. Cancer Res.
, vol.5
, pp. 1073-1081
-
-
Mhaidat, N.M.1
Thorne, R.F.2
Zhang, X.D.3
Hersey, P.4
-
70
-
-
56349170252
-
Involvement of endoplasmic reticulum stress in Docetaxel-induced JNK-dependent apoptosis of human melanoma
-
Mhaidat, N.M., Thorne, R., Zhang, X.D., and Hersey, P. (2008). Involvement of endoplasmic reticulum stress in Docetaxel-induced JNK-dependent apoptosis of human melanoma. Apoptosis 13, 1505-1512.
-
(2008)
Apoptosis
, vol.13
, pp. 1505-1512
-
-
Mhaidat, N.M.1
Thorne, R.2
Zhang, X.D.3
Hersey, P.4
-
71
-
-
33746114249
-
Epigenetic silencing of the PTEN gene in melanoma
-
Mirmohammadsadegh, A., Marini, A., Nambiar, S., Hassan, M., Tannapfel, A., Ruzicka, T., and Hengge, U.R. (2006). Epigenetic silencing of the PTEN gene in melanoma. Cancer Res. 66, 6546-6552.
-
(2006)
Cancer Res.
, vol.66
, pp. 6546-6552
-
-
Mirmohammadsadegh, A.1
Marini, A.2
Nambiar, S.3
Hassan, M.4
Tannapfel, A.5
Ruzicka, T.6
Hengge, U.R.7
-
72
-
-
0018579119
-
Effects of 12-O-tetradecanoylphorbol-13-acetate and mezerein on epidermal ornithine decarboxylase activity, isoproterenol-stimulated levels of cyclic adenosine 3′:5′-monophosphate, and induction of mouse skin tumors in vivo
-
Mufson, R.A., Fischer, S.M., Verma, A.K., Gleason, G.L., Slaga, T.J., and Boutwell, R.K. (1979). Effects of 12-O-tetradecanoylphorbol-13-acetate and mezerein on epidermal ornithine decarboxylase activity, isoproterenol-stimulated levels of cyclic adenosine 3′:5′-monophosphate, and induction of mouse skin tumors in vivo. Cancer Res. 39, 4791-4795.
-
(1979)
Cancer Res.
, vol.39
, pp. 4791-4795
-
-
Mufson, R.A.1
Fischer, S.M.2
Verma, A.K.3
Gleason, G.L.4
Slaga, T.J.5
Boutwell, R.K.6
-
73
-
-
0029003788
-
PKCζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid
-
Muller, G., Ayoub, M., Storz, P., Rennecke, J., Fabbro, D., and Pfizenmaier, K. (1995). PKCζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid. EMBO J. 14, 1961-1969.
-
(1995)
EMBO J.
, vol.14
, pp. 1961-1969
-
-
Muller, G.1
Ayoub, M.2
Storz, P.3
Rennecke, J.4
Fabbro, D.5
Pfizenmaier, K.6
-
74
-
-
0027535742
-
Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate
-
Nakanishi, H., Brewer, K.A., and Exton, J.H. (1993). Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3, 4, 5-trisphosphate. J. Biol. Chem. 268, 13-16.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 13-16
-
-
Nakanishi, H.1
Brewer, K.A.2
Exton, J.H.3
-
75
-
-
78650303507
-
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
-
Nazarian, R., Shi, H., Wang, Q. et al. (2010). Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 468, 973-977.
-
(2010)
Nature
, vol.468
, pp. 973-977
-
-
Nazarian, R.1
Shi, H.2
Wang, Q.3
-
76
-
-
0037337159
-
Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm
-
Newton, A.C. (2003). Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem. J. 370, 361-371.
-
(2003)
Biochem. J.
, vol.370
, pp. 361-371
-
-
Newton, A.C.1
-
77
-
-
0031012892
-
Determination of the specific substrate sequence motifs of protein kinase C isozymes
-
Nishikawa, K., Toker, A., Johannes, F.J., Songyang, Z., and Cantley, L.C. (1997). Determination of the specific substrate sequence motifs of protein kinase C isozymes. J. Biol. Chem. 272, 952-960.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 952-960
-
-
Nishikawa, K.1
Toker, A.2
Johannes, F.J.3
Songyang, Z.4
Cantley, L.C.5
-
78
-
-
0026451081
-
Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
-
Nishizuka, Y. (1992). Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258, 607-614.
-
(1992)
Science
, vol.258
, pp. 607-614
-
-
Nishizuka, Y.1
-
79
-
-
0026781998
-
Cloning and characterization of the major promoter of the human protein kinase C β gene. Regulation by phorbol esters
-
Obeid, L.M., Blobe, G.C., Karolak, L.A., and Hannun, Y.A. (1992). Cloning and characterization of the major promoter of the human protein kinase C β gene. Regulation by phorbol esters. J. Biol. Chem. 267, 20804-20810.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 20804-20810
-
-
Obeid, L.M.1
Blobe, G.C.2
Karolak, L.A.3
Hannun, Y.A.4
-
80
-
-
73849123750
-
The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma
-
O'Connell, M.P., Fiori, J.L., Xu, M. et al. (2010). The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. Oncogene 29, 34-44.
-
(2010)
Oncogene
, vol.29
, pp. 34-44
-
-
O'Connell, M.P.1
Fiori, J.L.2
Xu, M.3
-
81
-
-
0029893170
-
Deletion of specific protein kinase C subspecies in human melanoma cells
-
Oka, M., Ogita, K., Ando, H., Horikawa, T., Hayashibe, K., Saito, N., Kikkawa, U., and Ichihashi, M. (1996). Deletion of specific protein kinase C subspecies in human melanoma cells. J. Cell. Physiol. 167, 406-412.
-
(1996)
J. Cell. Physiol.
, vol.167
, pp. 406-412
-
-
Oka, M.1
Ogita, K.2
Ando, H.3
Horikawa, T.4
Hayashibe, K.5
Saito, N.6
Kikkawa, U.7
Ichihashi, M.8
-
82
-
-
30644475507
-
Expression of PKC isoforms in human melanocytic cells in situ
-
Oka, M., Nishigori, C., Kageshita, T., Hsu, M.Y., Penmatcha, S., and Herlyn, M. (2006). Expression of PKC isoforms in human melanocytic cells in situ. J. Dermatol. Sci. 41, 157-161.
-
(2006)
J. Dermatol. Sci.
, vol.41
, pp. 157-161
-
-
Oka, M.1
Nishigori, C.2
Kageshita, T.3
Hsu, M.Y.4
Penmatcha, S.5
Herlyn, M.6
-
83
-
-
37049013504
-
Protein kinase C-βII represses hepatocyte growth factor-induced invasion by preventing the association of adapter protein Gab1 and phosphatidylinositol 3-kinase in melanoma cells
-
Oka, M., Kikkawa, U., and Nishigori, C. (2008). Protein kinase C-βII represses hepatocyte growth factor-induced invasion by preventing the association of adapter protein Gab1 and phosphatidylinositol 3-kinase in melanoma cells. J. Invest. Dermatol. 128, 188-195.
-
(2008)
J. Invest. Dermatol.
, vol.128
, pp. 188-195
-
-
Oka, M.1
Kikkawa, U.2
Nishigori, C.3
-
84
-
-
0022452419
-
Two types of complementary DNAs of rat brain protein kinase C. Heterogeneity determined by alternative splicing
-
Ono, Y., Kurokawa, T., Fujii, T., Kawahara, K., Igarashi, K., Kikkawa, U., Ogita, K., and Nishizuka, Y. (1986). Two types of complementary DNAs of rat brain protein kinase C. Heterogeneity determined by alternative splicing. FEBS Lett. 206, 347-352.
-
(1986)
FEBS Lett.
, vol.206
, pp. 347-352
-
-
Ono, Y.1
Kurokawa, T.2
Fujii, T.3
Kawahara, K.4
Igarashi, K.5
Kikkawa, U.6
Ogita, K.7
Nishizuka, Y.8
-
85
-
-
0027314530
-
The β isoform of protein kinase C stimulates human melanogenesis by activating tyrosinase in pigment cells
-
Park, H.Y., Russakovsky, V., Ohno, S., and Gilchrest, B.A. (1993). The β isoform of protein kinase C stimulates human melanogenesis by activating tyrosinase in pigment cells. J. Biol. Chem. 268, 11742-11749.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 11742-11749
-
-
Park, H.Y.1
Russakovsky, V.2
Ohno, S.3
Gilchrest, B.A.4
-
86
-
-
0030601351
-
Alpha-melanocyte stimulating hormone-induced pigmentation is blocked by depletion of protein kinase C
-
Park, H.Y., Russakovsky, V., Ao, Y., Fernandez, E., and Gilchrest, B.A. (1996). Alpha-melanocyte stimulating hormone-induced pigmentation is blocked by depletion of protein kinase C. Exp. Cell Res. 227, 70-79.
-
(1996)
Exp. Cell Res.
, vol.227
, pp. 70-79
-
-
Park, H.Y.1
Russakovsky, V.2
Ao, Y.3
Fernandez, E.4
Gilchrest, B.A.5
-
87
-
-
0033523009
-
Protein kinase C-β activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain
-
Park, H.Y., Perez, J.M., Laursen, R., Hara, M., and Gilchrest, B.A. (1999). Protein kinase C-β activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain. J. Biol. Chem. 274, 16470-16478.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 16470-16478
-
-
Park, H.Y.1
Perez, J.M.2
Laursen, R.3
Hara, M.4
Gilchrest, B.A.5
-
88
-
-
1642534508
-
Topical application of a protein kinase C inhibitor reduces skin and hair pigmentation
-
Park, H.Y., Lee, J., Gonzalez, S., Middelkamp-Hup, M.A., Kapasi, S., Peterson, S., and Gilchrest, B.A. (2004a). Topical application of a protein kinase C inhibitor reduces skin and hair pigmentation. J. Invest. Dermatol. 122, 159-166.
-
(2004)
J. Invest. Dermatol.
, vol.122
, pp. 159-166
-
-
Park, H.Y.1
Lee, J.2
Gonzalez, S.3
Middelkamp-Hup, M.A.4
Kapasi, S.5
Peterson, S.6
Gilchrest, B.A.7
-
89
-
-
4444313466
-
The receptor for activated C-kinase-I (RACK-I) anchors activated PKC-β on melanosomes
-
Park, H.Y., Wu, H., Killoran, C.E., and Gilchrest, B.A. (2004b). The receptor for activated C-kinase-I (RACK-I) anchors activated PKC-β on melanosomes. J. Cell Sci. 117, 3659-3668.
-
(2004)
J. Cell Sci.
, vol.117
, pp. 3659-3668
-
-
Park, H.Y.1
Wu, H.2
Killoran, C.E.3
Gilchrest, B.A.4
-
90
-
-
33646256124
-
MITF mediates cAMP-induced protein kinase C-β expression in human melanocytes
-
Park, H.Y., Wu, C., Yonemoto, L., Murphy-Smith, M., Wu, H., Stachur, C.M., and Gilchrest, B.A. (2006). MITF mediates cAMP-induced protein kinase C-β expression in human melanocytes. Biochem. J. 395, 571-578.
-
(2006)
Biochem. J.
, vol.395
, pp. 571-578
-
-
Park, H.Y.1
Wu, C.2
Yonemoto, L.3
Murphy-Smith, M.4
Wu, H.5
Stachur, C.M.6
Gilchrest, B.A.7
-
91
-
-
0036289824
-
Differential localisation of nPKCδ during cell cycle progression
-
Perego, C., Porro, D., and La Porta, C.A. (2002). Differential localisation of nPKCδ during cell cycle progression. Biochem. Biophys. Res. Commun. 294, 127-131.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.294
, pp. 127-131
-
-
Perego, C.1
Porro, D.2
La Porta, C.A.3
-
92
-
-
33846817351
-
Protein kinase C β and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc
-
Pinton, P., Rimessi, A., Marchi, S. et al. (2007). Protein kinase C β and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc. Science, 315, 659-663.
-
(2007)
Science
, vol.315
, pp. 659-663
-
-
Pinton, P.1
Rimessi, A.2
Marchi, S.3
-
93
-
-
0024433286
-
Serum-free culture of normal human melanocytes: growth kinetics and growth factor requirements
-
Pittelkow, M.R., and Shipley, G.D. (1989). Serum-free culture of normal human melanocytes: growth kinetics and growth factor requirements. J. Cell. Physiol. 140, 565-576.
-
(1989)
J. Cell. Physiol.
, vol.140
, pp. 565-576
-
-
Pittelkow, M.R.1
Shipley, G.D.2
-
94
-
-
77949732073
-
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
-
Poulikakos, P.I., Zhang, C., Bollag, G., Shokat, K.M., and Rosen, N. (2010). RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 464, 427-430.
-
(2010)
Nature
, vol.464
, pp. 427-430
-
-
Poulikakos, P.I.1
Zhang, C.2
Bollag, G.3
Shokat, K.M.4
Rosen, N.5
-
95
-
-
83455254767
-
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
-
Poulikakos, P.I., Persaud, Y., Janakiraman, M. et al. (2011). RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature, 480, 387-390.
-
(2011)
Nature
, vol.480
, pp. 387-390
-
-
Poulikakos, P.I.1
Persaud, Y.2
Janakiraman, M.3
-
96
-
-
0027391003
-
Protein kinase C β expression in melanoma cells and melanocytes: differential expression correlates with biological responses to 12-O-tetradecanoylphorbol 13-acetate
-
Powell, M.B., Rosenberg, R.K., Graham, M.J., Birch, M.L., Yamanishi, D.T., Buckmeier, J.A., and Meyskens Jr, F.L. (1993). Protein kinase C β expression in melanoma cells and melanocytes: differential expression correlates with biological responses to 12-O-tetradecanoylphorbol 13-acetate. J. Cancer Res. Clin. Oncol. 119, 199-206.
-
(1993)
J. Cancer Res. Clin. Oncol.
, vol.119
, pp. 199-206
-
-
Powell, M.B.1
Rosenberg, R.K.2
Graham, M.J.3
Birch, M.L.4
Yamanishi, D.T.5
Buckmeier, J.A.6
Meyskens Jr., F.L.7
-
97
-
-
0031760304
-
A phase II study of bryostatin 1 in metastatic malignant melanoma
-
Propper, D.J., Macaulay, V., O'Byrne, K.J., Braybrooke, J.P., Wilner, S.M., Ganesan, T.S., Talbot, D.C., and Harris, A.L. (1998). A phase II study of bryostatin 1 in metastatic malignant melanoma. Br. J. Cancer 78, 1337-1341.
-
(1998)
Br. J. Cancer
, vol.78
, pp. 1337-1341
-
-
Propper, D.J.1
Macaulay, V.2
O'Byrne, K.J.3
Braybrooke, J.P.4
Wilner, S.M.5
Ganesan, T.S.6
Talbot, D.C.7
Harris, A.L.8
-
98
-
-
72449199923
-
Src, PKCα, and PKCδ are required for αvβ3 integrin-mediated metastatic melanoma invasion
-
Putnam, A.J., Schulz, V.V., Freiter, E.M., Bill, H.M., and Miranti, C.K. (2009). Src, PKCα, and PKCδ are required for αvβ3 integrin-mediated metastatic melanoma invasion. Cell Commun. Signal. 7, 10.
-
(2009)
Cell Commun. Signal.
, vol.7
, pp. 10
-
-
Putnam, A.J.1
Schulz, V.V.2
Freiter, E.M.3
Bill, H.M.4
Miranti, C.K.5
-
99
-
-
79952447390
-
The sap from Euphorbia peplus is effective against human nonmelanoma skin cancers
-
Ramsay, J.R., Suhrbier, A., Aylward, J.H., Ogbourne, S., Cozzi, S.J., Poulsen, M.G., Baumann, K.C., Welburn, P., Redlich, G.L., and Parsons, P.G. (2011). The sap from Euphorbia peplus is effective against human nonmelanoma skin cancers. Br. J. Dermatol. 164, 633-636.
-
(2011)
Br. J. Dermatol.
, vol.164
, pp. 633-636
-
-
Ramsay, J.R.1
Suhrbier, A.2
Aylward, J.H.3
Ogbourne, S.4
Cozzi, S.J.5
Poulsen, M.G.6
Baumann, K.C.7
Welburn, P.8
Redlich, G.L.9
Parsons, P.G.10
-
100
-
-
33748328365
-
Enzastaurin (LY317615), a protein kinase Cβ inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines
-
Rizvi, M.A., Ghias, K., Davies, K.M., Ma, C., Weinberg, F., Munshi, H.G., Krett, N.L., and Rosen, S.T. (2006). Enzastaurin (LY317615), a protein kinase Cβ inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines. Mol. Cancer Ther. 5, 1783-1789.
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 1783-1789
-
-
Rizvi, M.A.1
Ghias, K.2
Davies, K.M.3
Ma, C.4
Weinberg, F.5
Munshi, H.G.6
Krett, N.L.7
Rosen, S.T.8
-
101
-
-
35248864084
-
Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression
-
Ryu, B., Kim, D.S., Deluca, A.M., and Alani, R.M. (2007). Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression. PLoS ONE 2, e594.
-
(2007)
PLoS ONE
, vol.2
-
-
Ryu, B.1
Kim, D.S.2
Deluca, A.M.3
Alani, R.M.4
-
102
-
-
0023629814
-
Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells
-
Sako, T., Yuspa, S.H., Herald, C.L., Pettit, G.R., and Blumberg, P.M. (1987). Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells. Cancer Res. 47, 5445-5450.
-
(1987)
Cancer Res.
, vol.47
, pp. 5445-5450
-
-
Sako, T.1
Yuspa, S.H.2
Herald, C.L.3
Pettit, G.R.4
Blumberg, P.M.5
-
103
-
-
0034757405
-
Atypical protein kinase Cζ suppresses migration of mouse melanoma cells
-
Sanz-Navares, E., Fernandez, N., Kazanietz, M.G., and Rotenberg, S.A. (2001). Atypical protein kinase Cζ suppresses migration of mouse melanoma cells. Cell Growth Differ. 12, 517-524.
-
(2001)
Cell Growth Differ.
, vol.12
, pp. 517-524
-
-
Sanz-Navares, E.1
Fernandez, N.2
Kazanietz, M.G.3
Rotenberg, S.A.4
-
104
-
-
0035474310
-
Adaptor proteins in protein kinase C-mediated signal transduction
-
Schechtman, D., and Mochly-Rosen, D. (2001). Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene 20, 6339-6347.
-
(2001)
Oncogene
, vol.20
, pp. 6339-6347
-
-
Schechtman, D.1
Mochly-Rosen, D.2
-
105
-
-
0039791449
-
Activation of the mitogen-activated protein kinase/extracellular signal- regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
-
Schonwasser, D.C., Marais, R.M., Marshall, C.J., and Parker, P.J. (1998). Activation of the mitogen-activated protein kinase/extracellular signal- regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol. Cell. Biol. 18, 790-798.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 790-798
-
-
Schonwasser, D.C.1
Marais, R.M.2
Marshall, C.J.3
Parker, P.J.4
-
106
-
-
0025961690
-
Successful treatment of murine melanoma with bryostatin 1
-
Schuchter, L.M., Esa, A.H., May, S., Laulis, M.K., Pettit, G.R., and Hess, A.D. (1991). Successful treatment of murine melanoma with bryostatin 1. Cancer Res. 51, 682-687.
-
(1991)
Cancer Res.
, vol.51
, pp. 682-687
-
-
Schuchter, L.M.1
Esa, A.H.2
May, S.3
Laulis, M.K.4
Pettit, G.R.5
Hess, A.D.6
-
107
-
-
33847016103
-
Lysophosphatidylcholine mediates melanocyte dendricity through PKCζ activation
-
Scott, G.A., Arioka, M., and Jacobs, S.E. (2007). Lysophosphatidylcholine mediates melanocyte dendricity through PKCζ activation. J. Invest. Dermatol. 127, 668-675.
-
(2007)
J. Invest. Dermatol.
, vol.127
, pp. 668-675
-
-
Scott, G.A.1
Arioka, M.2
Jacobs, S.E.3
-
108
-
-
0035999087
-
Protein kinase C isoforms in normal and transformed cells of the melanocytic lineage
-
Selzer, E., Okamoto, I., Lucas, T., Kodym, R., Pehamberger, H., and Jansen, B. (2002). Protein kinase C isoforms in normal and transformed cells of the melanocytic lineage. Melanoma Res. 12, 201-209.
-
(2002)
Melanoma Res.
, vol.12
, pp. 201-209
-
-
Selzer, E.1
Okamoto, I.2
Lucas, T.3
Kodym, R.4
Pehamberger, H.5
Jansen, B.6
-
109
-
-
14844318039
-
Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane through 15(S)-hydroxyeicosatetraenoic acid synthesis
-
Sharma, G.D., Ottino, P., Bazan, N.G., and Bazan, H.E. (2005). Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane through 15(S)-hydroxyeicosatetraenoic acid synthesis. J. Biol. Chem. 280, 7917-7924.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 7917-7924
-
-
Sharma, G.D.1
Ottino, P.2
Bazan, N.G.3
Bazan, H.E.4
-
110
-
-
34447630662
-
Protein kinase C alpha and epsilon differentially modulate hepatocyte growth factor-induced epithelial proliferation and migration
-
Sharma, G.D., Kakazu, A., and Bazan, H.E. (2007). Protein kinase C alpha and epsilon differentially modulate hepatocyte growth factor-induced epithelial proliferation and migration. Exp. Eye Res. 85, 289-297.
-
(2007)
Exp. Eye Res.
, vol.85
, pp. 289-297
-
-
Sharma, G.D.1
Kakazu, A.2
Bazan, H.E.3
-
111
-
-
58249101137
-
PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: results of a randomized, double-blind, vehicle-controlled, multicentre, phase IIa study
-
Siller, G., Gebauer, K., Welburn, P., Katsamas, J., and Ogbourne, S.M. (2009). PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: results of a randomized, double-blind, vehicle-controlled, multicentre, phase IIa study. Australas. J. Dermatol. 50, 16-22.
-
(2009)
Australas. J. Dermatol.
, vol.50
, pp. 16-22
-
-
Siller, G.1
Gebauer, K.2
Welburn, P.3
Katsamas, J.4
Ogbourne, S.M.5
-
112
-
-
77951989505
-
PEP005 (ingenol mebutate) gel for the topical treatment of superficial basal cell carcinoma: results of a randomized phase IIa trial
-
Siller, G., Rosen, R., Freeman, M., Welburn, P., Katsamas, J., and Ogbourne, S.M. (2010). PEP005 (ingenol mebutate) gel for the topical treatment of superficial basal cell carcinoma: results of a randomized phase IIa trial. Australas. J. Dermatol. 51, 99-105.
-
(2010)
Australas. J. Dermatol.
, vol.51
, pp. 99-105
-
-
Siller, G.1
Rosen, R.2
Freeman, M.3
Welburn, P.4
Katsamas, J.5
Ogbourne, S.M.6
-
113
-
-
79951961755
-
Resistance to BRAF inhibition in melanomas
-
Solit, D.B., and Rosen, N. (2011). Resistance to BRAF inhibition in melanomas. N. Engl. J. Med. 364, 772-774.
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 772-774
-
-
Solit, D.B.1
Rosen, N.2
-
114
-
-
84863116743
-
Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
-
Sosman, J.A., Kim, K.B., Schuchter, L. et al. (2012). Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N. Engl. J. Med. 366, 707-714.
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 707-714
-
-
Sosman, J.A.1
Kim, K.B.2
Schuchter, L.3
-
115
-
-
33645048160
-
Proteomic and SAGE profiling of murine melanoma progression indicates the reduction of proteins responsible for ROS degradation
-
de Souza, G.A., Godoy, L.M., Teixeira, V.R. et al. (2006). Proteomic and SAGE profiling of murine melanoma progression indicates the reduction of proteins responsible for ROS degradation. Proteomics 6, 1460-1470.
-
(2006)
Proteomics
, vol.6
, pp. 1460-1470
-
-
de Souza, G.A.1
Godoy, L.M.2
Teixeira, V.R.3
-
116
-
-
0038243115
-
Loss of PTEN promotes tumor development in malignant melanoma
-
Stahl, J.M., Cheung, M., Sharma, A., Trivedi, N.R., Shanmugam, S., and Robertson, G.P. (2003). Loss of PTEN promotes tumor development in malignant melanoma. Cancer Res. 63, 2881-2890.
-
(2003)
Cancer Res.
, vol.63
, pp. 2881-2890
-
-
Stahl, J.M.1
Cheung, M.2
Sharma, A.3
Trivedi, N.R.4
Shanmugam, S.5
Robertson, G.P.6
-
117
-
-
58149237395
-
Model cell culture system for defining the molecular and biochemical events mediating terminal differentiation of human melanoma cells
-
Staudt, M.R., Depass, A.L., Sarkar, D., and Fisher, P.B. (2008). Model cell culture system for defining the molecular and biochemical events mediating terminal differentiation of human melanoma cells. J. Cell. Physiol. 218, 304-314.
-
(2008)
J. Cell. Physiol.
, vol.218
, pp. 304-314
-
-
Staudt, M.R.1
Depass, A.L.2
Sarkar, D.3
Fisher, P.B.4
-
118
-
-
0035839578
-
Binding specificity for RACK1 resides in the V5 region of βII protein kinase C
-
Stebbins, E.G., and Mochly-Rosen, D. (2001). Binding specificity for RACK1 resides in the V5 region of βII protein kinase C. J. Biol. Chem. 276, 29644-29650.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 29644-29650
-
-
Stebbins, E.G.1
Mochly-Rosen, D.2
-
119
-
-
0028902719
-
Long-term proliferation of human melanocytes is supported by the physiologic mitogens alpha-melanotropin, endothelin-1, and basic fibroblast growth factor
-
Swope, V.B., Medrano, E.E., Smalara, D., and Abdel-Malek, Z.A. (1995). Long-term proliferation of human melanocytes is supported by the physiologic mitogens alpha-melanotropin, endothelin-1, and basic fibroblast growth factor. Exp. Cell Res. 217, 453-459.
-
(1995)
Exp. Cell Res.
, vol.217
, pp. 453-459
-
-
Swope, V.B.1
Medrano, E.E.2
Smalara, D.3
Abdel-Malek, Z.A.4
-
120
-
-
0035177562
-
Associations of PKC isoforms with the cytoskeleton of B16F10 melanoma cells
-
Szalay, J., Bruno, P., Bhati, R., Adjodha, J., Schueler, D., Summerville, V., and Vazeos, R. (2001). Associations of PKC isoforms with the cytoskeleton of B16F10 melanoma cells. J. Histochem. Cytochem. 49, 49-66.
-
(2001)
J. Histochem. Cytochem.
, vol.49
, pp. 49-66
-
-
Szalay, J.1
Bruno, P.2
Bhati, R.3
Adjodha, J.4
Schueler, D.5
Summerville, V.6
Vazeos, R.7
-
121
-
-
0028055160
-
Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts
-
Szallasi, Z., Smith, C.B., Pettit, G.R., and Blumberg, P.M. (1994). Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts. J. Biol. Chem. 269, 2118-2124.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 2118-2124
-
-
Szallasi, Z.1
Smith, C.B.2
Pettit, G.R.3
Blumberg, P.M.4
-
122
-
-
0028960503
-
Differential regulation by anti-tumor-promoting 12-deoxyphorbol- 13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biological responses of primary mouse keratinocytes
-
Szallasi, Z., Kosa, K., Smith, C.B., Dlugosz, A.A., Williams, E.K., Yuspa, S.H., and Blumberg, P.M. (1995). Differential regulation by anti-tumor-promoting 12-deoxyphorbol- 13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biological responses of primary mouse keratinocytes. Mol. Pharmacol. 47, 258-265.
-
(1995)
Mol. Pharmacol.
, vol.47
, pp. 258-265
-
-
Szallasi, Z.1
Kosa, K.2
Smith, C.B.3
Dlugosz, A.A.4
Williams, E.K.5
Yuspa, S.H.6
Blumberg, P.M.7
-
123
-
-
0029892167
-
The bryostatins inhibit growth of B16/F10 melanoma cells in vitro through a protein kinase C-independent mechanism: dissociation of activities using 26-epi-bryostatin 1
-
Szallasi, Z., Du, L., Levine, R., Lewin, N.E., Nguyen, P.N., Williams, M.D., Pettit, G.R., and Blumberg, P.M. (1996). The bryostatins inhibit growth of B16/F10 melanoma cells in vitro through a protein kinase C-independent mechanism: dissociation of activities using 26-epi-bryostatin 1. Cancer Res. 56, 2105-2111.
-
(1996)
Cancer Res.
, vol.56
, pp. 2105-2111
-
-
Szallasi, Z.1
Du, L.2
Levine, R.3
Lewin, N.E.4
Nguyen, P.N.5
Williams, M.D.6
Pettit, G.R.7
Blumberg, P.M.8
-
124
-
-
0036137647
-
Antiangiogenic effects of a protein kinase C β-selective small molecule
-
Teicher, B.A., Alvarez, E., Menon, K., Esterman, M.A., Considine, E., Shih, C., and Faul, M.M. (2002). Antiangiogenic effects of a protein kinase C β-selective small molecule. Cancer Chemother. Pharmacol. 49, 69-77.
-
(2002)
Cancer Chemother. Pharmacol.
, vol.49
, pp. 69-77
-
-
Teicher, B.A.1
Alvarez, E.2
Menon, K.3
Esterman, M.A.4
Considine, E.5
Shih, C.6
Faul, M.M.7
-
125
-
-
14444269482
-
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines
-
Teng, D.H., Hu, R., Lin, H. et al. (1997). MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res. 57, 5221-5225.
-
(1997)
Cancer Res.
, vol.57
, pp. 5221-5225
-
-
Teng, D.H.1
Hu, R.2
Lin, H.3
-
126
-
-
0036829335
-
A randomized phase II study of two schedules of bryostatin-1 (NSC339555) in patients with advanced malignant melanoma: A National Cancer Institute of Canada Clinical Trials Group study
-
Tozer, R.G., Burdette-Radoux, S., Berlanger, K., Davis, M.L., Lohmann, R.C., Rusthoven, J.R., Wainman, N., Zee, B., and Seymour, L. (2002). A randomized phase II study of two schedules of bryostatin-1 (NSC339555) in patients with advanced malignant melanoma: A National Cancer Institute of Canada Clinical Trials Group study. Invest. New Drugs 20, 407-412.
-
(2002)
Invest. New Drugs
, vol.20
, pp. 407-412
-
-
Tozer, R.G.1
Burdette-Radoux, S.2
Berlanger, K.3
Davis, M.L.4
Lohmann, R.C.5
Rusthoven, J.R.6
Wainman, N.7
Zee, B.8
Seymour, L.9
-
127
-
-
0029789967
-
Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf
-
Ueda, Y., Hirai, S., Osada, S., Suzuki, A., Mizuno, K., and Ohno, S. (1996). Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J. Biol. Chem. 271, 23512-23519.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 23512-23519
-
-
Ueda, Y.1
Hirai, S.2
Osada, S.3
Suzuki, A.4
Mizuno, K.5
Ohno, S.6
-
128
-
-
59049107421
-
Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
-
Van Raamsdonk, C.D., Bezrookove, V., Green, G., Bauer, J., Gaugler, L., O'Brien, J.M., Simpson, E.M., Barsh, G.S., and Bastian, B.C. (2009). Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature 457, 599-602.
-
(2009)
Nature
, vol.457
, pp. 599-602
-
-
Van Raamsdonk, C.D.1
Bezrookove, V.2
Green, G.3
Bauer, J.4
Gaugler, L.5
O'Brien, J.M.6
Simpson, E.M.7
Barsh, G.S.8
Bastian, B.C.9
-
129
-
-
78651446131
-
Mutations in GNA11 in uveal melanoma
-
Van Raamsdonk, C.D., Griewank, K.G., Crosby, M.B. et al. (2010). Mutations in GNA11 in uveal melanoma. N. Engl. J. Med. 363, 2191-2199.
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 2191-2199
-
-
Van Raamsdonk, C.D.1
Griewank, K.G.2
Crosby, M.B.3
-
130
-
-
78650008177
-
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
-
Villanueva, J., Vultur, A., Lee, J.T. et al. (2010). Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell 18, 683-695.
-
(2010)
Cancer Cell
, vol.18
, pp. 683-695
-
-
Villanueva, J.1
Vultur, A.2
Lee, J.T.3
-
131
-
-
77949350426
-
Functional alterations in protein kinase C beta II expression in melanoma
-
Voris, J.P., Sitailo, L.A., Rahn, H.R., Defnet, A., Gerds, A.T., Sprague, R., Yadav, V., Caroline, L.P.I., and Denning, M.F. (2010). Functional alterations in protein kinase C beta II expression in melanoma. Pigment Cell Melanoma Res. 23, 216-224.
-
(2010)
Pigment Cell Melanoma Res.
, vol.23
, pp. 216-224
-
-
Voris, J.P.1
Sitailo, L.A.2
Rahn, H.R.3
Defnet, A.4
Gerds, A.T.5
Sprague, R.6
Yadav, V.7
Caroline, L.P.I.8
Denning, M.F.9
-
132
-
-
80051625929
-
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
-
Wagle, N., Emery, C., Berger, M.F. et al. (2011). Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. J. Clin. Oncol. 29, 3085-3096.
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 3085-3096
-
-
Wagle, N.1
Emery, C.2
Berger, M.F.3
-
133
-
-
0033601367
-
Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein
-
Wang, Q.J., Bhattacharyya, D., Garfield, S., Nacro, K., Marquez, V.E., and Blumberg, P.M. (1999). Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein. J. Biol. Chem. 274, 37233-37239.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37233-37239
-
-
Wang, Q.J.1
Bhattacharyya, D.2
Garfield, S.3
Nacro, K.4
Marquez, V.E.5
Blumberg, P.M.6
-
134
-
-
0034697324
-
The lipophilicity of phorbol esters as a critical factor in determining the pattern of translocation of protein kinase C delta fused to green fluorescent protein
-
Wang, Q.J., Fang, T.W., Fenick, D., Garfield, S., Bienfait, B., Marquez, V.E., and Blumberg, P.M. (2000). The lipophilicity of phorbol esters as a critical factor in determining the pattern of translocation of protein kinase C delta fused to green fluorescent protein. J. Biol. Chem. 275, 12136-12146.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 12136-12146
-
-
Wang, Q.J.1
Fang, T.W.2
Fenick, D.3
Garfield, S.4
Bienfait, B.5
Marquez, V.E.6
Blumberg, P.M.7
-
135
-
-
22544468543
-
Direct binding to ceramide activates protein kinase Cζ before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells
-
Wang, G., Silva, J., Krishnamurthy, K., Tran, E., Condie, B.G., and Bieberich, E. (2005). Direct binding to ceramide activates protein kinase Cζ before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells. J. Biol. Chem. 280, 26415-26424.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 26415-26424
-
-
Wang, G.1
Silva, J.2
Krishnamurthy, K.3
Tran, E.4
Condie, B.G.5
Bieberich, E.6
-
136
-
-
0036528247
-
Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma
-
Weeraratna, A.T., Jiang, Y., Hostetter, G., Rosenblatt, K., Duray, P., Bittner, M., and Trent, J.M. (2002). Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 1, 279-288.
-
(2002)
Cancer Cell
, vol.1
, pp. 279-288
-
-
Weeraratna, A.T.1
Jiang, Y.2
Hostetter, G.3
Rosenblatt, K.4
Duray, P.5
Bittner, M.6
Trent, J.M.7
-
137
-
-
1942506706
-
V599EB-RAF is an oncogene in melanocytes
-
V599EB-RAF is an oncogene in melanocytes. Cancer Res. 64, 2338-2342.
-
(2004)
Cancer Res.
, vol.64
, pp. 2338-2342
-
-
Wellbrock, C.1
Ogilvie, L.2
Hedley, D.3
Karasarides, M.4
Martin, J.5
Niculescu-Duvaz, D.6
Springer, C.J.7
Marais, R.8
-
138
-
-
84862691752
-
A double-blind, randomized, placebo-controlled, phase 2 study of maintenance enzastaurin with 5-fluorouracil/leucovorin plus bevacizumab after first-line therapy for metastatic colorectal cancer
-
doi: 10.1002/cncr.26692.
-
Wolff, R.A., Fuchs, M., Di Bartolomeo, M., Hossain, A.M., Stoffregen, C., Nicol, S., and Heinemann, V. (2011). A double-blind, randomized, placebo-controlled, phase 2 study of maintenance enzastaurin with 5-fluorouracil/leucovorin plus bevacizumab after first-line therapy for metastatic colorectal cancer. Cancer doi: 10.1002/cncr.26692.
-
(2011)
Cancer
-
-
Wolff, R.A.1
Fuchs, M.2
Di Bartolomeo, M.3
Hossain, A.M.4
Stoffregen, C.5
Nicol, S.6
Heinemann, V.7
-
139
-
-
84855782488
-
The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma
-
Wu, X., Zhu, M., Fletcher, J.A., Giobbie-Hurder, A., and Hodi, F.S. (2012). The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma. PLoS ONE 7, e29622.
-
(2012)
PLoS ONE
, vol.7
-
-
Wu, X.1
Zhu, M.2
Fletcher, J.A.3
Giobbie-Hurder, A.4
Hodi, F.S.5
-
140
-
-
2642709170
-
Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
-
Xia, P., Aiello, L.P., Ishii, H., Jiang, Z.Y., Park, D.J., Robinson, G.S., Takagi, H., Newsome, W.P., Jirousek, M.R., and King, G.L. (1996). Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J. Clin. Invest. 98, 2018-2026.
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 2018-2026
-
-
Xia, P.1
Aiello, L.P.2
Ishii, H.3
Jiang, Z.Y.4
Park, D.J.5
Robinson, G.S.6
Takagi, H.7
Newsome, W.P.8
Jirousek, M.R.9
King, G.L.10
-
141
-
-
77749264374
-
Loss of protein kinase C δ gene expression in human squamous cell carcinomas: a laser capture microdissection study
-
Yadav, V., Yanez, N.C., Fenton, S.E., and Denning, M.F. (2010). Loss of protein kinase C δ gene expression in human squamous cell carcinomas: a laser capture microdissection study. Am. J. Pathol. 176, 1091-1096.
-
(2010)
Am. J. Pathol.
, vol.176
, pp. 1091-1096
-
-
Yadav, V.1
Yanez, N.C.2
Fenton, S.E.3
Denning, M.F.4
-
142
-
-
0025981422
-
The differential expression of protein kinase C genes in normal human neonatal melanocytes and metastatic melanomas
-
Yamanishi, D.T., Graham, M., Buckmeier, J.A., and Meyskens Jr, F.L. (1991). The differential expression of protein kinase C genes in normal human neonatal melanocytes and metastatic melanomas. Carcinogenesis 12, 105-109.
-
(1991)
Carcinogenesis
, vol.12
, pp. 105-109
-
-
Yamanishi, D.T.1
Graham, M.2
Buckmeier, J.A.3
Meyskens Jr., F.L.4
-
143
-
-
51749094162
-
From UVs to metastases: modeling melanoma initiation and progression in the mouse
-
Zaidi, M.R., Day, C.P., and Merlino, G. (2008). From UVs to metastases: modeling melanoma initiation and progression in the mouse. J. Invest. Dermatol. 128, 2381-2391.
-
(2008)
J. Invest. Dermatol.
, vol.128
, pp. 2381-2391
-
-
Zaidi, M.R.1
Day, C.P.2
Merlino, G.3
-
144
-
-
12444337495
-
Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-α and translocating PKC-δ
-
Zhang, X.M., Chen, J., Xia, Y.G., and Xu, Q. (2005). Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-α and translocating PKC-δ. Cancer Chemother. Pharmacol. 55, 251-262.
-
(2005)
Cancer Chemother. Pharmacol.
, vol.55
, pp. 251-262
-
-
Zhang, X.M.1
Chen, J.2
Xia, Y.G.3
Xu, Q.4
|