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Volumn 25, Issue 4, 2012, Pages 466-476

Specifying protein kinase C functions in melanoma

Author keywords

Melanocyte; Protein kinase C; Signal transduction

Indexed keywords

BRYOSTATIN; BRYOSTATIN 1; ENZASTAURIN; INGENOL MEBUTATE; PROTEIN KINASE C; PROTEIN KINASE C BETA; PROTEIN SERINE THREONINE KINASE; VEMURAFENIB;

EID: 84862703651     PISSN: 17551471     EISSN: 1755148X     Source Type: Journal    
DOI: 10.1111/j.1755-148X.2012.01015.x     Document Type: Review
Times cited : (30)

References (144)
  • 1
    • 0025012050 scopus 로고
    • Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression
    • Albelda, S.M., Mette, S.A., Elder, D.E., Stewart, R., Damjanovich, L., Herlyn, M., and Buck, C.A. (1990). Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression. Cancer Res. 50, 6757-6764.
    • (1990) Cancer Res. , vol.50 , pp. 6757-6764
    • Albelda, S.M.1    Mette, S.A.2    Elder, D.E.3    Stewart, R.4    Damjanovich, L.5    Herlyn, M.6    Buck, C.A.7
  • 2
    • 65749118370 scopus 로고    scopus 로고
    • Randomized, double-blind, double-dummy, vehicle-controlled study of ingenol mebutate gel 0.025% and 0.05% for actinic keratosis
    • Anderson, L., Schmieder, G.J., Werschler, W.P., Tschen, E.H., Ling, M.R., Stough, D.B., and Katsamas, J. (2009). Randomized, double-blind, double-dummy, vehicle-controlled study of ingenol mebutate gel 0.025% and 0.05% for actinic keratosis. J. Am. Acad. Dermatol. 60, 934-943.
    • (2009) J. Am. Acad. Dermatol. , vol.60 , pp. 934-943
    • Anderson, L.1    Schmieder, G.J.2    Werschler, W.P.3    Tschen, E.H.4    Ling, M.R.5    Stough, D.B.6    Katsamas, J.7
  • 3
    • 0026808452 scopus 로고
    • Growth of human melanocyte cultures supported by 12-O-tetradecanoylphorbol-13-acetate is mediated through protein kinase C activation
    • Arita, Y., O'Driscoll, K.R., and Weinstein, I.B. (1992). Growth of human melanocyte cultures supported by 12-O-tetradecanoylphorbol-13-acetate is mediated through protein kinase C activation. Cancer Res. 52, 4514-4521.
    • (1992) Cancer Res. , vol.52 , pp. 4514-4521
    • Arita, Y.1    O'Driscoll, K.R.2    Weinstein, I.B.3
  • 4
    • 0028266194 scopus 로고
    • Growth inhibition of human melanoma-derived cells by 12-O-tetradecanoyl phorbol 13-acetate
    • Arita, Y., O'Driscoll, K.R., and Weinstein, I.B. (1994). Growth inhibition of human melanoma-derived cells by 12-O-tetradecanoyl phorbol 13-acetate. Int. J. Cancer 56, 229-235.
    • (1994) Int. J. Cancer , vol.56 , pp. 229-235
    • Arita, Y.1    O'Driscoll, K.R.2    Weinstein, I.B.3
  • 5
    • 34548787911 scopus 로고    scopus 로고
    • Protein kinase Cε interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer
    • Aziz, M.H., Manoharan, H.T., Church, D.R., Dreckschmidt, N.E., Zhong, W., Oberley, T.D., Wilding, G., and Verma, A.K. (2007a). Protein kinase Cε interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer. Cancer Res. 67, 8828-8838.
    • (2007) Cancer Res. , vol.67 , pp. 8828-8838
    • Aziz, M.H.1    Manoharan, H.T.2    Church, D.R.3    Dreckschmidt, N.E.4    Zhong, W.5    Oberley, T.D.6    Wilding, G.7    Verma, A.K.8
  • 6
    • 33847019644 scopus 로고    scopus 로고
    • Protein kinase C ε, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3
    • Aziz, M.H., Manoharan, H.T., and Verma, A.K. (2007b). Protein kinase C ε, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3. Cancer Res. 67, 1385-1394.
    • (2007) Cancer Res. , vol.67 , pp. 1385-1394
    • Aziz, M.H.1    Manoharan, H.T.2    Verma, A.K.3
  • 9
    • 17444403210 scopus 로고    scopus 로고
    • The C2 domain of PKCδ is a phosphotyrosine binding domain
    • Benes, C.H., Wu, N., Elia, A.E., Dharia, T., Cantley, L.C., and Soltoff, S.P. (2005). The C2 domain of PKCδ is a phosphotyrosine binding domain. Cell 121, 271-280.
    • (2005) Cell , vol.121 , pp. 271-280
    • Benes, C.H.1    Wu, N.2    Elia, A.E.3    Dharia, T.4    Cantley, L.C.5    Soltoff, S.P.6
  • 10
    • 0034601455 scopus 로고    scopus 로고
    • Molecular classification of cutaneous malignant melanoma by gene expression profiling
    • Bittner, M., Meltzer, P., Chen, Y. et al. (2000). Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature 406, 536-540.
    • (2000) Nature , vol.406 , pp. 536-540
    • Bittner, M.1    Meltzer, P.2    Chen, Y.3
  • 11
    • 77952241390 scopus 로고    scopus 로고
    • RNAi-mediated knockdown of protein kinase C-alpha inhibits cell migration in MM-RU human metastatic melanoma cell line
    • Byers, H.R., Boissel, S.J., Tu, C., and Park, H.Y. (2010). RNAi-mediated knockdown of protein kinase C-alpha inhibits cell migration in MM-RU human metastatic melanoma cell line. Melanoma Res. 20, 171-178.
    • (2010) Melanoma Res. , vol.20 , pp. 171-178
    • Byers, H.R.1    Boissel, S.J.2    Tu, C.3    Park, H.Y.4
  • 12
    • 33748670455 scopus 로고    scopus 로고
    • Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer
    • Carducci, M.A., Musib, L., Kies, M.S. et al. (2006). Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer. J. Clin. Oncol. 24, 4092-4099.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 4092-4099
    • Carducci, M.A.1    Musib, L.2    Kies, M.S.3
  • 13
    • 77952290430 scopus 로고    scopus 로고
    • PhosphoMARCKS drives motility of mouse melanoma cells
    • Chen, X., and Rotenberg, S.A. (2010). PhosphoMARCKS drives motility of mouse melanoma cells. Cell Signal. 22, 1097-1103.
    • (2010) Cell Signal. , vol.22 , pp. 1097-1103
    • Chen, X.1    Rotenberg, S.A.2
  • 15
    • 33745699726 scopus 로고    scopus 로고
    • Protein kinase Cζ mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase
    • Cohen, E.E., Lingen, M.W., Zhu, B., Zhu, H., Straza, M.W., Pierce, C., Martin, L.E., and Rosner, M.R. (2006). Protein kinase Cζ mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase. Cancer Res. 66, 6296-6303.
    • (2006) Cancer Res. , vol.66 , pp. 6296-6303
    • Cohen, E.E.1    Lingen, M.W.2    Zhu, B.3    Zhu, H.4    Straza, M.W.5    Pierce, C.6    Martin, L.E.7    Rosner, M.R.8
  • 16
    • 33750536856 scopus 로고    scopus 로고
    • Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-dependent hyperactivation of the mitogen-activated protein kinase pathway
    • Cozzi, S.J., Parsons, P.G., Ogbourne, S.M., Pedley, J., and Boyle, G.M. (2006). Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-dependent hyperactivation of the mitogen-activated protein kinase pathway. Cancer Res. 66, 10083-10091.
    • (2006) Cancer Res. , vol.66 , pp. 10083-10091
    • Cozzi, S.J.1    Parsons, P.G.2    Ogbourne, S.M.3    Pedley, J.4    Boyle, G.M.5
  • 17
    • 30944435449 scopus 로고    scopus 로고
    • The proapoptotic tumor suppressor protein kinase C-δ is lost in human squamous cell carcinomas
    • D'Costa, A.M., Robinson, J.K., Maududi, T., Chaturvedi, V., Nickoloff, B.J., and Denning, M.F. (2006). The proapoptotic tumor suppressor protein kinase C-δ is lost in human squamous cell carcinomas. Oncogene 25, 378-386.
    • (2006) Oncogene , vol.25 , pp. 378-386
    • D'Costa, A.M.1    Robinson, J.K.2    Maududi, T.3    Chaturvedi, V.4    Nickoloff, B.J.5    Denning, M.F.6
  • 18
    • 33645452703 scopus 로고    scopus 로고
    • Chondrocyte cell death mediated by reactive oxygen species-dependent activation of PKC-βI
    • DelCarlo, M., and Loeser, R.F. (2006). Chondrocyte cell death mediated by reactive oxygen species-dependent activation of PKC-βI. Am. J. Physiol. Cell Physiol. 290, C802-C811.
    • (2006) Am. J. Physiol. Cell Physiol. , vol.290
    • DelCarlo, M.1    Loeser, R.F.2
  • 19
    • 0027332733 scopus 로고
    • Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C δ
    • Denning, M.F., Dlugosz, A.A., Howett, M.K., and Yuspa, S.H. (1993). Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C δ. J. Biol. Chem. 268, 26079-26081.
    • (1993) J. Biol. Chem. , vol.268 , pp. 26079-26081
    • Denning, M.F.1    Dlugosz, A.A.2    Howett, M.K.3    Yuspa, S.H.4
  • 20
    • 0032491318 scopus 로고    scopus 로고
    • Protein kinase Cδ is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes
    • Denning, M.F., Wang, Y., Nickoloff, B.J., and Wrone-Smith, T. (1998). Protein kinase Cδ is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes. J. Biol. Chem. 273, 29995-30002.
    • (1998) J. Biol. Chem. , vol.273 , pp. 29995-30002
    • Denning, M.F.1    Wang, Y.2    Nickoloff, B.J.3    Wrone-Smith, T.4
  • 21
    • 0036144679 scopus 로고    scopus 로고
    • Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocyte requires activation of protein kinase C
    • Denning, M.F., Wang, Y., Tibudan, S., Nickoloff, B.J., and Qin, J.Z. (2002). Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocyte requires activation of protein kinase C. Cell Death Differ. 9, 40-52.
    • (2002) Cell Death Differ. , vol.9 , pp. 40-52
    • Denning, M.F.1    Wang, Y.2    Tibudan, S.3    Nickoloff, B.J.4    Qin, J.Z.5
  • 22
    • 0037110732 scopus 로고    scopus 로고
    • Nuclear import of PKCδ is required for apoptosis: identification of a novel nuclear import sequence
    • DeVries, T.A., Neville, M.C., and Reyland, M.E. (2002). Nuclear import of PKCδ is required for apoptosis: identification of a novel nuclear import sequence. EMBO J. 21, 6050-6060.
    • (2002) EMBO J. , vol.21 , pp. 6050-6060
    • DeVries, T.A.1    Neville, M.C.2    Reyland, M.E.3
  • 23
    • 34447131518 scopus 로고    scopus 로고
    • The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition
    • Dissanayake, S.K., Wade, M., Johnson, C.E. et al. (2007). The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J. Biol. Chem. 282, 17259-17271.
    • (2007) J. Biol. Chem. , vol.282 , pp. 17259-17271
    • Dissanayake, S.K.1    Wade, M.2    Johnson, C.E.3
  • 24
    • 57749098673 scopus 로고    scopus 로고
    • Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation
    • Dissanayake, S.K., Olkhanud, P.B., O'Connell, M.P. et al. (2008). Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation. Cancer Res. 68, 10205-10214.
    • (2008) Cancer Res. , vol.68 , pp. 10205-10214
    • Dissanayake, S.K.1    Olkhanud, P.B.2    O'Connell, M.P.3
  • 25
    • 0001418906 scopus 로고
    • Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin
    • Eisinger, M., and Marko, O. (1982). Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin. Proc. Natl. Acad. Sci. U.S.A. 79, 2018-2022.
    • (1982) Proc. Natl. Acad. Sci. U.S.A. , vol.79 , pp. 2018-2022
    • Eisinger, M.1    Marko, O.2
  • 26
    • 0020954606 scopus 로고
    • Stimulation of growth of human melanocytes by tumor promoters
    • Eisinger, M., Marko, O., and Weinstein, I.B. (1983). Stimulation of growth of human melanocytes by tumor promoters. Carcinogenesis 4, 779-781.
    • (1983) Carcinogenesis , vol.4 , pp. 779-781
    • Eisinger, M.1    Marko, O.2    Weinstein, I.B.3
  • 27
    • 13344259987 scopus 로고
    • Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells
    • Emoto, Y., Manome, Y., Meinhardt, G. et al. (1995). Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells. EMBO J. 14, 6148-6156.
    • (1995) EMBO J. , vol.14 , pp. 6148-6156
    • Emoto, Y.1    Manome, Y.2    Meinhardt, G.3
  • 29
    • 21244435590 scopus 로고    scopus 로고
    • Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1
    • Feldman, R.I., Wu, J.M., Polokoff, M.A. et al. (2005). Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J. Biol. Chem. 280, 19867-19874.
    • (2005) J. Biol. Chem. , vol.280 , pp. 19867-19874
    • Feldman, R.I.1    Wu, J.M.2    Polokoff, M.A.3
  • 30
    • 77956030786 scopus 로고    scopus 로고
    • Inhibition of mutated, activated BRAF in metastatic melanoma
    • Flaherty, K.T., Puzanov, I., Kim, K.B. et al. (2010). Inhibition of mutated, activated BRAF in metastatic melanoma. N. Engl. J. Med. 363, 809-819.
    • (2010) N. Engl. J. Med. , vol.363 , pp. 809-819
    • Flaherty, K.T.1    Puzanov, I.2    Kim, K.B.3
  • 31
    • 42449148790 scopus 로고    scopus 로고
    • The reactive oxygen-driven tumor: relevance to melanoma
    • Fried, L., and Arbiser, J.L. (2008). The reactive oxygen-driven tumor: relevance to melanoma. Pigment Cell Melanoma Res. 21, 117-122.
    • (2008) Pigment Cell Melanoma Res. , vol.21 , pp. 117-122
    • Fried, L.1    Arbiser, J.L.2
  • 32
    • 21844478747 scopus 로고    scopus 로고
    • Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
    • Garraway, L.A., Widlund, H.R., Rubin, M.A. et al. (2005). Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 436, 117-122.
    • (2005) Nature , vol.436 , pp. 117-122
    • Garraway, L.A.1    Widlund, H.R.2    Rubin, M.A.3
  • 33
    • 0034902972 scopus 로고    scopus 로고
    • Loss of expression of protein kinase C β is a common phenomenon in human malignant melanoma: a result of transformation or differentiation?
    • Gilhooly, E.M., Morse-Gaudio, M., Bianchi, L., Reinhart, L., Rose, D.P., Connolly, J.M., Reed, J.A., and Albino, A.P. (2001). Loss of expression of protein kinase C β is a common phenomenon in human malignant melanoma: a result of transformation or differentiation? Melanoma Res. 11, 355-369.
    • (2001) Melanoma Res. , vol.11 , pp. 355-369
    • Gilhooly, E.M.1    Morse-Gaudio, M.2    Bianchi, L.3    Reinhart, L.4    Rose, D.P.5    Connolly, J.M.6    Reed, J.A.7    Albino, A.P.8
  • 34
    • 12344274453 scopus 로고    scopus 로고
    • Ingenol 3-angelate induces dual modes of cell death and differentially regulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in melanoma cells
    • Gillespie, S.K., Zhang, X.D., and Hersey, P. (2004). Ingenol 3-angelate induces dual modes of cell death and differentially regulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in melanoma cells. Mol. Cancer Ther. 3, 1651-1658.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 1651-1658
    • Gillespie, S.K.1    Zhang, X.D.2    Hersey, P.3
  • 35
    • 22744447211 scopus 로고    scopus 로고
    • Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis
    • Giorgio, M., Migliaccio, E., Orsini, F. et al. (2005). Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 122, 221-233.
    • (2005) Cell , vol.122 , pp. 221-233
    • Giorgio, M.1    Migliaccio, E.2    Orsini, F.3
  • 36
    • 0033407483 scopus 로고    scopus 로고
    • Treatment of patients with metastatic melanoma with bryostatin-1--a phase II study
    • Gonzalez, R., Ebbinghaus, S., Henthorn, T.K., Miller, D., and Kraft, A.S. (1999). Treatment of patients with metastatic melanoma with bryostatin-1--a phase II study. Melanoma Res. 9, 599-606.
    • (1999) Melanoma Res. , vol.9 , pp. 599-606
    • Gonzalez, R.1    Ebbinghaus, S.2    Henthorn, T.K.3    Miller, D.4    Kraft, A.S.5
  • 38
    • 33847417986 scopus 로고    scopus 로고
    • Overexpression of Akt converts radial growth melanoma to vertical growth melanoma
    • Govindarajan, B., Sligh, J.E., Vincent, B.J. et al. (2007). Overexpression of Akt converts radial growth melanoma to vertical growth melanoma. J. Clin. Invest. 117, 719-729.
    • (2007) J. Clin. Invest. , vol.117 , pp. 719-729
    • Govindarajan, B.1    Sligh, J.E.2    Vincent, B.J.3
  • 39
    • 23844521568 scopus 로고    scopus 로고
    • The protein kinase Cβ-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
    • Graff, J.R., McNulty, A.M., Hanna, K.R. et al. (2005). The protein kinase Cβ-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res. 65, 7462-7469.
    • (2005) Cancer Res. , vol.65 , pp. 7462-7469
    • Graff, J.R.1    McNulty, A.M.2    Hanna, K.R.3
  • 40
    • 0030777104 scopus 로고    scopus 로고
    • Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
    • Guldberg, P., thor, S.P., Birck, A., Ahrenkiel, V., Kirkin, A.F., and Zeuthen, J. (1997). Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res. 57, 3660-3663.
    • (1997) Cancer Res. , vol.57 , pp. 3660-3663
    • Guldberg, P.1    Thor, S.P.2    Birck, A.3    Ahrenkiel, V.4    Kirkin, A.F.5    Zeuthen, J.6
  • 41
    • 23744432856 scopus 로고    scopus 로고
    • PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC
    • Hampson, P., Chahal, H., Khanim, F., Hayden, R., Mulder, A., Assi, L.K., Bunce, C.M., and Lord, J.M. (2005). PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. Blood 106, 1362-1368.
    • (2005) Blood , vol.106 , pp. 1362-1368
    • Hampson, P.1    Chahal, H.2    Khanim, F.3    Hayden, R.4    Mulder, A.5    Assi, L.K.6    Bunce, C.M.7    Lord, J.M.8
  • 42
    • 34248631942 scopus 로고    scopus 로고
    • Antitumor activity of enzastaurin (LY317615.HCl) against human cancer cell lines and freshly explanted tumors investigated in in-vitro [corrected] soft-agar cloning experiments
    • Hanauske, A.R., Oberschmidt, O., Hanauske-Abel, H., Lahn, M.M., and Eismann, U. (2007). Antitumor activity of enzastaurin (LY317615.HCl) against human cancer cell lines and freshly explanted tumors investigated in in-vitro [corrected] soft-agar cloning experiments. Invest. New Drugs 25, 205-210.
    • (2007) Invest. New Drugs , vol.25 , pp. 205-210
    • Hanauske, A.R.1    Oberschmidt, O.2    Hanauske-Abel, H.3    Lahn, M.M.4    Eismann, U.5
  • 43
    • 77949685981 scopus 로고    scopus 로고
    • RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
    • Hatzivassiliou, G., Song, K., Yen, I. et al. (2010). RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 464, 431-435.
    • (2010) Nature , vol.464 , pp. 431-435
    • Hatzivassiliou, G.1    Song, K.2    Yen, I.3
  • 44
    • 0023253596 scopus 로고
    • Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin
    • Hennings, H., Blumberg, P.M., Pettit, G.R., Herald, C.L., Shores, R., and Yuspa, S.H. (1987). Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin. Carcinogenesis 8, 1343-1346.
    • (1987) Carcinogenesis , vol.8 , pp. 1343-1346
    • Hennings, H.1    Blumberg, P.M.2    Pettit, G.R.3    Herald, C.L.4    Shores, R.5    Yuspa, S.H.6
  • 45
    • 0642376906 scopus 로고    scopus 로고
    • Protein kinase Cζ (PKCζ): activation mechanisms and cellular functions
    • Hirai, T., and Chida, K. (2003). Protein kinase Cζ (PKCζ): activation mechanisms and cellular functions. J. Biochem. 133, 1-7.
    • (2003) J. Biochem. , vol.133 , pp. 1-7
    • Hirai, T.1    Chida, K.2
  • 46
    • 0035513616 scopus 로고    scopus 로고
    • Endothelins are involved in regulating the proliferation and differentiation of mouse epidermal melanocytes in serum-free primary culture
    • Hirobe, T. (2001). Endothelins are involved in regulating the proliferation and differentiation of mouse epidermal melanocytes in serum-free primary culture. J. Invest. Dermatol. Symp. Proc. 6, 25-31.
    • (2001) J. Invest. Dermatol. Symp. Proc. , vol.6 , pp. 25-31
    • Hirobe, T.1
  • 47
    • 3442894137 scopus 로고    scopus 로고
    • Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas
    • Hoek, K., Rimm, D.L., Williams, K.R. et al. (2004). Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Cancer Res. 64, 5270-5282.
    • (2004) Cancer Res. , vol.64 , pp. 5270-5282
    • Hoek, K.1    Rimm, D.L.2    Williams, K.R.3
  • 48
    • 76849106075 scopus 로고    scopus 로고
    • Interaction with AKAP79 modifies the cellular pharmacology of PKC
    • Hoshi, N., Langeberg, L.K., Gould, C.M., Newton, A.C., and Scott, J.D. (2010). Interaction with AKAP79 modifies the cellular pharmacology of PKC. Mol. Cell 37, 541-550.
    • (2010) Mol. Cell , vol.37 , pp. 541-550
    • Hoshi, N.1    Langeberg, L.K.2    Gould, C.M.3    Newton, A.C.4    Scott, J.D.5
  • 49
    • 0031203749 scopus 로고    scopus 로고
    • The role of endothelin-1 in epidermal hyperpigmentation and signaling mechanisms of mitogenesis and melanogenesis
    • Imokawa, G., Kobayashi, T., Miyagishi, M., Higashi, K., and Yada, Y. (1997). The role of endothelin-1 in epidermal hyperpigmentation and signaling mechanisms of mitogenesis and melanogenesis. Pigment Cell Res. 10, 218-228.
    • (1997) Pigment Cell Res. , vol.10 , pp. 218-228
    • Imokawa, G.1    Kobayashi, T.2    Miyagishi, M.3    Higashi, K.4    Yada, Y.5
  • 50
    • 78650309875 scopus 로고    scopus 로고
    • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
    • Johannessen, C.M., Boehm, J.S., Kim, S.Y. et al. (2010). COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 468, 968-972.
    • (2010) Nature , vol.468 , pp. 968-972
    • Johannessen, C.M.1    Boehm, J.S.2    Kim, S.Y.3
  • 51
    • 0034025493 scopus 로고    scopus 로고
    • Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters
    • Kazanietz, M.G. (2000). Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters. Mol. Carcinog. 28, 5-11.
    • (2000) Mol. Carcinog. , vol.28 , pp. 5-11
    • Kazanietz, M.G.1
  • 52
    • 0027297104 scopus 로고
    • Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes
    • Kazanietz, M.G., Areces, L.B., Bahador, A., Mischak, H., Goodnight, J., Mushinski, J.F., and Blumberg, P.M. (1993). Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes. Mol. Pharmacol. 44, 298-307.
    • (1993) Mol. Pharmacol. , vol.44 , pp. 298-307
    • Kazanietz, M.G.1    Areces, L.B.2    Bahador, A.3    Mischak, H.4    Goodnight, J.5    Mushinski, J.F.6    Blumberg, P.M.7
  • 54
    • 79959731072 scopus 로고    scopus 로고
    • A novel mouse PKCdelta splice variant, PKCdeltaIX, inhibits etoposide-induced apoptosis
    • Kim, J.D., Seo, K.W., Lee, E.A., Quang, N.N., Cho, H.R., and Kwon, B. (2011). A novel mouse PKCdelta splice variant, PKCdeltaIX, inhibits etoposide-induced apoptosis. Biochem. Biophys. Res. Commun. 410, 177-182.
    • (2011) Biochem. Biophys. Res. Commun. , vol.410 , pp. 177-182
    • Kim, J.D.1    Seo, K.W.2    Lee, E.A.3    Quang, N.N.4    Cho, H.R.5    Kwon, B.6
  • 55
    • 0029887701 scopus 로고    scopus 로고
    • Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein
    • Klauck, T.M., Faux, M.C., Labudda, K., Langeberg, L.K., Jaken, S., and Scott, J.D. (1996). Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein. Science 271, 1589-1592.
    • (1996) Science , vol.271 , pp. 1589-1592
    • Klauck, T.M.1    Faux, M.C.2    Labudda, K.3    Langeberg, L.K.4    Jaken, S.5    Scott, J.D.6
  • 56
    • 84863012289 scopus 로고    scopus 로고
    • PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria
    • Lau, E., Kluger, H., Varsano, T., Lee, K., Scheffler, I., Rimm, D.L., Ideker, T., and Ronai, Z.A. (2012). PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Cell 148, 543-555.
    • (2012) Cell , vol.148 , pp. 543-555
    • Lau, E.1    Kluger, H.2    Varsano, T.3    Lee, K.4    Scheffler, I.5    Rimm, D.L.6    Ideker, T.7    Ronai, Z.A.8
  • 57
    • 0029759727 scopus 로고    scopus 로고
    • Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation
    • Lewis, J.M., Cheresh, D.A., and Schwartz, M.A. (1996). Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation. J. Cell Biol. 134, 1323-1332.
    • (1996) J. Cell Biol. , vol.134 , pp. 1323-1332
    • Lewis, J.M.1    Cheresh, D.A.2    Schwartz, M.A.3
  • 58
    • 0033233483 scopus 로고    scopus 로고
    • Protein kinase C δ targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector
    • Li, L., Lorenzo, P.S., Bogi, K., Blumberg, P.M., and Yuspa, S.H. (1999). Protein kinase C δ targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector. Mol. Cell. Biol. 19, 8547-8558.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 8547-8558
    • Li, L.1    Lorenzo, P.S.2    Bogi, K.3    Blumberg, P.M.4    Yuspa, S.H.5
  • 59
    • 77953155672 scopus 로고    scopus 로고
    • The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature
    • Li, L., Shukla, S., Lee, A., Garfield, S.H., Maloney, D.J., Ambudkar, S.V., and Yuspa, S.H. (2010). The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. Cancer Res. 70, 4509-4519.
    • (2010) Cancer Res. , vol.70 , pp. 4509-4519
    • Li, L.1    Shukla, S.2    Lee, A.3    Garfield, S.H.4    Maloney, D.J.5    Ambudkar, S.V.6    Yuspa, S.H.7
  • 61
    • 34247606483 scopus 로고    scopus 로고
    • Rewired ERK-JNK signaling pathways in melanoma
    • Lopez-Bergami, P., Huang, C., Goydos, J.S. et al. (2007). Rewired ERK-JNK signaling pathways in melanoma. Cancer Cell 11, 447-460.
    • (2007) Cancer Cell , vol.11 , pp. 447-460
    • Lopez-Bergami, P.1    Huang, C.2    Goydos, J.S.3
  • 62
    • 74049109400 scopus 로고    scopus 로고
    • c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis
    • Lopez-Bergami, P., Kim, H., Dewing, A., Goydos, J., Aaronson, S., and Ronai, Z. (2010). c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis. J. Biol. Chem. 285, 903-913.
    • (2010) J. Biol. Chem. , vol.285 , pp. 903-913
    • Lopez-Bergami, P.1    Kim, H.2    Dewing, A.3    Goydos, J.4    Aaronson, S.5    Ronai, Z.6
  • 63
    • 0027965006 scopus 로고
    • Protein kinase C ζ isoform is critical for κB-dependent promoter activation by sphingomyelinase
    • Lozano, J., Berra, E., Municio, M.M., Diaz-Meco, M.T., Dominguez, I., Sanz, L., and Moscat, J. (1994). Protein kinase C ζ isoform is critical for κB-dependent promoter activation by sphingomyelinase. J. Biol. Chem. 269, 19200-19202.
    • (1994) J. Biol. Chem. , vol.269 , pp. 19200-19202
    • Lozano, J.1    Berra, E.2    Municio, M.M.3    Diaz-Meco, M.T.4    Dominguez, I.5    Sanz, L.6    Moscat, J.7
  • 64
    • 77949732137 scopus 로고    scopus 로고
    • 3-phosphoinositide-dependent protein kinase-1 regulates proliferation and survival of cancer cells with an activated mitogen-activated protein kinase pathway
    • Lu, Z., Cox-Hipkin, M.A., Windsor, W.T., and Boyapati, A. (2010). 3-phosphoinositide-dependent protein kinase-1 regulates proliferation and survival of cancer cells with an activated mitogen-activated protein kinase pathway. Mol. Cancer Res. 8, 421-432.
    • (2010) Mol. Cancer Res. , vol.8 , pp. 421-432
    • Lu, Z.1    Cox-Hipkin, M.A.2    Windsor, W.T.3    Boyapati, A.4
  • 65
    • 34250902930 scopus 로고    scopus 로고
    • Targeting the protein kinase C family: are we there yet?
    • Mackay, H.J., and Twelves, C.J. (2007). Targeting the protein kinase C family: are we there yet? Nat. Rev. Cancer 7, 554-562.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 554-562
    • Mackay, H.J.1    Twelves, C.J.2
  • 66
    • 33646372468 scopus 로고    scopus 로고
    • Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates ERK1/2 via PKCε
    • Marin, Y.E., Namkoong, J., Cohen-Solal, K., Shin, S.S., Martino, J.J., Oka, M., and Chen, S. (2006). Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates ERK1/2 via PKCε. Cell. Signal. 18, 1279-1286.
    • (2006) Cell. Signal. , vol.18 , pp. 1279-1286
    • Marin, Y.E.1    Namkoong, J.2    Cohen-Solal, K.3    Shin, S.S.4    Martino, J.J.5    Oka, M.6    Chen, S.7
  • 67
    • 77956061891 scopus 로고    scopus 로고
    • The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells
    • Mason, S.A., Cozzi, S.J., Pierce, C.J., Pavey, S.J., Parsons, P.G., and Boyle, G.M. (2009). The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells. Invest. New Drugs 28, 575-586.
    • (2009) Invest. New Drugs , vol.28 , pp. 575-586
    • Mason, S.A.1    Cozzi, S.J.2    Pierce, C.J.3    Pavey, S.J.4    Parsons, P.G.5    Boyle, G.M.6
  • 69
    • 35948958991 scopus 로고    scopus 로고
    • Regulation of docetaxel-induced apoptosis of human melanoma cells by different isoforms of protein kinase C
    • Mhaidat, N.M., Thorne, R.F., Zhang, X.D., and Hersey, P. (2007). Regulation of docetaxel-induced apoptosis of human melanoma cells by different isoforms of protein kinase C. Mol. Cancer Res. 5, 1073-1081.
    • (2007) Mol. Cancer Res. , vol.5 , pp. 1073-1081
    • Mhaidat, N.M.1    Thorne, R.F.2    Zhang, X.D.3    Hersey, P.4
  • 70
    • 56349170252 scopus 로고    scopus 로고
    • Involvement of endoplasmic reticulum stress in Docetaxel-induced JNK-dependent apoptosis of human melanoma
    • Mhaidat, N.M., Thorne, R., Zhang, X.D., and Hersey, P. (2008). Involvement of endoplasmic reticulum stress in Docetaxel-induced JNK-dependent apoptosis of human melanoma. Apoptosis 13, 1505-1512.
    • (2008) Apoptosis , vol.13 , pp. 1505-1512
    • Mhaidat, N.M.1    Thorne, R.2    Zhang, X.D.3    Hersey, P.4
  • 72
    • 0018579119 scopus 로고
    • Effects of 12-O-tetradecanoylphorbol-13-acetate and mezerein on epidermal ornithine decarboxylase activity, isoproterenol-stimulated levels of cyclic adenosine 3′:5′-monophosphate, and induction of mouse skin tumors in vivo
    • Mufson, R.A., Fischer, S.M., Verma, A.K., Gleason, G.L., Slaga, T.J., and Boutwell, R.K. (1979). Effects of 12-O-tetradecanoylphorbol-13-acetate and mezerein on epidermal ornithine decarboxylase activity, isoproterenol-stimulated levels of cyclic adenosine 3′:5′-monophosphate, and induction of mouse skin tumors in vivo. Cancer Res. 39, 4791-4795.
    • (1979) Cancer Res. , vol.39 , pp. 4791-4795
    • Mufson, R.A.1    Fischer, S.M.2    Verma, A.K.3    Gleason, G.L.4    Slaga, T.J.5    Boutwell, R.K.6
  • 73
    • 0029003788 scopus 로고
    • PKCζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid
    • Muller, G., Ayoub, M., Storz, P., Rennecke, J., Fabbro, D., and Pfizenmaier, K. (1995). PKCζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid. EMBO J. 14, 1961-1969.
    • (1995) EMBO J. , vol.14 , pp. 1961-1969
    • Muller, G.1    Ayoub, M.2    Storz, P.3    Rennecke, J.4    Fabbro, D.5    Pfizenmaier, K.6
  • 74
    • 0027535742 scopus 로고
    • Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate
    • Nakanishi, H., Brewer, K.A., and Exton, J.H. (1993). Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3, 4, 5-trisphosphate. J. Biol. Chem. 268, 13-16.
    • (1993) J. Biol. Chem. , vol.268 , pp. 13-16
    • Nakanishi, H.1    Brewer, K.A.2    Exton, J.H.3
  • 75
    • 78650303507 scopus 로고    scopus 로고
    • Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
    • Nazarian, R., Shi, H., Wang, Q. et al. (2010). Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 468, 973-977.
    • (2010) Nature , vol.468 , pp. 973-977
    • Nazarian, R.1    Shi, H.2    Wang, Q.3
  • 76
    • 0037337159 scopus 로고    scopus 로고
    • Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm
    • Newton, A.C. (2003). Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem. J. 370, 361-371.
    • (2003) Biochem. J. , vol.370 , pp. 361-371
    • Newton, A.C.1
  • 77
    • 0031012892 scopus 로고    scopus 로고
    • Determination of the specific substrate sequence motifs of protein kinase C isozymes
    • Nishikawa, K., Toker, A., Johannes, F.J., Songyang, Z., and Cantley, L.C. (1997). Determination of the specific substrate sequence motifs of protein kinase C isozymes. J. Biol. Chem. 272, 952-960.
    • (1997) J. Biol. Chem. , vol.272 , pp. 952-960
    • Nishikawa, K.1    Toker, A.2    Johannes, F.J.3    Songyang, Z.4    Cantley, L.C.5
  • 78
    • 0026451081 scopus 로고
    • Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
    • Nishizuka, Y. (1992). Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258, 607-614.
    • (1992) Science , vol.258 , pp. 607-614
    • Nishizuka, Y.1
  • 79
    • 0026781998 scopus 로고
    • Cloning and characterization of the major promoter of the human protein kinase C β gene. Regulation by phorbol esters
    • Obeid, L.M., Blobe, G.C., Karolak, L.A., and Hannun, Y.A. (1992). Cloning and characterization of the major promoter of the human protein kinase C β gene. Regulation by phorbol esters. J. Biol. Chem. 267, 20804-20810.
    • (1992) J. Biol. Chem. , vol.267 , pp. 20804-20810
    • Obeid, L.M.1    Blobe, G.C.2    Karolak, L.A.3    Hannun, Y.A.4
  • 80
    • 73849123750 scopus 로고    scopus 로고
    • The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma
    • O'Connell, M.P., Fiori, J.L., Xu, M. et al. (2010). The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. Oncogene 29, 34-44.
    • (2010) Oncogene , vol.29 , pp. 34-44
    • O'Connell, M.P.1    Fiori, J.L.2    Xu, M.3
  • 83
    • 37049013504 scopus 로고    scopus 로고
    • Protein kinase C-βII represses hepatocyte growth factor-induced invasion by preventing the association of adapter protein Gab1 and phosphatidylinositol 3-kinase in melanoma cells
    • Oka, M., Kikkawa, U., and Nishigori, C. (2008). Protein kinase C-βII represses hepatocyte growth factor-induced invasion by preventing the association of adapter protein Gab1 and phosphatidylinositol 3-kinase in melanoma cells. J. Invest. Dermatol. 128, 188-195.
    • (2008) J. Invest. Dermatol. , vol.128 , pp. 188-195
    • Oka, M.1    Kikkawa, U.2    Nishigori, C.3
  • 84
    • 0022452419 scopus 로고
    • Two types of complementary DNAs of rat brain protein kinase C. Heterogeneity determined by alternative splicing
    • Ono, Y., Kurokawa, T., Fujii, T., Kawahara, K., Igarashi, K., Kikkawa, U., Ogita, K., and Nishizuka, Y. (1986). Two types of complementary DNAs of rat brain protein kinase C. Heterogeneity determined by alternative splicing. FEBS Lett. 206, 347-352.
    • (1986) FEBS Lett. , vol.206 , pp. 347-352
    • Ono, Y.1    Kurokawa, T.2    Fujii, T.3    Kawahara, K.4    Igarashi, K.5    Kikkawa, U.6    Ogita, K.7    Nishizuka, Y.8
  • 85
    • 0027314530 scopus 로고
    • The β isoform of protein kinase C stimulates human melanogenesis by activating tyrosinase in pigment cells
    • Park, H.Y., Russakovsky, V., Ohno, S., and Gilchrest, B.A. (1993). The β isoform of protein kinase C stimulates human melanogenesis by activating tyrosinase in pigment cells. J. Biol. Chem. 268, 11742-11749.
    • (1993) J. Biol. Chem. , vol.268 , pp. 11742-11749
    • Park, H.Y.1    Russakovsky, V.2    Ohno, S.3    Gilchrest, B.A.4
  • 86
    • 0030601351 scopus 로고    scopus 로고
    • Alpha-melanocyte stimulating hormone-induced pigmentation is blocked by depletion of protein kinase C
    • Park, H.Y., Russakovsky, V., Ao, Y., Fernandez, E., and Gilchrest, B.A. (1996). Alpha-melanocyte stimulating hormone-induced pigmentation is blocked by depletion of protein kinase C. Exp. Cell Res. 227, 70-79.
    • (1996) Exp. Cell Res. , vol.227 , pp. 70-79
    • Park, H.Y.1    Russakovsky, V.2    Ao, Y.3    Fernandez, E.4    Gilchrest, B.A.5
  • 87
    • 0033523009 scopus 로고    scopus 로고
    • Protein kinase C-β activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain
    • Park, H.Y., Perez, J.M., Laursen, R., Hara, M., and Gilchrest, B.A. (1999). Protein kinase C-β activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain. J. Biol. Chem. 274, 16470-16478.
    • (1999) J. Biol. Chem. , vol.274 , pp. 16470-16478
    • Park, H.Y.1    Perez, J.M.2    Laursen, R.3    Hara, M.4    Gilchrest, B.A.5
  • 89
    • 4444313466 scopus 로고    scopus 로고
    • The receptor for activated C-kinase-I (RACK-I) anchors activated PKC-β on melanosomes
    • Park, H.Y., Wu, H., Killoran, C.E., and Gilchrest, B.A. (2004b). The receptor for activated C-kinase-I (RACK-I) anchors activated PKC-β on melanosomes. J. Cell Sci. 117, 3659-3668.
    • (2004) J. Cell Sci. , vol.117 , pp. 3659-3668
    • Park, H.Y.1    Wu, H.2    Killoran, C.E.3    Gilchrest, B.A.4
  • 91
    • 0036289824 scopus 로고    scopus 로고
    • Differential localisation of nPKCδ during cell cycle progression
    • Perego, C., Porro, D., and La Porta, C.A. (2002). Differential localisation of nPKCδ during cell cycle progression. Biochem. Biophys. Res. Commun. 294, 127-131.
    • (2002) Biochem. Biophys. Res. Commun. , vol.294 , pp. 127-131
    • Perego, C.1    Porro, D.2    La Porta, C.A.3
  • 92
    • 33846817351 scopus 로고    scopus 로고
    • Protein kinase C β and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc
    • Pinton, P., Rimessi, A., Marchi, S. et al. (2007). Protein kinase C β and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc. Science, 315, 659-663.
    • (2007) Science , vol.315 , pp. 659-663
    • Pinton, P.1    Rimessi, A.2    Marchi, S.3
  • 93
    • 0024433286 scopus 로고
    • Serum-free culture of normal human melanocytes: growth kinetics and growth factor requirements
    • Pittelkow, M.R., and Shipley, G.D. (1989). Serum-free culture of normal human melanocytes: growth kinetics and growth factor requirements. J. Cell. Physiol. 140, 565-576.
    • (1989) J. Cell. Physiol. , vol.140 , pp. 565-576
    • Pittelkow, M.R.1    Shipley, G.D.2
  • 94
    • 77949732073 scopus 로고    scopus 로고
    • RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
    • Poulikakos, P.I., Zhang, C., Bollag, G., Shokat, K.M., and Rosen, N. (2010). RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 464, 427-430.
    • (2010) Nature , vol.464 , pp. 427-430
    • Poulikakos, P.I.1    Zhang, C.2    Bollag, G.3    Shokat, K.M.4    Rosen, N.5
  • 95
    • 83455254767 scopus 로고    scopus 로고
    • RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
    • Poulikakos, P.I., Persaud, Y., Janakiraman, M. et al. (2011). RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature, 480, 387-390.
    • (2011) Nature , vol.480 , pp. 387-390
    • Poulikakos, P.I.1    Persaud, Y.2    Janakiraman, M.3
  • 96
    • 0027391003 scopus 로고
    • Protein kinase C β expression in melanoma cells and melanocytes: differential expression correlates with biological responses to 12-O-tetradecanoylphorbol 13-acetate
    • Powell, M.B., Rosenberg, R.K., Graham, M.J., Birch, M.L., Yamanishi, D.T., Buckmeier, J.A., and Meyskens Jr, F.L. (1993). Protein kinase C β expression in melanoma cells and melanocytes: differential expression correlates with biological responses to 12-O-tetradecanoylphorbol 13-acetate. J. Cancer Res. Clin. Oncol. 119, 199-206.
    • (1993) J. Cancer Res. Clin. Oncol. , vol.119 , pp. 199-206
    • Powell, M.B.1    Rosenberg, R.K.2    Graham, M.J.3    Birch, M.L.4    Yamanishi, D.T.5    Buckmeier, J.A.6    Meyskens Jr., F.L.7
  • 98
    • 72449199923 scopus 로고    scopus 로고
    • Src, PKCα, and PKCδ are required for αvβ3 integrin-mediated metastatic melanoma invasion
    • Putnam, A.J., Schulz, V.V., Freiter, E.M., Bill, H.M., and Miranti, C.K. (2009). Src, PKCα, and PKCδ are required for αvβ3 integrin-mediated metastatic melanoma invasion. Cell Commun. Signal. 7, 10.
    • (2009) Cell Commun. Signal. , vol.7 , pp. 10
    • Putnam, A.J.1    Schulz, V.V.2    Freiter, E.M.3    Bill, H.M.4    Miranti, C.K.5
  • 100
    • 33748328365 scopus 로고    scopus 로고
    • Enzastaurin (LY317615), a protein kinase Cβ inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines
    • Rizvi, M.A., Ghias, K., Davies, K.M., Ma, C., Weinberg, F., Munshi, H.G., Krett, N.L., and Rosen, S.T. (2006). Enzastaurin (LY317615), a protein kinase Cβ inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines. Mol. Cancer Ther. 5, 1783-1789.
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 1783-1789
    • Rizvi, M.A.1    Ghias, K.2    Davies, K.M.3    Ma, C.4    Weinberg, F.5    Munshi, H.G.6    Krett, N.L.7    Rosen, S.T.8
  • 101
    • 35248864084 scopus 로고    scopus 로고
    • Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression
    • Ryu, B., Kim, D.S., Deluca, A.M., and Alani, R.M. (2007). Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression. PLoS ONE 2, e594.
    • (2007) PLoS ONE , vol.2
    • Ryu, B.1    Kim, D.S.2    Deluca, A.M.3    Alani, R.M.4
  • 102
    • 0023629814 scopus 로고
    • Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells
    • Sako, T., Yuspa, S.H., Herald, C.L., Pettit, G.R., and Blumberg, P.M. (1987). Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells. Cancer Res. 47, 5445-5450.
    • (1987) Cancer Res. , vol.47 , pp. 5445-5450
    • Sako, T.1    Yuspa, S.H.2    Herald, C.L.3    Pettit, G.R.4    Blumberg, P.M.5
  • 104
    • 0035474310 scopus 로고    scopus 로고
    • Adaptor proteins in protein kinase C-mediated signal transduction
    • Schechtman, D., and Mochly-Rosen, D. (2001). Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene 20, 6339-6347.
    • (2001) Oncogene , vol.20 , pp. 6339-6347
    • Schechtman, D.1    Mochly-Rosen, D.2
  • 105
    • 0039791449 scopus 로고    scopus 로고
    • Activation of the mitogen-activated protein kinase/extracellular signal- regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
    • Schonwasser, D.C., Marais, R.M., Marshall, C.J., and Parker, P.J. (1998). Activation of the mitogen-activated protein kinase/extracellular signal- regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol. Cell. Biol. 18, 790-798.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 790-798
    • Schonwasser, D.C.1    Marais, R.M.2    Marshall, C.J.3    Parker, P.J.4
  • 107
    • 33847016103 scopus 로고    scopus 로고
    • Lysophosphatidylcholine mediates melanocyte dendricity through PKCζ activation
    • Scott, G.A., Arioka, M., and Jacobs, S.E. (2007). Lysophosphatidylcholine mediates melanocyte dendricity through PKCζ activation. J. Invest. Dermatol. 127, 668-675.
    • (2007) J. Invest. Dermatol. , vol.127 , pp. 668-675
    • Scott, G.A.1    Arioka, M.2    Jacobs, S.E.3
  • 108
    • 0035999087 scopus 로고    scopus 로고
    • Protein kinase C isoforms in normal and transformed cells of the melanocytic lineage
    • Selzer, E., Okamoto, I., Lucas, T., Kodym, R., Pehamberger, H., and Jansen, B. (2002). Protein kinase C isoforms in normal and transformed cells of the melanocytic lineage. Melanoma Res. 12, 201-209.
    • (2002) Melanoma Res. , vol.12 , pp. 201-209
    • Selzer, E.1    Okamoto, I.2    Lucas, T.3    Kodym, R.4    Pehamberger, H.5    Jansen, B.6
  • 109
    • 14844318039 scopus 로고    scopus 로고
    • Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane through 15(S)-hydroxyeicosatetraenoic acid synthesis
    • Sharma, G.D., Ottino, P., Bazan, N.G., and Bazan, H.E. (2005). Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane through 15(S)-hydroxyeicosatetraenoic acid synthesis. J. Biol. Chem. 280, 7917-7924.
    • (2005) J. Biol. Chem. , vol.280 , pp. 7917-7924
    • Sharma, G.D.1    Ottino, P.2    Bazan, N.G.3    Bazan, H.E.4
  • 110
    • 34447630662 scopus 로고    scopus 로고
    • Protein kinase C alpha and epsilon differentially modulate hepatocyte growth factor-induced epithelial proliferation and migration
    • Sharma, G.D., Kakazu, A., and Bazan, H.E. (2007). Protein kinase C alpha and epsilon differentially modulate hepatocyte growth factor-induced epithelial proliferation and migration. Exp. Eye Res. 85, 289-297.
    • (2007) Exp. Eye Res. , vol.85 , pp. 289-297
    • Sharma, G.D.1    Kakazu, A.2    Bazan, H.E.3
  • 111
    • 58249101137 scopus 로고    scopus 로고
    • PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: results of a randomized, double-blind, vehicle-controlled, multicentre, phase IIa study
    • Siller, G., Gebauer, K., Welburn, P., Katsamas, J., and Ogbourne, S.M. (2009). PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: results of a randomized, double-blind, vehicle-controlled, multicentre, phase IIa study. Australas. J. Dermatol. 50, 16-22.
    • (2009) Australas. J. Dermatol. , vol.50 , pp. 16-22
    • Siller, G.1    Gebauer, K.2    Welburn, P.3    Katsamas, J.4    Ogbourne, S.M.5
  • 112
    • 77951989505 scopus 로고    scopus 로고
    • PEP005 (ingenol mebutate) gel for the topical treatment of superficial basal cell carcinoma: results of a randomized phase IIa trial
    • Siller, G., Rosen, R., Freeman, M., Welburn, P., Katsamas, J., and Ogbourne, S.M. (2010). PEP005 (ingenol mebutate) gel for the topical treatment of superficial basal cell carcinoma: results of a randomized phase IIa trial. Australas. J. Dermatol. 51, 99-105.
    • (2010) Australas. J. Dermatol. , vol.51 , pp. 99-105
    • Siller, G.1    Rosen, R.2    Freeman, M.3    Welburn, P.4    Katsamas, J.5    Ogbourne, S.M.6
  • 113
    • 79951961755 scopus 로고    scopus 로고
    • Resistance to BRAF inhibition in melanomas
    • Solit, D.B., and Rosen, N. (2011). Resistance to BRAF inhibition in melanomas. N. Engl. J. Med. 364, 772-774.
    • (2011) N. Engl. J. Med. , vol.364 , pp. 772-774
    • Solit, D.B.1    Rosen, N.2
  • 114
    • 84863116743 scopus 로고    scopus 로고
    • Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
    • Sosman, J.A., Kim, K.B., Schuchter, L. et al. (2012). Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N. Engl. J. Med. 366, 707-714.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 707-714
    • Sosman, J.A.1    Kim, K.B.2    Schuchter, L.3
  • 115
    • 33645048160 scopus 로고    scopus 로고
    • Proteomic and SAGE profiling of murine melanoma progression indicates the reduction of proteins responsible for ROS degradation
    • de Souza, G.A., Godoy, L.M., Teixeira, V.R. et al. (2006). Proteomic and SAGE profiling of murine melanoma progression indicates the reduction of proteins responsible for ROS degradation. Proteomics 6, 1460-1470.
    • (2006) Proteomics , vol.6 , pp. 1460-1470
    • de Souza, G.A.1    Godoy, L.M.2    Teixeira, V.R.3
  • 117
    • 58149237395 scopus 로고    scopus 로고
    • Model cell culture system for defining the molecular and biochemical events mediating terminal differentiation of human melanoma cells
    • Staudt, M.R., Depass, A.L., Sarkar, D., and Fisher, P.B. (2008). Model cell culture system for defining the molecular and biochemical events mediating terminal differentiation of human melanoma cells. J. Cell. Physiol. 218, 304-314.
    • (2008) J. Cell. Physiol. , vol.218 , pp. 304-314
    • Staudt, M.R.1    Depass, A.L.2    Sarkar, D.3    Fisher, P.B.4
  • 118
    • 0035839578 scopus 로고    scopus 로고
    • Binding specificity for RACK1 resides in the V5 region of βII protein kinase C
    • Stebbins, E.G., and Mochly-Rosen, D. (2001). Binding specificity for RACK1 resides in the V5 region of βII protein kinase C. J. Biol. Chem. 276, 29644-29650.
    • (2001) J. Biol. Chem. , vol.276 , pp. 29644-29650
    • Stebbins, E.G.1    Mochly-Rosen, D.2
  • 119
    • 0028902719 scopus 로고
    • Long-term proliferation of human melanocytes is supported by the physiologic mitogens alpha-melanotropin, endothelin-1, and basic fibroblast growth factor
    • Swope, V.B., Medrano, E.E., Smalara, D., and Abdel-Malek, Z.A. (1995). Long-term proliferation of human melanocytes is supported by the physiologic mitogens alpha-melanotropin, endothelin-1, and basic fibroblast growth factor. Exp. Cell Res. 217, 453-459.
    • (1995) Exp. Cell Res. , vol.217 , pp. 453-459
    • Swope, V.B.1    Medrano, E.E.2    Smalara, D.3    Abdel-Malek, Z.A.4
  • 121
    • 0028055160 scopus 로고
    • Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts
    • Szallasi, Z., Smith, C.B., Pettit, G.R., and Blumberg, P.M. (1994). Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts. J. Biol. Chem. 269, 2118-2124.
    • (1994) J. Biol. Chem. , vol.269 , pp. 2118-2124
    • Szallasi, Z.1    Smith, C.B.2    Pettit, G.R.3    Blumberg, P.M.4
  • 122
    • 0028960503 scopus 로고
    • Differential regulation by anti-tumor-promoting 12-deoxyphorbol- 13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biological responses of primary mouse keratinocytes
    • Szallasi, Z., Kosa, K., Smith, C.B., Dlugosz, A.A., Williams, E.K., Yuspa, S.H., and Blumberg, P.M. (1995). Differential regulation by anti-tumor-promoting 12-deoxyphorbol- 13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biological responses of primary mouse keratinocytes. Mol. Pharmacol. 47, 258-265.
    • (1995) Mol. Pharmacol. , vol.47 , pp. 258-265
    • Szallasi, Z.1    Kosa, K.2    Smith, C.B.3    Dlugosz, A.A.4    Williams, E.K.5    Yuspa, S.H.6    Blumberg, P.M.7
  • 123
    • 0029892167 scopus 로고    scopus 로고
    • The bryostatins inhibit growth of B16/F10 melanoma cells in vitro through a protein kinase C-independent mechanism: dissociation of activities using 26-epi-bryostatin 1
    • Szallasi, Z., Du, L., Levine, R., Lewin, N.E., Nguyen, P.N., Williams, M.D., Pettit, G.R., and Blumberg, P.M. (1996). The bryostatins inhibit growth of B16/F10 melanoma cells in vitro through a protein kinase C-independent mechanism: dissociation of activities using 26-epi-bryostatin 1. Cancer Res. 56, 2105-2111.
    • (1996) Cancer Res. , vol.56 , pp. 2105-2111
    • Szallasi, Z.1    Du, L.2    Levine, R.3    Lewin, N.E.4    Nguyen, P.N.5    Williams, M.D.6    Pettit, G.R.7    Blumberg, P.M.8
  • 125
    • 14444269482 scopus 로고    scopus 로고
    • MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines
    • Teng, D.H., Hu, R., Lin, H. et al. (1997). MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res. 57, 5221-5225.
    • (1997) Cancer Res. , vol.57 , pp. 5221-5225
    • Teng, D.H.1    Hu, R.2    Lin, H.3
  • 126
    • 0036829335 scopus 로고    scopus 로고
    • A randomized phase II study of two schedules of bryostatin-1 (NSC339555) in patients with advanced malignant melanoma: A National Cancer Institute of Canada Clinical Trials Group study
    • Tozer, R.G., Burdette-Radoux, S., Berlanger, K., Davis, M.L., Lohmann, R.C., Rusthoven, J.R., Wainman, N., Zee, B., and Seymour, L. (2002). A randomized phase II study of two schedules of bryostatin-1 (NSC339555) in patients with advanced malignant melanoma: A National Cancer Institute of Canada Clinical Trials Group study. Invest. New Drugs 20, 407-412.
    • (2002) Invest. New Drugs , vol.20 , pp. 407-412
    • Tozer, R.G.1    Burdette-Radoux, S.2    Berlanger, K.3    Davis, M.L.4    Lohmann, R.C.5    Rusthoven, J.R.6    Wainman, N.7    Zee, B.8    Seymour, L.9
  • 127
    • 0029789967 scopus 로고    scopus 로고
    • Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf
    • Ueda, Y., Hirai, S., Osada, S., Suzuki, A., Mizuno, K., and Ohno, S. (1996). Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J. Biol. Chem. 271, 23512-23519.
    • (1996) J. Biol. Chem. , vol.271 , pp. 23512-23519
    • Ueda, Y.1    Hirai, S.2    Osada, S.3    Suzuki, A.4    Mizuno, K.5    Ohno, S.6
  • 130
    • 78650008177 scopus 로고    scopus 로고
    • Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
    • Villanueva, J., Vultur, A., Lee, J.T. et al. (2010). Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell 18, 683-695.
    • (2010) Cancer Cell , vol.18 , pp. 683-695
    • Villanueva, J.1    Vultur, A.2    Lee, J.T.3
  • 132
    • 80051625929 scopus 로고    scopus 로고
    • Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
    • Wagle, N., Emery, C., Berger, M.F. et al. (2011). Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. J. Clin. Oncol. 29, 3085-3096.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3085-3096
    • Wagle, N.1    Emery, C.2    Berger, M.F.3
  • 133
    • 0033601367 scopus 로고    scopus 로고
    • Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein
    • Wang, Q.J., Bhattacharyya, D., Garfield, S., Nacro, K., Marquez, V.E., and Blumberg, P.M. (1999). Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein. J. Biol. Chem. 274, 37233-37239.
    • (1999) J. Biol. Chem. , vol.274 , pp. 37233-37239
    • Wang, Q.J.1    Bhattacharyya, D.2    Garfield, S.3    Nacro, K.4    Marquez, V.E.5    Blumberg, P.M.6
  • 134
    • 0034697324 scopus 로고    scopus 로고
    • The lipophilicity of phorbol esters as a critical factor in determining the pattern of translocation of protein kinase C delta fused to green fluorescent protein
    • Wang, Q.J., Fang, T.W., Fenick, D., Garfield, S., Bienfait, B., Marquez, V.E., and Blumberg, P.M. (2000). The lipophilicity of phorbol esters as a critical factor in determining the pattern of translocation of protein kinase C delta fused to green fluorescent protein. J. Biol. Chem. 275, 12136-12146.
    • (2000) J. Biol. Chem. , vol.275 , pp. 12136-12146
    • Wang, Q.J.1    Fang, T.W.2    Fenick, D.3    Garfield, S.4    Bienfait, B.5    Marquez, V.E.6    Blumberg, P.M.7
  • 135
    • 22544468543 scopus 로고    scopus 로고
    • Direct binding to ceramide activates protein kinase Cζ before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells
    • Wang, G., Silva, J., Krishnamurthy, K., Tran, E., Condie, B.G., and Bieberich, E. (2005). Direct binding to ceramide activates protein kinase Cζ before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells. J. Biol. Chem. 280, 26415-26424.
    • (2005) J. Biol. Chem. , vol.280 , pp. 26415-26424
    • Wang, G.1    Silva, J.2    Krishnamurthy, K.3    Tran, E.4    Condie, B.G.5    Bieberich, E.6
  • 138
    • 84862691752 scopus 로고    scopus 로고
    • A double-blind, randomized, placebo-controlled, phase 2 study of maintenance enzastaurin with 5-fluorouracil/leucovorin plus bevacizumab after first-line therapy for metastatic colorectal cancer
    • doi: 10.1002/cncr.26692.
    • Wolff, R.A., Fuchs, M., Di Bartolomeo, M., Hossain, A.M., Stoffregen, C., Nicol, S., and Heinemann, V. (2011). A double-blind, randomized, placebo-controlled, phase 2 study of maintenance enzastaurin with 5-fluorouracil/leucovorin plus bevacizumab after first-line therapy for metastatic colorectal cancer. Cancer doi: 10.1002/cncr.26692.
    • (2011) Cancer
    • Wolff, R.A.1    Fuchs, M.2    Di Bartolomeo, M.3    Hossain, A.M.4    Stoffregen, C.5    Nicol, S.6    Heinemann, V.7
  • 139
    • 84855782488 scopus 로고    scopus 로고
    • The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma
    • Wu, X., Zhu, M., Fletcher, J.A., Giobbie-Hurder, A., and Hodi, F.S. (2012). The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma. PLoS ONE 7, e29622.
    • (2012) PLoS ONE , vol.7
    • Wu, X.1    Zhu, M.2    Fletcher, J.A.3    Giobbie-Hurder, A.4    Hodi, F.S.5
  • 140
    • 2642709170 scopus 로고    scopus 로고
    • Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
    • Xia, P., Aiello, L.P., Ishii, H., Jiang, Z.Y., Park, D.J., Robinson, G.S., Takagi, H., Newsome, W.P., Jirousek, M.R., and King, G.L. (1996). Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J. Clin. Invest. 98, 2018-2026.
    • (1996) J. Clin. Invest. , vol.98 , pp. 2018-2026
    • Xia, P.1    Aiello, L.P.2    Ishii, H.3    Jiang, Z.Y.4    Park, D.J.5    Robinson, G.S.6    Takagi, H.7    Newsome, W.P.8    Jirousek, M.R.9    King, G.L.10
  • 141
    • 77749264374 scopus 로고    scopus 로고
    • Loss of protein kinase C δ gene expression in human squamous cell carcinomas: a laser capture microdissection study
    • Yadav, V., Yanez, N.C., Fenton, S.E., and Denning, M.F. (2010). Loss of protein kinase C δ gene expression in human squamous cell carcinomas: a laser capture microdissection study. Am. J. Pathol. 176, 1091-1096.
    • (2010) Am. J. Pathol. , vol.176 , pp. 1091-1096
    • Yadav, V.1    Yanez, N.C.2    Fenton, S.E.3    Denning, M.F.4
  • 142
    • 0025981422 scopus 로고
    • The differential expression of protein kinase C genes in normal human neonatal melanocytes and metastatic melanomas
    • Yamanishi, D.T., Graham, M., Buckmeier, J.A., and Meyskens Jr, F.L. (1991). The differential expression of protein kinase C genes in normal human neonatal melanocytes and metastatic melanomas. Carcinogenesis 12, 105-109.
    • (1991) Carcinogenesis , vol.12 , pp. 105-109
    • Yamanishi, D.T.1    Graham, M.2    Buckmeier, J.A.3    Meyskens Jr., F.L.4
  • 143
    • 51749094162 scopus 로고    scopus 로고
    • From UVs to metastases: modeling melanoma initiation and progression in the mouse
    • Zaidi, M.R., Day, C.P., and Merlino, G. (2008). From UVs to metastases: modeling melanoma initiation and progression in the mouse. J. Invest. Dermatol. 128, 2381-2391.
    • (2008) J. Invest. Dermatol. , vol.128 , pp. 2381-2391
    • Zaidi, M.R.1    Day, C.P.2    Merlino, G.3
  • 144
    • 12444337495 scopus 로고    scopus 로고
    • Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-α and translocating PKC-δ
    • Zhang, X.M., Chen, J., Xia, Y.G., and Xu, Q. (2005). Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-α and translocating PKC-δ. Cancer Chemother. Pharmacol. 55, 251-262.
    • (2005) Cancer Chemother. Pharmacol. , vol.55 , pp. 251-262
    • Zhang, X.M.1    Chen, J.2    Xia, Y.G.3    Xu, Q.4


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