The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Wu, Xinqi ^a,b   Zhu, Meijun ^c   Fletcher, Jonathan A ^c   Giobbie Hurder, Anita ^b   Hodi, F Stephen ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; ENZASTAURIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BCL 2; PROTEIN KINASE C; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA II; PROTEIN KINASE C EPSILON; PROTEIN KINASE C THETA; SHORT HAIRPIN RNA; SURVIVIN; UNCLASSIFIED DRUG; BROXURIDINE; CCND1 PROTEIN, HUMAN; CYCLIN D1; GNAQ PROTEIN, HUMAN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; INDOLE DERIVATIVE; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION REGULATION; GENE MUTATION; GNAQ GENE; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR GENE; UPREGULATION; UVEA MELANOMA; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; CELL SURVIVAL; DRUG ANTAGONISM; DRUG SCREENING; ENZYMOLOGY; GENETICS; HUMAN; MELANOMA; METABOLISM; MOLECULAR GENETICS; MUTATION; PATHOLOGY; TUMOR CELL LINE; UVEA TUMOR;

APOPTOSIS; BROMODEOXYURIDINE; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GTP-BINDING PROTEIN ALPHA SUBUNITS; HUMANS; INDOLES; ISOENZYMES; MELANOMA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; UVEAL NEOPLASMS;

EID: 84855782488     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029622     Document Type: Article

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