Aberrant redox regulation in human metastatic melanoma cells compared to normal melanocytes

Free Radical Biology and Medicine

Volumn 31, Issue 6, 2001, Pages 799-808

  Meyskens Jr, Frank L ^a,b   McNulty, Susan E ^a   Buckmeier, Julie A ^a   Tohidian, Nilou B ^a   Spillane, Thomas J ^a   Kahlon, Ravi S ^a   Gonzalez, Rachel I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chelator; Free radicals; Hydrogen peroxide; Superoxide anion

Indexed keywords

1,10 PHENANTHROLINE; DEFEROXAMINE MESYLATE; DICHLOROFLUORESCEIN; ETHIDIUM BROMIDE; FERRIC ION; FERROUS ION; FLUORESCENT DYE; HYDROETHIDINE; HYDROGEN PEROXIDE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; MELANIN; METAL CHELATE; POLYMER; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE; RNA; SUPEROXIDE; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL LEVEL; CELL LINE; CELL TYPE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENSITOMETRY; DOWN REGULATION; ELECTROPHORETIC MOBILITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MELANOCYTE; MELANOMA; MELANOMA CELL; NEWBORN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PREPUCE; PRIORITY JOURNAL; PROTEIN BINDING; SKIN METASTASIS;

ANNEXIN A5; APOPTOSIS; CHELATING AGENTS; HOMEOSTASIS; HUMANS; HYDROGEN PEROXIDE; MELANOCYTES; MELANOMA; NF-KAPPA B; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SUPEROXIDES; TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED;

EID: 0035884882     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00650-5     Document Type: Article

References (44)

1. Chemotherapy of melanoma
2. 6-alkylguanine-DNA-alkyltransferase
3. Collateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1, N11-diethylnorspermine
4. Constitutive activation of NF-κB in human melanoma cells and the effect of oxidative stress
5. The NF-κB transcription factor and cancer: High expression of NF-κB- and IκB-related proteins in tumor cell lines
6. Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory disease
7. Superoxide anion inhibits drug-induced tumor cell death
8. Role of NF-κB in the apoptotic-resistant phenotype of keratinocytes
9. Alpha-melanocyte-stimulating hormone inhibits NF-κB activation in human melanocytes and melanoma cells
10. Expression of c-jun, jun-B, and c-fos proto-oncogenes in human primary melanocytes and metastatic melanomas
11. Defective gene expression of MnSOD in cancer cells
12. Imbalance in the antioxidant pool in melanoma cells and normal melanocytes from patients with melanoma
13. Correlation between antioxidants and phototypes in melanocyte cultures. A possible link of physiologic and pathologic relevance
14. Reactive oxygen species in tumorigenesis
15. Antioxidant enzyme levels in cancer
16. Luminol-enhanced chemiluminescent response of human melanocytes and melanoma cells to hydrogen peroxide stress
17. Role of deferoxamine in tumor therapy
18. Lithiocarbamates and the redox regulation of cell death
19. Preparation and analysis of RNA
20. Viral induction of the human β interferon promoter: Modulation of transcription by NF-κB/rel proteins and interferon regulatory factors
21. Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical
22. Flow cytometric detection of hydrogen peroxide production induced by doxorubicin in cancer cells
23. Changes in antioxidant defense systems by cyclosporine A in cultures of hepatocytes from 2- and 12-month-old rats
24. Role of oxidants in NF-κB activation and TNF-α gene transcription induced by hypoxia and endotoxin
25. Regulation of the transcription factors NF-κB and AP-1 by redox changes
26. Reactive oxygen species as cellular messengers
27. Role of peroxide and superoxide anion during tumor cell apoptosis
28. Apoptosis induced by hydrogen peroxide is mediated by decreased superoxide anion concentration and reduction of intracellular milieu
29. Intracellular oxidation/reduction status in the regulation of transcription factors NF-κB and AP-1
30. Production of large amounts of hydrogen peroxide by human tumor cells
31. Persistent oxidative stress in cancer
32. Keratinocyte superoxide generation
33. Production of superoxide by human malignant melanoma cells
34. Melanogenesis as a targeting strategy against metastatic melanoma: A reassessment
35. 5,6-Dihydroxyindoles in the fenton reaction: A model study of the role of melanin precursors in oxidative stress and hyperpigmentary processes
36. Cytotoxicity and superoxide anion generation by some naturally occurring quinones
37. Synthetic melanin and ferric ions promote superoxide anion-mediated lipid peroxidation
38. Iron chelators inhibit the growth and induce the apoptosis of Kaposi's sarcoma cells and of their putative endothelial precursors
39. Enhanced degradation of IκBα contributes to endogenous activation of NF-κB in Hs294T melanoma cells
40. Inhibition of homologue of slimb (HOS) function sensitizes human melanoma cells for apoptosis
41. Expression of apoptosis regulators in cutaneous malignant melanoma
42. Nuclear factor-κB activity correlates with growth, angiogenesis, and metastatasis of human melanoma cells in nude mice
43. Death receptors in cutaneous biology and disease
44. Differential effect of hydrogen peroxide and superoxide anion on apoptosis and proliferation of vascular smooth muscle cells