PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC

Blood

Volumn 106, Issue 4, 2005, Pages 1362-1368

  Hampson, Peter ^a   Chahal, Hema ^a   Khanim, Farhat ^a   Hayden, Rachel ^a   Mulder, Anneke ^a   Assi, Lakhvir Kaur ^a   Bunce, Christopher M ^a   Lord, Janet M ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; ENHANCED GREEN FLUORESCENT PROTEIN; EUPHORBIA PEPLUS EXTRACT; INGENOL 3 ANGELATE; PEP005; PLANT EXTRACT; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C DELTA; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; EUPHORBIA; EUPHORBIA PEPLUS; HUMAN; HUMAN CELL; MYELOBLAST; MYELOID LEUKEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; UMBILICAL CORD BLOOD;

EID: 23744432856     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-10-4117     Document Type: Article

References (41)

1. Schoch C, Kern W, Schnittger S, Buchner T, Hiddemann W, Haferlach T. The influence of age on prognosis of de novo acute myeloid leukemia differs according to cytogenetic subgroups. Haematologica. 2004;89:1082-1090.
2. Astrom M, Bodin L, Nilsson I, Tidefelt U. Treatment, long-term outcome and prognostic variables in 214 unselected AML patients in Sweden. Br J Cancer. 2000;82:1387-1392.
3. Lutz W, Sanderson W, Scherbov S. Doubling of world population unlikely. Nature. 1997;387:803-805.
4. Capdeville R, Buchdunger E, Zimmermann J, Matter A. Glivec (ST1571, Imatinib), a rationally developed, targeted anticancer drug. Nature Rev Drug Discov. 2002;1:493-502.
5. Green AC, Beardmore GL. Home treatment of skin cancer and solar keratoses. Australas J Dermatol. 1988;29:127-130.
6. Weedon D, Chick J. Home treatment of basal cell carcinoma. Med J Aust. 1976:1:928.
7. Ogbourne SM, Suhrbier A, Jones B, et al. Antitumor activity of 3-ingenyl angelate: plasma membrane and mitochondrial disruption and necrotic cell death. Cancer Res. 2004;64:2833-2839.
8. Kedei N, Lundberg DJ, Toth A, et al. Characterization of the interaction of ingenol 3-angelate with protein kinase C. Cancer Res. 2004;64:3243-3255.
9. Deacon EM, Pongracz J, Griffiths G, Lord JM. Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis. J Clin Pathol Mol Pathol. 1997;50:124-131.
10. Mellor H, Parker PJ. The extended protein kinase C superfamily. Biochem J. 1998;332:281-292.
11. Gescher A. Staurosporine analogues: pharmacological toys or useful antitumour agents? Crit Rev Oncol Hematol. 2000;34:127-135.
12. Clamp A, Jayson GC. The clinical development of the bryostatins. Anticancer Drugs. 2002;13:673-683.
13. Man ZT, Zhu XX, Yang RY, et al. Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity. Proc Natl Acad Sci U S A. 1998;95:5357-5361.
14. Telford WG, King LE, Fraker PJ. Rapid quantitation of apoptosis in pure and heterogeneous cell populations using flow cytometry. J Immunol Methods. 1994;172:1-16.
15. Holleman A, den Boer ML, Kazemier KM, Janka-Schaub GE, Refers R. Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia. Blood. 2003;102:4541-4546.
16. Toksoz D, Bunce CM, Stone PCW, Michell RH, Brown G. Variant cell lines from the human promyelocyte cell line HL60. Leukemia Res. 1982;6:491-498.
17. Dempsey EC, Newton AC, Mochly-Rosen D, et al. Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol. 2000;279:L429-L438.
18. Nowak G. Protein kinase C-alpha and ERK1/2 mediate mitochondrial dysfunction, decreases in active Na+ transport, and cisplatin-induced apoptosis in renal cells. J Biol Chem. 2002;277:43377-43388.
19. Kambhampati S, Li YZ, Verma A, et al. Activation of protein kinase C delta by all-trans-retinoic acid. J Biol Chem. 2003;278:32544-32551.
20. Voss OH, Kim S, Wewers MD, Doseff Al. Regulation of monocyte apoptosis by the protein kinase C δ (PKCδ)-dependent phosphorylation of caspase-3. J Biol Chem. 2005;280:17371-17379.
21. Scheel-Toellner D, Pilling D, Akbar AN, et al. Inhibition of T cell apoptosis by IFN-beta rapidly reverses nuclear translocation of protein kinase C-delta. Eur J Immunol. 1999;29:2603-2612.
22. Cross T, Griffiths G, Deacon E, et al. PKC-delta is an apoptotic lamin kinase. Oncogene. 2000;19:2331-2337.
23. Prudhomme M. Indolocarbazoles as anti-cancer agents. Curr Pharmaceutical Design. 1997;3:265-290.
24. Hornia A, Lu ZM, Sukezane T, et al. Antagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor. Mol Cell Biol. 1999;19:7672-7680.
25. Jiffar T, Kurinna S, Suck G, et al. PKC alpha mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation. Leukemia. 2004;18:505-512.
26. Perletti GP, Marras E, Concari P, Piccinini F, Tashjian AH. PKC delta acts as a growth and tumor suppressor in rat colonic epithelial cells. Oncogene. 1999;18:1251-1256.
27. Ghayur T, Hugunin M, Talanian RV, et al. Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis. J Exp Med. 1996;184:2399-2404.
28. Emoto Y, Kisaki H, Manome Y, Kharbanda S, Kufe D. Activation of protein kinase C delta in human myeloid leukemia cells treated with 1-beta-D- arabinofuranosylcytosine. Blood. 1996;87:1990-1996.
29. Schmidmaier R, Oellerich M, Baumgart J, Emmerich B, Meinhardt G. Treosulfan-induced apoptosis in acute myeloid leukemia cells is accompanied by translocation of protein kinase C delta and enhanced by bryostatin-1. Exp Hematol. 2004;32:76-86.
30. Griffiths G, Garrone B, Deacon E, et al. The polyether bistratene A activates protein kinase C-delta and induces growth arrest in HL60 cells. Biochem Biophys Res Commun. 1996;222:802-808.
31. Gschwendt M, Muller HJ, Kielbassa K, et al. Rottlerin a novel protein kinase inhibitor. Biochem Biophys Res Commun. 1994;199:93-98.
32. Graflon G, Bunce CM, Sheppard MC, Brown G, Baxter MA. Changes in the kinetics of inositol transport during TPA-induced differentiation of HL60 cells towards monocytes. FEBS Lett. 1991;286:229-232.
33. Wan QJ, Fang TW, Fenick D, et al. The lipophilicity of phorbol esters as a critical factor in determining the pattern of translocation of protein kinase C delta fused to green fluorescent protein. J Biol Chem. 2000;275:12136-12146.
34. Meinhardt G, Roth J, Totok G, et al. Signaling defect in the activation of caspase-3 and PKC delta in human TUR leukemia cells is associated with resistance to apoptosis. Exp Cell Res. 1999;247:534-542.
35. Pongracz J, Webb P, Wang KQ, et al. Spontaneous neutrophil apoptosis involves caspase 3-mediated activation of protein kinase C-delta. J Biol Chem. 1999;274:37329-37334.
36. Scheel-Toellner D, Wang KQ, Henriquez NV, et al. Cytokine-mediated inhibition of apoptosis in non-transformed T cells and neutrophils can be dissociated from protein kinase B activation. Eur J Immunol. 2002;32:486-493.
37. Liu JH, Chen J, Dai Q, Lee RM. Phospholipid scramblase 3 is the mitochondrial target of protein kinase C delta-induced apoptosis. Cancer Res. 2003;63:1153-1156.
38. Bharti A, Kraeft SK, Gounder M, et al. Inactivation of DNA-dependent protein kinase by protein kinase C delta: implications for apoptosis. Mol Cell Biol. 1998;18:6719-6728.
39. Mischak H, Pierce JH, Goodnight J, et al. Phorbol ester induced myeloid differentiation is mediated by protein kinase C alpha and kinase C delta and not by protein kinase C beta-II, kinase C zeta and kinase C eta. J Biol Chem. 1993;268:20110-20115.
40. Tallman MS, Nabhan C, Feusner JH, Rowe JM. Acute promyelocytic leukemia: evolving therapeutic strategies. Blood. 2002;99:759-767.
41. Lee HY, Walsh GL, Dawson MI, Hong WK, Kurie JM. All-trans-retinoic acid inhibits jun N-terminal kinase-dependent signaling pathways. J Biol Chem. 1998;273:7066-7071.