The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells

Investigational New Drugs

Volumn 28, Issue 5, 2010, Pages 575-586

  Mason, Sharon A ^a   Cozzi, Sarah Jane ^a   Pierce, Carly J ^a   Pavey, Sandra J ^b,c   Parsons, Peter G ^a   Boyle, Glen M ^a  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Diterpene ester; MAPK; PEP008; PKC; Senescence; TPA

Indexed keywords

12 O TETRADECANOYLPHORBOR 13 ACETATE; 20 O ACETYLINGENOL 3 ANGELATE; BISINDOLYLMALEIMIDE; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLINE; DITERPENE; MITOGEN ACTIVATED PROTEIN KINASE; PEP 008; PROTEIN HRASLS3; PROTEIN KINASE C; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F1; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; BETA GALACTOSIDASE; CALCIUM INDEPENDENT PHOSPHOLIPASE A2; ENZYME ACTIVATOR; ESTER; ISOENZYME; PHORBOL 13 ACETATE 12 MYRISTATE; PLA2G16 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE; COLON CANCER; CONTROLLED STUDY; CYTOSTASIS; DEPHOSPHORYLATION; DNA SYNTHESIS; DOWN REGULATION; DRUG SENSITIVITY; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MELANOMA CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SENESCENCE; CELL AGING; CELL PROLIFERATION; DNA MICROARRAY; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY; PHENOTYPE; TUMOR CELL LINE;

BETA-GALACTOSIDASE; CELL AGING; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DITERPENES; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; ENZYME ACTIVATORS; ESTERS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOENZYMES; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PROTEIN KINASE C; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS; PHOSPHOLIPASES A2, CALCIUM-INDEPENDENT;

EID: 77956061891     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-009-9292-y     Document Type: Article

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