-
1
-
-
0002509929
-
Neoplasms, malignant melanoma
-
T. B. Fitzpatrick, A Z Eisen, K. Wollf, I M. Freedberg, and K. F. Austen (eds.), New York. McGraw-Hill, Inc
-
Barnhill, R. L., Mihm, M. C , Jr., Fitzpatrick, T B., and Sober, A. J. Neoplasms, malignant melanoma. In: T. B. Fitzpatrick, A Z Eisen, K. Wollf, I M. Freedberg, and K. F. Austen (eds.), Dermatology in General Medicine, pp. 1078-1115 New York. McGraw-Hill, Inc , 1993.
-
(1993)
Dermatology in General Medicine
, pp. 1078-1115
-
-
Barnhill, R.L.1
Mihm Jr., M.C.2
Fitzpatrick, T.B.3
Sober, A.J.4
-
2
-
-
0026532012
-
Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: In vitro versus in vivo activity
-
Hornung, R. L , Pearson, J W., Beckwith, M., and Longo, D L Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: in vitro versus in vivo activity. Cancer Res., 52: 101-107, 1992.
-
(1992)
Cancer Res.
, vol.52
, pp. 101-107
-
-
Hornung, R.L.1
Pearson, J.W.2
Beckwith, M.3
Longo, D.L.4
-
3
-
-
0025961690
-
Successful treatment of murine melanoma with bryostatin 1
-
Schuchter, L. M., Esa, A. H , May, S., Laulis, M. K., Pettit, G. R., and Hess, A. D. Successful treatment of murine melanoma with bryostatin 1. Cancer Res., 51: 682-687, 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 682-687
-
-
Schuchter, L.M.1
Esa, A.H.2
May, S.3
Laulis, M.K.4
Pettit, G.R.5
Hess, A.D.6
-
4
-
-
0027326957
-
Phase I study of intravenous bryostatin 1 in patients with advanced cancer
-
Prendivlle, J., Crowther, D., Thatcher, N., Woll, P. J., Fox, B. W., McGown, A., Testa, N., Stern, P., McDermott, R , Potter, M., and Pettit, G. R. A Phase I study of intravenous bryostatin 1 in patients with advanced cancer. Br. J. Cancer, 68: 418-424, 1993.
-
(1993)
Br. J. Cancer
, vol.68
, pp. 418-424
-
-
Prendivlle, J.1
Crowther, D.2
Thatcher, N.3
Woll, P.J.4
Fox, B.W.5
McGown, A.6
Testa, N.7
Stern, P.8
McDermott, R.9
Potter, M.10
Pettit, G.R.A.11
-
5
-
-
0027489606
-
Phase I study of bryostatin 1: Assessment of interleukin 6 and tumor necrosis factor α induction in vivo
-
Philip, P. A., Rea, D , Thavasu, P., Carmichel, J., Stuart, N S. A., Rockett, H., Talbot, D. C., Ganesan, T. Pettit, G. R , Balkwill, F., and Harris, A. L. Phase I study of bryostatin 1: assessment of interleukin 6 and tumor necrosis factor α induction in vivo. J. Natl. Cancer Inst., 85, 1812-1818, 1993.
-
(1993)
J. Natl. Cancer Inst.
, vol.85
, pp. 1812-1818
-
-
Philip, P.A.1
Rea, D.2
Thavasu, P.3
Carmichel, J.4
Stuart, N.S.A.5
Rockett, H.6
Talbot, D.C.7
Ganesan, T.8
Pettit, G.R.9
Balkwill, F.10
Harris, A.L.11
-
7
-
-
0010543768
-
Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60
-
Kraft, A S., Smith, J. B., and Berkow, R. L. Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60. Proc. Natl. Acad. Sci. USA, 83 1334-1338, 1986.
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 1334-1338
-
-
Kraft, A.S.1
Smith, J.B.2
Berkow, R.L.3
-
9
-
-
0000168479
-
The bryostatins, a family of protein kinase C activators with therapeutic potential
-
P. Krogsgaard-Larsen, C. Brogger Christensen, and H. Kofod (eds ), Copenhagen, Denmark: Munksgaard
-
Blumberg, P. M., and Pettit, G. R. The bryostatins, a family of protein kinase C activators with therapeutic potential In: P. Krogsgaard-Larsen, C. Brogger Christensen, and H. Kofod (eds ), New Leads and Targets in Drug Research, Alfred Benzon Symposium 33, pp. 273-285. Copenhagen, Denmark: Munksgaard, 1992.
-
(1992)
New Leads and Targets in Drug Research, Alfred Benzon Symposium
, vol.33
, pp. 273-285
-
-
Blumberg, P.M.1
Pettit, G.R.2
-
10
-
-
0028126624
-
Bryostatin 1 protects protein kinase C-δ from down-regulation in mouse keratinocytes in parallel with us inhibition of phorbol ester induced differentiation
-
Szallasi, Z , Denning, M. F., Smith C. B., Dlugosz, A. A., Yuspa, S. H., Pettit, G. R., and Blumberg, P. M. Bryostatin 1 protects protein kinase C-δ from down-regulation in mouse keratinocytes in parallel with us inhibition of phorbol ester induced differentiation. Mol. Pharmacol , 46: 840-850, 1994.
-
(1994)
Mol. Pharmacol
, vol.46
, pp. 840-850
-
-
Szallasi, Z.1
Denning, M.F.2
Smith, C.B.3
Dlugosz, A.A.4
Yuspa, S.H.5
Pettit, G.R.6
Blumberg, P.M.7
-
11
-
-
0028055160
-
Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts
-
Szallasi, Z., Smith, C B., Pettit, G R., and Blumberg, P. M. Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts. J. Biol Chem., 269: 2118-2124, 1994.
-
(1994)
J. Biol Chem.
, vol.269
, pp. 2118-2124
-
-
Szallasi, Z.1
Smith, C.B.2
Pettit, G.R.3
Blumberg, P.M.4
-
12
-
-
0023603491
-
Inhibition by bryostatin 1 of the phorbol ester-induced blockage of differentiation in hexamethylene bisacetamide-treated Friend erythroleukemia cells
-
Dell'Aquilla, M. L., Nguyen, H. T., Herald, C. H., Pettit, G. R , and Blumberg, P. M. Inhibition by bryostatin 1 of the phorbol ester-induced blockage of differentiation in hexamethylene bisacetamide-treated Friend erythroleukemia cells Cancer Res., 47: 6006-6009, 1987.
-
(1987)
Cancer Res.
, vol.47
, pp. 6006-6009
-
-
Dell'Aquilla, M.L.1
Nguyen, H.T.2
Herald, C.H.3
Pettit, G.R.4
Blumberg, P.M.5
-
13
-
-
0023721850
-
Differential effects of bryostatins and phorbol esters on arachidonic acid metabolite release and epidermal growth factor binding in C3H10T/2 cells
-
Dell'Aquilla, M. L., Herald, C. H., Kamano, Y , Pettit, G. R., and Blumberg, P M. Differential effects of bryostatins and phorbol esters on arachidonic acid metabolite release and epidermal growth factor binding in C3H10T/2 cells. Cancer Res., 48: 3702-3708, 1988.
-
(1988)
Cancer Res.
, vol.48
, pp. 3702-3708
-
-
Dell'Aquilla, M.L.1
Herald, C.H.2
Kamano, Y.3
Pettit, G.R.4
Blumberg, P.M.5
-
14
-
-
0027297104
-
Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes
-
Kazanietz, M G., Areces, L. B , Bahador, A., Mishak, H , Goodnight, J., Mushinski, J. F , and Blumberg, P M Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes. Mol. Pharmacol., 44: 298-307, 1993.
-
(1993)
Mol. Pharmacol.
, vol.44
, pp. 298-307
-
-
Kazanietz, M.G.1
Areces, L.B.2
Bahador, A.3
Mishak, H.4
Goodnight, J.5
Mushinski, J.F.6
Blumberg, P.M.7
-
15
-
-
0019979849
-
Biological assays for irritant tumor-initiating and -promoting activities. I. Kinetics of the irritant response in relation to the initiation-promoting activity of polyfunctional diterpenes representing tigliane and some daphnane types
-
Hergenhahn, M., Furstenberger, G., Opferfcuch, H. J., Adolf, W., Mack, H., and Hecker, E. Biological assays for irritant tumor-initiating and -promoting activities. I. Kinetics of the irritant response in relation to the initiation-promoting activity of polyfunctional diterpenes representing tigliane and some daphnane types. J. Cancer Res. Clin. Oncol., 104: 31-39, 1982.
-
(1982)
J. Cancer Res. Clin. Oncol.
, vol.104
, pp. 31-39
-
-
Hergenhahn, M.1
Furstenberger, G.2
Opferfcuch, H.J.3
Adolf, W.4
Mack, H.5
Hecker, E.6
-
16
-
-
0015425060
-
Zum Wirkungsmechanismus Cocarcinogener Pflanzenmhaltsstoffe
-
Furstenberger, G., and Hecker, E Zum Wirkungsmechanismus Cocarcinogener Pflanzenmhaltsstoffe. Planta Med., 22: 241-266, 1972.
-
(1972)
Planta Med.
, vol.22
, pp. 241-266
-
-
Furstenberger, G.1
Hecker, E.2
-
17
-
-
0021289463
-
Structure activity relations of polyfunctional diterpenes of the tiguane type, VI
-
Zayed, S., Sorg, B., and Hecker, E. Structure activity relations of polyfunctional diterpenes of the tiguane type, VI. Planta Med., 34: 65-69, 1984
-
(1984)
Planta Med.
, vol.34
, pp. 65-69
-
-
Zayed, S.1
Sorg, B.2
Hecker, E.3
-
18
-
-
0028979464
-
Structural basis for membrane and tumor-promoter binding by protein kinase C
-
Zhang, G., Kazanietz, M G , Blumberg, P. M., and Hurley, J H. Structural basis for membrane and tumor-promoter binding by protein kinase C. Cell, 81: 917-924, 1995.
-
(1995)
Cell
, vol.81
, pp. 917-924
-
-
Zhang, G.1
Kazanietz, M.G.2
Blumberg, P.M.3
Hurley, J.H.4
-
19
-
-
0026513625
-
Structural basis of protein kinase C activation by diacylglycerol and tumor promoters
-
Rando, R. R., and Kishi, Y. Structural basis of protein kinase C activation by diacylglycerol and tumor promoters. Biochemistry, 11: 2211-2218, 1992.
-
(1992)
Biochemistry
, vol.11
, pp. 2211-2218
-
-
Rando, R.R.1
Kishi, Y.2
-
20
-
-
0000852678
-
Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C
-
Wender, P. A., Cribbs, C. M., Koehler, K. F., Sharkey, N. E., Herald, C. L., Kamano, Y., Pettit, G. R., and Blumberg, P. M. Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C Proc. Natl. Acad. Sci USA, 85: 7197-7201, 1988.
-
(1988)
Proc. Natl. Acad. Sci USA
, vol.85
, pp. 7197-7201
-
-
Wender, P.A.1
Cribbs, C.M.2
Koehler, K.F.3
Sharkey, N.E.4
Herald, C.L.5
Kamano, Y.6
Pettit, G.R.7
Blumberg, P.M.8
-
22
-
-
0020408957
-
Isolation and structure of bryostatin 1
-
Pettit, G. R., Herald, C. L., Doubek, D. L., Arnold, E , and Clardy, J. Isolation and structure of bryostatin 1. J. Am. Chem. Soc., 104: 6846-6848, 1982
-
(1982)
J. Am. Chem. Soc.
, vol.104
, pp. 6846-6848
-
-
Pettit, G.R.1
Herald, C.L.2
Doubek, D.L.3
Arnold, E.4
Clardy, J.5
-
23
-
-
0026579522
-
Structural modifications of bryostatin 2
-
Pettit, G. R , Sengupta, D., Blumberg, P. M., Lewin, N E., Schmidt, J. M , and Kraft, A S. Structural modifications of bryostatin 2. Anti-Cancer Drug Des., 7: 101-113. 1992.
-
(1992)
Anti-Cancer Drug Des.
, vol.7
, pp. 101-113
-
-
Pettit, G.R.1
Sengupta, D.2
Blumberg, P.M.3
Lewin, N.E.4
Schmidt, J.M.5
Kraft, A.S.6
-
24
-
-
0000629930
-
Selection of successive tumor lines for metastasis
-
Fidler, I. J. Selection of successive tumor lines for metastasis. Nature (Lond ), 242: 148-149, 1973.
-
(1973)
Nature (Lond )
, vol.242
, pp. 148-149
-
-
Fidler, I.J.1
-
25
-
-
0023876867
-
Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action
-
Nakadate, T., Jeng, A. Y., and Blumberg, P. M. Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action. Biochem. Pharmacol., 37: 1541-1545, 1988.
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 1541-1545
-
-
Nakadate, T.1
Jeng, A.Y.2
Blumberg, P.M.3
-
26
-
-
0025942516
-
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
-
Toullec, D., Pianetti, P , Coste, H., Bellevergue, P., Grand-Perret, T , Ajakane, M., Baudet, V , Boissini, P., Boursier, E., Loriolle, F., Duhamel, L , Charon, D , and Kirilovsky, J The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C J. Biol Chem , 266: 15771-15781, 1991.
-
(1991)
J. Biol Chem
, vol.266
, pp. 15771-15781
-
-
Toullec, D.1
Pianetti, P.2
Coste, H.3
Bellevergue, P.4
Grand-Perret, T.5
Ajakane, M.6
Baudet, V.7
Boissini, P.8
Boursier, E.9
Loriolle, F.10
Duhamel, L.11
Charon, D.12
Kirilovsky, J.13
|