A/ASP/VAL allele combination of IGF1R, IRS2, and UCP2 genes is associated with better metabolic profile, preserved energy expenditure parameters, and low mortality rate in longevity

Age

Volumn 34, Issue 1, 2012, Pages 235-245

  Barbieri, Michelangela ^a   Boccardi, Virginia ^a   Esposito, Antonietta ^a   Papa, Michela ^a   Vestini, Francesco ^a   Rizzo, Maria Rosaria ^a   Paolisso, Giuseppe ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Energy expenditure; IGF1R IRS2 UCP2 haplotype; Longevity; Metabolic profile; Mortality rate

Indexed keywords

ALANINE; ASPARTIC ACID; INSULIN RECEPTOR SUBSTRATE 2; SOMATOMEDIN C RECEPTOR; UNCOUPLING PROTEIN 2; VALINE; INSULIN RECEPTOR SUBSTRATE; ION CHANNEL; IRS2 PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2;

ADULT; ALLELE; AMINO ACID SEQUENCE; ARTICLE; BODY COMPOSITION; CONTROLLED STUDY; DNA POLYMORPHISM; ENERGY EXPENDITURE; ENERGY METABOLISM; ETHNIC GROUP; FEMALE; FOLLOW UP; GENE FUNCTION; GENE INTERACTION; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HAPLOTYPE; HUMAN; HUMAN EXPERIMENT; IGF1R GENE; IRS2 GENE; ITALIAN; LONGEVITY; MALE; METABOLIC CAPACITY; METABOLIC PARAMETERS; METABOLIC RATE; MORTALITY; NORMAL HUMAN; PRESERVED ENERGY EXPENDITURE; PROBABILITY; RESPIRATORY QUOTIENT; SENESCENCE; UCP2 GENE; AGED; AGING; ALGORITHM; GENETICS; METABOLOME; MIDDLE AGED; RETROSPECTIVE STUDY; SURVIVAL;

ADULT; AGED; AGED, 80 AND OVER; AGING; ALGORITHMS; ALLELES; ENERGY METABOLISM; FEMALE; FOLLOW-UP STUDIES; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; ION CHANNELS; LONGEVITY; MALE; METABOLOME; MIDDLE AGED; MITOCHONDRIAL PROTEINS; RECEPTOR, IGF TYPE 1; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS;

EID: 84862317570     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-011-9210-z     Document Type: Article

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