Claspin: Timing the cell cycle arrest when the genome is damaged

Cell Cycle

Volumn 5, Issue 24, 2006, Pages 2831-2834

  Freire, Raimundo ^a   Van Vugt, Marcel A T M ^b   Mamely, Ivan ^a   Medema, René H ^c  

^a HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Checkpoint recovery; Chk1; Claspin; DNA damage checkpoint; F box protein; Mitosis; Phospho degron; Plk1; Proteasome; TrCP SCF

Indexed keywords

CHECKPOINT KINASE 1; CLASPIN ENZYME; PROTEIN SERINE THREONINE KINASE;

AMINO TERMINAL SEQUENCE; CELL CYCLE ARREST; DNA DAMAGE; ENZYME ACTIVATION; ENZYME BINDING; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; NONHUMAN; REVIEW;

EID: 33845658109     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.24.3559     Document Type: Review

References (44)

1. Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, Jackson SP. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 2006; 8:37-45.
2. 2/M DNA damage checkpoint. Genes Dev 2000; 14:1448-59.
3. Matsuoka S, Huang M, Elledge SJ. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 1998; 282:1893-7.
4. Zou L, Cortez D, Elledge SJ. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev 2002; 16:198-208.
5. Kumagai A, Dunphy WG. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol Cell 2000; 6:839-49.
6. Alcasabas AA, Osborn AJ, Bachant J, Hu F, Werler PJ, Bousset K, Furuya K, Diffley JF, Carr AM, Elledge SJ. Mrc1 transduces signals of DNA replication stress to activate Rad53. Nat Cell Biol 2001; 3:958-65.
7. Tanaka K, Russell P. Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1. Nat Cell Biol 2001; 3:966-72.
8. Osborn AJ, Elledge SJ. Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev 2003; 17:1755-67.
9. Sar F, Lindsey-Boltz LA, Subramanian D, Croteau DL, Hutsell SQ, Griffith JD, Sancar A. Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures. J Biol Chem 2004; 279:39289-95.
10. Chini CC, Chen J. Claspin, a regulator of Chk1 in DNA replication stress pathway. DNA Repair (Amst) 2004; 3:1033-7.
11. Kumagai A, Dunphy WG. Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1. Nat Cell Biol 2003; 5:161-5.
12. Chini CC, Chen J. Repeated phosphopeptide motifs in human claspin are phosphorylated by chk1 and mediate claspin function. J Biol Chem 2006; 281:33276-82.
13. Clarke CA, Clarke PR. DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. Biochem J 2005; 388:705-12.
14. Yoo HY, Jeong SY, Dunphy WG. Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures. Genes Dev 2006; 20:772-83.
15. Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG. Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase. Cell 2004; 117:575-88.
16. van de Weerdt BC, Medema RH. Polo-like kinases: A team in control of the division. Cell Cycle 2006; 5:853-64.
17. Smits VA, Klompmaker R, Arnaud L, Rijksen G, Nigg EA, Medema RH. Polo-like kinase-1 is a target of the DNA damage checkpoint. Nat Cell Biol 2000; 2:672-6.
18. van Vugt MA, Medema RH. Checkpoint adaptation and recovery: Back with Polo after the break. Cell Cycle 2004; 3:1383-6.
19. van Vugt MA, Bras A, Medema RH. Restarting the cell cycle when the checkpoint comes to a halt. Cancer Res 2005; 65:7037-40.
20. den Elzen N, Kosoy A, Christopoulos H, O'Connell MJ. Resisting arrest: Recovery from checkpoint arrest through dephosphorylation of Chk1 by PP1. Cell Cycle 2004; 3:529-33.
21. den Elzen NR, O'Connell MJ. Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1. Embo J 2004; 23:908-18.
22. 2/M arrest. Mol Cell 2001; 7:293-300.
23. 2 DNA damage-induced arrest in mammalian cells. Mol Cell 2004; 15:799-811.
24. Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Proc Natl Acad Sci USA 2004; 101:4419-24.
25. Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, Hershko A, Pagano M, Draetta GF. Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature 2003; 426:87-91.
26. Maniatis T. A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways. Genes Dev 1999; 13:505-10.
27. Chowdhury D, Keogh MC, Ishii H, Peterson CL, Buratowski S, Lieberman J. gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol Cell 2005; 20:801-9.
28. Keogh MC, Kim JA, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, Greenblatt JF, Krogan NJ. A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature 2006; 439:497-501.
29. Leroy C, Lee SE, Vaze MB, Ochsenbien F, Guerois R, Haber JE, Marsolier-Kergoat MC. PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break. Mol Cell 2003; 11:827-35.
30. Lu X, Nannenga B, Donehower LA. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev 2005; 19:1162-74.
31. Lu X, Nguyen TA, Donehower LA. Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D. Cell Cycle 2005; 4:1060-4.
32. Shreeram S, Demidov ON, Hee WK, Yamaguchi H, Onishi N, Kek C, Timofeev ON, Dudgeon C, Fornace AJ, Anderson CW, Minami Y, Appella E, Bulavin DV. Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell 2006; 23:757-64.
33. Bennett LN, Clarke PR. Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation. FEBS Lett 2006; 580:4176-81.
34. Mailand N, Bekker-Jensen S, Bartek J, Lukos J. Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell 2006; 23:307-18.
35. Mamely I, van Vugt MA, Smits VA, Semple JI, Lemmens B, Perrakis A, Medema RH, Freire R. Polo-like kinase-1 controls proteasome-dependent degradation of claspin during checkpoint recovery. Curr Biol 2006.
36. Peschiaroli A, Dorrello NV, Guardavaccaro D, Venere M, Halazonetis T, Sherman NE, Pagano M. SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol Cell 2006; 23:319-29.
37. Zhang D, Zaugg K, Mak TW, Elledge SJ. A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell 2006; 126:529-42.
38. Amerik AY, Hochstrasser M. Mechanism and function of deubiquitinating enzymes. Biochim Biophys Acta 2004; 1695:189-207.
39. Chini CC, Wood J, Chen J. Chk1 is required to maintain claspin stability. Oncogene 2006; 25:4165-71.
40. Fiscella M, Zhang H, Fan S, Sakaguchi K, Shen S, Mercer WE, Vande Woude GF, O'Connor PM, Appella E. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc Natl Acad Sci USA 1997; 94:6048-53.
41. Chini CC, Chen J. Human claspin is required for replication checkpoint control. J Biol Chem 2003; 278:30057-62.
42. Mendez J, Zou-Yang XH, Kim SY, Hidaka M, Tansey WP, Stillman B. Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. Mol Cell 2002; 9:481-91.
43. Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zieger K, Guldberg P, Sehested M, Nesland JM, Lukas C, Orntoft T, Lukas J, Bartek J. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005; 434:864-70.
44. Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, Ditullio Jr RA, Kastrinakis NG, Levy B, Kletsas D, Yoneta A, Herlyn M, Kittas C, Halazonetis TD. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005; 434:907-13.