Structure and composition of pulmonary arteries, capillaries, and veins

Comprehensive Physiology

Volumn 2, Issue 1, 2012, Pages 675-709

  Townsley, Mary I ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ARTICLE; AUDIOVISUAL EQUIPMENT; CAPILLARY; CELL JUNCTION; ELECTRON MICROSCOPY; HISTOLOGY; HUMAN; INNERVATION; LUNG; PULMONARY ARTERY; PULMONARY VEIN; RADIOGRAPHY; SPECIES DIFFERENCE; ULTRASTRUCTURE; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASCULARIZATION;

ANIMALS; CAPILLARIES; ENDOTHELIUM, VASCULAR; HUMANS; INTERCELLULAR JUNCTIONS; LUNG; MICROSCOPY, ELECTRON; MODELS, ANATOMIC; MUSCLE, SMOOTH, VASCULAR; PULMONARY ARTERY; PULMONARY VEINS; SPECIES SPECIFICITY;

EID: 84862002344     PISSN: None     EISSN: 20404603     Source Type: Journal    
DOI: 10.1002/cphy.c100081     Document Type: Article

References (355)

1. Adachi T, Ishikawa K, Hida W, Matsumoto H, Masuda T, Date F, Ogawa K, Takeda K, Furuyama K, Zhang Y, Kitamuro T, Ogawa H, Maruyama Y, Shibahara S. Hypoxemia and blunted hypoxic ventilatory responses in mice lacking heme oxygenase-2. Biochem Biophys Res Commun, 320, 2004, 514-522
2. Aguirre JI, Morrell NW, Long L, Clift P, Upton PD, Polak JM, Wilkins MR. Vascular remodeling and ET-1 expression in rat strains with different responses to chronic hypoxia. Am J Physiol Lung Cell Mol Physiol, 278, 2000, L981-L987
3. Aharinejad S, Bock P, Lametschwandtner A, Firbas W. Scanning and transmission electron microscopy of venous sphincters in the rat lung. Anat Rec, 233, 1992, 555-568
4. Aharinejad S, Egerbacher M, Nourani F, Bock P, Friederici C, Schraufnagel DE. Pulmonary venous sphincters in cattle. Anat Rec, 246, 1996, 356-363
5. Aiello VD, Gutierrez PS, Chaves MJ, Lopes AA, Higuchi ML, Ramires JA. Morphology of the internal elastic lamina in arteries from pulmonary hypertensive patients: A confocal laser microscopy study. Mod Pathol, 16, 2003, 411-416
6. Alexander IG, Ritchie BC, Maloney JE. Scanning electron microscopy of pulmonary alveolar capillary vessels. Thorax, 28, 1973, 222-227
7. Allen KM, Wharton J, Polak JM, Haworth SG. A study of nerves containing peptides in the pulmonary vasculature of healthy infants and children and of those with pulmonary hypertension. Br Heart J, 62, 1989, 353-360
8. Alvarez DF, King JA, Weber D, Addison E, Liedtke W, Townsley MI. Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: A novel mechanism of acute lung injury. Circ Res, 99, 2006, 988-995
9. Anderson RH, Brown NA, Moorman AF. Development and structures of the venous pole of the heart. Dev Dyn, 235, 2006, 2-9
10. Andersson CK, Mori M, Bjermer L, Lofdahl CG, Erjefalt JS. Novel site-specific mast cell subpopulations in the human lung. Thorax, 64, 2009, 297-305
11. Andersson CK, Mori M, Bjermer L, Lofdahl CG, Erjefalt JS. Alterations in lung mast cell populations in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 181, 2010, 206-217
12. Arciniegas E, Graterol A, Sanchez F. Characterization of nonmuscle cells present in the intima of normal adult bovine pulmonary artery. Anat Rec, 258, 2000, 262-268
13. Bachofen H, Wangensteen D, Weibel ER. Surfaces and volumes of alveolar tissue under zone II and zone III conditions. J Appl Physiol, 53, 1982, 879-885
14. Barnes PJ, Liu SF. Regulation of pulmonary vascular tone. Pharmacol Rev, 47, 1995, 87-131
15. Ben Driss A, Devaux C, Henrion D, Duriez M, Thuillez C, Levy BI, Michel JB. Hemodynamic stresses induce endothelial dysfunction and remodeling of pulmonary artery in experimental compensated heart failure. Circulation, 101, 2000, 2764-2770
16. Benedek I, Hintea T, Toganel R. Myocardial fibres in pulmonary veins-possible compensatory factor in dilated cardiomyopathy. Rom J Intern Med, 36, 1998, 175-181
17. Beppu H, Ichinose F, Kawai N, Jones RC, Yu PB, Zapol WM, Miyazono K, Li E, Bloch KD. BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am J Physiol Lung Cell Mol Physiol, 287, 2004, L1241-L1247
18. Berendsen PB, Ritter AB, De Fouw DO. An ultrastructural morphometric comparison of the peripheral with the hilar air-blood barrier of dog lung. Anat Rec, 209, 1984, 535-540
19. Best PV, Heath D. Interpretation of the appearances of the small pulmonary blood vessels in animals. Circ Res, 9, 1961, 288-294
20. Bishop JE, Guerreiro D, Laurent GJ. Changes in the composition and metabolism of arterial collagens during the development of pulmonary hypertension in rabbits. Am Rev Respir Dis, 141, 1990, 450-455
21. Burbach JA, Waltz WF, Goodman BE, Schlenker EH. Structural abnormalities underlying alveolar hypoventilation and fluid imbalance in the dystrophic hamster lung. Anat Rec, 256, 1999, 321-333
22. Burnstock G. Autonomic neuromuscular junctions: Current developments and future directions. J Anat, 146, 1986, 1-30
23. Burnstock G. Non-synaptic transmission at autonomic neuroeffector junctions. Neurochem Int, 52, 2008, 14-25
24. Burnstock G. Purinergic cotransmission. Exp Physiol, 94, 2009, 20-24
25. Burri PH. Cellular components of the alveolar unit. Curr Probl Clin Biochem, 13, 1983, 11-22
26. Burri PH, Tarek MR. A novel mechanism of capillary growth in the rat pulmonary microcirculation. Anat Rec, 228, 1990, 35-45
27. Burrowes KS, Hunter PJ, Tawhai MH. Anatomically based finite element models of the human pulmonary arterial and venous trees including supernumerary vessels. J Appl Physiol, 99, 2005, 731-738
28. Castillo Y, Kruger H, Arias-Stella J, Hurtado A, Harris P, Heath D. Histology, extensibility, and chemical composition of pulmonary trunk in persons living at sea-level and at high altitude in Peru. Br Heart J, 29, 1967, 120-128
29. Cha TJ, Ehrlich JR, Zhang L, Chartier D, Leung TK, Nattel S. Atrial tachycardia remodeling of pulmonary vein cardiomyocytes: Comparison with left atrium and potential relation to arrhythmogenesis. Circulation, 111, 2005, 728-735
30. Challice CE, Wilkens JL, Chohan KS. Electrical impulse conduction in pulmonary veins. Biophys J, 14, 1974, 901-904
31. Chambers RC, Laurent GJ. Collagens. In: Crystal RG, West JB, Barnes PJ, Weibel ER, editors. The Lung: Scientific Foundations. Philadelphia: Lippincott-Raven Publishers, 1997, p. 709-727.
32. Chang LY, Overby LH, Brody AR, Crapo JD. Progressive lung cell reactions and extracellular matrix production after a brief exposure to asbestos. Am J Pathol, 131, 1988, 156-170
33. Chazova I, Loyd JE, Zhdanov VS, Newman JH, Belenkov Y, Meyrick B. Pulmonary artery adventitial changes and venous involvement in primary pulmonary hypertension. Am J Pathol, 146, 1995, 389-397
34. Chen YF, Feng JA, Li P, Xing D, Zhang Y, Serra R, Ambalavanan N, Majid-Hassan E, Oparil S. Dominant negative mutation of the TGF-ßreceptor blocks hypoxia-induced pulmonary vascular remodeling. J Appl Physiol, 100, 2006, 564-571
35. Cheung DW. Electrical activity of the pulmonary vein and its interaction with the right atrium in the guinea-pig. J Physiol, 314, 1981, 445-456
36. Chou CC, Nihei M, Zhou S, Tan A, Kawase A, Macias ES, Fishbein MC, Lin SF, Chen PS. Intracellular calcium dynamics and anisotropic reentry in isolated canine pulmonary veins and left atrium. Circulation, 111, 2005, 2889-2897
37. Ciurea D, Gil J. Morphometry of capillaries in three zones of rabbit lungs fixed by vascular perfusion. Anat Rec, 244, 1996, 182-192
38. Coalson JJ, King RJ, Winter VT, Prihoda TJ, Anzueto AR, Peters JI, Johanson WG Jr. O2- and pneumonia-induced lung injury. I. Pathological and morphometric studies. J Appl Physiol, 67, 1989, 346-356
39. Coflesky JT, Jones RC, Reid LM, Evans JN. Mechanical properties and structure of isolated pulmonary arteries remodeled by chronic hyperoxia. Am Rev Respir Dis, 136, 1987, 388-394
40. Coulombe PA, Cote MG. Application of linear integration in the morphometric study of mild and severe pulmonary alveolar injury. Exp Mol Pathol, 48, 1988, 77-96
41. 2+-handling properties of canine pulmonary vein and left atrial cardiomyocytes. Am J Physiol Heart Circ Physiol, 291, 2006, H2290-H2300
42. Cowan KN, Heilbut A, Humpl T, Lam C, Ito S, Rabinovitch M. Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Nat Med, 6, 2000, 698-702
43. Crapo JD, Barry BE, Foscue HA, Shelburne J. Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen. Am Rev Respir Dis, 122, 1980, 123-143
44. Crapo JD, Barry BE, Gehr P, Bachofen M, Weibel ER. Cell number and cell characteristics of the normal human lung. Am Rev Respir Dis, 125, 1982, 740-745
45. Crapo JD, Hayatdavoudi G, Knapp MJ, Fracica PJ, Wolfe WG, Piantadosi CA. Progressive alveolar septal injury in primates exposed to 60% oxygen for 14 days. Am J Physiol, 267, 1994, L797-L806
46. Crapo JD, Marsh-Salin J, Ingram P, Pratt PC. Tolerance and crosstolerance using NO2 and O2 II. Pulmonary morphology and morphometry. J Appl Physiol, 44, 1978, 370-379
47. Crapo JD, Young SL, Fram EK, Pinkerton KE, Barry BE, Crapo RO. Morphometric characteristics of cells in the alveolar region of mammalian lungs. Am Rev Respir Dis, 128, 1983, S42-S46
48. Culver BH, Butler J. Mechanical influences on the pulmonary microcirculation. Annu Rev Physiol, 42, 1980, 187-198
49. Davidson JM. Biochemistry and turnover of lung interstitium. Eur Respir J, 3, 1990, 1048-1063
50. Davies P, Burke G, Reid L. The structure of thewall of the rat intraacinar pulmonary artery: An electron microscopic study of microdissected preparations. Microvasc Res, 32, 1986, 50-63
51. Davies P, Maddalo F, Reid L. Effects of chronic hypoxia on structure and reactivity of rat lung microvessels. J Appl Physiol, 58, 1985, 795-801
52. Davies P, McBride J, Murray GF, Wilcox BR, Shallal JA, Reid L. Structural changes in the canine lung and pulmonary arteries after pneumonectomy. J Appl Physiol, 53, 1982, 859-864
53. Davies PF, Olesen SP, Clapham DE, Morrel EM, Schoen FJ. Endothelial communication. State of the art lecture. Hypertension, 11, 1988, 563-572
54. De Fouw DO. Vesicle numerical densities and cellular attenuation: Comparisons between endothelium and epithelium of the alveolar septa in normal dog lungs. Anat Rec, 209, 1984, 77-84
55. De Fouw DO. Structural heterogeneity within the pulmonary microcirculation of the normal rat. Anat Rec, 221, 1988, 645-654
56. De Fouw DO, Chinard FP. Variations in cellular attenuation and vesicle numerical densities in capillary endothelium and type I epithelium of isolated, perfused dog lungs after acute severe edema formation. Microvasc Res, 26, 1983, 15-26
57. De Fouw DO, Shumko JZ. Pulmonary microcirculation: Differences in endothelia of subpleural and alveolar capillaries. Microvasc Res, 32, 1986, 348-358
58. de Mello DE, Reid LM. Arteries and veins. In: Crystal RG, West JB, Weibel ER, Barnes PJ, editors. The Lung: Scientific Foundations,. Philadelphia: Lippincott-Raven, 1997, p. 1117-1127.
59. Dey RD, Shannon WA Jr, Said SI. Localization of VIP-immunoreactive nerves in airways and pulmonary vessels of dogs, cat, and human subjects. Cell Tissue Res, 220, 1981, 231-238
60. Dornan JC, Meban C. The capillary plexus in the gas exchange zone of human neonatal lung: An ultrastructural study. Thorax, 40, 1985, 787-792
61. Dunsmore SE, Rannels DE. Extracellular matrix biology in the lung. Am J Physiol, 270, 1996, L3-L27
62. Durmowicz AG, Hofmeister S, Kadyraliev TK, Aldashev AA, Stenmark KR. Functional and structural adaptation of the yak pulmonary circulation to residence at high altitude. J Appl Physiol, 74, 1993, 2276-2285
63. Effros RM, Parker JC. Pulmonary vascular heterogeneity and the Starling hypothesis. Microvasc Res, 78, 2009, 71-77
64. El-Bermani AW. Pulmonary noradrenergic innervation of rat and monkey: A comparative study. Thorax, 33, 1978, 167-174
65. El-Bermani AW, Bloomquist EI, Montvilo JA. Distribution of pulmonary cholinergic nerves in the rabbit. Thorax, 37, 1982, 703-710
66. El-Bizri N, Wang L, Merklinger SL, Guignabert C, Desai T, Urashima T, Sheikh AY, Knutsen RH, Mecham RP, Mishina Y, Rabinovitch M. Smooth muscle protein 22a-mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling. Circ Res, 102, 2008, 380-388
67. Elliott FM, Reid L. Some new facts about the pulmonary artery and its branching pattern. Clin Radiol, 16, 1965, 193-198
68. Endo H, Kurohmaru M, Nishida T, Hattori S, Hayashi Y. Cardiac musculature of the intrapulmonary vein in the musk shrew. J Vet Med Sci, 54, 1992, 119-123
69. Endo H, Mifune H, Maeda S, Kimura J, Yamada J, Rerkamnuaychoke W, Chungsamarnyart N, Ogawa K, Kurohmaru M, Hayashi Y, Nishida T. Cardiac-like musculature of the intrapulmonary venous wall of the long-clawed shrew (Sorex unguiculatus), common tree shrew (Tupaia glis) and common marmoset (Callithrix jacchus). Anat Rec, 247, 1997, 46-52
70. Fillenz M. Innervation of pulmonary capillaries. Experientia, 1969 25: 842.
71. Fillenz M. Innervation of pulmonary and bronchial blood vessels of the dog. J Anat, 106, 1970, 449-461
72. Forrest JB, Weibel ER. Morphometric estimation of pulmonary diffusion capacity. VII. The normal Guinea pig lung. Respir Physiol, 24, 1975, 191-202
73. Fox B, Bull TB, Guz A. Innervation of alveolar walls in the human lung: An electron microscopic study. J Anat, 131, 1980, 683-692
74. Fracica PJ, Caminiti SP, Piantadosi CA, Duhaylongsod FG, Crapo JD, Young SL. Natural surfactant and hyperoxic lung injury in primates. II. Morphometric analyses. J Appl Physiol, 76, 1994, 1002-1010
75. Frey U, Hislop A, Silverman M. Branching properties of the pulmonary arterial tree during pre- and postnatal development. Respir Physiol Neurobiol, 139, 2004, 179-189
76. Frid MG, Moiseeva EP, Stenmark KR. Multiple phenotypically distinct smooth muscle cell populations exist in the adult and developing bovine pulmonary arterial media in vivo. Circ Res, 75, 1994, 669-681
77. Fry GN, Devine CE, Burnstock G. Freeze-fracture studies of nexuses between smooth muscle cells. Close relationship to sarcoplasmic reticulum. J Cell Biol, 72, 1977, 26-34
78. Fung YC, Sobin SS, Tremer H, Yen MR, Ho HH. Patency and compliance of pulmonary veins when airway pressure exceeds blood pressure. J Appl Physiol, 54, 1983, 1538-1549
79. Gan RZ, Tian Y, Yen RT, Kassab GS. Morphometry of the dog pulmonary venous tree. J Appl Physiol, 75, 1993, 432-440
80. Gan RZ, Yen RT. Vascular impedance analysis in dog lung with detailed morphometric and elasticity data. J Appl Physiol, 77, 1994, 706-717
81. Gao Y, Raj JU. Role of veins in regulation of pulmonary circulation. Am J Physiol Lung Cell Mol Physiol, 288, 2005, L213-L226
82. Gebb S, Stevens T. On lung endothelial cell heterogeneity. Microvasc Res, 68, 2004, 1-12
83. Gebrane-Younes J, Drouet L, Caen JP, Orcel L. Heterogeneous distribution of Weibel-Palade bodies and von Willebrand factor along the porcine vascular tree. Am J Pathol, 139, 1991, 1471-1484
84. Gehr P, Bachofen M, Weibel ER. The normal human lung: Ultrastructure and morphometric estimation of diffusion capacity. Respir Physiol, 32, 1978, 121-140
85. Gehr P, Erni H. Morphometric estimation of pulmonary diffusion capacity in two horse lungs. Respir Physiol, 41, 1980, 199-210
86. Gehr P, Mwangi DK, Ammann A, Maloiy GM, Taylor CR, Weibel ER. Design of the mammalian respiratory system. V. Scaling morphometric pulmonary diffusing capacity to body mass: Wild and domestic mammals. Respir Physiol, 44, 1981, 61-86
87. Geiser M, Zimmermann B, Baumann M, Cruz-Orive LM. Does lack of Cftr gene lead to developmental abnormalities in the lung? Exp Lung Res, 26, 2000, 551-564
88. Gherghiceanu M, Hinescu ME, Andrei F, Mandache E, Macarie CE, Faussone-Pellegrini MS, Popescu LM. Interstitial Cajal-like cells (ICLC) in myocardial sleeves of human pulmonary veins. J Cell Mol Med, 12, 2008, 1777-1781
89. Gibbins IL. Lack of correlation between ultrastructural and pharmacological types of non-adrenergic autonomic nerves. Cell Tissue Res, 221, 1982, 551-581
90. Gibbins IL, Morris JL. Pathway specific expression of neuropeptides and autonomic control of the vasculature. Regul Pept, 93, 2000, 93-107
91. Gil J. The normal lung circulation. State of the art. Chest, 93, 1988, 80S-82S
92. Gil J, McNiff JM. Interstitial cells at the boundary between alveolar and extraalveolar connective tissue in the lung. J Ultrastruct Res, 76, 1981, 149-157
93. Gil J, Silage DA, McNiff JM. Distribution of vesicles in cells of airblood barrier in the rabbit. J Appl Physiol, 50, 1981, 334-340
94. Glazier JB, Hughes JM, Maloney JE, West JB. Measurements of capillary dimensions and blood volume in rapidly frozen lungs. J Appl Physiol, 26, 1969, 65-76
95. Godbey PS, Graham JA, Presson RG Jr, Wagner WW Jr, Lloyd TC Jr Effect of capillary pressure and lung distension on capillary recruitment. J Appl Physiol, 79, 1995, 1142-1147
96. Guembe L, Villaro AC. Histochemical demonstration of neuronal nitric oxide synthase during development of mouse respiratory tract. Am J Respir Cell Mol Biol, 20, 1999, 342-351
97. Guntheroth WG, Luchtel DL, Kawabori I. Pulmonary microcirculation: Tubules rather than sheet and post. J Appl Physiol, 53, 1982, 510-515
98. Guntheroth WG, Luchtel DL, Kawabori I. Functional implications of the pulmonary microcirculation. An update. Chest, 101, 1992, 1131-1134
99. Haberberger R, Schemann M, Sann H, Kummer W. Innervation pattern of guinea pig pulmonary vasculature depends on vascular diameter. J Appl Physiol, 82, 1997, 426-434
100. Haies DM, Gil J, Weibel ER. Morphometric study of rat lung cells. I. Numerical and dimensional characteristics of parenchymal cell population. Am Rev Respir Dis, 123, 1981, 533-541
101. Hale KA, Ewing SL, Gosnell BA, Niewoehner DE. Lung disease in long-term cigarette smokers with and without chronic air-flow obstruction. Am Rev Respir Dis, 130, 1984, 716-721
102. Hales CA, Kradin RL, Brandstetter RD, Zhu YJ. Impairment of hypoxic pulmonary artery remodeling by heparin in mice. Am Rev Respir Dis, 128, 1983, 747-751
103. Hall SM, Haworth SG. Normal adaptation of pulmonary arterial intima to extrauterine life in the pig: Ultrastructural studies. J Pathol, 149, 1986, 55-66
104. Harhun MI, Pucovsky V, Povstyan OV, Gordienko DV, Bolton TB. Interstitial cells in the vasculature. J Cell Mol Med, 9, 2005, 232-243
105. Harris P, Heath D, Apostolopoulos A. Extensibility of the human pulmonary trunk. Br Heart J, 27, 1965, 651-659
106. Hashizume H, Tango M, Ushiki T. Three-dimensional cytoarchitecture of rat pulmonary venous walls: A light and scanning electron microscopic study. Anat Embryol (Berl), 198, 1998, 473-480
107. Hassink RJ, Aretz HT, Ruskin J, Keane D. Morphology of atrial myocardium in human pulmonary veins:Apostmortem analysis in patients with and without atrial fibrillation. J Am Coll Cardiol, 42, 2003, 1108-1114
108. Haworth SG, Hislop AA. Pulmonary vascular development: Normal values of peripheral vascular structure. Am J Cardiol, 52, 1983, 578-583
109. Hayatdavoudi G, O'Neil JJ, Barry BE, Freeman BA, Crapo JD. Pulmonary injury in rats following continuous exposure to 60% O2 for 7 days. J Appl Physiol, 51, 1981, 1220-1231
110. Heath D, Smith P. The pulmonary endothelial cell. Thorax, 34, 1979, 200-208
111. Heath D, Smith P, Williams D, Harris P, Arias-Stella J, Kruger H. The heart and pulmonary vasculature of the llama (Lama glama). Thorax, 29, 1974, 463-471
112. Heath D, Wood EH, Dushane JW, Edwards JE. The structure of the pulmonary trunk at different ages and in cases of pulmonary hypertension and pulmonary stenosis. J Pathol Bacteriol, 77, 1959, 443-456
113. Hirschi KK, D'Amore PA. Pericytes in the microvasculature. Cardiovasc Res, 32, 1996, 687-698
114. Hislop A, Reid L. Pulmonary arterial development during childhood: Branching pattern and structure. Thorax, 28, 1973, 129-135
115. Hislop A, Reid L. Development of the acinus in the human lung. Thorax, 29, 1974, 90-94
116. Hislop A, Reid L. Normal structure and dimensions of the pulmonary arteries in the rat. J Anat, 125, 1978, 71-83
117. Ho SY, Cabrera JA, Tran VH, Farre J, Anderson RH, Sanchez-Quintana D. Architecture of the pulmonary veins: Relevance to radiofrequency ablation. Heart, 86, 2001, 265-270
118. Horsfield K. Morphometry of the small pulmonary arteries in man. Circ Res, 42, 1978, 593-597
119. Horsfield K. Axial pathways compared with complete data in morphological studies of the lung. Respir Physiol, 55, 1984, 317-324
120. Horsfield K, Gordon WI. Morphometry of pulmonary veins in man. Lung, 159, 1981, 211-218
121. Horsfield K, Thomas M. Morphometry of pulmonary arteries from angiograms in chronic obstructive lung disease. Thorax, 36, 1981, 360-365
122. Howell K, Preston RJ, McLoughlin P. Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation. J Physiol, 547, 2003, 133-145
123. Hsia CC, Hyde DM, Ochs M, Weibel ER. How to measure lung structure-what for? On the "Standards for the quantitative assessment of lung structure". Respir Physiol Neurobiol, 171, 2010, 72-74
124. Hsia CC, Hyde DM, Ochs M, Weibel ER. An official research policy statement of the American Thoracic Society/European Respiratory Society: Standards for quantitative assessment of lung structure. Am J Respir Crit Care Med, 181, 2010, 394-418
125. Hsia CC, Johnson RL Jr. Further examination of alveolar septal adaptation to left pneumonectomy in the adult lung. Respir Physiol Neurobiol, 151, 2006, 167-177
126. Hu LM, Jones R. Injury and remodeling of pulmonary veins by high oxygen. A morphometric study. Am J Pathol, 134, 1989, 253-262
127. Huang W, Yen RT, McLaurine M, Bledsoe G. Morphometry of the human pulmonary vasculature. J Appl Physiol, 81, 1996, 2123-2133
128. Hung KS, Hertweck MS, Hardy JD, Loosli CG. Innervation of pulmonary alveoli of the mouse lung: An electron microscopic study. Am J Anat, 135, 1972, 477-495
129. Hung KS, Hertweck MS, Hardy JD, Loosli CG. Electron microscopic observations of nerve endings in the alveolar walls of mouse lungs. Am Rev Respir Dis, 108, 1973, 328-333
130. Hyde DM, Tyler NK, Plopper CG. Morphometry of the respiratory tract: Avoiding the sampling, size, orientation, and reference traps. Toxicol Pathol, 35, 2007, 41-48
131. Hyde DM, Tyler NK, Putney LF, Singh P, Gundersen HJ. Total number and mean size of alveoli in mammalian lung estimated using fractionator sampling and unbiased estimates of the Euler characteristic of alveolar openings. Anat Rec A Discov Mol Cell Evol Biol, 277, 2004, 216-226
132. Ilkiw R, Todorovich-Hunter L, Maruyama K, Shin J, Rabinovitch M. SC-39026, a serine elastase inhibitor, prevents muscularization of peripheral arteries, suggesting a mechanism of monocrotaline-induced pulmonary hypertension in rats. Circ Res, 64, 1989, 814-825
133. Jaenke RS, Alexander AF. Fine structural alterations of bovine peripheral pulmonary arteries in hypoxia-induced hypertension. Am J Pathol, 73, 1973, 377-398
134. Jiang Y, Dai A, Li Q, Hu R. Hypoxia induces transforming growth factor-ß1 gene expression in the pulmonary artery of rats via hypoxiainducible factor-1a. Acta Biochim Biophys Sin (Shanghai), 39, 2007, 73-80
135. Jiang ZL, Kassab GS, Fung YC. Diameter-defined Strahler system and connectivity matrix of the pulmonary arterial tree. J Appl Physiol, 76, 1994, 882-892
136. Johnson JE, Perkett EA, Meyrick B. Pulmonary veins and bronchial vessels undergo remodeling in sustained pulmonary hypertension induced by continuous air embolization into sheep. Exp Lung Res, 23, 1997, 459-473
137. Jones R. Ultrastructural analysis of contractile cell development in lung microvessels in hyperoxic pulmonary hypertension. Fibroblasts and intermediate cells selectively reorganize nonmuscular segments. Am J Pathol, 141, 1992, 1491-1505
138. Jones R, Jacobson M, Steudel W. a-Smooth-muscle actin and microvascular precursor smooth-muscle cells in pulmonary hypertension. Am J Respir Cell Mol Biol, 20, 1999, 582-594
139. Jones R, Kirton OC. Lung microvessel injury from peritoneal abscesses and gram-negative bacteremia. Microvasc Res, 52, 1996, 84-100
140. Jones R, Zapol WM, Reid L. Pulmonary artery remodeling and pulmonary hypertension after exposure to hyperoxia for 7 days. A morphometric and hemodynamic study. Am J Pathol, 117, 1984, 273-285
141. Jones R, Zapol WM, Reid L. Oxygen toxicity and restructuring of pulmonary arteries-a morphometric study. The response to 4 weeks' exposure to hyperoxia and return to breathing air. Am J Pathol, 121, 1985, 212-223
142. Jones SA, Yamamoto M, Tellez JO, Billeter R, Boyett MR, Honjo H, Lancaster MK. Distinguishing properties of cells from the myocardial sleeves of the pulmonary veins: A comparison of normal and abnormal pacemakers. Circ Arrhythm Electrophysiol 1: 39-48, 2008. 1/1/39 [pii] 10.1161/CIRCEP.107.748467
143. Jones WK, Sanchez A, Robbins J. Murine pulmonary myocardium: Developmental analysis of cardiac gene expression. Dev Dyn, 200, 1994, 117-128
144. Kadowitz PJ, Knight DS, Hibbs RG, Ellison JP, Joiner PD, Brody MJ, Hyman AL. Influence of 5- and 6-hydroxydopamine on adrenergic transmission and nerve terminal morphology in the canine pulmonary vascular bed. Circ Res, 39, 1976, 191-199
145. Kalk J, Benjamin J, Comite H, Hutchins G, Traystman R, Menkes H. Vascular interdependence in postmortem human lungs. Am Rev Respir Dis, 112, 1975, 505-511
146. Kapanci Y, Gabbiani G. Contractile cells in pulmonary alveolar tissue. In: Crystal RC, West JB, Barnes PJ, Weibel ER, editors. The Lung: Scientific Foundations. Philadelphia: Lippincott-Raven Publishers, 1997, p. 697-707.
147. Kapanci Y, Ribaux C, Chaponnier C, Gabbiani G. Cytoskeletal features of alveolar myofibroblasts and pericytes in normal human and rat lung. J Histochem Cytochem, 40, 1992, 1955-1963
148. Kaplan NB, Grant MM, Brody JS. The lipid interstitial cell of the pulmonary alveolus. Age and species differences. Am Rev Respir Dis, 132, 1985, 1307-1312
149. Karau KL, Johnson RH, Molthen RC, Dhyani AH, Haworth ST, Hanger CC, Roerig DL, Dawson CA. Microfocal X-ray CT imaging and pulmonary arterial distensibility in excised rat lungs. Am J Physiol Heart Circ Physiol, 281, 2001, H1447-H1457
150. Karau KL, Molthen RC, Dhyani A, Haworth ST, Hanger CC, Roerig DL, Johnson RH, Dawson CA. Pulmonary arterial morphometry from microfocal X-ray computed tomography. Am J Physiol Heart Circ Physiol, 281, 2001, H2747-H2756
151. Karrer HE. The striated musculature of blood vessels. I. General cell morphology. J Biophys Biochem Cytol, 6, 1959, 383-392
152. Kay JM. Comparative morphologic features of the pulmonary vasculature in mammals. Am Rev Respir Dis, 128, 1983, S53-S57
153. Kim H, Yung GL, Marsh JJ, Konopka RG, Pedersen CA, Chiles PG, Morris TA, Channick RN. Endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension. Eur Respir J 15: 640-648, 2000a.
154. Kim H, Yung GL, Marsh JJ, Konopka RG, Pedersen CA, Chiles PG, Morris TA, Channick RN. Pulmonary vascular remodeling distal to pulmonary artery ligation is accompanied by upregulation of endothelin receptors and nitric oxide synthase. Exp Lung Res 26: 287-301, 2000b.
155. King J, Hamil T, Creighton J, Wu S, Bhat P, McDonald F, Stevens T. Structural and functional characteristics of lung macro- and microvascular endothelial cell phenotypes. Microvasc Res, 67, 2004, 139-151
156. Kistler GS, Caldwell PR, Weibel ER. Development of fine structural damage to alveolar and capillary lining cells in oxygen-poisoned rat lungs. J Cell Biol, 32, 1967, 605-628
157. Klavins JV. Demonstration of striated muscle in the pulmonary veins of the rat. J Anat, 97, 1963, 239-241
158. Knight DS, Ellison JP, Hibbs RG, Hyman AL, Kadowitz PJ. A light and electron microscopic study of the innervation of pulmonary arteries in the cat. Anat Rec, 201, 1981, 513-521
159. Knust J, Ochs M, Gundersen HJ, Nyengaard JR. Stereological estimates of alveolar number and size and capillary length and surface area in mice lungs. Anat Rec (Hoboken), 292, 2009, 113-122
160. Ko YS, Yeh HI, Rothery S, Dupont E, Coppen SR, Severs NJ. Connexin make-up of endothelial gap junctions in the rat pulmonary artery as revealed by immunoconfocal microscopy and triple-label immunogold electron microscopy. J Histochem Cytochem, 47, 1999, 683-692
161. Kwon KY, Park KK, Chang ES. Scanning electron microscopic study of capillary change in bleomycin-induced pulmonary fibrosis. J Korean Med Sci, 6, 1991, 234-245
162. La Bourene JI, Coles JG, Johnson DJ, Mehra A, Keeley FW, Rabinovitch M. Alterations in elastin and collagen related to the mechanism of progressive pulmonary venous obstruction in a piglet model. Ahemodynamic, ultrastructural, and biochemical study. Circ Res, 66, 1990, 438-456
163. Laitinen LA, Laitinen A. Neural system. In: Crystal RC, West JB, Weibel ER, Barnes PJ, editors. The Lung: Scientific Foundations. Philadelphia: Lippincott-Raven, 1997, p. 1107-1116.
164. Larsen TH, Saetersdal T, Rumyantsev PP. Striated myocytes and atrial specific granules in the pulmonary veins of chronically infarcted rat hearts. Res Exp Med (Berl), 187, 1987, 225-236
165. Laurent GJ. Rates of collagen synthesis in lung, skin and muscle obtained in vivo by a simplified method using [3H]proline. Biochem J, 206, 1982, 535-544
166. Laurent GJ. Lung collagen:More than scaffolding. Thorax, 41, 1986, 418-428
167. Le Cras TD, Fernandez LG, Pastura PA, Laubach VE. Vascular growth and remodeling in compensatory lung growth following right lobectomy. J Appl Physiol, 98, 2005, 1140-1148
168. Littler CM, Wehling CA, Wick MJ, Fagan KA, Cool CD, Messing RO, Dempsey EC. Divergent contractile and structural responses of the murine PKC-epsilon null pulmonary circulation to chronic hypoxia. Am J Physiol Lung Cell Mol Physiol, 289, 2005, L1083-L1093
169. Long L, MacLean MR, Jeffery TK, Morecroft I, Yang X, Rudarakanchana N, Southwood M, James V, Trembath RC, Morrell NW. Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice. Circ Res, 98, 2006, 818-827
170. Ludatscher RM. Fine structure of the muscular wall of rat pulmonary veins. J Anat, 103, 1968, 345-357
171. Luts A, Sundler F. Peptide-containing nerve fibers in the respiratory tract of the ferret. Cell Tissue Res, 258, 1989, 259-267
172. Mackay EH, Banks J, Sykes B, Lee G. Structural basis for the changing physical properties of human pulmonary vessels with age. Thorax, 33, 1978, 335-344
173. Macklin CC. Evidences of increase in the capacity of the pulmonary arteries and veins of dogs, cats and rabbits during inflation of the freshly excised lung. Rev Can Biol, 5, 1946, 199-232
174. Magee F, Wright JL, Wiggs BR, Pare PD, Hogg JC. Pulmonary vascular structure and function in chronic obstructive pulmonary disease. Thorax, 43, 1988, 183-189
175. Maina JN. The morphology and morphometry of the adult normal baboon lung (Papio anubis). J Anat, 150, 1987, 229-245
176. Maina JN, van Gils P. Morphometric characterization of the airway and vascular systems of the lung of the domestic pig, Sus scrofa: Comparison of the airway, arterial and venous systems. Comp Biochem Physiol A Mol Integr Physiol, 130, 2001, 781-798
177. Mandache E, Popescu LM, Gherghiceanu M. Myocardial interstitial Cajal-like cells (ICLC) and their nanostructural relationships with intercalated discs: Shed vesicles as intermediates. J Cell Mol Med, 11, 2007, 1175-1184
178. Martling CR, Matran R, Alving K, Hokfelt T, Lundberg JM. Innervation of lower airways and neuropeptide effects on bronchial and vascular tone in the pig. Cell Tissue Res, 260, 1990, 223-233
179. Masani F. Node-like cells in the myocardial layer of the pulmonary vein of rats: An ultrastructural study. J Anat, 145, 1986, 133-142
180. Mastin JP, Shelburne JD, Thet LA. Subcellular changes in capillary endothelial cells during repair of hyperoxic lung injury. J Appl Physiol, 64, 1988, 689-696
181. Mayhew TM, Muhlfeld C, Vanhecke D, Ochs M. A review of recent methods for efficiently quantifying immunogold and other nanoparticles using TEM sections through cells, tissues and organs. Ann Anat, 191, 2009, 153-170
182. Mays PK, McAnulty RJ, Campa JS, Laurent GJ. Age-related changes in collagen synthesis and degradation in rat tissues. Importance of degradation of newly synthesized collagen in regulating collagen production. Biochem J, 1991 276(Pt 2): 307-313.
183. Mazzone RW. Influence of vascular and transpulmonary pressures on the functional morphology of the pulmonary microcirculation. Microvasc Res, 20, 1980, 295-306
184. Mazzone RW, Durand CM, West JB. Electron microscopy of lung rapidly frozen under controlled physiological conditions. J Appl Physiol, 45, 1978, 325-333
185. McAnulty RJ, Laurent GJ. Collagen synthesis and degradation in vivo. Evidence for rapid rates of collagen turnoverwith extensive degradation of newly synthesized collagen in tissues of the adult rat. Coll Relat Res, 7, 1987, 93-104
186. McLaughlin RF Jr, Tyler WS, Canada RO. A study of the subgross pulmonary anatomy in various mammals. Am J Anat, 198, 1961, 149-165
187. McLaughlin RF Jr, Tyler WS, Canada RO. Subgross pulmonary anatomy of the rabbit, rat, and guinea pig, with additional notes on the human lung. Am Rev Respir Dis, 94, 1966, 380-387
188. McNiff JM, Gil J. Secretion of Weibel-Palade bodies observed in extra-alveolar vessels of rabbit lung. J Appl Physiol, 54, 1983, 1284-1286
189. Melnyk P, Ehrlich JR, Pourrier M, Villeneuve L, Cha TJ, Nattel S. Comparison of ion channel distribution and expression in cardiomyocytes of canine pulmonary veins versus left atrium. Cardiovasc Res, 65, 2005, 104-116
190. Mercer RR, Crapo JD. Spatial distribution of collagen and elastin fibers in the lungs. J Appl Physiol, 69, 1990, 756-765
191. Mercer RR, Russell ML, Crapo JD. Alveolar septal structure in different species. J Appl Physiol, 77, 1994, 1060-1066
192. Merklinger SL, Wagner RA, Spiekerkoetter E, Hinek A, Knutsen RH, Kabir MG, Desai K, Hacker S, Wang L, Cann GM, Ambartsumian NS, Lukanidin E, Bernstein D, Husain M, Mecham RP, Starcher B, Yanagisawa H, Rabinovitch M. Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension. Circ Res, 97, 2005, 596-604
193. Meyrick B. Structure function correlates in the pulmonary vasculature during acute lung injury and chronic pulmonary hypertension. Toxicol Pathol, 19, 1991, 447-457
194. Meyrick B, Hislop A, Reid L. Pulmonary arteries of the normal rat: The thick walled oblique muscle segment. J Anat, 125, 1978, 209-221
195. Meyrick B, Reid L. Intra-alveolar wall nerve in rat lung: An electronmicroscopic study. J Physiol 214: 6P-7P, 1971a.
196. Meyrick B, Reid L. Nerves in rat intra-acinar alveoli: An electron microscopic study. Respir Physiol 11: 367-377, 1971b.
197. Meyrick B, Reid L. The effect of continued hypoxia on rat pulmonary arterial circulation. An ultrastructural study. Lab Invest, 38, 1978, 188-200
198. Meyrick B, Reid L. Ultrastructural features of the distended pulmonary arteries of the normal rat. Anat Rec, 193, 1979, 71-97
199. Meyrick B, Reid L. Hypoxia-induced structural changes in the media and adventitia of the rat hilar pulmonary artery and their regression. Am J Pathol 100: 151-178, 1980a.
200. Meyrick B, Reid L. Ultrastructural findings in lung biopsy material from children with congenital heart defects. Am J Pathol 101: 527-542, 1980b.
201. Meyrick B, Reid L. Normal postnatal development of the media of the rat hilar pulmonary artery and its remodeling by chronic hypoxia. Lab Invest, 46, 1982, 505-514
202. Michel RP. Arteries and veins of the normal dog lung: Qualitative and quantitative structural differences. Am J Anat, 164, 1982, 227-241
203. Michel RP, Gordon JB, Chu K. Development of the pulmonary vasculature in newborn lambs: Structure-function relationships. J Appl Physiol, 70, 1991, 1255-1264
204. Michel RP, Hakim TS. Increased resistance in postobstructive pulmonary vasculopathy: Structure-function relationships. J Appl Physiol, 71, 1991, 601-610
205. Michel RP, Hu F, Meyrick BO. Myoendothelial junctional complexes in postobstructive pulmonary vasculopathy: A quantitative electron microscopic study. Exp Lung Res, 21, 1995, 437-452
206. Michelakis ED, Weir EK, Wu X, Nsair A, Waite R, Hashimoto K, Puttagunta L, Knaus HG, Archer SL. Potassium channels regulate tone in rat pulmonary veins. Am J Physiol Lung Cell Mol Physiol, 280, 2001, L1138-L1147
207. Miller AA, Hislop AA, Vallance PJ, Haworth SG. Deletion of the eNOS gene has a greater impact on the pulmonary circulation of male than female mice. Am J Physiol Lung Cell Mol Physiol, 289, 2005, L299-L306
208. Millino C, Sarinella F, Tiveron C, Villa A, Sartore S, Ausoni S. Cardiac and smooth muscle cell contribution to the formation of the murine pulmonary veins. Dev Dyn, 218, 2000, 414-425
209. Mitani Y, Maruyama K, Sakurai M. Prolonged administration of Larginine ameliorates chronic pulmonary hypertension and pulmonary vascular remodeling in rats. Circulation, 96, 1997, 689-697
210. Miyamoto Y, Moll W. Measurements of dimensions and pathway of red cells in rapidly frozen lungs in situ. Respir Physiol, 12, 1971, 141-156
211. Miyata M, Sakuma F, Ito M, Ohira H, Sato Y, Kasukawa R. Athymic nude rats develop severe pulmonary hypertension following monocrotaline administration. Int Arch Allergy Immunol, 121, 2000, 246-252
212. Molthen RC, Karau KL, Dawson CA. Quantitative models of the rat pulmonary arterial tree morphometry applied to hypoxia-induced arterial remodeling. J Appl Physiol, 97, 2004, 2372-2384
213. Mommersteeg MT, Brown NA, Prall OW, de Gier-de Vries C, Harvey RP, Moorman AF, Christoffels VM. Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium. Circ Res, 101, 2007, 902-909
214. Morel E, Meyronet D, Thivolet-Bejuy F, Chevalier P. Identification and distribution of interstitial Cajal cells in human pulmonary veins. Heart Rhythm, 5, 2008, 1063-1067
215. Morrell NW, Morris KG, Stenmark KR. Role of angiotensin-converting enzyme and angiotensin II in development of hypoxic pulmonary hypertension. Am J Physiol, 269, 1995, H1186-H1194
216. Mueller-Hoecker J, Beitinger F, Fernandez B, Bahlmann O, Assmann G, Troidl C, Dimomeletis I, Kaab S, Deindl E. Of rodents and humans: A light microscopic and ultrastructural study on cardiomyocytes in pulmonary veins. Int J Med Sci, 5, 2008, 152-158
217. Mühlfeld C, Nyengaard JR, Mayhew TM. A review of state-of-the-art stereology for better quantitative 3D morphology in cardiac research. Cardiovasc Pathol, 19, 2010, 65-82
218. Mühlfeld C, Weibel ER, Hahn U, Kummer W, Nyengaard JR, Ochs M. Is length an appropriate estimator to characterize pulmonary alveolar capillaries?Acritical evaluation in the human lung. Anat Rec (Hoboken), 293, 2010, 1270-1275
219. Nathan H, Eliakim M. The junction between the left atrium and the pulmonary veins. An anatomic study of human hearts. Circulation, 34, 1966, 412-422
220. Nathan H, Gloobe H. Myocardial atrio-venous junctions and extensions (sleeves) over the pulmonary and caval veins. Anatomical observations in various mammals. Thorax, 25, 1970, 317-324
221. Nishi Y, Kitamura N, Otani M, Hondo E, Taguchi K, Yamada J. Distribution of capsaicin-sensitive substance P- and calcitonin gene-related peptide-immunoreactive nerves in bovine respiratory tract. Ann Anat, 182, 2000, 319-326
222. Nohr D, Eiden LE, Weihe E. Coexpression of vasoactive intestinal peptide, calcitonin gene-related peptide and substance P immunoreactivity in parasympathetic neurons of the rhesus monkey lung. Neurosci Lett, 199, 1995, 25-28
223. Nohr D, Weihe E. Tachykinin-, calcitonin gene-related peptide-, and protein gene product 9.5-immunoreactive nerve fibers in alveolar walls of mammals. Neurosci Lett, 134, 1991, 17-20
224. Nyengaard JR, Gundersen HJ. Direct and efficient stereological estimation of total cell quantities using electron microscopy. J Microsc, 222, 2006, 182-187
225. Ochs M. A brief update on lung stereology. J Microsc, 222, 2006, 188-200
226. Ofori-Acquah SF, King J, Voelkel N, Schaphorst KL, Stevens T. Heterogeneity of barrier function in the lung reflects diversity in endothelial cell junctions. Microvasc Res, 75, 2008, 391-402
227. Ohar JA, Waller KS, Williams TJ, Luke DA, Demello DE. Computerized morphometry of the pulmonary vasculature over a range of intravascular pressures. Anat Rec, 252, 1998, 92-101
228. Ohtani O. Microvasculature of the rat lung as revealed by scanning electron microscopy of corrosion casts. Scan Electron Microsc, 1980 349-356.
229. Oldmixon EH, Hoppin FG Jr Distribution of elastin and collagen in canine lung alveolar parenchyma. J Appl Physiol, 67, 1989, 1941-1949
230. Paes de Almeida O, Bohm CM, de Paula Carvalho M, Paes de Carvalho A. The cardiac muscle in the pulmonary vein of the rat:Amorphological and electrophysiological study. J Morphol, 145, 1975, 409-433
231. Palade GE, Simionescu M, Simionescu N. Structural aspects of the permeability of the microvascular endothelium. Acta Physiol Scand Suppl, 463, 1979, 11-32
232. Parker JC, Stevens T, Randall J, Weber DS, King JA. Hydraulic conductance of pulmonary microvascular and macrovascular endothelial cell monolayers. Am J Physiol Lung Cell Mol Physiol, 291, 2006, L30-L37
233. Peao MN, Aguas AP, de Sa CM, Grande NR. Identification of vascular sphincters at the junction between alveolar capillaries and pulmonary venules of the mouse lung. Anat Rec, 241, 1995, 383-390
234. Perez-Lugones A, McMahon JT, Ratliff NB, Saliba WI, Schweikert RA, Marrouche NF, Saad EB, Navia JL, McCarthy PM, Tchou P, Gillinov AM, Natale A. Evidence of specialized conduction cells in human pulmonary veins of patients with atrial fibrillation. J Cardiovasc Electrophysiol, 14, 2003, 803-809
235. Perkett EA, Brigham KL, Meyrick B. Continuous air embolization into sheep causes sustained pulmonary hypertension and increased pulmonary vasoreactivity. Am J Pathol, 132, 1988, 444-454
236. Pietra GG, Szidon JP, Leventhal MM, Fishman AP. Hemoglobin as a tracer in hemodynamic pulmonary edema. Science, 166, 1969, 1643-1646
237. Plato M, Kummer W, Haberberger RV. Structural and neurochemical comparison of vagal and spinal afferent neurons projecting to the rat lung. Neurosci Lett, 395, 2006, 215-219
238. Plopper CG, Dungworth DL, Tyler WS. Morphometric evaluation of pulmonary lesions in rats exposed to ozone. Am J Pathol, 71, 1973, 395-408
239. Popescu LM, Gherghiceanu M, Cretoiu D, Radu E. The connective connection: Interstitial cells of Cajal (ICC) and ICC-like cells establish synapses with immunoreactive cells. Electron microscope study in situ. J Cell Mol Med, 9, 2005, 714-730
240. Pump KK. The circulation in the peripheral parts of the human lung. Dis Chest, 49, 1966, 119-129
241. Qi JG, Ding YG, Tang CS, Du JB. Chronic administration of adrenomedullin attenuates hypoxic pulmonary vascular structural remodeling and inhibits proadrenomedullin N-terminal 20-peptide production in rats. Peptides, 28, 2007, 910-919
242. Rabinovitch M, Haworth SG, Castaneda AR, Nadas AS, Reid LM. Lung biopsy in congenital heart disease: A morphometric approach to pulmonary vascular disease. Circulation, 58, 1978, 1107-1122
243. Racke K, Matthiesen S. The airway cholinergic system: Physiology and pharmacology. Pulm Pharmacol Ther, 17, 2004, 181-198
244. Randell SH, Mercer RR, Young SL. Neonatal hyperoxia alters the pulmonary alveolar and capillary structure of 40-day-old rats. Am J Pathol, 136, 1990, 1259-1266
245. Rannels DE, Stockstill B, Mercer RR, Crapo JD. Cellular changes in the lungs of adrenalectomized rats following left pneumonectomy. Am J Respir Cell Mol Biol, 5, 1991, 351-362
246. Ray L, Mathieu M, Jespers P, Hadad I, Mahmoudabady M, Pensis A, Motte S, Peters IR, Naeije R, McEntee K. Early increase in pulmonary vascular reactivity with overexpression of endothelin-1 and vascular endothelial growth factor in canine experimental heart failure. Exp Physiol, 93, 2008, 434-442
247. Reeves JT, Leathers JE, Quigley MB. Microradiography of pulmonary arterioles, capillaries, and venules of the rabbit. Anat Rec, 151, 1965, 531-545
248. Rehan VK, Sugano S, Wang Y, Santos J, Romero S, Dasgupta C, Keane MP, Stahlman MT, Torday JS. Evidence for the presence of lipofibroblasts in human lung. Exp Lung Res, 32, 2006, 379-393
249. Reid A, Heard BE. Preliminary studies of human pulmonary capillaries by India ink injection. Med Thorac, 19, 1962, 215-219
250. Reid L. The angiogram and pulmonary artery structure and branching (in the normal and with reference to disease). Proc R Soc Med, 58, 1965, 681-684
251. Reid L, Meyrick B. Microcirculation: Definition and organization at tissue level. Ann N Y Acad Sci, 384, 1982, 3-20
252. Reid LM. Structure and function in pulmonary hypertension. New perceptions. Chest, 89, 1986, 279-288
253. Rendas A, Branthwaite M, Lennox S, Reid L. Response of the pulmonary circulation to acute hypoxia in the growing pig. J Appl Physiol, 52, 1982, 811-814
254. Rendas A, Branthwaite M, Reid L. Growth of pulmonary circulation in normal pig-structural analysis and cardiopulmonary function. J Appl Physiol, 45, 1978, 806-817
255. Rhodin JA. Microscopic anatomy of the pulmonary vascular bed in the cat lung. Microvasc Res, 15, 1978, 169-193
256. Ricci A, Mariotta S, Greco S, Pallone G, Papale M, Bisetti A. Age-related changes of the noradrenergic innervation of rat tracheobronchial tree and pulmonary vasculature. Mech Ageing Dev, 99, 1997, 245-255
257. Richardson JB. The innervation of the lung. Eur J Respir Dis Suppl, 117, 1982, 13-31
258. Richardson JB. Recent progress in pulmonary innervation. Am Rev Respir Dis, 128, 1983, S65-S68
259. Ritman EL. Micro-computed tomography of the lungs and pulmonaryvascular system. Proc Am Thorac Soc, 2, 2005, 477-480
260. Rosenberg HC, Rabinovitch M. Endothelial injury and vascular reactivity in monocrotaline pulmonary hypertension. Am J Physiol, 255, 1988, H1484-H1491
261. Rosenberg HG, Williams WG, Trusler GA, Higa T, Rabinovitch M. Structural composition of central pulmonary arteries. Growth potential after surgical shunts. J Thorac Cardiovasc Surg, 94, 1987, 498-503
262. Said SI, Hamidi SA, Dickman KG, Szema AM, Lyubsky S, Lin RZ, Jiang YP, Chen JJ, Waschek JA, Kort S. Moderate pulmonary arterial hypertension in male mice lacking the vasoactive intestinal peptide gene. Circulation, 115, 2007, 1260-1268
263. Saldana M, Arias-Stella J. Studies on the structure of the pulmonary trunk. I. Normal changes in the elastic configuration of the human pulmonary trunk at different ages. Circulation 27: 1086-1093, 1963a.
264. Saldana M, Arias-Stella J. Studies on the structure of the pulmonary trunk. II. The evolution of the elastic configuration of the pulmonary trunk in people native to high altitudes. Circulation 27: 1094-1100, 1963b.
265. Schneeberger EE. Ultrastructural basis for alveolar-capillary permeability to protein. Ciba Found Symp, 1976 3-28.
266. Schneeberger EE. Ultrastructure of intercellular junctions in the freeze fractured alveolar-capillary membrane of mouse lung. Chest, 71, 1977, 299-300
267. Schneeberger EE. Structure of intercellular junctions in different segments of the intrapulmonary vasculature. Ann N Y Acad Sci, 384, 1982, 54-63
268. Schneeberger EE, Lynch RD. Tight junctions. Their structure, composition, and function. Circ Res, 55, 1984, 723-733
269. Schneeberger EE, Lynch RD. Structure, function, and regulation of cellular tight junctions. Am J Physiol, 262, 1992, L647-L661
270. Schnittler HJ. Structural and functional aspects of intercellular junctions in vascular endothelium. Basic Res Cardiol 93 Suppl, 3, 1998, 30-39
271. Schraufnagel DE, Agaram NP, Faruqui A, Jain S, Jain L, Ridge KM, Sznajder JI. Pulmonary lymphatics and edema accumulation after brief lung injury. Am J Physiol Lung Cell Mol Physiol, 284, 2003, L891-L897
272. Schraufnagel DE, Malik R, Goel V, Ohara N, Chang SW. Lung capillary changes in hepatic cirrhosis in rats. Am J Physiol, 272, 1997, L139-L147
273. Schraufnagel DE, Patel KR. Sphincters in pulmonary veins. An anatomic study in rats. Am Rev Respir Dis, 141, 1990, 721-726
274. Shapiro SD, Endicott SK, Province MA, Pierce JA, Campbell EJ. Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon. J Clin Invest, 87, 1991, 1828-1834
275. Shaw AM, Bunton DC, Fisher A, McGrath JC, Montgomery I, Daly C, MacDonald A. V-shaped cushion at the origin of bovine pulmonary supernumerary arteries: Structure and putative function. J Appl Physiol, 87, 1999, 2348-2356
276. Shelton DM, Keal E, Reid L. The pulmonary circulation in chronic bronchitis and emphysema. Chest, 71, 1977, 303-306
277. Sheppard MN, Polak JM, Allen JM, Bloom SR. Neuropeptide tyrosine (NPY): A newly discovered peptide is present in the mammalian respiratory tract. Thorax, 39, 1984, 326-330
278. Shi W, Cernacek P, Hu F, Michel RP. Endothelin reactivity and receptor profile of pulmonary vessels in postobstructive pulmonary vasculopathy. Am J Physiol, 273, 1997, H2558-H2564
279. Shi W, Giaid A, Hu F, Michel RP. Increased reactivity to endothelin of pulmonary arteries in long-term post-obstructive pulmonary vasculopathy in rats. Pulm Pharmacol Ther, 11, 1998, 189-196
280. Shi W, Hu F, Kassouf W, Michel RP. Altered reactivity of pulmonary vessels in postobstructive pulmonary vasculopathy. J Appl Physiol, 88, 2000, 17-25
281. Shi W, Wang CG, Dandurand RJ, Eidelman DH, Michel RP. Differential responses of pulmonary arteries and veins to histamine and 5-HT in lung explants of guinea-pigs. Br J Pharmacol, 123, 1998, 1525-1532
282. Shifren A, Durmowicz AG, Knutsen RH, Faury G, Mecham RP. Elastin insufficiency predisposes to elevated pulmonary circulatory pressures through changes in elastic artery structure. J Appl Physiol, 105, 2008, 1610-1619
283. Short AC, Montoya ML, Gebb SA, Presson RG Jr, Wagner WW Jr, Capen RL. Pulmonary capillary diameters and recruitment characteristics in subpleural and interior networks. J Appl Physiol, 80, 1996, 1568-1573
284. Simionescu M. Lung endothelium: Structure-function correlates. In: Crystal RC, West JB, Barnes PJ, Weibel ER, editors. The Lung: Scientific Foundations. Philadelphia: Lippincott-Raven Publishers, 1997, p. 615-628.
285. Simons P, Reid L. Muscularity of pulmonary artery branches in the upper and lower lobes of the normal young and aged lung. Br J Dis Chest, 63, 1969, 38-44
286. Singhal S, Henderson R, Horsfield K, Harding K, Cumming G. Morphometry of the human pulmonary arterial tree. Circ Res, 33, 1973, 190-197
287. Sirianni FE, Chu FS, Walker DC. Human alveolar wall fibroblasts directly link epithelial type 2 cells to capillary endothelium. Am J Respir Crit Care Med, 168, 2003, 1532-1537
288. Smith P, Heath D, Mooi W. Observations on some ultrastructural features of normal pulmonary blood vessels in collapsed and distended lungs. J Anat, 128, 1979, 85-96
289. Snow RL, Davies P, Pontoppidan H, Zapol WM, Reid L. Pulmonary vascular remodeling in adult respiratory distress syndrome. Am Rev Respir Dis, 126, 1982, 887-892
290. Sobin SS, Chen PC. Ultrastructural changes in the pulmonary arterioles in acute hypoxic pulmonary hypertension in the rat. High Alt Med Biol, 1, 2000, 311-322
291. Sobin SS, Tremer HM, Fung YC. Morphometric basis of the sheet-flow concept of the pulmonary alveolar microcirculation in the cat. Circ Res, 26, 1970, 397-414
292. Soufan AT, van den Hoff MJ, Ruijter JM, de Boer PA, Hagoort J, Webb S, Anderson RH, Moorman AF. Reconstruction of the patterns of gene expression in the developing mouse heart reveals an architectural arrangement that facilitates the understanding of atrial malformations and arrhythmias. Circ Res, 95, 2004, 1207-1215
293. Spencer H, Leof D. The innervation of the human lung. J Anat, 98, 1964, 599-609
294. Springall DR, Bhatnagar M, Wharton J, Hamid Q, Gulbenkian S, Hedges M, Meleagros L, Bloom SR, Polak JM. Expression of the atrial natriuretic peptide gene in the cardiac muscle of rat extrapulmonary and intrapulmonary veins. Thorax, 43, 1988, 44-52
295. Staub NC. The interdependence of pulmonary structure and function. Anesthesiology, 24, 1963, 831-854
296. Staub NC, Schultz EL. Pulmonary capillary length in dogs, cat and rabbit. Respir Physiol, 5, 1968, 371-378
297. Stenmark KR, Frid MG. Smooth muscle cell heterogeneity: Role of specific smooth muscle cell subpopulations in pulmonary vascular disease. Chest, 114, 1998, 82S-90S
298. Stevens T. Molecular and cellular determinants of lung endothelial cell heterogeneity. Chest, 128, 2005, 558S-564S
299. Stevens T, Phan S, Frid MG, Alvarez D, Herzog E, Stenmark KR. Lung vascular cell heterogeneity: Endothelium, smooth muscle, and fibroblasts. Proc Am Thorac Soc, 5, 2008, 783-791
300. Stone KC, Mercer RR, Freeman BA, Chang LY, Crapo JD. Distribution of lung cell numbers and volumes between alveolar and nonalveolar tissue. Am Rev Respir Dis, 146, 1992, 454-456
301. Su C, Bevan RD, Duckles SP, Bevan JA. Functional studies of the small pulmonary arteries. Microvasc Res, 15, 1978, 37-44
302. Tachihara A, Jin E, Matsuoka T, Ghazizadeh M, Yoshino S, Takemura T, D Travis W, Kawanami O. Critical roles of capillary endothelial cells for alveolar remodeling in nonspecific and usual interstitial pneumonias. J Nippon Med Sch, 73, 2006, 203-213
303. Tan AY, Li H, Wachsmann-Hogiu S, Chen LS, Chen PS, Fishbein MC. Autonomic innervation and segmental muscular disconnections at the human pulmonary vein-atrial junction: Implications for catheter ablation of atrial-pulmonary vein junction. J Am Coll Cardiol, 48, 2006, 132-143
304. Taylor AE, Granger DN. Equivalent pore modeling: Vesicles and channels. Fed Proc, 42, 1983, 2440-2445
305. Taylor AE, Granger DN. Exchange of macromolecules across the microcirculation. In: Renkin EM, Michel CC, editors. Handbook of Physiology Section 2: The Cardiovascular System. Bethesda: American Physiological Society, 1984, p. 467-520.
306. Taylor AE, Parker JC. Pulmonary interstitial spaces and lymphatics. In: Fishman AP, Fisher AB, editors. Handbook of Physiology Section 3: The Respiratory System. Bethesda: American Physiological Society, 1985, p. 167-230.
307. Thet LA, Law DJ. Changes in cell number and lung morphology during early postpneumonectomy lung growth. J Appl Physiol, 56, 1984, 975-978
308. Toshima M, Ohtani Y, Ohtani O. Three-dimensional architecture of elastin and collagen fiber networks in the human and rat lung. Arch Histol Cytol, 67, 2004, 31-40
309. Toshimori H, Nakazato M, Toshimori K, Asai J, Matsukura S, Oura C, Matsuo H. Distribution of atrial natriuretic polypeptide (ANP)-containing cells in the rat heart and pulmonary vein. Immunohistochemical study and radioimmunoassay. Cell Tissue Res, 251, 1988, 541-546
310. Townsley MI, Fu Z, Mathieu-Costello O, West JB. Pulmonary microvascular permeability. Responses to high vascular pressure after induction of pacing-induced heart failure in dogs. Circ Res, 77, 1995, 317-325
311. Townsley MI, Snell KS, Ivey CL, Culberson DE, Liu DC, Reed RK, Mathieu-Costello O. Remodeling of lung interstitium but not resistance vessels in canine pacing-induced heart failure. J Appl Physiol, 87, 1999, 1823-1830
312. Tozzi CA, Thakker-Varia S, Yu SY, Bannett RF, Peng BW, Poiani GJ, Wilson FJ, Riley DJ. Mast cell collagenase correlates with regression of pulmonary vascular remodeling in the rat. Am J Respir Cell Mol Biol, 18, 1998, 497-510
313. Tsukimoto K, Mathieu-Costello O, Prediletto R, Elliott AR, West JB. Ultrastructural appearances of pulmonary capillaries at high transmural pressures. J Appl Physiol, 71, 1991, 573-582
314. Tucker A, McMurtry IF, Alexander AF, Reeves JT, Grover RF. Lung mast cell density and distribution in chronically hypoxic animals. J Appl Physiol, 42, 1977, 174-178
315. Tucker A, McMurtry IF, Reeves JT, Alexander AF, Will DH, Grover RF. Lung vascular smooth muscle as a determinant of pulmonary hypertension at high altitude. Am J Physiol, 228, 1975, 762-767
316. Uddman R, Sundler R, Cardell L-O, Luts A. Neuropeptides in the lung. In: Crystal RC, West JB, Weibel ER, Barnes PJ, editors. The Lung: Scientific Foundations. Philadelphia: Lippincott-Raven Publishers, 1997, p. 103-115.
317. Vaccaro C, Brody JS. Ultrastructure of developing alveoli. I. The role of the interstitial fibroblast. Anat Rec, 192, 1978, 467-479
318. Vaccaro CA, Brody JS. Structural features of alveolar wall basement membrane in the adult rat lung. J Cell Biol, 91, 1981, 427-437
319. Vaitkevicius R, Saburkina I, Rysevaite K, Vaitkeviciene I, Pauziene N, Zaliunas R, Schauerte P, Jalife J, Pauza DH. Nerve supply of the human pulmonary veins: An anatomical study. Heart Rhythm, 6, 2009, 221-228
320. Verheule S, Wilson EE, Arora R, Engle SK, Scott LR, Olgin JE. Tissue structure and connexin expression of canine pulmonary veins. Cardiovasc Res, 55, 2002, 727-738
321. Verity MA, Bevan JA. Fine structural study of the terminal effecror plexus, neuromuscular and intermuscular relationships in the pulmonary artery. J Anat, 103, 1968, 49-63
322. Vermeersch P, Buys E, Pokreisz P, Marsboom G, Ichinose F, Sips P, Pellens M, Gillijns H, Swinnen M, Graveline A, Collen D, Dewerchin M, Brouckaert P, Bloch KD, Janssens S. Soluble guanylate cyclase-a1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia. Circulation, 116, 2007, 936-943
323. von Hayek H. The Human Lung. New York: Hafner Publishing Co., Inc., 1960.
324. Wagenseil JE, Mecham RP. Vascular extracellular matrix and arterial mechanics. Physiol Rev, 89, 2009, 957-989
325. Wagenvoort CA. Morphologic changes in intrapulmonary veins. Hum Pathol, 1, 1970, 205-213
326. Wagenvoort CA, Dingemans KP. Pulmonary vascular smooth muscle and its interaction with endothelium. Morphologic considerations. Chest, 88, 1985, 200S-202S
327. Walch L, Taisne C, Gascard JP, Nashashibi N, Brink C, Norel X. Cholinesterase activity in human pulmonary arteries and veins. Br J Pharmacol, 121, 1997, 986-990
328. Walker DC, Behzad AR, Chu F. Neutrophil migration through preexisting holes in the basal laminae of alveolar capillaries and epithelium during streptococcal pneumonia. Microvasc Res, 50, 1995, 397-416
329. Walker DC, MacKenzie A, Hosford S. The structure of the tricellular region of endothelial tight junctions of pulmonary capillaries analyzed by freeze-fracture. Microvasc Res, 48, 1994, 259-281
330. Walker DC, MacKenzie AL, Wiggs BR, Montaner JG, Hogg JC. Assessment of tight junctions between pulmonary epithelial and endothelial cells. J Appl Physiol, 64, 1988, 2348-2356
331. Ward SM, Sanders KM, Hirst GD. Role of interstitial cells of Cajal in neural control of gastrointestinal smooth muscles. Neurogastroenterol Motil 16 Suppl, 1, 2004, 112-117
332. Watanabe N, Horie S, Michael GJ, Keir S, Spina D, Page CP, Priestley JV. Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system. Neuroscience, 141, 2006, 1533-1543
333. Weibel ER. Morphological basis of alveolar-capillary gas exchange. Physiol Rev, 53, 1973, 419-495
334. Weibel ER. On pericytes, particularly their existence on lung capillaries. Microvasc Res, 8, 1974, 218-235
335. Weibel ER. Lung cell biology. In: Fishman AP, editor. Handbook of Physiology: The Respiratory System. Bethesda: American Physiological Society, 1985, sect. 3, p. 47-91.
336. Weibel ER, Crystal RC. Organization of the lung interstitium. In: Crystal RC, West JB, Barnes PJ, Weibel ER, editors. The Lung: Scientific Foundations. Philadelphia: Lippincott-Raven Publishers, 1997, p. 685-695.
337. Weibel ER, Hsia CC, Ochs M. How much is there really? Why stereology is essential in lung morphometry. J Appl Physiol, 102, 2007, 459-467
338. Weibel ER, Palade GE. New cytoplasmic components in arterial endothelia. J Cell Biol, 23, 1964, 101-112
339. Welle M. Development, significance, and heterogeneity of mast cells with particular regard to the mast cell-specific proteases chymase and tryptase. J Leukoc Biol, 61, 1997, 233-245
340. Wessler I, Kirkpatrick CJ. Acetylcholine beyond neurons: The nonneuronal cholinergic system in humans. Br J Pharmacol, 154, 2008, 1558-1571
341. Winkler GC, Cheville NF. Morphometry of postnatal development in the porcine lung. Anat Rec, 211, 1985, 427-433
342. Wu DX, Weibel ER, Bachofen H, Schurch S. Lung lesions in experimental hydrostatic pulmonary edema: An electron microscopic and morphometric study. Exp Lung Res, 21, 1995, 711-730
343. Yan X, Bellotto DJ, Foster DJ, Johnson RL Jr, Hagler HK, Estrera AS, Hsia CC. Retinoic acid induces nonuniform alveolar septal growth after right pneumonectomy. J Appl Physiol, 96, 2004, 1080-1089
344. Yeh HI, Lai YJ, Lee YN, Chen YJ, Chen YC, Chen CC, Chen SA, Lin CI, Tsai CH. Differential expression of connexin43 gap junctions in cardiomyocytes isolated from canine thoracic veins. J Histochem Cytochem, 51, 2003, 259-266
345. Yeh HI, Rothery S, Dupont E, Coppen SR, Severs NJ. Individual gap junction plaques contain multiple connexins in arterial endothelium. Circ Res, 83, 1998, 1248-1263
346. Yen RT, Sobin SS. Elasticity of arterioles and venules in postmortem human lungs. J Appl Physiol, 64, 1988, 611-619
347. Yen RT, Zhuang FY, Fung YC, Ho HH, Tremer H, Sobin SS. Morphometry of cat pulmonary venous tree. J Appl Physiol, 55, 1983, 236-242
348. Yen RT, Zhuang FY, Fung YC, Ho HH, Tremer H, Sobin SS. Morphometry of cat's pulmonary arterial tree. J Biomech Eng, 106, 1984, 131-136
349. Yoneda K. Regional differences in the intercellular junctions of the alveolar-capillary membrane in the human lung. Am Rev Respir Dis, 126, 1982, 893-897
350. Zaidi SH, You XM, Ciura S, Husain M, Rabinovitch M. Overexpression of the serine elastase inhibitor elafin protects transgenic mice from hypoxic pulmonary hypertension. Circulation, 105, 2002, 516-521
351. Zeltner TB, Bertacchini M, Messerli A, Burri PH. Morphometric estimation of regional differences in the rat lung. Exp Lung Res, 16, 1990, 145-158
352. Zeltner TB, Burri PH. The postnatal development and growth of the human lung. II. Morphology. Respir Physiol, 67, 1987, 269-282
353. Zeltner TB, Caduff JH, Gehr P, Pfenninger J, Burri PH. The postnatal development and growth of the human lung. I. Morphometry. Respir Physiol, 67, 1987, 247-267
354. Zhou C, Chen H, King JA, Sellak H, Kuebler WM, Yin J, Townsley MI, Shin HS, Wu S. The a1G T-type calcium channel selectively regulates P-selectin surface expression in pulmonary capillary endothelium. Am J Physiol Lung Cell Mol Physiol 2010.
355. Zhuang FY, Yen MR, Fung YC, Sobin SS. How many pulmonary alveoli are supplied by a single arteriole and drained by a single venule? Microvasc Res, 29, 1985, 18-31