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Volumn 191, Issue 2, 2009, Pages 153-170

A review of recent methods for efficiently quantifying immunogold and other nanoparticles using TEM sections through cells, tissues and organs

Author keywords

Chi squared analysis; Colloidal gold; Nanoparticles; Quantification; Relative labelling or deposition index; Stereology; Transmission electron microscopy

Indexed keywords

COLLOIDAL GOLD; NANOPARTICLE; QUANTUM DOT;

EID: 62549147047     PISSN: 09409602     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aanat.2008.11.001     Document Type: Review
Times cited : (117)

References (112)
  • 3
    • 0036815763 scopus 로고    scopus 로고
    • Electron tomography: towards visualizing the molecular organization of the cytoplasm
    • Baumeister W. Electron tomography: towards visualizing the molecular organization of the cytoplasm. Curr. Opin. Struct. Biol. 12 (2002) 679-684
    • (2002) Curr. Opin. Struct. Biol. , vol.12 , pp. 679-684
    • Baumeister, W.1
  • 4
    • 14544297527 scopus 로고    scopus 로고
    • From proteomic inventory to architecture
    • Baumeister W. From proteomic inventory to architecture. FEBS Lett. 579 (2005) 933-937
    • (2005) FEBS Lett. , vol.579 , pp. 933-937
    • Baumeister, W.1
  • 5
    • 0033082710 scopus 로고    scopus 로고
    • Electron tomography of molecules and cells
    • Baumeister W., Grimm R., and Walz J. Electron tomography of molecules and cells. Trends Cell Biol. 9 (1999) 81-85
    • (1999) Trends Cell Biol. , vol.9 , pp. 81-85
    • Baumeister, W.1    Grimm, R.2    Walz, J.3
  • 6
    • 0021703031 scopus 로고
    • Protein A - gold electron microscopic immunocytochemistry methods: application and limitation
    • Bendayan M. Protein A - gold electron microscopic immunocytochemistry methods: application and limitation. J. Electron. Microsc. Technol. 1 (1984) 243-270
    • (1984) J. Electron. Microsc. Technol. , vol.1 , pp. 243-270
    • Bendayan, M.1
  • 7
    • 4043122640 scopus 로고    scopus 로고
    • Not just a plasma membrane protein: in cardiac muscle cells, alpha-II spectrin also shows a close association with myofibrils
    • Bennett P.M., Baines A.J., Lecomte M.-C., Maggs A.M., and Pinder J.C. Not just a plasma membrane protein: in cardiac muscle cells, alpha-II spectrin also shows a close association with myofibrils. J. Musc. Res. Cell Motil. 25 (2004) 119-126
    • (2004) J. Musc. Res. Cell Motil. , vol.25 , pp. 119-126
    • Bennett, P.M.1    Baines, A.J.2    Lecomte, M.-C.3    Maggs, A.M.4    Pinder, J.C.5
  • 8
    • 0034687769 scopus 로고    scopus 로고
    • Toward detecting and identifying macromolecules in a cellular context: template matching applied to electron tomograms
    • Böhm J., Frangakis A.S., Hegerl R., Nickell S., Typke D., and Baumeister W. Toward detecting and identifying macromolecules in a cellular context: template matching applied to electron tomograms. Proc. Natl. Acad. Sci. USA 97 (2000) 14245-14250
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 14245-14250
    • Böhm, J.1    Frangakis, A.S.2    Hegerl, R.3    Nickell, S.4    Typke, D.5    Baumeister, W.6
  • 9
    • 23644442880 scopus 로고    scopus 로고
    • Zooming in on electron tomography
    • Bonnetta L. Zooming in on electron tomography. Nat. Methods 2 (2005) 139-145
    • (2005) Nat. Methods , vol.2 , pp. 139-145
    • Bonnetta, L.1
  • 10
    • 0029817026 scopus 로고    scopus 로고
    • Quantitation of L-selectin distribution on human leukocyte microvilli by immunogold labelling and electron microscopy
    • Bruehl R.E., Springer T.A., and Bainton D.F. Quantitation of L-selectin distribution on human leukocyte microvilli by immunogold labelling and electron microscopy. J. Histochem. Cytochem. 44 (1996) 835-844
    • (1996) J. Histochem. Cytochem. , vol.44 , pp. 835-844
    • Bruehl, R.E.1    Springer, T.A.2    Bainton, D.F.3
  • 12
    • 18744407272 scopus 로고    scopus 로고
    • Subcellular localization of phosducin in rod photoreceptors
    • Chen J., Yoshida T., Nakano K., and Bitensky M.W. Subcellular localization of phosducin in rod photoreceptors. Vis. Neurosci. 22 (2005) 19-25
    • (2005) Vis. Neurosci. , vol.22 , pp. 19-25
    • Chen, J.1    Yoshida, T.2    Nakano, K.3    Bitensky, M.W.4
  • 13
    • 0030027461 scopus 로고    scopus 로고
    • Methods for determining numbers of cells and synapses: a case for more uniform standards of review
    • Coggeshall R.E., and Lekhan H.A. Methods for determining numbers of cells and synapses: a case for more uniform standards of review. J. Comp. Neurol. 364 (1996) 6-15
    • (1996) J. Comp. Neurol. , vol.364 , pp. 6-15
    • Coggeshall, R.E.1    Lekhan, H.A.2
  • 14
    • 0019824169 scopus 로고
    • Sampling designs for stereology
    • Cruz-Orive L.M., and Weibel E.R. Sampling designs for stereology. J. Microsc. 122 (1981) 235-257
    • (1981) J. Microsc. , vol.122 , pp. 235-257
    • Cruz-Orive, L.M.1    Weibel, E.R.2
  • 15
    • 33646383648 scopus 로고    scopus 로고
    • From analog to digital: exploring cell dynamics with single quantum dots
    • Dahan M. From analog to digital: exploring cell dynamics with single quantum dots. Histochem. Cell Biol. 125 (2006) 451-456
    • (2006) Histochem. Cell Biol. , vol.125 , pp. 451-456
    • Dahan, M.1
  • 16
    • 33646245286 scopus 로고    scopus 로고
    • Vacuolar H+ - ATPase activity is required for endocytic and secretory trafficking in Arabidopsis
    • Dettmer J., Hong-Hermesdorf A., Stierhof Y.-D., and Schumacher K. Vacuolar H+ - ATPase activity is required for endocytic and secretory trafficking in Arabidopsis. Plant Cell 18 (2006) 715-730
    • (2006) Plant Cell , vol.18 , pp. 715-730
    • Dettmer, J.1    Hong-Hermesdorf, A.2    Stierhof, Y.-D.3    Schumacher, K.4
  • 18
    • 33845905221 scopus 로고    scopus 로고
    • Dynein is required for receptor sorting and the morphogenesis of early endosomes
    • Driskell O.J., Mironov A., Allan V.J., and Woodman P.G. Dynein is required for receptor sorting and the morphogenesis of early endosomes. Nat. Cell Biol. 9 (2007) 113-120
    • (2007) Nat. Cell Biol. , vol.9 , pp. 113-120
    • Driskell, O.J.1    Mironov, A.2    Allan, V.J.3    Woodman, P.G.4
  • 19
    • 37549060014 scopus 로고    scopus 로고
    • Effect of voluntary exercise on number and volume of cardiomyocytes and their mitochondria in the mouse left ventricle
    • Eisele J., Schaefer I., Nyengaard J.R., Post H., Liebetanz D., Brüel A., and Mühlfeld C. Effect of voluntary exercise on number and volume of cardiomyocytes and their mitochondria in the mouse left ventricle. Basic Res. Cardiol. 103 (2008) 12-21
    • (2008) Basic Res. Cardiol. , vol.103 , pp. 12-21
    • Eisele, J.1    Schaefer, I.2    Nyengaard, J.R.3    Post, H.4    Liebetanz, D.5    Brüel, A.6    Mühlfeld, C.7
  • 20
    • 26244434201 scopus 로고    scopus 로고
    • Improved lung preservation relates to an increase in tubular myelin-associated surfactant protein A
    • Fehrenbach H., Tews S., Fehrenbach A., Ochs M., Wittwer T., Wahlers T., and Richter J. Improved lung preservation relates to an increase in tubular myelin-associated surfactant protein A. Respir. Res. 6 (2005) 1-12
    • (2005) Respir. Res. , vol.6 , pp. 1-12
    • Fehrenbach, H.1    Tews, S.2    Fehrenbach, A.3    Ochs, M.4    Wittwer, T.5    Wahlers, T.6    Richter, J.7
  • 23
    • 0029937619 scopus 로고    scopus 로고
    • Synapse restructuring associated with the maintenance phase of hippocampal long-term potentiation
    • Geinisman Y., Detoledo-Morrell L., Morrell F., Persina I.S., and Beatty M.A. Synapse restructuring associated with the maintenance phase of hippocampal long-term potentiation. J. Comp. Neurol. 368 (1996) 413-423
    • (1996) J. Comp. Neurol. , vol.368 , pp. 413-423
    • Geinisman, Y.1    Detoledo-Morrell, L.2    Morrell, F.3    Persina, I.S.4    Beatty, M.A.5
  • 24
    • 0025027475 scopus 로고
    • Assessment of particle retention and clearance in the intrapulmonary conducting airways of hamster lungs with the fractionator
    • Geiser M., Cruz-Orive L.M., Im Hof V., and Gehr P. Assessment of particle retention and clearance in the intrapulmonary conducting airways of hamster lungs with the fractionator. J. Microsc. 160 (1990) 75-88
    • (1990) J. Microsc. , vol.160 , pp. 75-88
    • Geiser, M.1    Cruz-Orive, L.M.2    Im Hof, V.3    Gehr, P.4
  • 26
    • 27144475807 scopus 로고    scopus 로고
    • Correlated light and electron microscopic imaging of multiple endogenous proteins using quantum dots
    • Giepmans B.N.G., Deerinck T.J., Smarr B.L., Jones Y.Z., and Ellisman M.H. Correlated light and electron microscopic imaging of multiple endogenous proteins using quantum dots. Nat. Methods 2 (2005) 743-749
    • (2005) Nat. Methods , vol.2 , pp. 743-749
    • Giepmans, B.N.G.1    Deerinck, T.J.2    Smarr, B.L.3    Jones, Y.Z.4    Ellisman, M.H.5
  • 27
    • 33645798851 scopus 로고    scopus 로고
    • The fluorescent toolbox for assessing protein location and function
    • Giepmans B.N.G., Adams S.R., Ellisman M.H., and Tsien R.Y. The fluorescent toolbox for assessing protein location and function. Science 312 (2006) 217-224
    • (2006) Science , vol.312 , pp. 217-224
    • Giepmans, B.N.G.1    Adams, S.R.2    Ellisman, M.H.3    Tsien, R.Y.4
  • 28
    • 1642527386 scopus 로고    scopus 로고
    • Oxidant mechanisms in response to ambient air particles
    • Gonzalez-Flecha B. Oxidant mechanisms in response to ambient air particles. Mol. Asp. Med. 25 (2004) 169-182
    • (2004) Mol. Asp. Med. , vol.25 , pp. 169-182
    • Gonzalez-Flecha, B.1
  • 30
    • 0022509767 scopus 로고
    • Quantitation in immunocytochemistry: correlation of immunogold labelling to absolute number of membrane antigens
    • Griffiths G., and Hoppeler H. Quantitation in immunocytochemistry: correlation of immunogold labelling to absolute number of membrane antigens. J. Histochem. Cytochem. 34 (1986) 1389-1398
    • (1986) J. Histochem. Cytochem. , vol.34 , pp. 1389-1398
    • Griffiths, G.1    Hoppeler, H.2
  • 31
    • 0021254977 scopus 로고
    • Density of newly synthesized plasma membrane proteins in intracellular membranes. I. Stereological studies
    • Griffiths G., Warren G., Quinn P., Mathieu-Costello O., and Hoppeler H. Density of newly synthesized plasma membrane proteins in intracellular membranes. I. Stereological studies. J. Cell Biol. 98 (1983) 2133-2141
    • (1983) J. Cell Biol. , vol.98 , pp. 2133-2141
    • Griffiths, G.1    Warren, G.2    Quinn, P.3    Mathieu-Costello, O.4    Hoppeler, H.5
  • 32
    • 0034780562 scopus 로고    scopus 로고
    • Electron microscopy applications for quantitative cellular microbiology
    • Griffiths G., Lucocq J.M., and Mayhew T.M. Electron microscopy applications for quantitative cellular microbiology. Cell Microbiol. 3 (2001) 659-668
    • (2001) Cell Microbiol. , vol.3 , pp. 659-668
    • Griffiths, G.1    Lucocq, J.M.2    Mayhew, T.M.3
  • 33
    • 84981459110 scopus 로고
    • Notes on the estimation of numerical density of arbitrary profiles: the edge effect
    • Gundersen H.J.G. Notes on the estimation of numerical density of arbitrary profiles: the edge effect. J. Microsc. 111 (1977) 219-223
    • (1977) J. Microsc. , vol.111 , pp. 219-223
    • Gundersen, H.J.G.1
  • 34
    • 84985187820 scopus 로고
    • Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson
    • Gundersen H.J.G. Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J. Microsc. 143 (1986) 3-45
    • (1986) J. Microsc. , vol.143 , pp. 3-45
    • Gundersen, H.J.G.1
  • 36
    • 0036381089 scopus 로고    scopus 로고
    • The smooth fractionator
    • Gundersen H.J.G. The smooth fractionator. J. Microsc. 207 (2002) 191-210
    • (2002) J. Microsc. , vol.207 , pp. 191-210
    • Gundersen, H.J.G.1
  • 37
    • 84985280160 scopus 로고
    • The efficiency of systematic sampling in stereology and its prediction
    • Gundersen H.J.G., and Jensen E.B. The efficiency of systematic sampling in stereology and its prediction. J. Microsc. 147 (1987) 229-263
    • (1987) J. Microsc. , vol.147 , pp. 229-263
    • Gundersen, H.J.G.1    Jensen, E.B.2
  • 38
    • 0033045425 scopus 로고    scopus 로고
    • The efficiency of systematic sampling in stereology - reconsidered
    • Gundersen H.J.G., Jensen E.B.V., Kiêu K., and Nielsen J. The efficiency of systematic sampling in stereology - reconsidered. J. Microsc. 193 (1999) 199-211
    • (1999) J. Microsc. , vol.193 , pp. 199-211
    • Gundersen, H.J.G.1    Jensen, E.B.V.2    Kiêu, K.3    Nielsen, J.4
  • 40
    • 62549087547 scopus 로고    scopus 로고
    • Standards for quantitative assessment of lung structure. An official research policy statement of the ATS/ERS
    • submitted
    • Hsia, C.C.W., Hyde, D.M., Ochs, M., Weibel, E.R., 2008. Standards for quantitative assessment of lung structure. An official research policy statement of the ATS/ERS. (submitted).
    • (2008)
    • Hsia, C.C.W.1    Hyde, D.M.2    Ochs, M.3    Weibel, E.R.4
  • 41
    • 34250792789 scopus 로고    scopus 로고
    • Chromatin breakdown by deoxyribonuclease 1 promotes acetaminophen-induced liver necrosis: an ultrastructural and histochemical study on male CD-1 mice
    • Jacob M., Mannherz H.G., and Napirei M. Chromatin breakdown by deoxyribonuclease 1 promotes acetaminophen-induced liver necrosis: an ultrastructural and histochemical study on male CD-1 mice. Histochem. Cell Biol. 128 (2007) 19-33
    • (2007) Histochem. Cell Biol. , vol.128 , pp. 19-33
    • Jacob, M.1    Mannherz, H.G.2    Napirei, M.3
  • 42
    • 26444548121 scopus 로고    scopus 로고
    • Design-based stereological analysis of the lung parenchymal architecture and alveolar type II cells in surfactant protein A and D double deficient mice
    • Jung A., Allen L., Nyengaard J.R., Gundersen H.J.G., Richter J., Hawgood S., and Ochs M. Design-based stereological analysis of the lung parenchymal architecture and alveolar type II cells in surfactant protein A and D double deficient mice. Anat. Rec. 286 (2005) 885-890
    • (2005) Anat. Rec. , vol.286 , pp. 885-890
    • Jung, A.1    Allen, L.2    Nyengaard, J.R.3    Gundersen, H.J.G.4    Richter, J.5    Hawgood, S.6    Ochs, M.7
  • 44
    • 0028838542 scopus 로고
    • Synapse-to-neuron ratio in the lateral geniculate nucleus of rats exposed chronically to ethanol
    • Kjellström C., and Conradi N. Synapse-to-neuron ratio in the lateral geniculate nucleus of rats exposed chronically to ethanol. Alcohol Clin. Exp. Res. 19 (1995) 1261-1264
    • (1995) Alcohol Clin. Exp. Res. , vol.19 , pp. 1261-1264
    • Kjellström, C.1    Conradi, N.2
  • 45
    • 0033793621 scopus 로고    scopus 로고
    • Making the counts count: the stereology revolution
    • Kordower J.H. Making the counts count: the stereology revolution. J. Chem. Neuroanat. 20 (2000) 1-2
    • (2000) J. Chem. Neuroanat. , vol.20 , pp. 1-2
    • Kordower, J.H.1
  • 47
    • 0035464228 scopus 로고    scopus 로고
    • Estimating the number of complex particles using the ConnEulor principle
    • Kroustrup J.P., and Gundersen H.J.G. Estimating the number of complex particles using the ConnEulor principle. J. Microsc. 203 (2001) 314-320
    • (2001) J. Microsc. , vol.203 , pp. 314-320
    • Kroustrup, J.P.1    Gundersen, H.J.G.2
  • 48
    • 0031661268 scopus 로고    scopus 로고
    • Global spatial sampling with isotropic virtual planes: estimators of length density and total length in thick, arbitrarily oriented sections
    • Larsen J.O., Gundersen H.J.G., and Nielsen J. Global spatial sampling with isotropic virtual planes: estimators of length density and total length in thick, arbitrarily oriented sections. J. Microsc. 191 (1998) 238-248
    • (1998) J. Microsc. , vol.191 , pp. 238-248
    • Larsen, J.O.1    Gundersen, H.J.G.2    Nielsen, J.3
  • 50
    • 33751015149 scopus 로고    scopus 로고
    • Wheat nitrogen metabolism during grain filling: comparative roles of glumes and the flag leaf
    • Lopes M.S., Cortadellas N., Kichey T., Dubois F., Habash D.Z., and Araus J.L. Wheat nitrogen metabolism during grain filling: comparative roles of glumes and the flag leaf. Planta 225 (2006) 165-181
    • (2006) Planta , vol.225 , pp. 165-181
    • Lopes, M.S.1    Cortadellas, N.2    Kichey, T.3    Dubois, F.4    Habash, D.Z.5    Araus, J.L.6
  • 51
    • 48749089692 scopus 로고    scopus 로고
    • Cryo-electron tomography of cells: connecting structure and function
    • Lucic V., Leis A., and Baumeister W. Cryo-electron tomography of cells: connecting structure and function. Histochem. Cell Biol. 130 (2008) 185-196
    • (2008) Histochem. Cell Biol. , vol.130 , pp. 185-196
    • Lucic, V.1    Leis, A.2    Baumeister, W.3
  • 52
    • 0026476534 scopus 로고
    • Quantitation of gold labelling and estimation of labelling efficiency with a stereological counting method
    • Lucocq J.M. Quantitation of gold labelling and estimation of labelling efficiency with a stereological counting method. J. Histochem. Cytochem. 40 (1992) 1929-1936
    • (1992) J. Histochem. Cytochem. , vol.40 , pp. 1929-1936
    • Lucocq, J.M.1
  • 53
    • 0028281636 scopus 로고
    • Quantitation of gold labelling and antigens in immunolabelled ultrathin sections
    • Lucocq J.M. Quantitation of gold labelling and antigens in immunolabelled ultrathin sections. J. Anat. 184 (1994) 1-13
    • (1994) J. Anat. , vol.184 , pp. 1-13
    • Lucocq, J.M.1
  • 55
    • 0032907782 scopus 로고    scopus 로고
    • The art of counting
    • Madsen K.M. The art of counting. J. Am. Soc. Nephrol. 10 (1999) 1124-1125
    • (1999) J. Am. Soc. Nephrol. , vol.10 , pp. 1124-1125
    • Madsen, K.M.1
  • 56
    • 0026536189 scopus 로고
    • The double disector: unbiased stereological estimation of the number of particles inside other particles
    • Marcussen N. The double disector: unbiased stereological estimation of the number of particles inside other particles. J. Microsc. 165 (1992) 417-426
    • (1992) J. Microsc. , vol.165 , pp. 417-426
    • Marcussen, N.1
  • 57
    • 0025148824 scopus 로고
    • Estimation of surface area and length with the orientator
    • Mattfeldt T., Mall G., Gharehbaghi H., and Möller P. Estimation of surface area and length with the orientator. J. Microsc. 159 (1990) 301-317
    • (1990) J. Microsc. , vol.159 , pp. 301-317
    • Mattfeldt, T.1    Mall, G.2    Gharehbaghi, H.3    Möller, P.4
  • 58
    • 33645912611 scopus 로고    scopus 로고
    • Stereology and the placenta - where's the point? - a review
    • Mayhew T.M. Stereology and the placenta - where's the point? - a review. Placenta 27, suppl. A, Troph. Res. 20 (2006) S17-S25
    • (2006) Placenta 27, suppl. A, Troph. Res. , vol.20
    • Mayhew, T.M.1
  • 59
    • 34548025320 scopus 로고    scopus 로고
    • Quantitative immunoelectron microscopy. Alternative ways of assessing subcellular patterns of gold labelling
    • Kuo J. (Ed), Humana Press Inc., Totowa, NJ, USA
    • Mayhew T.M. Quantitative immunoelectron microscopy. Alternative ways of assessing subcellular patterns of gold labelling. In: Kuo J. (Ed). Methods in Molecular Biology, Vol. 369. Electron Microscopy: Methods and Protocols. second ed. (2007), Humana Press Inc., Totowa, NJ, USA 309-329
    • (2007) Methods in Molecular Biology, Vol. 369. Electron Microscopy: Methods and Protocols. second ed. , pp. 309-329
    • Mayhew, T.M.1
  • 60
    • 37649025073 scopus 로고    scopus 로고
    • Taking tissue samples from the placenta: an illustration of principles and strategies
    • Mayhew T.M. Taking tissue samples from the placenta: an illustration of principles and strategies. Placenta 29 (2008) 1-14
    • (2008) Placenta , vol.29 , pp. 1-14
    • Mayhew, T.M.1
  • 61
    • 2542525291 scopus 로고    scopus 로고
    • A simple method for comparing immunogold distributions in two or more experimental groups illustrated using GLUT1 labelling of isolated trophoblast cells
    • Mayhew T.M., and Desoye G. A simple method for comparing immunogold distributions in two or more experimental groups illustrated using GLUT1 labelling of isolated trophoblast cells. Placenta 25 (2004) 580-584
    • (2004) Placenta , vol.25 , pp. 580-584
    • Mayhew, T.M.1    Desoye, G.2
  • 62
    • 0029968229 scopus 로고    scopus 로고
    • If you assume, you can make an ass out of u and me: a decade of the disector for stereological counting of particles in 3D space
    • Mayhew T.M., and Gundersen H.J.G. If you assume, you can make an ass out of u and me: a decade of the disector for stereological counting of particles in 3D space. J. Anat. 188 (1996) 1-15
    • (1996) J. Anat. , vol.188 , pp. 1-15
    • Mayhew, T.M.1    Gundersen, H.J.G.2
  • 63
    • 39749143900 scopus 로고    scopus 로고
    • Quantifying immunogold labelling patterns of cellular compartments when they comprise mixtures of membranes (surface-occupying) and organelles (volume-occupying)
    • Mayhew T.M., and Lucocq J.M. Quantifying immunogold labelling patterns of cellular compartments when they comprise mixtures of membranes (surface-occupying) and organelles (volume-occupying). Histochem. Cell Biol. 129 (2008) 367-378
    • (2008) Histochem. Cell Biol. , vol.129 , pp. 367-378
    • Mayhew, T.M.1    Lucocq, J.M.2
  • 64
    • 48749106923 scopus 로고    scopus 로고
    • Developments in cell biology for quantitative immunoelectron microscopy based on thin sections: a review
    • Mayhew T.M., and Lucocq J.M. Developments in cell biology for quantitative immunoelectron microscopy based on thin sections: a review. Histochem. Cell Biol. 130 (2008) 299-313
    • (2008) Histochem. Cell Biol. , vol.130 , pp. 299-313
    • Mayhew, T.M.1    Lucocq, J.M.2
  • 65
    • 0036125418 scopus 로고    scopus 로고
    • Relative labelling index: a novel stereological approach to test for non-random immunogold labelling of organelles and membranes on transmission electron microscopy thin sections
    • Mayhew T.M., Lucocq J.M., and Griffiths G. Relative labelling index: a novel stereological approach to test for non-random immunogold labelling of organelles and membranes on transmission electron microscopy thin sections. J. Microsc. 205 (2002) 153-164
    • (2002) J. Microsc. , vol.205 , pp. 153-164
    • Mayhew, T.M.1    Lucocq, J.M.2    Griffiths, G.3
  • 66
    • 0037688168 scopus 로고    scopus 로고
    • A simpler way of comparing the labelling densities of cellular compartments illustrated using data from VPARP and LAMP-1 immunogold labelling experiments
    • Mayhew T., Griffiths G., Habermann A., Lucocq J., Emre N., and Webster P. A simpler way of comparing the labelling densities of cellular compartments illustrated using data from VPARP and LAMP-1 immunogold labelling experiments. Histochem. Cell Biol. 119 (2003) 333-341
    • (2003) Histochem. Cell Biol. , vol.119 , pp. 333-341
    • Mayhew, T.1    Griffiths, G.2    Habermann, A.3    Lucocq, J.4    Emre, N.5    Webster, P.6
  • 67
    • 4544287006 scopus 로고    scopus 로고
    • Application of an efficient method for comparing immunogold labelling patterns in the same sets of compartments in different groups of cells
    • Mayhew T., Griffiths G., and Lucocq J. Application of an efficient method for comparing immunogold labelling patterns in the same sets of compartments in different groups of cells. Histochem. Cell Biol. 122 (2004) 171-177
    • (2004) Histochem. Cell Biol. , vol.122 , pp. 171-177
    • Mayhew, T.1    Griffiths, G.2    Lucocq, J.3
  • 68
    • 13444310742 scopus 로고    scopus 로고
    • Intracellular processing and activation of membrane type 1 matrix metalloprotease depends on its partitioning into lipid domains
    • Mazzone M., Balsassarre M., Beznoussenko G., Giacchetti G., Vao J., Zucker S., Luini A., and Buccione R. Intracellular processing and activation of membrane type 1 matrix metalloprotease depends on its partitioning into lipid domains. J. Cell Sci. 117 (2004) 6275-6287
    • (2004) J. Cell Sci. , vol.117 , pp. 6275-6287
    • Mazzone, M.1    Balsassarre, M.2    Beznoussenko, G.3    Giacchetti, G.4    Vao, J.5    Zucker, S.6    Luini, A.7    Buccione, R.8
  • 69
    • 19044391196 scopus 로고    scopus 로고
    • Endoplasmic reticulum positioning and partitioning in mitotic HeLa cells
    • McCullough S., and Lucocq J. Endoplasmic reticulum positioning and partitioning in mitotic HeLa cells. J. Anat. 206 (2005) 415-425
    • (2005) J. Anat. , vol.206 , pp. 415-425
    • McCullough, S.1    Lucocq, J.2
  • 70
    • 7844231673 scopus 로고    scopus 로고
    • Estimation of subcellular organelle volume from ultrathin sections through centrioles with a discretized version of the vertical rotator
    • Mironov Jr. A.A., and Mironov A.A. Estimation of subcellular organelle volume from ultrathin sections through centrioles with a discretized version of the vertical rotator. J. Microsc. 192 (1998) 29-36
    • (1998) J. Microsc. , vol.192 , pp. 29-36
    • Mironov Jr., A.A.1    Mironov, A.A.2
  • 72
    • 33749468527 scopus 로고    scopus 로고
    • High-pressure freezing and freeze substitution of rat myocardium for immunogold labeling of connexin 43
    • Mühlfeld C., and Richter J. High-pressure freezing and freeze substitution of rat myocardium for immunogold labeling of connexin 43. Anat. Rec. Part A 288A (2006) 1059-1067
    • (2006) Anat. Rec. Part A , vol.288 A , pp. 1059-1067
    • Mühlfeld, C.1    Richter, J.2
  • 73
    • 35448991054 scopus 로고    scopus 로고
    • Re-evaluation of pulmonary titanium dioxide nanoparticle distribution using the "relative deposition index": evidence for clearance through microvasculature
    • Mühlfeld C., Geiser M., Kapp N., Gehr P., and Rothen-Rutishauser B. Re-evaluation of pulmonary titanium dioxide nanoparticle distribution using the "relative deposition index": evidence for clearance through microvasculature. Particle Fibre Toxicol. 4 7 (2007) 1-8
    • (2007) Particle Fibre Toxicol. , vol.4 , Issue.7 , pp. 1-8
    • Mühlfeld, C.1    Geiser, M.2    Kapp, N.3    Gehr, P.4    Rothen-Rutishauser, B.5
  • 74
    • 37549055041 scopus 로고    scopus 로고
    • A novel quantitative method for analysing the distributions of nanoparticles between different tissue and intracellular compartments
    • Mühlfeld C., Mayhew T.M., Gehr P., and Rothen-Rutishauser B. A novel quantitative method for analysing the distributions of nanoparticles between different tissue and intracellular compartments. J. Aerosol. Med. 20 (2007) 395-407
    • (2007) J. Aerosol. Med. , vol.20 , pp. 395-407
    • Mühlfeld, C.1    Mayhew, T.M.2    Gehr, P.3    Rothen-Rutishauser, B.4
  • 75
    • 38549112487 scopus 로고    scopus 로고
    • Visualization and quantitative analysis of nanoparticles in the respiratory system by transmission electron microscopy
    • Mühlfeld C., Rothen-Rutishauser B., Vanhecke D., Blank F., Gehr P., and Ochs M. Visualization and quantitative analysis of nanoparticles in the respiratory system by transmission electron microscopy. Part Fibre Toxicol 4 11 (2007) 1-17
    • (2007) Part Fibre Toxicol , vol.4 , Issue.11 , pp. 1-17
    • Mühlfeld, C.1    Rothen-Rutishauser, B.2    Vanhecke, D.3    Blank, F.4    Gehr, P.5    Ochs, M.6
  • 78
    • 0347418285 scopus 로고    scopus 로고
    • Application of quantum dots as probes for correlative fluorescence, conventional, and energy-filtered transmission electron microscopy
    • Nisman R., Dellaire G., Ren Y., Li R., and Bazett-Jones D.P. Application of quantum dots as probes for correlative fluorescence, conventional, and energy-filtered transmission electron microscopy. J. Histochem. Cytochem. 52 (2004) 13-18
    • (2004) J. Histochem. Cytochem. , vol.52 , pp. 13-18
    • Nisman, R.1    Dellaire, G.2    Ren, Y.3    Li, R.4    Bazett-Jones, D.P.5
  • 79
    • 0026530168 scopus 로고
    • The isector: a simple and direct method for generating isotropic, uniform random sections from small specimens
    • Nyengaard J.R., and Gundersen H.J.G. The isector: a simple and direct method for generating isotropic, uniform random sections from small specimens. J. Microsc. 165 (1992) 427-431
    • (1992) J. Microsc. , vol.165 , pp. 427-431
    • Nyengaard, J.R.1    Gundersen, H.J.G.2
  • 80
    • 33745828119 scopus 로고    scopus 로고
    • Direct and efficient stereological estimation of total cell quantities using electron microscopy
    • Nyengaard J.R., and Gundersen H.J.G. Direct and efficient stereological estimation of total cell quantities using electron microscopy. J. Microsc. 222 (2006) 182-187
    • (2006) J. Microsc. , vol.222 , pp. 182-187
    • Nyengaard, J.R.1    Gundersen, H.J.G.2
  • 82
    • 20644449754 scopus 로고    scopus 로고
    • Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles
    • Oberdörster G., Oberdörster E., and Oberdörster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 113 (2002) 823-839
    • (2002) Environ. Health Perspect. , vol.113 , pp. 823-839
    • Oberdörster, G.1    Oberdörster, E.2    Oberdörster, J.3
  • 84
    • 33745830136 scopus 로고    scopus 로고
    • A brief update on lung stereology
    • Ochs M. A brief update on lung stereology. J. Microsc. 222 (2006) 188-200
    • (2006) J. Microsc. , vol.222 , pp. 188-200
    • Ochs, M.1
  • 85
  • 88
    • 33744780459 scopus 로고    scopus 로고
    • Uptake of C60 by human monocyte macrophages, its localization and implications for toxicity: studied by high resolution electron microscopy and electron tomography
    • Porter A.E., Muller K., Skepper J., Midgley P., and Welland M. Uptake of C60 by human monocyte macrophages, its localization and implications for toxicity: studied by high resolution electron microscopy and electron tomography. Acta Biomater. 2 4 (2006) 409-419
    • (2006) Acta Biomater. , vol.2 , Issue.4 , pp. 409-419
    • Porter, A.E.1    Muller, K.2    Skepper, J.3    Midgley, P.4    Welland, M.5
  • 89
    • 26844505013 scopus 로고    scopus 로고
    • Conformational variation of surface class II MHC proteins during myeloid dendritic cell differentiation accompanies structural changes in lysosomal MIIC
    • Potolicchio I., Chitta S., Xu X., Fonseca D., Crisi G., Horejsi V., Strominger J.L., Stern L.J., Raposo G., and Santambrogio L. Conformational variation of surface class II MHC proteins during myeloid dendritic cell differentiation accompanies structural changes in lysosomal MIIC. J. Immunol. 175 (2005) 4935-4947
    • (2005) J. Immunol. , vol.175 , pp. 4935-4947
    • Potolicchio, I.1    Chitta, S.2    Xu, X.3    Fonseca, D.4    Crisi, G.5    Horejsi, V.6    Strominger, J.L.7    Stern, L.J.8    Raposo, G.9    Santambrogio, L.10
  • 90
    • 0021268019 scopus 로고
    • Density of newly synthesized plasma membrane proteins in intracellular membranes. II. Biochemical studies
    • Quinn P., Griffiths G., and Warren G. Density of newly synthesized plasma membrane proteins in intracellular membranes. II. Biochemical studies. J. Cell Biol. 98 (1984) 2142-2147
    • (1984) J. Cell Biol. , vol.98 , pp. 2142-2147
    • Quinn, P.1    Griffiths, G.2    Warren, G.3
  • 91
    • 33746191803 scopus 로고    scopus 로고
    • Interaction of fine particles and nanoparticles with red blood cells visualized with advanced microscopic techniques
    • Rothen-Rutishauser B.M., Schürch S., Haenni B., Kapp N., and Gehr P. Interaction of fine particles and nanoparticles with red blood cells visualized with advanced microscopic techniques. Environ. Sci. Technol. 40 14 (2006) 4353-4359
    • (2006) Environ. Sci. Technol. , vol.40 , Issue.14 , pp. 4353-4359
    • Rothen-Rutishauser, B.M.1    Schürch, S.2    Haenni, B.3    Kapp, N.4    Gehr, P.5
  • 92
    • 77957342464 scopus 로고    scopus 로고
    • Interaction of particles with membranes
    • Donaldson K., and Borm P. (Eds), CRC, Boca Raton, FL
    • Rothen-Rutishauser B., Schürch S., and Gehr P. Interaction of particles with membranes. In: Donaldson K., and Borm P. (Eds). Toxicology of Particles (2007), CRC, Boca Raton, FL
    • (2007) Toxicology of Particles
    • Rothen-Rutishauser, B.1    Schürch, S.2    Gehr, P.3
  • 93
    • 27144488357 scopus 로고    scopus 로고
    • Involvement of caspase-cleaved and intact adaptor protein 1 complex in endosomal remodelling in maturing dendritic cells
    • Santambrogio L., Potolicchio I., Fessler S.P., Wong S.-H., Raposo G., and Strominger J.L. Involvement of caspase-cleaved and intact adaptor protein 1 complex in endosomal remodelling in maturing dendritic cells. Nat. Immunol. 6 (2005) 1020-1028
    • (2005) Nat. Immunol. , vol.6 , pp. 1020-1028
    • Santambrogio, L.1    Potolicchio, I.2    Fessler, S.P.3    Wong, S.-H.4    Raposo, G.5    Strominger, J.L.6
  • 94
    • 34548840599 scopus 로고    scopus 로고
    • Genotoxicity of poorly soluble particles
    • Schins R.P., and Knaapen A.M. Genotoxicity of poorly soluble particles. Inhal. Toxicol. 19 suppl 1 (2007) 189-198
    • (2007) Inhal. Toxicol. , vol.19 , Issue.SUPPL. 1 , pp. 189-198
    • Schins, R.P.1    Knaapen, A.M.2
  • 95
    • 27844593739 scopus 로고    scopus 로고
    • Distribution of surfactant proteins in type II pneumocytes of newborn, 14-day old, and adult rats: an immunoelectron microscopic and stereological study
    • Schmiedl A., Ochs M., Mühlfeld C., Johnen G., and Brasch F. Distribution of surfactant proteins in type II pneumocytes of newborn, 14-day old, and adult rats: an immunoelectron microscopic and stereological study. Histochem. Cell Biol. 124 (2005) 465-476
    • (2005) Histochem. Cell Biol. , vol.124 , pp. 465-476
    • Schmiedl, A.1    Ochs, M.2    Mühlfeld, C.3    Johnen, G.4    Brasch, F.5
  • 96
    • 0021234096 scopus 로고
    • The unbiased estimation of number and sizes of arbitrary particles using the disector
    • Sterio D.C. The unbiased estimation of number and sizes of arbitrary particles using the disector. J. Microsc. 134 (1984) 127-136
    • (1984) J. Microsc. , vol.134 , pp. 127-136
    • Sterio, D.C.1
  • 97
    • 0024853192 scopus 로고
    • Labeling properties of sucrose-infiltrated cryosections
    • Stierhof Y.-D., and Schwarz H. Labeling properties of sucrose-infiltrated cryosections. Scanning Microsc. suppl 3 (1989) 35-46
    • (1989) Scanning Microsc. , Issue.SUPPL. 3 , pp. 35-46
    • Stierhof, Y.-D.1    Schwarz, H.2
  • 98
    • 34247325579 scopus 로고    scopus 로고
    • Alpha smooth muscle actin distribution in cytoplasm and nuclear invaginations of connective tissue fibroblasts
    • Storch K.N., Taatjes D.J., Bouffard N.A., Locknar S., Bishop N.M., and Langevin H.M. Alpha smooth muscle actin distribution in cytoplasm and nuclear invaginations of connective tissue fibroblasts. Histochem. Cell Biol. 127 (2007) 523-530
    • (2007) Histochem. Cell Biol. , vol.127 , pp. 523-530
    • Storch, K.N.1    Taatjes, D.J.2    Bouffard, N.A.3    Locknar, S.4    Bishop, N.M.5    Langevin, H.M.6
  • 99
    • 54049097431 scopus 로고    scopus 로고
    • Electron microscopy of high pressure frozen samples: bridging the gap between cellular ultrastructure and atomic resolution, Histochem
    • Studer D., Humbel B.M., and Chiquet M. Electron microscopy of high pressure frozen samples: bridging the gap between cellular ultrastructure and atomic resolution, Histochem. Cell Biol 130 (2008) 877-889
    • (2008) Cell Biol , vol.130 , pp. 877-889
    • Studer, D.1    Humbel, B.M.2    Chiquet, M.3
  • 100
    • 0035452433 scopus 로고    scopus 로고
    • Total regional and global number of synapses in the human brain neocortex
    • Tang Y., Nyengaard J.R., De Groot D., and Gundersen H.J.G. Total regional and global number of synapses in the human brain neocortex. Synapse 41 (2001) 258-273
    • (2001) Synapse , vol.41 , pp. 258-273
    • Tang, Y.1    Nyengaard, J.R.2    De Groot, D.3    Gundersen, H.J.G.4
  • 101
    • 27144554923 scopus 로고    scopus 로고
    • Lectin-binding characteristics of Lyme borreliosis spirochete Borrelia burgdorferi sensu stricto
    • Vancova M., Nebesarova J., and Grubhoffer L. Lectin-binding characteristics of Lyme borreliosis spirochete Borrelia burgdorferi sensu stricto. Folia Microbiol. 50 (2005) 229-238
    • (2005) Folia Microbiol. , vol.50 , pp. 229-238
    • Vancova, M.1    Nebesarova, J.2    Grubhoffer, L.3
  • 102
    • 34548431379 scopus 로고    scopus 로고
    • Stereology meets electron tomography: towards quantitative 3D electron microscopy
    • Vanhecke D., Studer D., and Ochs M. Stereology meets electron tomography: towards quantitative 3D electron microscopy. J. Struct. Biol. 159 (2007) 443-450
    • (2007) J. Struct. Biol. , vol.159 , pp. 443-450
    • Vanhecke, D.1    Studer, D.2    Ochs, M.3
  • 103
    • 33748174648 scopus 로고    scopus 로고
    • IntraGolgi distribution of the conserved oligomeric Golgi (COG) complex
    • Vasile E., Oka T., Ericsson M., Nakamura N., and Krieger M. IntraGolgi distribution of the conserved oligomeric Golgi (COG) complex. Exp. Cell Res. 312 (2006) 3132-3141
    • (2006) Exp. Cell Res. , vol.312 , pp. 3132-3141
    • Vasile, E.1    Oka, T.2    Ericsson, M.3    Nakamura, N.4    Krieger, M.5
  • 107
    • 33846167119 scopus 로고    scopus 로고
    • How much is there really? Why stereology is essential in lung morphometry
    • Weibel E.R., Hsia C.C.W., and Ochs M. How much is there really? Why stereology is essential in lung morphometry. J. Appl. Physiol. 102 (2007) 459-467
    • (2007) J. Appl. Physiol. , vol.102 , pp. 459-467
    • Weibel, E.R.1    Hsia, C.C.W.2    Ochs, M.3
  • 108
    • 33749516615 scopus 로고    scopus 로고
    • Ultrastructural analysis of ESCRT proteins suggests a role for endosome-associated tubular-vesicular membranes in ESCRT function
    • Welsch S., Habermann A., Jäger S., Müller B., Krijnse-Locker J., and Kräusslich H.-G. Ultrastructural analysis of ESCRT proteins suggests a role for endosome-associated tubular-vesicular membranes in ESCRT function. Traffic 7 (2006) 1551-1566
    • (2006) Traffic , vol.7 , pp. 1551-1566
    • Welsch, S.1    Habermann, A.2    Jäger, S.3    Müller, B.4    Krijnse-Locker, J.5    Kräusslich, H.-G.6
  • 110
    • 33745827757 scopus 로고    scopus 로고
    • A new fractionator principle with varying sampling fractions: exemplified by estimation of synapse number using electron microscopy
    • Witgen B.M., Grady M.S., Nyengaard J.R., and Gundersen H.J.G. A new fractionator principle with varying sampling fractions: exemplified by estimation of synapse number using electron microscopy. J. Microsc. 222 (2006) 251-255
    • (2006) J. Microsc. , vol.222 , pp. 251-255
    • Witgen, B.M.1    Grady, M.S.2    Nyengaard, J.R.3    Gundersen, H.J.G.4
  • 111
    • 23044509179 scopus 로고    scopus 로고
    • Immunogold localisation of microcystins in cryosectioned cells of Microcystis
    • Young F.M., Thomson C., Metcalf J.S., Lucocq J.M., and Codd G.A. Immunogold localisation of microcystins in cryosectioned cells of Microcystis. J. Struct. Biol. 151 (2005) 208-214
    • (2005) J. Struct. Biol. , vol.151 , pp. 208-214
    • Young, F.M.1    Thomson, C.2    Metcalf, J.S.3    Lucocq, J.M.4    Codd, G.A.5
  • 112
    • 17044364728 scopus 로고    scopus 로고
    • The cellular distribution and stage-specific expression of two dynein light chains from the human blood fluke Schistosoma japonicum
    • Zhang L.-H., McManus D.P., Sunderland P., Lu X.-M., Ye J.-J., Loukas A., and Jones M.K. The cellular distribution and stage-specific expression of two dynein light chains from the human blood fluke Schistosoma japonicum. Int. J. Biochem. Cell Biol. 37 (2005) 1511-1524
    • (2005) Int. J. Biochem. Cell Biol. , vol.37 , pp. 1511-1524
    • Zhang, L.-H.1    McManus, D.P.2    Sunderland, P.3    Lu, X.-M.4    Ye, J.-J.5    Loukas, A.6    Jones, M.K.7


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