Does lack of Cftr gene lead to developmental abnormalities in the lung?

Experimental Lung Research

Volumn 26, Issue 7, 2000, Pages 551-564

  Geiser, M ^a   Zimmermann, B ^a   Baumann, M ^a   Cruz Orive, L M ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Cystic fibrosis; Lung; Mutant mice; Stereology; Vertical sections

Indexed keywords

TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CAUSE OF DEATH; CONTROLLED STUDY; CYSTIC FIBROSIS; GENE MUTATION; HOMOZYGOTE; LUNG DEVELOPMENT; LUNG DISEASE; LUNG STRUCTURE; LUNG VOLUME; MICROSCOPY; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; STEREOLOGY;

EID: 0033792703     PISSN: 01902148     EISSN: None     Source Type: Journal    
DOI: 10.1080/019021400750048090     Document Type: Article

References (20)

1. Cystic fibrosis
2. Identification of the cystic fibrosis gene: Genetic analysis
3. Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA
4. Identification of the cystic fibrosis gene: Chromosome walking and jumping
5. Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)
6. Demonstration that CFTR is a chloride channel by alteration of its anion selectivity
7. Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis
8. An animal model for cystic fibrosis made by gene targeting
9. Cystic fibrosis in the mouse by targeted insertional mutagenesis
10. Bioelectric characteristics of exon 10 insertional cystic fibrosis mouse: Comparison with humans
11. Long term survival of the exon 10 insertional cystic fibrosis mutant mouse is a consequence of low level residual wild type Cftr gene expression
12. Lung disease in the cystic fibrosis mouse exposed to bacterial pathogens
13. Vertical LM sectioning and parallel CT scanning designs for stereology: Application to human lung
14. Morphometric and stereological methods in respiratory physiology including fixation techniques
15. A simple method for volumetry of organs in quantitative stereology
16. Estimation of surface area from vertical sections
17. Paradoxical effects of bleomycin and heavy water in mice
18. Assessment of particle retention and clearance in the intrapulmonary conducting airways of hamster lungs with the fractionator
19. A murine model of cystic fibrosis