Configuration of the 5′-methyl group modulates the biophysical and biological properties of locked nucleic acid (LNA) oligonucleotides

Journal of Medicinal Chemistry

Volumn 53, Issue 23, 2010, Pages 8309-8318

  Seth, Punit P ^a   Allerson, Charles R ^a,b   Siwkowski, Andrew ^a   Vasquez, Guillermo ^a   Berdeja, Andres ^a   Migawa, Michael T ^a   Gaus, Hans ^a   Prakash, Thazha P ^a   Bhat, Balkrishen ^a,b   Swayze, Eric E ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b REGULUS THERAPEUTICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5' METHYL LOCKED NUCLEIC ACID; ANTISENSE OLIGONUCLEOTIDE; LOCKED NUCLEIC ACID; METHYL GROUP; UNCLASSIFIED DRUG; OLIGONUCLEOTIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; BIOPHYSICS; CONTROLLED STUDY; METHYLATION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEIC ACID HYBRIDIZATION; TORSION; CHEMISTRY; STRUCTURE ACTIVITY RELATION;

BIOPHYSICS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGONUCLEOTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649899322     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101207e     Document Type: Article

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