Insights from crystal structures into the opposite effects on RNA affinity caused by the S- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic acid

Biochemistry

Volumn 51, Issue 1, 2012, Pages 7-9

  Pallan, Pradeep S ^a   Yu, Jinghua ^b   Allerson, Charles R ^b   Swayze, Eric E ^b   Seth, Punit ^b   Egli, Martin ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE; HEXITOL NUCLEIC ACIDS; IMMUNE STIMULATION; IN-VIVO; LOCKED NUCLEIC ACID; METHYL GROUP; MODIFIED OLIGONUCLEOTIDES;

FUNCTIONAL GROUPS; OLIGONUCLEOTIDES; SUGARS;

RNA;

ANTISENSE OLIGONUCLEOTIDE; DNA; LOCKED NUCLEIC ACID; RNA;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DNA DETERMINATION; DNA STRUCTURE; PRIORITY JOURNAL; RNA BINDING;

CRYSTALLOGRAPHY, X-RAY; HEXOSEDIPHOSPHATES; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HETERODUPLEXES; OLIGONUCLEOTIDES, ANTISENSE; RNA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUGAR ALCOHOLS; THERMODYNAMICS;

EID: 84863063778     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201810r     Document Type: Article

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