Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA

Nucleic Acids Research

Volumn 39, Issue 8, 2011, Pages 3482-3495

  Pallan, Pradeep S ^a   Greene, Emily M ^b   Jicman, Paul Andrei ^b   Pandey, Rajendra K ^c   Manoharan, Muthiah ^c   Rozners, Eriks ^b   Egli, Martin ^a  

^a VANDERBILT UNIVERSITY   (United States)

^b BINGHAMTON UNIVERSITY   (United States)

^c ALNYLAM PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2' DEOXY 2' FLUORO RNA; COMPLEMENTARY RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; ENTHALPY; OSMOTIC STRESS; PRIORITY JOURNAL; RNA CONFORMATION; RNA INTERFERENCE; RNA STABILITY; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; FLUORINE; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; OSMOTIC PRESSURE; RNA STABILITY; RNA, DOUBLE-STRANDED; THERMODYNAMICS; WATER;

EID: 79955615650     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkq1270     Document Type: Article

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