Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3′-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides

Journal of the American Chemical Society

Volumn 133, Issue 41, 2011, Pages 16642-16649

  Egli, Martin ^a   Pallan, Pradeep S ^a   Allerson, Charles R ^b   Prakash, Thazha P ^b   Berdeja, Andres ^b   Yu, Jinghua ^b   Lee, Sam ^b   Watt, Andrew ^b   Gaus, Hans ^b   Bhat, Balkrishen ^b   Swayze, Eric E ^b   Seth, Punit P ^b  

^a VANDERBILT UNIVERSITY   (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENTS; ANTISENSE; ANTISENSE ACTIVITY; ANTISENSE OLIGONUCLEOTIDES; BIOLOGICAL PROPERTIES; DNA DUPLEXES; DOWN-REGULATION; FLUORINE ATOMS; HEPATOTOXICITY; HEXITOL NUCLEIC ACIDS; LIVER TISSUE; LOSS OF STABILITY; MODIFIED OLIGONUCLEOTIDES; NUCLEIC ACID STRUCTURE; NUCLEOBASES; PHOSPHORAMIDITES; PSEUDO-HYDROGEN; SEQUENCE-DEPENDENT; STERIC ORIGIN;

AROMATIC COMPOUNDS; BIOMOLECULES; FLUORINE; GENE EXPRESSION; HYDROGEN; ISOMERS; OLIGONUCLEOTIDES; RNA; SUGARS; TISSUE;

HYDROGEN BONDS;

ANTISENSE OLIGONUCLEOTIDE; DOUBLE STRANDED DNA; FLUORINE; MONOMER; PURINE; PYRIMIDINE; THYMINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; ATOM; BINDING AFFINITY; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; DOWN REGULATION; GENE EXPRESSION; HYDROGEN BOND; LIVER TOXICITY; MOUSE; NONHUMAN; NUCLEIC ACID STRUCTURE; RNA SEQUENCE; RNA STRUCTURE; SYNTHESIS;

MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEIC ACIDS; OLIGONUCLEOTIDES; RNA; STEREOISOMERISM; SUGAR ALCOHOLS;

EID: 80054756151     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja207086x     Document Type: Article

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