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Volumn 40, Issue 6, 2012, Pages 1949-1956

Cerulenin-induced apoptosis is mediated by disrupting the interaction between AIF and hexokinase II

Author keywords

AIF; Akt; Cerulenin; Fatty acid synthase; Hexokinase II

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; APOPTOSIS INDUCING FACTOR; CASPASE 3; CERULENIN; CYTOCHROME C; HEXOKINASE; HEXOKINASE ISOENZYME; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

EID: 84861790189     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1401     Document Type: Article
Times cited : (7)

References (37)
  • 1
    • 0034002793 scopus 로고    scopus 로고
    • Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology
    • Kuhajda FP: Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology. Nutrition 16: 202-208, 2000.
    • (2000) Nutrition , vol.16 , pp. 202-208
    • Kuhajda, F.P.1
  • 2
    • 2542445809 scopus 로고    scopus 로고
    • Fatty acid synthase: A metabolic oncogene in prostate cancer?
    • Baron A, Migita T, Tang D and Loda M: Fatty acid synthase: a metabolic oncogene in prostate cancer? J Cell Biochem 91: 47-53, 2004.
    • (2004) J Cell Biochem , vol.91 , pp. 47-53
    • Baron, A.1    Migita, T.2    Tang, D.3    Loda, M.4
  • 3
    • 0031007392 scopus 로고    scopus 로고
    • Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival
    • DOI 10.1016/S0046-8177(97)90177-5
    • Gansler TS, Hardman III W, Hunt DA, Schaffel S and Hennigar RA: Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival. Hum Pathol 28: 686-692, 1997. (Pubitemid 27258421)
    • (1997) Human Pathology , vol.28 , Issue.6 , pp. 686-692
    • Gansler, T.S.1    Hardman III, W.2    Hunt, D.A.3    Schaffel, S.4    Hennigar, R.A.5
  • 4
    • 33645462548 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis
    • Liu X, Shi Y, Giranda VL and Luo Y: Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis. Mol Cancer Ther 5: 494-501, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 494-501
    • Liu, X.1    Shi, Y.2    Giranda, V.L.3    Luo, Y.4
  • 5
    • 0032532655 scopus 로고    scopus 로고
    • Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines
    • Pizer ES, Chrest FJ, DiGiuseppe JA and Han WF: Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines. Cancer Res 58: 4611-4615, 1998. (Pubitemid 28480625)
    • (1998) Cancer Research , vol.58 , Issue.20 , pp. 4611-4615
    • Pizer, E.S.1    Chrest, F.J.2    DiGiuseppe, J.A.3    Han, W.F.4
  • 6
    • 0038418257 scopus 로고    scopus 로고
    • RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells
    • De Schrijver E, Brusselmans K, Heyns W, Verhoeven G and Swinnen JV: RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells. Cancer Res 63: 3799-3804, 2003. (Pubitemid 36793069)
    • (2003) Cancer Research , vol.63 , Issue.13 , pp. 3799-3804
    • De Schrijver, E.1    Brusselmans, K.2    Heyns, W.3    Verhoeven, G.4    Swinnen, J.V.5
  • 7
    • 0035133059 scopus 로고    scopus 로고
    • Increased fatty acid synthase is a therapeutic target in mesothelioma
    • Gabrielson EW, Pinn ML, Testa JR and Kuhajda FP: Increased fatty acid synthase is a therapeutic target in mesothelioma. Clin Cancer Res 7: 153-177, 2001.
    • (2001) Clin Cancer Res , vol.7 , pp. 153-177
    • Gabrielson, E.W.1    Pinn, M.L.2    Testa, J.R.3    Kuhajda, F.P.4
  • 9
    • 0029971427 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer
    • Pizer ES, Wood FD, Heine HS, Romantsev FR, Pasternack GR and Kuhajda FP: Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer. Cancer Res 56: 1189-1193, 1996. (Pubitemid 26080952)
    • (1996) Cancer Research , vol.56 , Issue.6 , pp. 1189-1193
    • Pizer, E.S.1    Wood, F.D.2    Heine, H.S.3    Romantsev, F.E.4    Pasternack, G.R.5    Kuhajda, F.P.6
  • 10
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • Vivanco I and Sawyers CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501, 2002. (Pubitemid 37328931)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 11
    • 19944374798 scopus 로고    scopus 로고
    • Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells
    • DOI 10.1038/sj.onc.1208463
    • Wang HQ, Altomare DA, Skele KL, Poulikakos PI, Kuhajda FP, Di Cristofano A and Testa JR: Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. Oncogene 24: 3574-3582, 2005. (Pubitemid 40756227)
    • (2005) Oncogene , vol.24 , Issue.22 , pp. 3574-3582
    • Wang, H.Q.1    Altomare, D.A.2    Skele, K.L.3    Poulikakos, P.I.4    Kuhajda, F.P.5    Di, C.A.6    Testa, J.R.7
  • 12
    • 0036385719 scopus 로고    scopus 로고
    • Activation of fatty acid synthesis during neoplastic transformation: Role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
    • Yang YA, Han WF, Morin PJ, Chrest FJ and Pizer ES: Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Exp. Cell Res 279: 80-90, 2002.
    • (2002) Exp. Cell Res , vol.279 , pp. 80-90
    • Yang, Y.A.1    Han, W.F.2    Morin, P.J.3    Chrest, F.J.4    Pizer, E.S.5
  • 13
    • 0036469122 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells
    • Van de Sande T, De Schrijver E, Heyns W, Verhoeven G and Swinnen JV: Role of the phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells. Cancer Res 62: 642-646, 2002. (Pubitemid 34126933)
    • (2002) Cancer Research , vol.62 , Issue.3 , pp. 642-646
    • Van De, S.T.1    De Schrijver, E.2    Heyns, W.3    Verhoeven, G.4    Swinnen, J.V.5
  • 14
    • 14444286453 scopus 로고    scopus 로고
    • Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway: Involvement of protein kinase B/Akt
    • DOI 10.1074/jbc.273.39.25420
    • Wang D and Sul HS: Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. Involvement of protein kinase B/Akt. J Biol Chem 273: 25420-25426, 1998. (Pubitemid 28443310)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.39 , pp. 25420-25426
    • Wang, D.1    Sul, H.S.2
  • 15
    • 1842333237 scopus 로고    scopus 로고
    • Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    • del Peso L, González-García M, Page C, Herrera R and Nuñez G: Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278: 687-689, 1997.
    • (1997) Science , vol.278 , pp. 687-689
    • Del Peso, L.1    González-García, M.2    Page, C.3    Herrera, R.4    Nuñez, G.5
  • 17
    • 33746927077 scopus 로고    scopus 로고
    • Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt
    • DOI 10.1038/sj.onc.1209595, PII 1209595
    • Robey RB and Hay N: Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene 25: 4683-4696, 2006. (Pubitemid 44187618)
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4683-4696
    • Robey, R.B.1    Hay, N.2
  • 18
    • 33746924468 scopus 로고    scopus 로고
    • Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
    • DOI 10.1038/sj.onc.1209603, PII 1209603
    • Mathupala SP, Ko YH and Pedersen PL: Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 25: 4777-4786, 2006. (Pubitemid 44187625)
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4777-4786
    • Mathupala, S.P.1    Ko, Y.H.2    Pedersen, P.L.3
  • 19
    • 0038714272 scopus 로고    scopus 로고
    • Isozymes of mammalian hexokinase: Structure, subcellular localization and metabolic function
    • Wilson JE: Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function. J Exp Biol 206: 2049-2057, 2003.
    • (2003) J Exp Biol , vol.206 , pp. 2049-2057
    • Wilson, J.E.1
  • 21
    • 28544436922 scopus 로고    scopus 로고
    • Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity
    • DOI 10.1158/0008-5472.CAN-05-1925
    • Pastorino JG, Hoek JB and Shulga N: Activation of glycogen synthase kinase 3b disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity. Cancer Res 65: 10545-10554, 2005. (Pubitemid 41743749)
    • (2005) Cancer Research , vol.65 , Issue.22 , pp. 10545-10554
    • Pastorino, J.G.1    Hoek, J.B.2    Shulga, N.3
  • 22
    • 39449114808 scopus 로고    scopus 로고
    • Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II
    • DOI 10.1038/sj.cdd.4402285, PII 4402285
    • Miyamoto S, Murphy AN and Brown JH: Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II. Cell Death Differ 15: 521-529, 2008. (Pubitemid 351267303)
    • (2008) Cell Death and Differentiation , vol.15 , Issue.3 , pp. 521-529
    • Miyamoto, S.1    Murphy, A.N.2    Brown, J.H.3
  • 23
    • 0034983918 scopus 로고    scopus 로고
    • Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
    • DOI 10.1101/gad.889901
    • Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB and Hay N: Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev 15: 1406-1418, 2001. (Pubitemid 32524647)
    • (2001) Genes and Development , vol.15 , Issue.11 , pp. 1406-1418
    • Gottlob, K.1    Majewski, N.2    Kennedy, S.3    Kandel, E.4    Robey, R.B.5    Hay, N.6
  • 24
    • 0030038191 scopus 로고    scopus 로고
    • Fatty acid synthase (FAS): A target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells
    • Pizer ES, Wood FD, Pasternack GR and Kuhajda FP: Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL6O promyelocytic leukemia cells. Cancer Res 4: 745-751, 1996. (Pubitemid 26055462)
    • (1996) Cancer Research , vol.56 , Issue.4 , pp. 745-751
    • Pizer, E.S.1    Wood, F.D.2    Pasternack, G.R.3    Kuhajda, F.P.4
  • 27
    • 0032566064 scopus 로고    scopus 로고
    • Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas
    • Maier D, Zhang ZW, Taylor E, Hamou MF, Gratzl O, van Meir EG, Scott RJ and Merlo A: Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas. Oncogene 16: 3331-3335, 1998. (Pubitemid 28330433)
    • (1998) Oncogene , vol.16 , Issue.25 , pp. 3331-3335
    • Maier, D.1    Zhang, Z.2    Taylor, E.3    Hamou, M.-F.4    Gratzl, O.5    Van Meir, E.G.6    Scott, R.J.7    Merlo, A.8
  • 28
    • 0032500108 scopus 로고    scopus 로고
    • Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas
    • Bose S, Wang SI, Terry MB, Hibshoosh H and Parsons R: Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas. Oncogene 17: 123-127, 1998. (Pubitemid 28360536)
    • (1998) Oncogene , vol.17 , Issue.1 , pp. 123-127
    • Bose, S.1    Wang, S.I.2    Terry, M.B.3    Hibshoosh, H.4    Parsons, R.5
  • 32
    • 23844434673 scopus 로고    scopus 로고
    • AIF suppresses chemical stress-induced apoptosis and maintains the transformed state of tumor cells
    • DOI 10.1038/sj.emboj.7600746
    • Urbano A, Lakshmanan U, Choo PH, Kwan JC, Ng PY, Guo K, Dhakshinamoorthy S and Porter A: AIF suppresses chemical stress-induced apoptosis and maintains the transformed state of tumor cells. EMBO J 24: 2815-2826, 2005. (Pubitemid 41170030)
    • (2005) EMBO Journal , vol.24 , Issue.15 , pp. 2815-2826
    • Urbano, A.1    Lakshmanan, U.2    Choo, P.H.3    Kwan, J.C.4    Ng, P.Y.5    Guo, K.6    Dhakshinamoorthy, S.7    Porter, A.8
  • 33
    • 0347986675 scopus 로고    scopus 로고
    • Akt Inhibits Apoptosis Downstream of BID Cleavage via a Glucose-Dependent Mechanism Involving Mitochondrial Hexokinases
    • DOI 10.1128/MCB.24.2.730-740.2004
    • Majewski N, Nogueira V, Robey RB and Hay N: Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Mol Cell Biol 24: 730-740, 2004. (Pubitemid 38057924)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.2 , pp. 730-740
    • Majewski, N.1    Nogueira, V.2    Robey, R.B.3    Hay, N.4
  • 34
    • 0036733979 scopus 로고    scopus 로고
    • Key role of mitochondria in cerulenin-mediated apoptosis
    • DOI 10.1038/sj.cdd.4401055
    • Heiligtag SJ, Bredehorst R and David KA: Key role of mitochondria in cerulenin-mediated apoptosis. Cell Death Differ 9: 1017-1025, 2002. (Pubitemid 35033433)
    • (2002) Cell Death and Differentiation , vol.9 , Issue.9 , pp. 1017-1025
    • Heiligtag, S.J.1    Bredehorst, R.2    David, K.A.3
  • 35
    • 14044266297 scopus 로고    scopus 로고
    • Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter
    • DOI 10.1074/jbc.M411534200
    • Kunkel MT, Ni Q, Tsien RY, Zhang J and Newton AC: Spatiotemporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J Biol Chem 280: 5581-5587, 2005. (Pubitemid 40280036)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.7 , pp. 5581-5587
    • Kunkel, M.T.1    Ni, Q.2    Tsien, R.Y.3    Zhang, J.4    Newton, A.C.5
  • 36
    • 0037192787 scopus 로고    scopus 로고
    • Increased hexokinase activity, of either ectopic or endogenous origin, protects renal epithelial cells against acute oxidant-induced cell death
    • DOI 10.1074/jbc.M110927200
    • Bryson JM, Coy PE, Gottlob K, Hay N and Robey RB: Increased hexokinase activity, of either ectopic or endogenous origin, protects renal epithelial cells against acute oxidant-induced cell death. J Biol Chem 277: 11392-11400, 2002. (Pubitemid 34952906)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.13 , pp. 11392-11400
    • Bryson, J.M.1    Coy, P.E.2    Gottlob, K.3    Hay, N.4    Brooks, R.R.5
  • 37
    • 0033564514 scopus 로고    scopus 로고
    • The phosphatidylinositol 3'-kinase pathway is a dominant growth factor- activated cell survival pathway in LNCaP human prostate carcinoma cells
    • Lin J, Adam R, Santiestevan E, and Freeman M: The phosphatidylinositol 3'-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells. Cancer Res 59: 2891-2897, 1999. (Pubitemid 29283128)
    • (1999) Cancer Research , vol.59 , Issue.12 , pp. 2891-2897
    • Lin, J.1    Adam, R.M.2    Santiestevan, E.3    Freeman, M.R.4


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