Functional redundancy and compensation among members of gap junction protein families?

Biochimica et Biophysica Acta - Biomembranes

Volumn 1818, Issue 8, 2012, Pages 1971-1984

  Bedner, Peter ^a   Steinhäuser, Christian ^a   Theis, Martin ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Connexins; Intercellular communication; Pannexins; Transgenic mice

Indexed keywords

CONNEXIN 25; CONNEXIN 30; CONNEXIN 31; CONNEXIN 32; CONNEXIN 33; CONNEXIN 36; CONNEXIN 39; CONNEXIN 40; CONNEXIN 43; CONNEXIN 45; CONNEXIN 47; CONNEXIN 50; CONNEXIN 57; CONNEXIN 59; GAP JUNCTION PROTEIN; INNEXIN PROTEIN; MEMBRANE PROTEIN; PANNEXIN PROTEIN; UNCLASSIFIED DRUG;

ASTROCYTE; B WAVE; BLOOD PRESSURE; CENTRAL NERVOUS SYSTEM; CONNEXIN GENE; DEVELOPMENTAL DISORDER; FUNCTIONAL COMPENSATION; FUNCTIONAL REDUNDANCY; GENE; GENE LOCUS; GENE MUTATION; GENETIC ASSOCIATION; HEARING IMPAIRMENT; HEART ELECTROPHYSIOLOGY; HEART VENTRICLE ARRHYTHMIA; HEREDITARY MOTOR SENSORY NEUROPATHY; HUMAN; HYPERTENSION; INTERNEURON; LOSS OF FUNCTION MUTATION; MICROGLIA; NONHUMAN; OCULODENTODIGITAL SYNDROME; OLIGODENDROGLIA; OVARY FOLLICLE DEVELOPMENT; PANNEXIN GENE; PELIZAEUS MERZBACHER DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SUBUNIT; RETINA NERVE CELL; REVIEW; SKIN DISEASE; SPERMATOGENESIS; TESTIS DEVELOPMENT; VASCULAR SMOOTH MUSCLE;

ANIMALS; ASTROCYTES; BIOPHYSICS; CONNEXINS; GAP JUNCTIONS; HUMANS; INTERNEURONS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROGLIA; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; NEURONS; OLIGODENDROGLIA; PHENOTYPE; TISSUE DISTRIBUTION;

MUS; MUS MUSCULUS;

EID: 84861608509     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2011.10.016     Document Type: Review

References (212)

1. C.M. Niessen, D. Leckband, and A.S. Yap Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation Physiol. Rev. 91 2011 691
2. S.M. Hansen, V. Berezin, and E. Bock Signaling mechanisms of neurite outgrowth induced by the cell adhesion molecules NCAM and N-cadherin Cell. Mol. Life Sci. 65 2008 3809
3. U.M. Fiuza, and A.M. Arias Cell and molecular biology of Notch J. Endocrinol. 194 2007 459
4. M.E. Pitulescu, and R.H. Adams Eph/ephrin molecules - a hub for signaling and endocytosis Genes Dev. 24 2010 2480
5. J.C. Saez, V.M. Berthoud, M.C. Branes, A.D. Martinez, and E.C. Beyer Plasma membrane channels formed by connexins: their regulation and functions Physiol. Rev. 83 2003 1359
6. M. Rackauskas, V. Neverauskas, and V.A. Skeberdis Diversity and properties of connexin gap junction channels Medicina (Kaunas) 46 2010 1
7. D. Fushiki, Y. Hamada, R. Yoshimura, and Y. Endo Phylogenetic and bioinformatic analysis of gap junction-related proteins, innexins, pannexins and connexins Biomed. Res. 31 2010 133
8. E. Scemes, D.C. Spray, and P. Meda Connexins, pannexins, innexins: novel roles of hemi-channels Pflugers Arch. 457 2009 1207
9. C. D'hondt, R. Ponsaerts, S.H. De, G. Bultynck, and B. Himpens Pannexins, distant relatives of the connexin family with specific cellular functions? Bioessays 31 2009 953
10. W.J. Larsen Structural diversity of gap junctions. A review Tissue Cell 9 1977 373
11. M.L. Epstein, and N.B. Gilula A study of communication specificity between cells in culture J. Cell Biol. 75 1977 769
12. A. Baranova, D. Ivanov, N. Petrash, A. Pestova, M. Skoblov, I. Kelmanson, D. Shagin, S. Nazarenko, E. Geraymovych, O. Litvin, A. Tiunova, T.L. Born, N. Usman, D. Staroverov, S. Lukyanov, and Y. Panchin The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins Genomics 83 2004 706
13. Y.V. Panchin Evolution of gap junction proteins - the pannexin alternative J. Exp. Biol. 208 2005 1415
14. V.I. Shestopalov, and Y. Panchin Pannexins and gap junction protein diversity Cell. Mol. Life Sci. 65 2008 376
15. R. Bruzzone, S.G. Hormuzdi, M.T. Barbe, A. Herb, and H. Monyer Pannexins, a family of gap junction proteins expressed in brain Proc. Natl. Acad. Sci. U. S. A. 100 2003 13644
16. S. Penuela, R. Bhalla, X.Q. Gong, K.N. Cowan, S.J. Celetti, B.J. Cowan, D. Bai, Q. Shao, and D.W. Laird Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins J. Cell Sci. 120 2007 3772
17. D. Boassa, C. Ambrosi, F. Qiu, G. Dahl, G. Gaietta, and G. Sosinsky Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane J. Biol. Chem. 282 2007 31733
18. E.M. Hur, and F.Q. Zhou GSK3 signalling in neural development Nat. Rev. Neurosci. 11 2010 539
19. G. Davidson, and C. Niehrs Emerging links between CDK cell cycle regulators and Wnt signaling Trends Cell Biol. 20 2010 453
20. M.V. Bennett, J.E. Contreras, F.F. Bukauskas, and J.C. Saez New roles for astrocytes: gap junction hemichannels have something to communicate Trends Neurosci. 26 2003 610
21. J.C. Saez, K.A. Schalper, M.A. Retamal, J.A. Orellana, K.F. Shoji, and M.V. Bennett Cell membrane permeabilization via connexin hemichannels in living and dying cells Exp. Cell Res. 316 2010 2377
22. J.A. Orellana, X.F. Figueroa, H.A. Sanchez, S. Contreras-Duarte, V. Velarde, and J.C. Saez Hemichannels in the neurovascular unit and white matter under normal and inflamed conditions CNS Neurol. Disord. Drug Targets 10 2011 404
23. J.A. Orellana, K.F. Shoji, V. Abudara, P. Ezan, E. Amigou, P.J. Saez, J.X. Jiang, C.C. Naus, J.C. Saez, and C. Giaume Amyloid beta-induced death in neurons involves glial and neuronal hemichannels J. Neurosci. 31 2011 4962
24. G. Sohl, and K. Willecke Gap junctions and the connexin protein family Cardiovasc. Res. 62 2004 228
25. R. Dobrowolski, and K. Willecke Connexin-caused genetic diseases and corresponding mouse models Antioxid. Redox Signal. 11 2009 283
26. A.L. Harris Connexin channel permeability to cytoplasmic molecules Prog. Biophys. Mol. Biol. 94 2007 120
27. D.B. Gros, and H.J. Jongsma Connexins in mammalian heart function Bioessays 18 1996 719
28. R.N. Nlend, L. Michon, S. Bavamian, N. Boucard, D. Caille, J. Cancela, A. Charollais, E. Charpantier, P. Klee, M. Peyrou, C. Populaire, L. Zulianello, and P. Meda Connexin36 and pancreatic beta-cell functions Arch. Physiol. Biochem. 112 2006 74
29. D. Eckardt, M. Theis, J. Degen, T. Ott, H.V. van Rijen, S. Kirchhoff, J.S. Kim, J.M. de Bakker, and K. Willecke Functional role of connexin43 gap junction channels in adult mouse heart assessed by inducible gene deletion J. Mol. Cell. Cardiol. 36 2004 101
30. H.V. van Rijen, D. Eckardt, J. Degen, M. Theis, T. Ott, K. Willecke, H.J. Jongsma, T. Opthof, and J.M. de Bakker Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43 Circulation 109 2004 1048
31. M. Theis, R. Jauch, L. Zhuo, D. Speidel, A. Wallraff, B. Doring, C. Frisch, G. Sohl, B. Teubner, C. Euwens, J. Huston, C. Steinhauser, A. Messing, U. Heinemann, and K. Willecke Accelerated hippocampal spreading depression and enhanced locomotory activity in mice with astrocyte-directed inactivation of connexin43 J. Neurosci. 23 2003 766
32. A. Wallraff, R. Kohling, U. Heinemann, M. Theis, K. Willecke, and C. Steinhauser The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus J. Neurosci. 26 2006 5438
33. N. Rouach, A. Koulakoff, V. Abudara, K. Willecke, and C. Giaume Astroglial metabolic networks sustain hippocampal synaptic transmission Science 322 2008 1551
34. D. Gosejacob, P. Dublin, P. Bedner, K. Huttmann, J. Zhang, O. Tress, K. Willecke, F. Pfrieger, C. Steinhauser, and M. Theis Role of astroglial connexin30 in hippocampal gap junction coupling Glia 59 2011 511
35. E. Scemes, S.O. Suadicani, G. Dahl, and D.C. Spray Connexin and pannexin mediated cell-cell communication Neuron Glia Biol. 3 2007 199
36. X. Li, N. Kamasawa, C. Ciolofan, C.O. Olson, S. Lu, K.G. Davidson, T. Yasumura, R. Shigemoto, J.E. Rash, and J.I. Nagy Connexin45-containing neuronal gap junctions in rodent retina also contain connexin36 in both apposing hemiplaques, forming bihomotypic gap junctions, with scaffolding contributed by zonula occludens-1 J. Neurosci. 28 2008 9769
37. B. Teubner, J. Degen, G. Sohl, M. Guldenagel, F.F. Bukauskas, E.B. Trexler, V.K. Verselis, C.I. De Zeeuw, C.G. Lee, C.A. Kozak, E. Petrasch-Parwez, R. Dermietzel, and K. Willecke Functional expression of the murine connexin 36 gene coding for a neuron-specific gap junctional protein J. Membr. Biol. 176 2000 249
38. M. Guldenagel, G. Sohl, A. Plum, O. Traub, B. Teubner, R. Weiler, and K. Willecke Expression patterns of connexin genes in mouse retina J. Comp. Neurol. 425 2000 193
39. S. Maxeiner, K. Dedek, U. Janssen-Bienhold, J. Ammermuller, H. Brune, T. Kirsch, M. Pieper, J. Degen, O. Kruger, K. Willecke, and R. Weiler Deletion of connexin45 in mouse retinal neurons disrupts the rod/cone signaling pathway between AII amacrine and ON cone bipolar cells and leads to impaired visual transmission J. Neurosci. 25 2005 566
40. M. Frank, B. Eiberger, and U. Janssen-Bienhold L.P.de Sevilla Muller, A. Tjarks, J.S. Kim, S. Maschke, R. Dobrowolski, P. Sasse, R. Weiler, B.K. Fleischmann, and K. Willecke, Neuronal connexin-36 can functionally replace connexin-45 in mouse retina but not in the developing heart J. Cell Sci. 123 2010 3605
41. C. Elfgang, R. Eckert, H. Lichtenberg-Frate, A. Butterweck, O. Traub, R.A. Klein, D.F. Hulser, and K. Willecke Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells J. Cell Biol. 129 1995 805
42. D. Manthey, K. Banach, T. Desplantez, C.G. Lee, C.A. Kozak, O. Traub, R. Weingart, and K. Willecke Intracellular domains of mouse connexin26 and -30 affect diffusional and electrical properties of gap junction channels J. Membr. Biol. 181 2001 137
43. D. Manthey, F. Bukauskas, C.G. Lee, C.A. Kozak, and K. Willecke Molecular cloning and functional expression of the mouse gap junction gene connexin-57 in human HeLa cells J. Biol. Chem. 274 1999 14716
44. T.W. White, D.L. Paul, D.A. Goodenough, and R. Bruzzone Functional analysis of selective interactions among rodent connexins Mol. Biol. Cell 6 1995 459
45. L.M. Magnotti, D.A. Goodenough, and D.L. Paul Functional heterotypic interactions between astrocyte and oligodendrocyte connexins Glia 59 2011 26
46. C.K. Abrams, M.M. Freidin, V.K. Verselis, T.A. Bargiello, D.P. Kelsell, G. Richard, M.V. Bennett, and F.F. Bukauskas Properties of human connexin 31, which is implicated in hereditary dermatological disease and deafness Proc. Natl. Acad. Sci. U. S. A. 103 2006 5213
47. M.M. Kreuzberg, G. Sohl, J.S. Kim, V.K. Verselis, K. Willecke, and F.F. Bukauskas Functional properties of mouse connexin30.2 expressed in the conduction system of the heart Circ. Res. 96 2005 1169
48. L.C. Barrio, T. Suchyna, T. Bargiello, L.X. Xu, R.S. Roginski, M.V. Bennett, and B.J. Nicholson Gap junctions formed by connexins 26 and 32 alone and in combination are differently affected by applied voltage Proc. Natl. Acad. Sci. U. S. A. 88 1991 8410
49. M.J. von, C. Euwens, K. Willecke, and G. Sohl The novel mouse connexin39 gene is expressed in developing striated muscle fibers J. Cell Sci. 117 2004 5381
50. R. Bruzzone, J.A. Haefliger, R.L. Gimlich, and D.L. Paul Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins Mol. Biol. Cell 4 1993 7
51. R. Bruzzone, T.W. White, and D.L. Paul Expression of chimeric connexins reveals new properties of the formation and gating behavior of gap junction channels J. Cell Sci. 107 Pt 4 1994 955
52. H. Hennemann, E. Dahl, J.B. White, H.J. Schwarz, P.A. Lalley, S. Chang, B.J. Nicholson, and K. Willecke Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin J. Biol. Chem. 267 1992 17225
53. H. Hennemann, T. Suchyna, H. Lichtenberg-Frate, S. Jungbluth, E. Dahl, J. Schwarz, B.J. Nicholson, and K. Willecke Molecular cloning and functional expression of mouse connexin40, a second gap junction gene preferentially expressed in lung J. Cell Biol. 117 1992 1299
54. T.W. White, R. Bruzzone, S. Wolfram, D.L. Paul, and D.A. Goodenough Selective interactions among the multiple connexin proteins expressed in the vertebrate lens: the second extracellular domain is a determinant of compatibility between connexins J. Cell Biol. 125 1994 879
55. M. Chang, R. Werner, and G. Dahl A role for an inhibitory connexin in testis? Dev. Biol. 175 1996 50
56. M. Rackauskas, V.K. Verselis, and F.F. Bukauskas Permeability of homotypic and heterotypic gap junction channels formed of cardiac connexins mCx30.2, Cx40, Cx43, and Cx45 Am. J. Physiol. Heart Circ. Physiol. 293 2007 H1729 H1736
57. S. Sonntag, G. Sohl, R. Dobrowolski, J. Zhang, M. Theis, E. Winterhager, F.F. Bukauskas, and K. Willecke Mouse lens connexin23 (Gje1) does not form functional gap junction channels but causes enhanced ATP release from HeLa cells Eur. J. Cell Biol. 88 2009 65
58. M. Ahn, J. Lee, A. Gustafsson, A. Enriquez, E. Lancaster, J.Y. Sul, P.G. Haydon, D.L. Paul, Y. Huang, C.K. Abrams, and S.S. Scherer Cx29 and Cx32, two connexins expressed by myelinating glia, do not interact and are functionally distinct J. Neurosci. Res. 86 2008 992
59. T. Desplantez, D. Halliday, E. Dupont, and R. Weingart Cardiac connexins Cx43 and Cx45: formation of diverse gap junction channels with diverse electrical properties Pflugers Arch. 448 2004 363
60. G.T. Cottrell, and J.M. Burt Heterotypic gap junction channel formation between heteromeric and homomeric Cx40 and Cx43 connexons Am. J. Physiol. Cell Physiol. 281 2001 C1559 C1567
61. V. Valiunas, R. Weingart, and P.R. Brink Formation of heterotypic gap junction channels by connexins 40 and 43 Circ. Res. 86 2000 E42 E49
62. A.L. Harris Emerging issues of connexin channels: biophysics fills the gap Q. Rev. Biophys. 34 2001 325
63. D. Locke, S. Jamieson, T. Stein, J. Liu, M.B. Hodgins, A.L. Harris, and B. Gusterson Nature of Cx30-containing channels in the adult mouse mammary gland Cell Tissue Res. 328 2007 97
64. D. Locke, N. Perusinghe, T. Newman, H. Jayatilake, W.H. Evans, and P. Monaghan Developmental expression and assembly of connexins into homomeric and heteromeric gap junction hemichannels in the mouse mammary gland J. Cell. Physiol. 183 2000 228
65. J. Gemel, X. Lin, R. Collins, R.D. Veenstra, and E.C. Beyer Cx30.2 can form heteromeric gap junction channels with other cardiac connexins Biochem. Biophys. Res. Commun. 369 2008 388
66. Q.V. Hoang, H. Qian, and H. Ripps Functional analysis of hemichannels and gap-junctional channels formed by connexins 43 and 46 Mol. Vis. 16 2010 1343
67. J.X. Jiang, and D.A. Goodenough Heteromeric connexons in lens gap junction channels Proc. Natl. Acad. Sci. U. S. A. 93 1996 1287
68. A.D. Martinez, V. Hayrapetyan, A.P. Moreno, and E.C. Beyer Connexin43 and connexin45 form heteromeric gap junction channels in which individual components determine permeability and regulation Circ. Res. 90 2002 1100
69. J. Gemel, V. Valiunas, P.R. Brink, and E.C. Beyer Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cells J. Cell Sci. 117 2004 2469
70. M.M. Falk, L.K. Buehler, N.M. Kumar, and N.B. Gilula Cell-free synthesis and assembly of connexins into functional gap junction membrane channels EMBO J. 16 1997 2703
71. E.C. Beyer, J. Gemel, A. Martinez, V.M. Berthoud, V. Valiunas, A.P. Moreno, and P.R. Brink Heteromeric mixing of connexins: compatibility of partners and functional consequences Cell Commun. Adhes. 8 2001 199
72. M. Yeager, and A.L. Harris Gap junction channel structure in the early 21st century: facts and fantasies Curr. Opin. Cell Biol. 19 2007 521
73. D. Carette, J. Gilleron, D. Segretain, and G. Pointis Heteromeric connexin 43/connexin 33 complex endocytosis: a connexin phosphorylation independent mechanism Biochimie 92 2010 555
74. V. Lagree, K. Brunschwig, P. Lopez, N.B. Gilula, G. Richard, and M.M. Falk Specific amino-acid residues in the N-terminus and TM3 implicated in channel function and oligomerization compatibility of connexin43 J. Cell Sci. 116 2003 3189
75. L.A. Elias, D.D. Wang, and A.R. Kriegstein Gap junction adhesion is necessary for radial migration in the neocortex Nature 448 2007 901
76. C. Cina, K. Maass, M. Theis, K. Willecke, J.F. Bechberger, and C.C. Naus Involvement of the cytoplasmic C-terminal domain of connexin43 in neuronal migration J. Neurosci. 29 2009 2009
77. D.A. Iacobas, S.O. Suadicani, S. Iacobas, C. Chrisman, M.A. Cohen, D.C. Spray, and E. Scemes Gap junction and purinergic P2 receptor proteins as a functional unit: insights from transcriptomics J. Membr. Biol. 217 2007 83
78. X. Dang, B.W. Doble, and E. Kardami The carboxy-tail of connexin-43 localizes to the nucleus and inhibits cell growth Mol. Cell. Biochem. 242 2003 35
79. C.J. Wei, R. Francis, X. Xu, and C.W. Lo Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells J. Biol. Chem. 280 2005 19925
80. Z. Ai, A. Fischer, D.C. Spray, A.M. Brown, and G.I. Fishman Wnt-1 regulation of connexin43 in cardiac myocytes J. Clin. Invest. 105 2000 161
81. C. Ambrosi, O. Gassmann, J.N. Pranskevich, D. Boassa, A. Smock, J. Wang, G. Dahl, C. Steinem, and G.E. Sosinsky Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other J. Biol. Chem. 285 2010 24420
82. S.J. Celetti, K.N. Cowan, S. Penuela, Q. Shao, J. Churko, and D.W. Laird Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation J. Cell Sci. 123 2010 1363
83. F. Anselmi, V.H. Hernandez, G. Crispino, A. Seydel, S. Ortolano, S.D. Roper, N. Kessaris, W. Richardson, G. Rickheit, M.A. Filippov, H. Monyer, and F. Mammano ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2 + signals across the inner ear Proc. Natl. Acad. Sci. U. S. A. 105 2008 18770
84. M. Kretz, K. Maass, and K. Willecke Expression and function of connexins in the epidermis, analyzed with transgenic mouse mutants Eur. J. Cell Biol. 83 2004 647
85. E. Nelles, C. Butzler, D. Jung, A. Temme, H.D. Gabriel, U. Dahl, O. Traub, F. Stumpel, K. Jungermann, J. Zielasek, K.V. Toyka, R. Dermietzel, and K. Willecke Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice Proc. Natl. Acad. Sci. U. S. A. 93 1996 9565
86. M.R. Deans, J.R. Gibson, C. Sellitto, B.W. Connors, and D.L. Paul Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing connexin36 Neuron 31 2001 477
87. S.G. Hormuzdi, I. Pais, F.E. LeBeau, S.K. Towers, A. Rozov, E.H. Buhl, M.A. Whittington, and H. Monyer Impaired electrical signaling disrupts gamma frequency oscillations in connexin 36-deficient mice Neuron 31 2001 487
88. M.M. Kreuzberg, J. Deuchars, E. Weiss, A. Schober, S. Sonntag, K. Wellershaus, A. Draguhn, and K. Willecke Expression of connexin30.2 in interneurons of the central nervous system in the mouse Mol. Cell. Neurosci. 37 2008 119
89. J.E. Rash, T. Yasumura, F.E. Dudek, and J.I. Nagy Cell-specific expression of connexins and evidence of restricted gap junctional coupling between glial cells and between neurons J. Neurosci. 21 2001 1983
90. C. Giaume, and M. Theis Pharmacological and genetic approaches to study connexin-mediated channels in glial cells of the central nervous system Brain Res. Rev. 63 2010 160
91. B.M. Altevogt, and D.L. Paul Four classes of intercellular channels between glial cells in the CNS J. Neurosci. 24 2004 4313
92. G.M. Kidder, and A.A. Mhawi Gap junctions and ovarian folliculogenesis Reproduction 123 2002 613
93. M.V. Bennett, and R.S. Zukin Electrical coupling and neuronal synchronization in the Mammalian brain Neuron 41 2004 495
94. L.P. Muller, K. Dedek, U. Janssen-Bienhold, A. Meyer, M.M. Kreuzberg, S. Lorenz, K. Willecke, and R. Weiler Expression and modulation of connexin 30.2, a novel gap junction protein in the mouse retina Vis. Neurosci. 27 2010 91
95. H.S. Duffy, A.G. Fort, and D.C. Spray Cardiac connexins: genes to nexus Adv. Cardiol. 42 2006 1
96. R.T. Mathias, T.W. White, and X. Gong Lens gap junctions in growth, differentiation, and homeostasis Physiol. Rev. 90 2010 179
97. V. Serre-Beinier, G.S. Le, N. Belluardo, A. Trovato-Salinaro, A. Charollais, J.A. Haefliger, D.F. Condorelli, and P. Meda Cx36 preferentially connects beta-cells within pancreatic islets Diabetes 49 2000 727
98. X.F. Figueroa, and B.R. Duling Gap junctions in the control of vascular function Antioxid. Redox Signal. 11 2009 251
99. G. Pointis, J. Gilleron, D. Carette, and D. Segretain Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis Philos. Trans. R. Soc. Lond. B Biol. Sci. 365 2010 1607
100. R.M. Mroue, M.E. El-Sabban, and R.S. Talhouk Connexins and the gap in context Integr. Biol. (Camb.) 3 2011 255
101. A. Malassine, and L. Cronier Involvement of gap junctions in placental functions and development Biochim. Biophys. Acta 1719 2005 117
102. M. Kibschull, A. Gellhaus, and E. Winterhager Analogous and unique functions of connexins in mouse and human placental development Placenta 29 2008 848
103. M. Vinken, T. Henkens, R.E. De, J. Fraczek, T. Vanhaecke, and V. Rogiers Biology and pathobiology of gap junctional channels in hepatocytes Hepatology 47 2008 1077
104. F. Hanner, C.M. Sorensen, N.H. Holstein-Rathlou, and J. Peti-Peterdi Connexins and the kidney Am. J. Physiol. Regul. Integr. Comp. Physiol. 298 2010 R1143 R1155
105. A. Forge, D. Becker, S. Casalotti, J. Edwards, N. Marziano, and G. Nevill Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals J. Comp. Neurol. 467 2003 207
106. C.K. Abrams, S. Oh, Y. Ri, and T.A. Bargiello Mutations in connexin 32: the molecular and biophysical bases for the X-linked form of Charcot-Marie-Tooth disease Brain Res. Brain Res. Rev. 32 2000 203
107. J.L. Orthmann-Murphy, C.K. Abrams, and S.S. Scherer Gap junctions couple astrocytes and oligodendrocytes J. Mol. Neurosci. 35 2008 101
108. B. Uhlenberg, M. Schuelke, F. Ruschendorf, N. Ruf, A.M. Kaindl, M. Henneke, H. Thiele, G. Stoltenburg-Didinger, F. Aksu, H. Topaloglu, P. Nurnberg, C. Hubner, B. Weschke, and J. Gartner Mutations in the gene encoding gap junction protein alpha 12 (connexin 46.6) cause Pelizaeus-Merzbacher-like disease Am. J. Hum. Genet. 75 2004 251
109. M. Bugiani, S.S. Al, E. Lamantea, A. Bizzi, E. Bakhsh, I. Moroni, M.R. Balestrini, G. Uziel, and M. Zeviani GJA12 mutations in children with recessive hypomyelinating leukoencephalopathy Neurology 67 2006 273
110. J.L. Orthmann-Murphy, E. Salsano, C.K. Abrams, A. Bizzi, G. Uziel, M.M. Freidin, E. Lamantea, M. Zeviani, S.S. Scherer, and D. Pareyson Hereditary spastic paraplegia is a novel phenotype for GJA12/GJC2 mutations Brain 132 2009 426
111. W.A. Paznekas, B. Karczeski, S. Vermeer, R.B. Lowry, M. Delatycki, F. Laurence, P.A. Koivisto, M.L. Van, S.A. Boyadjiev, J.N. Bodurtha, and E.W. Jabs GJA1 mutations, variants, and connexin 43 dysfunction as it relates to the oculodentodigital dysplasia phenotype Hum. Mutat. 30 2009 724
112. J.E. Lai-Cheong, K. Arita, and J.A. McGrath Genetic diseases of junctions J. Invest. Dermatol. 127 2007 2713
113. R. Dobrowolski, P. Sasse, J.W. Schrickel, M. Watkins, J.S. Kim, M. Rackauskas, C. Troatz, A. Ghanem, K. Tiemann, J. Degen, F.F. Bukauskas, R. Civitelli, T. Lewalter, B.K. Fleischmann, and K. Willecke The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans Hum. Mol. Genet. 17 2008 539
114. M. Schutz, P. Scimemi, P. Majumder, R.D. De Siati, G. Crispino, L. Rodriguez, M. Bortolozzi, R. Santarelli, A. Seydel, S. Sonntag, N. Ingham, K.P. Steel, K. Willecke, and F. Mammano The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice Hum. Mol. Genet. 19 2010 4759
115. U. Pannasch, L. Vargova, J. Reingruber, P. Ezan, D. Holcman, C. Giaume, E. Sykova, and N. Rouach Astroglial networks scale synaptic activity and plasticity Proc. Natl. Acad. Sci. U. S. A. 108 2011 8467
116. A. Kunze, M.R. Congreso, C. Hartmann, A. Wallraff-Beck, K. Huttmann, P. Bedner, R. Requardt, G. Seifert, C. Redecker, K. Willecke, A. Hofmann, A. Pfeifer, M. Theis, and C. Steinhauser Connexin expression by radial glia-like cells is required for neurogenesis in the adult dentate gyrus Proc. Natl. Acad. Sci. U. S. A. 106 2009 11336
117. S.E. Lutz, Y. Zhao, M. Gulinello, S.C. Lee, C.S. Raine, and C.F. Brosnan Deletion of astrocyte connexins 43 and 30 leads to a dysmyelinating phenotype and hippocampal CA1 vacuolation J. Neurosci. 29 2009 7743
118. D.M. Menichella, D.A. Goodenough, E. Sirkowski, S.S. Scherer, and D.L. Paul Connexins are critical for normal myelination in the CNS J. Neurosci. 23 2003 5963
119. B. Odermatt, K. Wellershaus, A. Wallraff, G. Seifert, J. Degen, C. Euwens, B. Fuss, H. Bussow, K. Schilling, C. Steinhauser, and K. Willecke Connexin 47 (Cx47)-deficient mice with enhanced green fluorescent protein reporter gene reveal predominant oligodendrocytic expression of Cx47 and display vacuolized myelin in the CNS J. Neurosci. 23 2003 4549
120. T. Nakase, G. Sohl, M. Theis, K. Willecke, and C.C. Naus Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes Am. J. Pathol. 164 2004 2067
121. A. Plum, G. Hallas, T. Magin, F. Dombrowski, A. Hagendorff, B. Schumacher, C. Wolpert, J. Kim, W.H. Lamers, M. Evert, P. Meda, O. Traub, and K. Willecke Unique and shared functions of different connexins in mice Curr. Biol. 10 2000 1083
122. T.W. White Unique and redundant connexin contributions to lens development Science 295 2002 319
123. A.G. Reaume, P.A. de Sousa, S. Kulkarni, B.L. Langille, D. Zhu, T.C. Davies, S.C. Juneja, G.M. Kidder, and J. Rossant Cardiac malformation in neonatal mice lacking connexin43 Science 267 1995 1831
124. H.D. Gabriel, D. Jung, C. Butzler, A. Temme, O. Traub, E. Winterhager, and K. Willecke Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient mice J. Cell Biol. 140 1998 1453
125. O. Kruger, A. Plum, J.S. Kim, E. Winterhager, S. Maxeiner, G. Hallas, S. Kirchhoff, O. Traub, W.H. Lamers, and K. Willecke Defective vascular development in connexin 45-deficient mice Development 127 2000 4179
126. M. Theis, W.C. de, T.M. Schlaeger, D. Eckardt, O. Kruger, B. Doring, W. Risau, U. Deutsch, U. Pohl, and K. Willecke Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene Genesis 29 2001 1
127. Y. Liao, K.H. Day, D.N. Damon, and B.R. Duling Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice Proc. Natl. Acad. Sci. U. S. A. 98 2001 9989
128. D.E. Gutstein, G.E. Morley, H. Tamaddon, D. Vaidya, M.D. Schneider, J. Chen, K.R. Chien, H. Stuhlmann, and G.I. Fishman Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43 Circ. Res. 88 2001 333
129. M. Cohen-Salmon, T. Ott, V. Michel, J.P. Hardelin, I. Perfettini, M. Eybalin, T. Wu, D.C. Marcus, P. Wangemann, K. Willecke, and C. Petit Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death Curr. Biol. 12 2002 1106
130. A.P. Moreno Biophysical properties of homomeric and heteromultimeric channels formed by cardiac connexins Cardiovasc. Res. 62 2004 276
131. G.T. Cottrell, and J.M. Burt Functional consequences of heterogeneous gap junction channel formation and its influence in health and disease Biochim. Biophys. Acta 1711 2005 126
132. W.H. Evans, and P.E. Martin Gap junctions: structure and function (Review) Mol. Membr. Biol. 19 2002 121
133. S. Sridharan, L. Simon, D.D. Meling, D.G. Cyr, D.E. Gutstein, G.I. Fishman, F. Guillou, and P.S. Cooke Proliferation of adult sertoli cells following conditional knockout of the Gap junctional protein GJA1 (connexin 43) in mice Biol. Reprod. 76 2007 804
134. R. Brehm, M. Zeiler, C. Ruttinger, K. Herde, M. Kibschull, E. Winterhager, K. Willecke, F. Guillou, C. Lecureuil, K. Steger, L. Konrad, K. Biermann, K. Failing, and M. Bergmann A sertoli cell-specific knockout of connexin43 prevents initiation of spermatogenesis Am. J. Pathol. 171 2007 19
135. E. Winterhager, N. Pielensticker, J. Freyer, A. Ghanem, J.W. Schrickel, J.S. Kim, R. Behr, R. Grummer, K. Maass, S. Urschel, T. Lewalter, K. Tiemann, M. Simoni, and K. Willecke Replacement of connexin43 by connexin26 in transgenic mice leads to dysfunctional reproductive organs and slowed ventricular conduction in the heart BMC Dev. Biol. 7 2007 26
136. Q. Zheng-Fischhofer, A. Ghanem, J.S. Kim, M. Kibschull, G. Schwarz, J.O. Schwab, J. Nagy, E. Winterhager, K. Tiemann, and K. Willecke Connexin31 cannot functionally replace connexin43 during cardiac morphogenesis in mice J. Cell Sci. 119 2006 693
137. M. Kumai, K. Nishii, K. Nakamura, N. Takeda, M. Suzuki, and Y. Shibata Loss of connexin45 causes a cushion defect in early cardiogenesis Development 127 2000 3501
138. S. Kirchhoff, E. Nelles, A. Hagendorff, O. Kruger, O. Traub, and K. Willecke Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice Curr. Biol. 8 1998 299
139. A.M. Simon, D.A. Goodenough, and D.L. Paul Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block Curr. Biol. 8 1998 295
140. H.S. Tamaddon, D. Vaidya, A.M. Simon, D.L. Paul, J. Jalife, and G.E. Morley High-resolution optical mapping of the right bundle branch in connexin40 knockout mice reveals slow conduction in the specialized conduction system Circ. Res. 87 2000 929
141. H.V. van Rijen, T.A. van Veen, M.J. van Kempen, F.J. Wilms-Schopman, M. Potse, O. Krueger, K. Willecke, T. Opthof, H.J. Jongsma, and J.M. de Bakker Impaired conduction in the bundle branches of mouse hearts lacking the gap junction protein connexin40 Circulation 103 2001 1591
142. W.C. de, F. Roos, S.S. Bolz, and U. Pohl Lack of vascular connexin 40 is associated with hypertension and irregular arteriolar vasomotion Physiol. Genomics 13 2003 169
143. C. Wagner, W.C. de, L. Kurtz, C. Grunberger, A. Kurtz, and F. Schweda Connexin40 is essential for the pressure control of renin synthesis and secretion Circ. Res. 100 2007 556
144. T.W. White, D.A. Goodenough, and D.L. Paul Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts J. Cell Biol. 143 1998 815
145. S. Alcolea, T. Jarry-Guichard, B.J. de, D. Gonzalez, W. Lamers, S. Coppen, L. Barrio, H. Jongsma, D. Gros, and R.H. van Replacement of connexin40 by connexin45 in the mouse: impact on cardiac electrical conduction Circ. Res. 94 2004 100
146. N. Dicke, N. Pielensticker, J. Degen, J. Hecker, O. Tress, T. Bald, A. Gellhaus, E. Winterhager, and K. Willecke Peripheral lymphangiogenesis in mice depends on ectodermal connexin-26 (Gjb2) J. Cell Sci. 124 2011 2806
147. J. Degen, M. Schutz, N. Dicke, N. Strenzke, M. Jokwitz, T. Moser, and K. Willecke Connexin32 can restore hearing in connexin26 deficient mice Eur. J. Cell Biol. 90 2011 817
148. F.F. Bukauskas, C. Elfgang, K. Willecke, and R. Weingart Heterotypic gap junction channels (connexin26-connexin32) violate the paradigm of unitary conductance Pflugers Arch. 429 1995 870
149. S. Alcolea, M. Theveniau-Ruissy, T. Jarry-Guichard, I. Marics, E. Tzouanacou, J.P. Chauvin, J.P. Briand, A.F. Moorman, W.H. Lamers, and D.B. Gros Downregulation of connexin 45 gene products during mouse heart development Circ. Res. 84 1999 1365
150. L.C. Barrio, J. Capel, J.A. Jarillo, C. Castro, and A. Revilla Species-specific voltage-gating properties of connexin-45 junctions expressed in Xenopus oocytes Biophys. J. 73 1997 757
151. R.D. Veenstra, H.Z. Wang, D.A. Beblo, M.G. Chilton, A.L. Harris, E.C. Beyer, and P.R. Brink Selectivity of connexin-specific gap junctions does not correlate with channel conductance Circ. Res. 77 1995 1156
152. K. Stergiopoulos, J.L. Alvarado, M. Mastroianni, J.F. Ek-Vitorin, S.M. Taffet, and M. Delmar Hetero-domain interactions as a mechanism for the regulation of connexin channels Circ. Res. 84 1999 1144
153. G. Sohl, S. Maxeiner, and K. Willecke Expression and functions of neuronal gap junctions Nat. Rev. Neurosci. 6 2005 191
154. D. Gonzalez-Nieto, J.M. Gomez-Hernandez, B. Larrosa, C. Gutierrez, M.D. Munoz, I. Fasciani, J. O'Brien, A. Zappala, F. Cicirata, and L.C. Barrio Regulation of neuronal connexin-36 channels by pH Proc. Natl. Acad. Sci. U. S. A. 105 2008 17169
155. V. Gaussin Offbeat mice Anat. Rec. A Discov. Mol. Cell. Evol. Biol. 280 2004 1022
156. S.C. Juneja, K.J. Barr, G.C. Enders, and G.M. Kidder Defects in the germ line and gonads of mice lacking connexin43 Biol. Reprod. 60 1999 1263
157. W.A. Roscoe, K.J. Barr, A.A. Mhawi, D.K. Pomerantz, and G.M. Kidder Failure of spermatogenesis in mice lacking connexin43 Biol. Reprod. 65 2001 829
158. C.S. Wright, D.L. Becker, J.S. Lin, A.E. Warner, and K. Hardy Stage-specific and differential expression of gap junctions in the mouse ovary: connexin-specific roles in follicular regulation Reproduction 121 2001 77
159. E. Gershon, V. Plaks, I. Aharon, D. Galiani, Y. Reizel, S. Sela-Abramovich, I. Granot, E. Winterhager, and N. Dekel Oocyte-directed depletion of connexin43 using the Cre-LoxP system leads to subfertility in female mice Dev. Biol. 313 2008 1
160. A.C. Brisset, B.E. Isakson, and B.R. Kwak Connexins in vascular physiology and pathology Antioxid. Redox Signal. 11 2009 267
161. P.R. Brink, J. Ricotta, and G.J. Christ Biophysical characteristics of gap junctions in vascular wall cells: implications for vascular biology and disease Braz. J. Med. Biol. Res. 33 2000 415
162. D.S. He, J.X. Jiang, S.M. Taffet, and J.M. Burt Formation of heteromeric gap junction channels by connexins 40 and 43 in vascular smooth muscle cells Proc. Natl. Acad. Sci. U. S. A. 96 1999 6495
163. L. Kurtz, F. Schweda, W.C. de, W. Kriz, R. Witzgall, R. Warth, A. Sauter, A. Kurtz, and C. Wagner Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium J. Am. Soc. Nephrol. 18 2007 1103
164. S.E. Wolfle, V.J. Schmidt, B. Hoepfl, A. Gebert, S. Alcolea, D. Gros, and W.C. de Connexin45 cannot replace the function of connexin40 in conducting endothelium-dependent dilations along arterioles Circ. Res. 101 2007 1292
165. F. Schweda, L. Kurtz, W.C. de, U. Janssen-Bienhold, A. Kurtz, and C. Wagner Substitution of connexin40 with connexin45 prevents hyperreninemia and attenuates hypertension Kidney Int. 75 2009 482
166. L. Kurtz, M. Gerl, W. Kriz, C. Wagner, and A. Kurtz Replacement of connexin 40 by connexin 45 causes ectopic localization of renin-producing cells in the kidney but maintains in vivo control of renin gene expression Am. J. Physiol. Renal Physiol. 297 2009 F403 F409
167. D. Lopez, A. Rodriguez-Sinovas, E. Agullo, A. Garcia, J.A. Sanchez, and D. Garcia-Dorado Replacement of connexin 43 by connexin 32 in a knock-in mice model attenuates aortic endothelium-derived hyperpolarizing factor-mediated relaxation Exp. Physiol. 94 2009 1088
168. J.A. Haefliger, N. Krattinger, D. Martin, T. Pedrazzini, A. Capponi, B. Doring, A. Plum, A. Charollais, K. Willecke, and P. Meda Connexin43-dependent mechanism modulates renin secretion and hypertension J. Clin. Invest. 116 2006 405
169. K. Dedek, K. Schultz, M. Pieper, P. Dirks, S. Maxeiner, K. Willecke, R. Weiler, and U. Janssen-Bienhold Localization of heterotypic gap junctions composed of connexin45 and connexin36 in the rod pathway of the mouse retina Eur. J. Neurosci. 24 2006 1675
170. D.A. Goodenough The crystalline lens. A system networked by gap junctional intercellular communication Semin. Cell Biol. 3 1992 49
171. L. Ebihara, X. Xu, C. Oberti, E.C. Beyer, and V.M. Berthoud Co-expression of lens fiber connexins modifies hemi-gap-junctional channel behavior Biophys. J. 76 1999 198
172. A.M. DeRosa, C.H. Xia, X. Gong, and T.W. White The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins J. Cell Sci. 120 2007 4107
173. F.J. Martinez-Wittinghan, C. Sellitto, L. Li, X. Gong, P.R. Brink, R.T. Mathias, and T.W. White Dominant cataracts result from incongruous mixing of wild-type lens connexins J. Cell Biol. 161 2003 969
174. Y. Gao, and D.C. Spray Structural changes in lenses of mice lacking the gap junction protein connexin43 Invest. Ophthalmol. Vis. Sci. 39 1998 1198
175. C.C. Naus, J.F. Bechberger, Y. Zhang, L. Venance, H. Yamasaki, S.C. Juneja, G.M. Kidder, and C. Giaume Altered gap junctional communication, intercellular signaling, and growth in cultured astrocytes deficient in connexin43 J. Neurosci. Res. 49 1997 528
176. E. Scemes, R. Dermietzel, and D.C. Spray Calcium waves between astrocytes from Cx43 knockout mice Glia 24 1998 65
177. R. Dermietzel, Y. Gao, E. Scemes, D. Vieira, M. Urban, M. Kremer, M.V. Bennett, and D.C. Spray Connexin43 null mice reveal that astrocytes express multiple connexins Brain Res. Brain Res. Rev. 32 2000 45
178. M. Theis, D. Speidel, and K. Willecke Astrocyte cultures from conditional connexin43-deficient mice Glia 46 2004 130
179. P. Kunzelmann, W. Schroder, O. Traub, C. Steinhauser, R. Dermietzel, and K. Willecke Late onset and increasing expression of the gap junction protein connexin30 in adult murine brain and long-term cultured astrocytes Glia 25 1999 111
180. A. Koulakoff, P. Ezan, and C. Giaume Neurons control the expression of connexin 30 and connexin 43 in mouse cortical astrocytes Glia 56 2008 1299
181. J.E. Contreras, H.A. Sanchez, E.A. Eugenin, D. Speidel, M. Theis, K. Willecke, F.F. Bukauskas, M.V. Bennett, and J.C. Saez Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture Proc. Natl. Acad. Sci. U. S. A. 99 2002 495
182. S. Fushiki, J.L. Perez Velazquez, L. Zhang, J.F. Bechberger, P.L. Carlen, and C.C. Naus Changes in neuronal migration in neocortex of connexin43 null mutant mice J. Neuropathol. Exp. Neurol. 62 2003 304
183. A.E. Wiencken-Barger, B. Djukic, K.B. Casper, and K.D. McCarthy A role for Connexin43 during neurodevelopment Glia 55 2007 675
184. V. Valiunas, D. Manthey, R. Vogel, K. Willecke, and R. Weingart Biophysical properties of mouse connexin30 gap junction channels studied in transfected human HeLa cells J. Physiol. 519 Pt 3 1999 631
185. C. Frisch, M. Theis, M.A. De Souza Silva, E. Dere, G. Sohl, B. Teubner, K. Namestkova, K. Willecke, and J.P. Huston Mice with astrocyte-directed inactivation of connexin43 exhibit increased exploratory behaviour, impaired motor capacities, and changes in brain acetylcholine levels Eur. J. Neurosci. 18 2003 2313
186. E. Dere, M.A. De Souza-Silva, C. Frisch, B. Teubner, G. Sohl, K. Willecke, and J.P. Huston Connexin30-deficient mice show increased emotionality and decreased rearing activity in the open-field along with neurochemical changes Eur. J. Neurosci. 18 2003 629
187. J. Eiberger, M. Kibschull, N. Strenzke, A. Schober, H. Bussow, C. Wessig, S. Djahed, H. Reucher, D.A. Koch, J. Lautermann, T. Moser, E. Winterhager, and K. Willecke Expression pattern and functional characterization of connexin29 in transgenic mice Glia 53 2006 601
188. P. Anzini, D.H. Neuberg, M. Schachner, E. Nelles, K. Willecke, J. Zielasek, K.V. Toyka, U. Suter, and R. Martini Structural abnormalities and deficient maintenance of peripheral nerve myelin in mice lacking the gap junction protein connexin 32 J. Neurosci. 17 1997 4545
189. S.S. Scherer, Y.T. Xu, E. Nelles, K. Fischbeck, K. Willecke, and L.J. Bone Connexin32-null mice develop demyelinating peripheral neuropathy Glia 24 1998 8
190. B. Sutor, C. Schmolke, B. Teubner, C. Schirmer, and K. Willecke Myelination defects and neuronal hyperexcitability in the neocortex of connexin 32-deficient mice Cereb. Cortex 10 2000 684
191. B. Teubner, B. Odermatt, M. Guldenagel, G. Sohl, J. Degen, F. Bukauskas, J. Kronengold, V.K. Verselis, Y.T. Jung, C.A. Kozak, K. Schilling, and K. Willecke Functional expression of the new gap junction gene connexin47 transcribed in mouse brain and spinal cord neurons J. Neurosci. 21 2001 1117
192. J. Degen, C. Meier, R.S. Van Der Giessen, G. Sohl, E. Petrasch-Parwez, S. Urschel, R. Dermietzel, K. Schilling, C.I. De Zeeuw, and K. Willecke Expression pattern of lacZ reporter gene representing connexin36 in transgenic mice J. Comp. Neurol. 473 2004 511
193. K. Wellershaus, J. Degen, J. Deuchars, M. Theis, A. Charollais, D. Caille, B. Gauthier, U. Janssen-Bienhold, S. Sonntag, P. Herrera, P. Meda, and K. Willecke A new conditional mouse mutant reveals specific expression and functions of connexin36 in neurons and pancreatic beta-cells Exp. Cell Res. 314 2008 997
194. N. Maier, M. Guldenagel, G. Sohl, H. Siegmund, K. Willecke, and A. Draguhn Reduction of high-frequency network oscillations (ripples) and pathological network discharges in hippocampal slices from connexin 36-deficient mice J. Physiol. 541 2002 521
195. C. Frisch, M.A. De Souza-Silva, G. Sohl, M. Guldenagel, K. Willecke, J.P. Huston, and E. Dere Stimulus complexity dependent memory impairment and changes in motor performance after deletion of the neuronal gap junction protein connexin36 in mice Behav. Brain Res. 157 2005 177
196. K. Allen, E.C. Fuchs, H. Jaschonek, D.M. Bannerman, and H. Monyer Gap junctions between interneurons are required for normal spatial coding in the hippocampus and short-term spatial memory J. Neurosci. 31 2011 6542
197. E.A. Eugenin, D. Eckardt, M. Theis, K. Willecke, M.V. Bennett, and J.C. Saez Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha Proc. Natl. Acad. Sci. U. S. A. 98 2001 4190
198. S. Garg, S.M. Md, and T. Kielian Staphylococcus aureus-derived peptidoglycan induces Cx43 expression and functional gap junction intercellular communication in microglia J. Neurochem. 95 2005 475
199. N. Rouach, C.F. Calvo, J. Glowinski, and C. Giaume Brain macrophages inhibit gap junctional communication and downregulate connexin 43 expression in cultured astrocytes Eur. J. Neurosci. 15 2002 403
200. W. Meme, P. Ezan, L. Venance, J. Glowinski, and C. Giaume ATP-induced inhibition of gap junctional communication is enhanced by interleukin-1 beta treatment in cultured astrocytes Neuroscience 126 2004 95
201. W. Meme, C.F. Calvo, N. Froger, P. Ezan, E. Amigou, A. Koulakoff, and C. Giaume Proinflammatory cytokines released from microglia inhibit gap junctions in astrocytes: potentiation by beta-amyloid FASEB J. 20 2006 494
202. P.M. Faustmann, C.G. Haase, S. Romberg, D. Hinkerohe, D. Szlachta, D. Smikalla, D. Krause, and R. Dermietzel Microglia activation influences dye coupling and Cx43 expression of the astrocytic network Glia 42 2003 101
203. R. Parenti, A. Campisi, A. Vanella, and F. Cicirata Immunocytochemical and RT-PCR analysis of connexin36 in cultures of mammalian glial cells Arch. Ital. Biol. 140 2002 101
204. K. Dobrenis, H.Y. Chang, M.H. Pina-Benabou, A. Woodroffe, S.C. Lee, R. Rozental, D.C. Spray, and E. Scemes Human and mouse microglia express connexin36, and functional gap junctions are formed between rodent microglia and neurons J. Neurosci. Res. 82 2005 306
205. H. Takeuchi, S. Jin, J. Wang, G. Zhang, J. Kawanokuchi, R. Kuno, Y. Sonobe, T. Mizuno, and A. Suzumura Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner J. Biol. Chem. 281 2006 21362
206. M. Mayford, M.E. Bach, Y.Y. Huang, L. Wang, R.D. Hawkins, and E.R. Kandel Control of memory formation through regulated expression of a CaMKII transgene Science 274 1996 1678
207. W. Roell, T. Lewalter, P. Sasse, Y.N. Tallini, B.R. Choi, M. Breitbach, R. Doran, U.M. Becher, S.M. Hwang, T. Bostani, M.J. von, A. Hofmann, S. Reining, B. Eiberger, B. Gabris, A. Pfeifer, A. Welz, K. Willecke, G. Salama, J.W. Schrickel, M.I. Kotlikoff, and B.K. Fleischmann Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia Nature 450 2007 819
208. V. Houades, A. Koulakoff, P. Ezan, I. Seif, and C. Giaume Gap junction-mediated astrocytic networks in the mouse barrel cortex J. Neurosci. 28 2008 5207
209. K. Maass, A. Ghanem, J.S. Kim, M. Saathoff, S. Urschel, G. Kirfel, R. Grummer, M. Kretz, T. Lewalter, K. Tiemann, E. Winterhager, V. Herzog, and K. Willecke Defective epidermal barrier in neonatal mice lacking the C-terminal region of connexin43 Mol. Biol. Cell 15 2004 4597
210. M.G. Kozoriz, J.F. Bechberger, G.R. Bechberger, M.W. Suen, A.P. Moreno, K. Maass, K. Willecke, and C.C. Naus The connexin43 C-terminal region mediates neuroprotection during stroke J. Neuropathol. Exp. Neurol. 69 2010 196
211. J.H. Lin, T. Takano, M.L. Cotrina, G. Arcuino, J. Kang, S. Liu, Q. Gao, L. Jiang, F. Li, H. Lichtenberg-Frate, S. Haubrich, K. Willecke, S.A. Goldman, and M. Nedergaard Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells J. Neurosci. 22 2002 4302
212. D.L. Beahm, A. Oshima, G.M. Gaietta, G.M. Hand, A.E. Smock, S.N. Zucker, M.M. Toloue, A. Chandrasekhar, B.J. Nicholson, and G.E. Sosinsky Mutation of a conserved threonine in the third transmembrane helix of alpha- and beta-connexins creates a dominant-negative closed gap junction channel J. Biol. Chem. 281 2006 7994