Mutation of a conserved threonine in the third transmembrane helix of α- and β-connexins creates a dominant-negative closed gap junction channel

Journal of Biological Chemistry

Volumn 281, Issue 12, 2006, Pages 7994-8009

  Beahm, Derek L ^a   Oshima, Atsunori ^b,c   Gaietta, Guido M ^b   Hand, Galen M ^b   Smock, Amy E ^b   Zucker, Shoshanna N ^a   Toloue, Masoud M ^a,d   Chandrasekhar, Anjana ^a,d   Nicholson, Bruce J ^a,d   Sosinsky, Gina E ^b,e  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c KYOTO UNIVERSITY   (Japan)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; CYTOLOGY; IMAGE ANALYSIS; MICROSCOPIC EXAMINATION; VIRUSES;

CRYOELECTRON MICROSCOPY; THREONINE RESIDUES; TRANSMEMBRANE HELIX;

BIOLOGICAL MEMBRANES;

CYSTEINE; GAP JUNCTION PROTEIN; THREONINE; COMPLEMENTARY DNA; COMPLEMENTARY RNA; CONNEXIN 26; CONNEXIN 43; FLUORESCENT DYE; OXYGEN;

ARTICLE; BACULOVIRUS; CELL LINE; CELL MEMBRANE; CELL MUTANT; CONTROLLED STUDY; CORRELATION ANALYSIS; COUPLING FACTOR; CRYOELECTRON MICROSCOPY; CYTOPLASM; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INSECT; MAMMAL CELL; OOCYTE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE; XENOPUS; AMINO ACID SEQUENCE; ANIMAL; CELL JUNCTION; CHEMISTRY; DOMINANT GENE; ELECTRON MICROSCOPY; ELECTROPHYSIOLOGY; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; GENETICS; IMAGE PROCESSING; KERATINOCYTE; LIGHT; METABOLISM; MOLECULAR GENETICS; MUTATION; PHYLOGENY; RAT; SITE DIRECTED MUTAGENESIS; TIME;

GAMMAPROTEOBACTERIA; INSECTA; MAMMALIA;

AMINO ACID SEQUENCE; ANIMALS; BACULOVIRIDAE; CELL LINE; CELL MEMBRANE; CONNEXIN 43; CONNEXINS; CRYOELECTRON MICROSCOPY; CYSTEINE; CYTOPLASM; DNA, COMPLEMENTARY; ELECTROPHYSIOLOGY; FLUORESCENT DYES; GAP JUNCTIONS; GENES, DOMINANT; HELA CELLS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INSECTS; KERATINOCYTES; LIGHT; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; OOCYTES; OXYGEN; PHYLOGENY; POINT MUTATION; RATS; RNA, COMPLEMENTARY; THREONINE; TIME FACTORS; TRANSFECTION; XENOPUS;

EID: 33646366159     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M506533200     Document Type: Article

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