Oocyte-directed depletion of connexin43 using the Cre-LoxP system leads to subfertility in female mice

Developmental Biology

Volumn 313, Issue 1, 2008, Pages 1-12

  Gershon, Eran ^a   Plaks, Vicki ^a   Aharon, Idan ^a   Galiani, Dalia ^a   Reizel, Yitzhak ^a   Sela Abramovich, Sagit ^a   Granot, Irit ^b   Winterhager, Elke ^c   Dekel, Nava ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b KAPLAN MEDICAL CENTER   (Israel)

^c UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Connexin43; Cre Lox system; Embryo implantation; Fertility; Meiosis; Oocyte; Ovulation

Indexed keywords

CONNEXIN 43; CRE RECOMBINASE; LUCIFER YELLOW; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIRTH; BLASTOCYST; CELL COMMUNICATION; CONTROLLED STUDY; CORPUS LUTEUM; CUMULUS OOPHORUS; EMBRYO; EMBRYO DEVELOPMENT; EXPERIMENTAL MOUSE; FEMALE; FEMALE SUBFERTILITY; GAP JUNCTION; GRANULOSA CELL; HISTOCHEMISTRY; LOXP SITE; MALE; MEIOSIS; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; OOCYTE; OVARY; OVARY FOLLICLE; OVARY FOLLICLE DEVELOPMENT; OVULATION; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN EXPRESSION; SEX DIFFERENCE; SOMATIC CELL; WILD TYPE;

MUS;

EID: 37349116061     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ydbio.2007.08.041     Document Type: Article

References (36)

1. Ackert C.L., Gittens J.E., O'Brien M.J., Eppig J.J., and Kidder G.M. Intercellular communication via connexin43 gap junctions is required for ovarian folliculogenesis in the mouse. Dev. Biol. 233 (2001) 258-270
2. Buccione R., Schroeder A.C., and Eppig J.J. Interactions between somatic cells and germ cells throughout mammalian oogenesis. Biol. Reprod. 43 (1990) 543-547
3. Canipari R., Epifano O., Siracusa G., and Salustri A. Mouse oocytes inhibit plasminogen activator production by ovarian cumulus and granulosa cells. Dev. Biol. 167 (1995) 371-378
4. de Boever J.G., Kohen F., and Bosmans E. Binding of homologous and heterologous isoluminal- and enzyme-labelled progestrone conjugated to monoclonal antibodies. Anal. Chim. Acta 290 (1994) 239-245
5. de Vries W.N., Binns L.T., Fancher K.S., Dean J., Moore R., Kemler R., and Knowles B.B. Expression of Cre recombinase in mouse oocytes: a means to study maternal effect genes. Genesis 26 (2000) 110-112
6. Dekel N., and Piontkewitz Y. Induction of maturation of rat oocytes by interruption of communication in the cumulus-oocyte complex. Bull. Assoc. Anat. (Nancy) 75 (1991) 51-54
7. Epifano O., Liang L.F., Familari M., Moos Jr. M.C., and Dean J. Coordinate expression of the three zona pellucida genes during mouse oogenesis. Development 121 (1995) 1947-1956
8. Eppig J.J. Coordination of nuclear and cytoplasmic oocyte maturation in eutherian mammals. Reprod. Fertil. Dev. 8 (1996) 485-489
9. Giepmans B.N. Gap junctions and connexin-interacting proteins. Cardiovasc. Res. 62 (2004) 233-245
10. Giepmans B.N., Verlaan I., Hengeveld T., Janssen H., Calafat J., Falk M.M., and Moolenaar W.H. Gap junction protein connexin-43 interacts directly with microtubules. Curr. Biol. 11 (2001) 1364-1368
11. Girsh E., and Dekel N. Involvement of endothelin-1 and its receptors in PGF2alpha-induced luteolysis in the rat. Mol. Reprod. Dev. 63 (2002) 71-78
12. Granot I., and Dekel N. Cell-to-cell communication in the ovarian follicle: developmental and hormonal regulation of the expression of connexin43. Hum. Reprod. 13 Suppl. 4 (1998) 85-97
13. Granot I., Bechor E., Barash A., and Dekel N. Connexin43 in rat oocytes: developmental modulation of its phosphorylation. Biol. Reprod. 66 (2002) 568-573
14. Greep Ro, Astwood A.E., and Geiger S.R. Handbook of Physiology (1973) washington
15. Israely T., Dafni H., Granot D., Nevo N., Tsafriri A., and Neeman M. Vascular remodeling and angiogenesis in ectopic ovarian transplants: a crucial role of pericytes and vascular smooth muscle cells in maintenance of ovarian grafts. Biol. Reprod. 68 (2003) 2055-2064
16. Jorgez C.J., Klysik M., Jamin S.P., Behringer R.R., and Matzuk M.M. Granulosa cell-specific inactivation of follistatin causes female fertility defects. Mol. Endocrinol. 18 (2004) 953-967
17. Juneja S.C., Barr K.J., Enders G.C., and Kidder G.M. Defects in the germ line and gonads of mice lacking connexin43. Biol. Reprod. 60 (1999) 1263-1270
18. Ke F.C., Fang S.H., Lee M.T., Sheu S.Y., Lai S.Y., Chen Y.G., Huang F.L., Wang P.S., Stocco D.M., and Hwang J.J. Lindane, a gap junction blocker, suppresses FSH and transforming growth factor β1-induced connexin43 gap junction formation and steroidogenesis in rat granulosa cells. J. Endocrinol. 184 (2005) 555-566
19. Kehler J., Tolkunova E., Koschorz B., Pesce M., Gentile L., Boiani M., Lomeli H., Nagy A., McLaughlin K.J., Scholer H.R., and Tomilin A. Oct4 is required for primordial germ cell survival. EMBO Rep. 5 (2004) 1078-1083
20. Lan Z.J., Xu X., and Cooney A.J. Differential oocyte-specific expression of Cre recombinase activity in GDF-9-iCre, Zp3cre, and Msx2Cre transgenic mice. Biol. Reprod. 71 (2004) 1469-1474
21. Lewandoski M., Wassarman K.M., and Martin G.R. Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line. Curr. Biol. 7 (1997) 148-151
22. Li R., and Mather J.P. Lindane, an inhibitor of gap junction formation, abolishes oocyte directed follicle organizing activity in vitro. Endocrinology 138 (1997) 4477-4480
23. Plaks V., Kalchenko V., Dekel N., and Neeman M. MRI analysis of angiogenesis during mouse embryo implantation. Magn. Reson. Med. 55 (2006) 1013-1022
24. Reaume A.G., de Sousa P.A., Kulkarni S., Langille B.L., Zhu D., Davies T.C., Juneja S.C., Kidder G.M., and Rossant J. Cardiac malformation in neonatal mice lacking connexin43. Science 267 (1995) 1831-1834
25. Rozental R., Srinivas M., Gokhan S., Urban M., Dermietzel R., Kessler J.A., Spray D.C., and Mehler M.F. Temporal expression of neuronal connexins during hippocampal ontogeny. Brain Res. Brain Res. Rev. 32 (2000) 57-71
26. Sela-Abramovich S., Edry I., Galiani D., Nevo N., and Dekel N. Disruption of gap junctional communication within the ovarian follicle induces oocyte maturation. Endocrinology 147 (2006) 2280-2286
27. Sherizly I., Galiani D., and Dekel N. Regulation of oocyte maturation: communication in the rat cumulus-oocyte complex. Hum. Reprod. 3 (1988) 761-766
28. Shibata Y., Kumai M., Nishii K., and Nakamura K. Diversity and molecular anatomy of gap junctions. Med. Electron. Microsc. 34 (2001) 153-159
29. Simon A.M., Goodenough D.A., Li E., and Paul D.L. Female infertility in mice lacking connexin 37. Nature 385 (1997) 525-529
30. Sutovsky P., Flechon J.E., Flechon B., Motlik J., Peynot N., Chesne P., and Heyman Y. Dynamic changes of gap junctions and cytoskeleton during in vitro culture of cattle oocyte cumulus complexes. Biol. Reprod. 49 (1993) 1277-1287
31. Theis M., de Wit C., Schlaeger T.M., Eckardt D., Kruger O., Doring B., Risau W., Deutsch U., Pohl U., and Willecke K. Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene. Genesis 29 (2001) 1-13
32. Tong D., Gittens G.E., Kidder G.M., and Bai D. Patch-clamp study reveals that the importance of connexin43-mediated gap junctional communication for ovarian folliculogenesis is strain specific in the mouse. Am. J. Physiol.: Cell Physiol. 290 (2006) 290-297
33. Valdimarsson G., De Sousa P.A., and Kidder G.M. Coexpression of gap junction proteins in the cumulus-oocyte complex. Mol. Reprod. Dev. 36 (1993) 7-15
34. Vanderhyden B.C., Cohen J.N., and Morley P. Mouse oocytes regulate granulosa cell steroidogenesis. Endocrinology 133 (1993) 423-426
35. Veitch G.I., Gittens J.E., Shao Q., Laird D.W., and Kidder G.M. Selective assembly of connexin37 into heterocellular gap junctions at the oocyte/granulosa cell interface. J. Cell. Sci. 117 (2004) 2699-2707
36. Xu X., Li W.E., Huang G.Y., Meyer R., Chen T., Luo Y., Thomas M.P., Radice G.L., and Lo C.W. Modulation of mouse neural crest cell motility by N-cadherin and connexin 43 gap junctions. J. Cell Biol. 154 (2001) 217-230