Defects in the germ line and gonads of mice lacking connexin43

Biology of Reproduction

Volumn 60, Issue 5, 1999, Pages 1263-1270

  Juneja, Subhash C ^a,c   Barr, Kevin J ^a   Enders, George C ^b   Kidder, Gerald M ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; FETUS; GAP JUNCTION; GENE MUTATION; GERM LINE; GONAD DEVELOPMENT; MALE; MOUSE; NEWBORN; NONHUMAN; ORGAN CULTURE; OVARY FOLLICLE DEVELOPMENT; PRIORITY JOURNAL; PROTEIN DEFECT;

EID: 0032916234     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod60.5.1263     Document Type: Article

References (48)

1. White TW, Bruzzone R, Paul DL. The connexin family of intercellular channel forming proteins. Kidney Int 1995; 48:1148-1157.
2. Bruzzone R, White TW, Paul DL. Connections with connexins: the molecular basis of direct intercellular signaling. Eur J Biochem 1996; 238:1-27.
3. Dahl E, Manthey D, Chen Y, Schwartz H-J, Chang YS, Lalley PA, Nicholson BJ, Willecke K. Molecular cloning and functional expression of mouse connexin30, a gap junction gene highly expressed in adult brain and skin. J Biol Chem 1996; 271:17903-17910.
4. Condorelli DF, Parenti R, Spinella F, Salinaro AT, Belluardo N, Cardile V, Cicirata F. Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons. Eur J Neurosci 1998; 10:1202-1208.
5. Sáez JC, Connor JA, Spray DC, Bennett MVL. Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions. Proc Natl Acad Sci USA 1989; 86:2708-2712.
6. Charles AC, Naus CCG, Zhu D, Kidder GM, Dirksen ER, Sanderson MJ. Intercellular calcium signaling via gap junctions in glioma cells. J Cell Biol 1992; 118:195-201.
7. De Sousa PA, Valdimarsson G, Nicholson BJ, Kidder GM. Connexin trafficking and the control of gap junction assembly in mouse preimplantation embryos. Development 1993; 117:1355-1367.
8. Dahl E, Winterhager E, Reuβ B, Traub O, Butterweck A, Willecke K. Expression of the gap junction proteins connexin31 and connexin43 correlates with communication compartments in extraembryonic tissues and in the gastrulating mouse embryo, respectively. J Cell Sci 1996; 109:191-197.
9. Davies TC, Barr KJ, Jones DH, Zhu D, Kidder GM. Multiple members of the connexin gene family participate in preimplantation development of the mouse. Dev Genet 1996; 18:234-243.
10. De Sousa PA, Juneja SC, Caveney S, Davies TC, Reaume AG, Rossant J, Kidder GM. Normal development of preimplantation mouse embryos deficient in gap junctional coupling. J Cell Sci 1997; 110: 1751-1758.
11. Reaume A, De Sousa PA, Kulkarni S, Langille BL, Zhu D, Davies TC, Juneja SC, Kidder GM, Rossant J. Cardiac malformation in neonatal mice lacking connexin43. Science 1995; 267:1831-1834.
12. Valdimarsson G, De Sousa PA, Kidder GM. Coexpression of gap junction proteins in the cumulus-oocyte complex. Mol Reprod Dev 1993; 36:7-15.
13. Wiesen JF, Midgley AR. Changes in expression of connexin43 gap junction messenger ribonucleic acid and protein during ovarian follicular growth. Endocrinology 1993; 133:741-746.
14. Granot I, Dekel N. Phosphorylation and expression of connexin-43 ovarian gap junction protein are regulated by luteinizing hormone. J Biol Chem 1994; 269:30502-30509.
15. Okuma A, Kuraoka A, Iida H, Inai T, Wasano K, Shibata Y. Colocalization of connexin 43 and connexin 45 but absence of connexin 40 in granulosa cell gap junctions of rat ovary. J Reprod Fertil 1996; 107:255-264.
16. Simon AM, Goodenough DA, Li E, Paul DL. Female infertility in mice lacking connexin37. Nature 1997; 385:525-529.
17. Risley MS, Tan IP, Roy C, Saéz JC. Cell-, age-, and stage-dependent distribution of connexin43 gap junctions in testes. J Cell Sci 1992; 103:81-96.
18. Tan IP, Roy C, Sáez JC, Sáez CG, Paul DL, Risley MS. Regulated assembly of connexin33 and connexin43 into rat Sertoli cell gap junctions. Biol Reprod 1996; 54:1300-1310.
19. Pelletier R-M. The distribution of connexin43 is associated with the germ cell differentiation and with the modulation of the Sertoli cell junctional barrier in continual (guinea pig) and seasonal breeders' (mink) testes. J Androl 1995; 16:400-409.
20. Juneja SC, Enders GC, Kidder GM. Developmental defects in mouse gonads resulting from a connexin43 null mutation. Biol Reprod 1996; 54(suppl 1):195 (abstract 553).
21. Enders GC, May II JJ. Developmentally regulated expression of a mouse germ cell nuclear antigen examined from embryonic day 11 to adult in male and female mice. Dev Biol 1994, 163:331-340.
22. Laird DW, Revel J-P. Biochemical and immunochemical analysis of the arrangement of connexin43 in rat heart gap junction membranes. J Cell Sci 1990; 97:109-117.
23. Eppig JJ, O'Brien MJ. Development in vitro of mouse oocytes from primordial follicles. Biol Reprod 1996; 54:197-207.
24. Mitchell PA, Burghardt RC. The ontogeny of nexuses (gap junctions) in the ovary of the fetal mouse. Anat Rec 1986; 214:283-288.
25. Mayerhofer A, Garfield RE. Immunocytochemical analysis of the expression of gap junction protein connexin43 in the rat ovary. Mol Reprod Dev 1995, 41:331-338.
26. McCarrey JR. Development of the germ cell. In: Desjardins C, Ewing LL (eds.), Cell and Molecular Biology of the Testis. New York: Oxford University Press; 1993: 58-87.
27. McLaren A. Primordial germ cells in mammals. In: Zagris N, Duprat AM, Durston A (eds.), Organization of the Early Vertebrate Embryo. New York: Plenum Press; 1995: 1-9.
28. Ginsburg M, Snow MHL, McLaren A. Primordial germ cells in the mouse embryo during gastrulation. Development 1990; 110:521-528.
29. Gomperts M, Garcia-Castro M, Wylie C, Heasman J. Interactions between primordial germ cells play a role in their migration in mouse embryos. Development 1994; 120:135-141.
30. Eppig JJ, O'Brien M, Wigglesworth K. Mammalian oocyte growth and development in vitro. Mol Reprod Dev 1996; 44:260-273.
31. Besmer P, Manova K, Duttlinger R, Huang EJ, Packer A, Gyssler C, Bachvarova RF. The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis. Dev Suppl 1993; 125-137.
32. e mouse embryos. Dev Dynam 1993; 198:182-189.
33. Pesce M, Farrace MG, Piacentini M, Dolci S, De Felici M. Stem cell factor and leukemia inhibitory factor promote primordial germ cell survival by suppressing programmed cell death (apoptosis). Development 1993; 118:1089-1094.
34. Kawase E, Yamamoto H, Hashimoto K, Nakatsuji N. Tumor necrosis factor-α (TNF-α) stimulates proliferation of mouse primordial germ cells in culture. Dev Biol 1994; 161:91-95.
35. Koshimizu U, Taga T, Watanabe M, Saito M, Shirayoshi Y, Kishimoto T, Nakatsuji N. Functional requirement of gp 130-mediated signaling for growth and survival of mouse primordial germ cells in vitro and derivation of embryonic germ (EG) cells. Development 1996; 122: 1235-1242.
36. Cheng L, Gearing DP, White LS, Compton DL, Schooley K, Donovan PJ. Role of leukemia inhibitory factor and its receptor in mouse primordial germ cell growth. Development 1994; 120:3145-3153.
37. Cooke JE, Heasman J, Wylie CC. The role of interleukin-4 in the regulation of mouse primordial germ cell numbers. Dev Biol 1996; 174:14-21.
38. Pesce M, Canipari R, Ferri G-L, Siracusa G, De Felici M. Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates adenylate cyclase and promotes proliferation of mouse primordial germ cells. Development 1996; 122:215-221.
39. Ruangvoravat CP, Lo CW. Connexin 43 expression in the mouse embryo: localization of transcripts within developmentally significant domains. Dev Dynam 1992; 194:261-281.
40. Larsen WJ, Wert SE. Roles of cell junctions in gametogenesis and in early embryonic development. Tissue Cell 1988; 20:809-848.
41. Eppig JJ. Intercommunication between mammalian oocytes and companion follicle cells. Bioessays 1991; 13:569-574.
42. Dong J, Albertini DF, Nishimori K, Kumar TR, Lu N, Matzuk MM. Growth differentiation factor-9 is required during early ovarian folliculogenesis. Nature 1996; 383.531-535.
43. Manova K, Nocka K, Besmer P, Bachvarova RF, Gonadal expression of c-kit encoded at the W locus of the mouse. Development 1990; 110:1057-1069.
44. Manova K, Huang EJ, Angeles M, De Leon V, Sanchez S, Pronovost SM, Besmer P, Bachvarova RF. The expression pattern of the c-kit ligand in gonads of mice supports a role for the c-kit receptor in oocyte growth and in proliferation of spermatogonia. Dev Biol 1993; 157:85-99.
45. Packer AI, Hsu YC, Besmer P, Bachvarova RF. The ligand of the c-kit receptor promotes oocyte growth. Dev Biol 1994; 161:194-205.
46. Yoshida H, Takakura N, Kataoka H, Kunisada T, Okamura H, Nishikawa S-I. Stepwise requirement of c-kit tyrosine kinase in mouse ovarian follicular development. Dev Biol 1997; 184:122-137.
47. Huang EJ, Manova K, Packer AI, Sanchez S, Bachvarova RF, Besmer P. The murine Steel panda mutation affects kit ligand expression and growth of early ovarian follicles. Dev Biol 1993; 157:100-109.
48. Bedell MA, Brannan CI, Evans EP, Copeland NG, Jenkins NA, Donovan PJ. DNA rearrangements located over 100 kb 5′ of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development. Genes Dev 1995; 9:455-470.