TRIM28 prevents autoinflammatory T cell development in vivo

Nature Immunology

Volumn 13, Issue 6, 2012, Pages 596-603

  Chikuma, Shunsuke ^a   Suita, Naomasa ^b   Okazaki, Il Mi ^c   Shibayama, Shiro ^b   Honjo, Tasuku ^a  

^a KYOTO UNIVERSITY   (Japan)

^b ONO PHARMACEUTICAL CO   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; PROTEIN; PROTEIN TRIM28; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; AUTOINFLAMMATORY DISEASE; CD4+ T LYMPHOCYTE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTOPENIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH17 CELL;

ANIMALS; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; CELL CYCLE; DNA; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INFLAMMATION; INTERLEUKIN-2; JURKAT CELLS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL; REPRESSOR PROTEINS; SPECIFIC PATHOGEN-FREE ORGANISMS; TH17 CELLS; TRANSFORMING GROWTH FACTOR BETA3;

EID: 84861228227     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2293     Document Type: Article

References (46)

1. Cantrell, D. T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 14, 259-274 (1996). (Pubitemid 26130185)
2. Weaver, C.T., Harrington, L.E., Mangan, P.R., Gavrieli, M. & Murphy, K.M. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24, 677-688 (2006). (Pubitemid 43867371)
3. Jordan, M.S. et al. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2, 301-306 (2001). (Pubitemid 33706340)
4. Apostolou, I., Sarukhan, A., Klein, L. & von Boehmer, H. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3, 756-763 (2002).
5. Marks, B.R. et al. Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation. Nat. Immunol. 10, 1125-1132 (2009).
6. Bettelli, E. et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441, 235-238 (2006).
7. Mangan, P.R. et al. Transforming growth factor-β induces development of the TH17 lineage. Nature 441, 231-234 (2006).
8. Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M. & Stockinger, B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24, 179-189 (2006). (Pubitemid 43214587)
9. Zhou, X. et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat. Immunol. 10, 1000-1007 (2009).
10. Tsuji, M. et al. Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science 323, 1488-1492 (2009).
11. Lee, Y.K. et al. Late developmental plasticity in the T helper 17 lineage. Immunity 30, 92-107 (2009).
12. Reymond, A. et al. The tripartite motif family identifies cell compartments. EMBO J. 20, 2140-2151 (2001). (Pubitemid 32410584)
13. Le Douarin, B. et al. A possible involvement of TIF1α and TIF1β in the epigenetic control of transcription by nuclear receptors. EMBO J. 15, 6701-6715 (1996). (Pubitemid 26413802)
14. Friedman, J.R. et al. KAP-1, a novel corepressor for the highly conserved KRAB repression domain. Genes Dev. 10, 2067-2078 (1996). (Pubitemid 26346114)
15. Moosmann, P., Georgiev, O., Le Douarin, B., Bourquin, J.P. & Schaffner, W. Transcriptional repression by RING finger protein TIF1β that interacts with the KRAB repressor domain of KOX1. Nucleic Acids Res. 24, 4859-4867 (1996). (Pubitemid 27007888)
16. Nielsen, A.L. et al. Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. EMBO J. 18, 6385-6395 (1999). (Pubitemid 29533242)
17. Schultz, D.C., Ayyanathan, K., Negorev, D., Maul, G.G. & Rauscher, F.J. 3rd SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev. 16, 919-932 (2002). (Pubitemid 34408542)
18. Wolf, D. & Goff, S.P. TRIM28 mediates primer binding site-targeted silencing of murine leukemia virus in embryonic cells. Cell 131, 46-57 (2007). (Pubitemid 47498526)
19. Rowe, H.M. et al. KAP1 controls endogenous retroviruses in embryonic stem cells. Nature 463, 237-240 (2010).
20. White, D.E. et al. KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions. Cancer Res. 66, 11594-11599 (2006). (Pubitemid 46094169)
21. Noon, A.T. et al. 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nat. Cell Biol. 12, 177-184 (2010).
22. Ziv, Y. et al. Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM-and KAP-1 dependent pathway. Nat. Cell Biol. 8, 870-876 (2006). (Pubitemid 44151591)
23. Gack, M.U. et al. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 446, 916-920 (2007). (Pubitemid 46633167)
24. Tsuchida, T. et al. The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA. Immunity 33, 765-776 (2010).
25. Okazaki, I.M. et al. Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation. Proc. Natl. Acad. Sci. USA 108, 7920-7925 (2011).
26. Navarro, M.N., Goebel, J., Feijoo-Carnero, C., Morrice, N. & Cantrell, D.A. Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes. Nat. Immunol. 12, 352-361 (2011).
27. Chang, C.W. et al. Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1β/KAP1. BMC Mol. Biol. 9, 61 (2008).
28. Stefanová, I., Dorfman, J.R. & Germain, R.N. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature 420, 429-434 (2002). (Pubitemid 35415655)
29. Cammas, F. et al. Mice lacking the transcriptional corepressor TIF1β are defective in early postimplantation development. Development 127, 2955-2963 (2000). (Pubitemid 30487613)
30. Takahama, Y. et al. Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene. Eur. J. Immunol. 28, 2159-2166 (1998). (Pubitemid 28321300)
31. Linton, P.J., Haynes, L., Tsui, L., Zhang, X. & Swain, S. From naive to effector-alterations with aging. Immunol. Rev. 160, 9-18 (1997).
32. Veldhoen, M., Hocking, R.J., Flavell, R.A. & Stockinger, B. Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat. Immunol. 7, 1151-1156 (2006). (Pubitemid 44594310)
33. Nelson, B.H. IL-2, regulatory T cells, and tolerance. J. Immunol. 172, 3983-3988 (2004).
34. Laurence, A. et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26, 371-381 (2007). (Pubitemid 46413906)
35. Zhou, X. et al. Selective miRNA disruption in Treg cells leads to uncontrolled autoimmunity. J. Exp. Med. 205, 1983-1991 (2008).
36. Graycar, J.L. et al. Human transforming growth factor-β3: recombinant expression, purification, and biological activities in comparison with transforming growth factors-β1 and-β2. Mol. Endocrinol. 3, 1977-1986 (1989). (Pubitemid 20036903)
37. Webster, K.E. et al. In vivo expansion of Treg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J. Exp. Med. 206, 751-760 (2009).
38. King, C., Ilic, A., Koelsch, K. & Sarvetnick, N. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 117, 265-277 (2004). (Pubitemid 38496245)
39. Kench, J.A. et al. Aberrant wound healing and TGF-β production in the autoimmune-prone MRL/+ mouse. Clin. Immunol. 92, 300-310 (1999). (Pubitemid 29439677)
40. Lowrance, J.H., O'Sullivan, F.X., Caver, T.E., Waegell, W. & Gresham, H.D. Spontaneous elaboration of transforming growth factor β suppresses host defense against bacterial infection in autoimmune MRL/lpr mice. J. Exp. Med. 180, 1693-1703 (1994). (Pubitemid 24328561)
41. Zhang, Z., Kyttaris, V.C. & Tsokos, G.C. The role of IL-23/IL-17 axis in lupus nephritis. J. Immunol. 183, 3160-3169 (2009).
42. Caver, T.E., O'Sullivan, F.X., Gold, L.I. & Gresham, H.D. Intracellular demonstration of active TGFβ1 in B cells and plasma cells of autoimmune mice. IgG-bound TGFβ1 suppresses neutrophil function and host defense against Staphylococcus aureus infection. J. Clin. Invest. 98, 2496-2506 (1996). (Pubitemid 26415070)
43. Münoz-Valle, J.F. et al. The functional class evaluated in rheumatoid arthritis is associated with soluble TGF-β1 serum levels but not with G915C (Arg25Pro) TGF-β1 polymorphism. Rheumatol. Int. 32, 367-372 (2010).
44. Gutcher, I. et al. Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation. Immunity 34, 396-408 (2011).
45. Beyer, M. et al. Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat. Immunol. 12, 898-907 (1038).
46. Maloy, K.J. Induction and regulation of inflammatory bowel disease in immunodeficient mice by distinct CD4+ T-cell subsets. Methods Mol. Biol. 380, 327-335 (2007). (Pubitemid 350183337)