Induction of holomycin production and complex metabolic changes by the argR mutation in Streptomyces clavuligerus NP1

Applied and Environmental Microbiology

Volumn 78, Issue 9, 2012, Pages 3431-3441

  Yin, Hua ^a   Xiang, Sihai ^a   Zheng, Jianting ^a   Fan, Keqiang ^a   Yu, Tingting ^a   Yang, Xu ^a   Peng, Yanfeng ^a   Wang, Haibin ^b   Feng, Deqin ^a   Luo, Yuanming ^a   Bai, Hua ^b   Yang, Keqian ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b Hisun Pharmaceutical Company Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL-COA; ANTIBIOTIC PRODUCTION; ARGININE BIOSYNTHESIS; BIOSYNTHETIC GENE; CLAVULANIC ACID; CYSTEINE BIOSYNTHESIS; EXPRESSION LEVELS; METABOLIC CHANGES; METABOLIC PATHWAYS; OVER-EXPRESSION; PARALOGS; PHENOTYPIC CHANGES; PRODUCTION LEVEL; PROTEOMIC STUDIES; SECONDARY METABOLISM; STREPTOMYCES CLAVULIGERUS;

ARGININE; BACTERIA; BIOCHEMISTRY; CARBOXYLIC ACIDS; GENE EXPRESSION; GENE EXPRESSION REGULATION; METABOLISM; PROTEINS;

BIOSYNTHESIS;

ACETYL COENZYME A; ARGR PROTEIN, BACTERIA; BACTERIAL PROTEIN; CLAVULANIC ACID; CYSTEINE; HOLOMYCIN; LACTAM; PROTEOME; REPRESSOR PROTEIN;

ANTIBIOTICS; BACTERIUM; GENE EXPRESSION; GROWTH RATE; METABOLISM; MUTATION; PHENOTYPE; PROTEIN;

ARTICLE; BIOSYNTHESIS; COMPARATIVE STUDY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; STREPTOMYCES;

ACETYL COENZYME A; BACTERIAL PROTEINS; CLAVULANIC ACID; CYSTEINE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; GENE KNOCKOUT TECHNIQUES; LACTAMS; PROTEOME; REPRESSOR PROTEINS; STREPTOMYCES;

STREPTOMYCES CLAVULIGERUS;

EID: 84861122640     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.07699-11     Document Type: Article

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