Enhancement of clavulanic acid production in Streptomyces clavuligerus with ornithine feeding

Enzyme and Microbial Technology

Volumn 32, Issue 1, 2003, Pages 152-156

  Chen, Kuo Cheng ^a   Lin, Yun Huin ^a   Wu, Jane Yii ^a   Hwang, Sz Chwun John ^b  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b CHUNG HUA UNIVERSITY   (Taiwan)

Author keywords

Arginine; Clavulanic acid; Fed batch; Glycerol; Ornithine; Streptomyces clavuligerus

Indexed keywords

BATCH CELL CULTURE; BIOSYNTHESIS; FEEDING; GLYCEROL;

PRECURSOR;

BIOTECHNOLOGY;

AMINO ACID; CLAVULANIC ACID; ORNITHINE;

ACIDITY; ARTICLE; FEEDING; FUNGUS CULTURE; NONHUMAN; STREPTOMYCES CLAVULIGERUS;

STREPTOMYCES CLAVULIGERUS;

EID: 0037413384     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0141-0229(02)00280-6     Document Type: Article

References (18)

1. Brown A.G., Butterworth D., Cole M., Hanscomb G., Hood J.D., Reading C.et al. Naturally occurring β-lactamase inhibitors with antibacterial activity. J. Antibiot. 29:1976;668-669.
2. Aharonowitz Y., Demain A.L. Catabolite regulation of cephalosporin production in Streptomyces clavuligerus. Antimicrob. Agents Chemother. 14:1978;159-164.
3. Reed G, Peppler HJ. Backers' yeast production. In: Yeast Technology. Westport: AVI; 1973, p. 53-102.
4. Queener S, Swartz R. Penicillins: Biosynthetic and semisynthetic. In: Rose AH, editor. Economic Microbiology. Secondary Products of Metabolism, vol. 3. London: Academic Press; 1979, p. 35-123.
5. Bushell M.E., Bell S.L., Scott M.F., Spier R.E., Wardel J.N., Sanders P.G. Enhancement of monoclonal antibody yield by hybridoma fed-batch culture, resulting in extended maintenance of viable cell population. Biotechnol. Bioeng. 44:1994;1099-1106.
6. Ives P.R., Bushell M.E. Manipulation of the physiology of clavulanic acid production in Streptomyces clavuligerus. Microbiology. 143:1997;3573-3579.
7. 13C -labelled precursors J. Antibiot. 31:1978;586-592.
8. 5 unit. J. Am. Chem. Soc. 107:1985;1066-1068.
9. Baggaley K.H., Brown A.G., Schofield C.J. Chemistry and biosynthesis of clavulanic acid and other clavams. Nat. Prod. Rep. 14:1997;309-333.
10. Foulstone M., Reading C. Assay of amoxicillin and clavulanic acid, the components of Augmentin, in biological fluids with high-performance liquid chromatography. Antimicrob. Agents Chemother. 22:1982;753-762.
11. Romero J., Liras P., Martin J.F. Dissociation of cephamycin and clavulanic acid biosynthesis in Streptomyces clavuligerus. Appl. Microbial. Biotechnol. 20:1984;318-325.
12. Mayer A.F., Deckwer W.D. Simultaneous production and decomposition of clavulanic acid during Streptomyces clavuligerus cultivations. Appl. Microbial Biotechnol. 45:1996;41-46.
13. Hu W.S., Brana A.F., Demain A.L. Carbon source regulation of cephem antibiotic production by resting cell of Streptomyces clavuligerus and its reversal by protein synthesis inhibitors. Enzyme Microb. Technol. 6:1984;155-160.
14. Romero J., Liras P., Martin J.F. Utilization of ornithine and arginine as specific precursors of clavulanic acid. Appl. Environ. Microbiol. 52:1986;892-897.
15. Kirk S., Avignone-Rossa C.A., Bushell M.E. Growth limiting substrate affected antibiotics production and associated metabolic fluxes in S. clavuliderus. Biotechnol. Lett. 22:2000;1803-1809.
16. 13C -labelled precursor J. Antibiot. 31:1978;586-592.
17. Mendz G.L., Hazell S.L. The urea cycle of Helicobater pylori. Microbiology. 142:1996;2959-2967.
18. Valentine BP, Bailey CR, Doherty A, Morris J, Elson SW, Baggaley KH, et al. Evidence that arginine is a later metabolic intermediate than ornithine in the biosynthesis of clavulanic acid by Streptomyces clavuligerus. J Chem Soc Chem Commun 1993;15:1210-11.