Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Kratschmar, Denise V ^a   Calabrese, Diego ^b   Walsh, Jo ^c   Lister, Adam ^a   Birk, Julia ^a   Appenzeller Herzog, Christian ^a   Moulin, Pierre ^b   Goldring, Chris E ^c   Odermatt, Alex ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; HYDROCORTISONE; HYDROGEN PEROXIDE; NFE2L2 PROTEIN, RAT; NQO1 PROTEIN, RAT; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SULFORAFAN; THIOCYANIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CATALYSIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME REPRESSION; ENZYME SYNTHESIS; FEMALE; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE TARGETING; GST2A GENE; HMOX1 GENE; HUMAN; HUMAN CELL; INSULIN SENSITIVITY; LIVER CELL; MALE; NONHUMAN; NQO1 GENE; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PLASMID; RAT; SEX DIFFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; CELL STRAIN HEK293; CYTOLOGY; DNA MICROARRAY; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; LIVER; METABOLISM; REPORTER GENE; SEXUAL DEVELOPMENT; TRANSCRIPTION INITIATION; TUMOR CELL LINE; WISTAR RAT;

RATTUS;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; ANTIOXIDANTS; CELL LINE, TUMOR; DOWN-REGULATION; FEMALE; GENES, REPORTER; GLUCOCORTICOIDS; HEK293 CELLS; HUMANS; HYDROCORTISONE; HYDROGEN PEROXIDE; LIVER; MALE; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; RATS; RATS, WISTAR; RECEPTORS, GLUCOCORTICOID; RECOMBINANT PROTEINS; SEX CHARACTERISTICS; THIOCYANATES; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION;

EID: 84861012259     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036774     Document Type: Article

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