L1 expression and regulation in humans and rodents

Frontiers in Bioscience - Elite

Volumn 4 E, Issue 6, 2012, Pages 2203-2225

  Rosser, James M ^a   An, Wenfeng ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

5'UTR; Blastocyst; DNA methylation; Embryonal carcinoma cell; Embryonic stem cell; Gene expression; Gene regulation; Germ cell tumor; L1; LINE 1; Long interspersed element; Morula; Mouse model; Neurogenesis; Non LTR retrotransposon; ORF1; ORF2; PiRNA; Postimplantation; Preimplantation; Primordial germ cell; Review; SiRNA; Spermatogenesis; Transcription factor; Transgene; Tumor

Indexed keywords

L1 PROTEIN; MESSENGER RNA; MILI PROTEIN; MIWI2 PROTEIN; PIWI INTERACTING RNA; PROTEIN P53; RIBONUCLEOPROTEIN; TRANSCRIPTION FACTOR RUNX3; TRANSCRIPTION FACTOR SOX; TRANSCRIPTION FACTOR YY1; TREX1 PROTEIN; TUDOR DOMAIN CONTAINING PROTEIN 1; TUDOR DOMAIN CONTAINING PROTEIN 9; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ARTICLE; BREAST CANCER; CELL DIFFERENTIATION; DNA METHYLATION; DOWN REGULATION; EMBRYO DEVELOPMENT; EMBRYONAL CARCINOMA STEM CELL; GAMETOGENESIS; GENE SILENCING; GERM CELL TUMOR; HUMAN; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NONHUMAN; POSTNATAL DEVELOPMENT; PREIMPLANTATION EMBRYO; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROCESSING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA METHYLATION; SEMINIFEROUS TUBULE; SEMINOMA; SOMATIC CELL; SPERMATOGENESIS; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; LONG INTERSPERSED REPEAT; MOUSE; REVIEW; TRANSGENIC MOUSE;

MAMMALIA; MUS MUSCULUS; RATTUS; RODENTIA;

ANIMALS; GENE EXPRESSION REGULATION; HUMANS; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; MICE; MICE, TRANSGENIC;

EID: 84860862478     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: None     Document Type: Article

References (173)

1. R. A. Gibbs, G. M. Weinstock, M. L. Metzker, D. M. Muzny, E. J. Sodergren, S. Scherer, G. Scott, D. Steffen, K. C. Worley, P. E. Burch, G. Okwuonu, S. Hines, L. Lewis, C. DeRamo, O. Delgado, S. Dugan-Rocha, G. Miner, M. Morgan, A. Hawes, R. Gill, Celera, R. A. Holt, M. D. Adams, P. G. Amanatides, H. Baden-Tillson, M. Barnstead, S. Chin, C. A. Evans, S. Ferriera, C. Fosler, A. Glodek, Z. Gu, D. Jennings, C. L. Kraft, T. Nguyen, C. M. Pfannkoch, C. Sitter, G. G. Sutton, J. C. Venter, T. Woodage, D. Smith, H. M. Lee, E. Gustafson, P. Cahill, A. Kana, L. Doucette-Stamm, K. Weinstock, K. Fechtel, R. B. Weiss, D. M. Dunn, E. D. Green, R. W. Blakesley, G. G. Bouffard, P. J. De Jong, K. Osoegawa, B. Zhu, M. Marra, J. Schein, I. Bosdet, C. Fjell, S. Jones, M. Krzywinski, C. Mathewson, A. Siddiqui, N. Wye, J. McPherson, S. Zhao, C. M. Fraser, J. Shetty, S. Shatsman, K. Geer, Y. Chen, S. Abramzon, W. C. Nierman, P. H. Havlak, R. Chen, K. J. Durbin, A. Egan, Y. Ren, X. Z. Song, B. Li, Y. Liu, X. Qin, S. Cawley, A. J. Cooney, L. M. D'Souza, K. Martin, J. Q. Wu, M. L. Gonzalez-Garay, A. R. Jackson, K. J. Kalafus, M. P. McLeod, A. Milosavljevic, D. Virk, A. Volkov, D. A. Wheeler, Z. Zhang, J. A. Bailey, E. E. Eichler, E. Tuzun, E. Birney, E. Mongin, A. Ureta-Vidal, C. Woodwark, E. Zdobnov, P. Bork, M. Suyama, D. Torrents, M. Alexandersson, B. J. Trask, J. M. Young, H. Huang, H. Wang, H. Xing, S. Daniels, D. Gietzen, J. Schmidt, K. Stevens, U. Vitt, J. Wingrove, F. Camara, M. Mar Alba, J. F. Abril, R. Guigo, A. Smit, I. Dubchak, E. M. Rubin, O. Couronne, A. Poliakov, N. Hubner, D. Ganten, C. Goesele, O. Hummel, T. Kreitler, Y. A. Lee, J. Monti, H. Schulz, H. Zimdahl, H. Himmelbauer, H. Lehrach, H. J. Jacob, S. Bromberg, J. Gullings-Handley, M. I. Jensen-Seaman, A. E. Kwitek, J. Lazar, D. Pasko, P. J. Tonellato, S. Twigger, C. P. Ponting, J. M. Duarte, S. Rice, L. Goodstadt, S. A. Beatson, R. D. Emes, E. E. Winter, C. Webber, P. Brandt, G. Nyakatura, M. Adetobi, F. Chiaromonte, L. Elnitski, P. Eswara, R. C. Hardison, M. Hou, D. Kolbe, K. Makova, W. Miller, A. Nekrutenko, C. Riemer, S. Schwartz, J. Taylor, S. Yang, Y. Zhang, K. Lindpaintner, T. D. Andrews, M. Caccamo, M. Clamp, L. Clarke, V. Curwen, R. Durbin, E. Eyras, S. M. Searle, G. M. Cooper, S. Batzoglou, M. Brudno, A. Sidow, E. A. Stone, B. A. Payseur, G. Bourque, C. Lopez-Otin, X. S. Puente, K. Chakrabarti, S. Chatterji, C. Dewey, L. Pachter, N. Bray, V. B. Yap, A. Caspi, G. Tesler, P. A. Pevzner, D. Haussler, K. M. Roskin, R. Baertsch, H. Clawson, T. S. Furey, A. S. Hinrichs, D. Karolchik, W. J. Kent, K. R. Rosenbloom, H. Trumbower, M. Weirauch, D. N. Cooper, P. D. Stenson, B. Ma, M. Brent, M. Arumugam, D. Shteynberg, R. R. Copley, M. S. Taylor, H. Riethman, U. Mudunuri, J. Peterson, M. Guyer, A. Felsenfeld, S. Old, S. Mockrin and F. Collins: Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature, 428 (6982), 493-521 (2004))
2. E. S. Lander, L. M. Linton, B. Birren, C. Nusbaum, M. C. Zody, J. Baldwin, K. Devon, K. Dewar, M. Doyle, W. FitzHugh, R. Funke, D. Gage, K. Harris, A. Heaford, J. Howland, L. Kann, J. Lehoczky, R. LeVine, P. McEwan, K. McKernan, J. Meldrim, J. P. Mesirov, C. Miranda, W. Morris, J. Naylor, C. Raymond, M. Rosetti, R. Santos, A. Sheridan, C. Sougnez, N. Stange-Thomann, N. Stojanovic, A. Subramanian, D. Wyman, J. Rogers, J. Sulston, R. Ainscough, S. Beck, D. Bentley, J. Burton, C. Clee, N. Carter, A. Coulson, R. Deadman, P. Deloukas, A. Dunham, I. Dunham, R. Durbin, L. French, D. Grafham, S. Gregory, T. Hubbard, S. Humphray, A. Hunt, M. Jones, C. Lloyd, A. McMurray, L. Matthews, S. Mercer, S. Milne, J. C. Mullikin, A. Mungall, R. Plumb, M. Ross, R. Shownkeen, S. Sims, R. H. Waterston, R. K. Wilson, L. W. Hillier, J. D. McPherson, M. A. Marra, E. R. Mardis, L. A. Fulton, A. T. Chinwalla, K. H. Pepin, W. R. Gish, S. L. Chissoe, M. C. Wendl, K. D. Delehaunty, T. L. Miner, A. Delehaunty, J. B. Kramer, L. L. Cook, R. S. Fulton, D. L. Johnson, P. J. Minx, S. W. Clifton, T. Hawkins, E. Branscomb, P. Predki, P. Richardson, S. Wenning, T. Slezak, N. Doggett, J. F. Cheng, A. Olsen, S. Lucas, C. Elkin, E. Uberbacher, M. Frazier, R. A. Gibbs, D. M. Muzny, S. E. Scherer, J. B. Bouck, E. J. Sodergren, K. C. Worley, C. M. Rives, J. H. Gorrell, M. L. Metzker, S. L. Naylor, R. S. Kucherlapati, D. L. Nelson, G. M. Weinstock, Y. Sakaki, A. Fujiyama, M. Hattori, T. Yada, A. Toyoda, T. Itoh, C. Kawagoe, H. Watanabe, Y. Totoki, T. Taylor, J. Weissenbach, R. Heilig, W. Saurin, F. Artiguenave, P. Brottier, T. Bruls, E. Pelletier, C. Robert, P. Wincker, D. R. Smith, L. Doucette-Stamm, M. Rubenfield, K. Weinstock, H. M. Lee, J. Dubois, A. Rosenthal, M. Platzer, G. Nyakatura, S. Taudien, A. Rump, H. Yang, J. Yu, J. Wang, G. Huang, J. Gu, L. Hood, L. Rowen, A. Madan, S. Qin, R. W. Davis, N. A. Federspiel, A. P. Abola, M. J. Proctor, R. M. Myers, J. Schmutz, M. Dickson, J. Grimwood, D. R. Cox, M. V. Olson, R. Kaul, N. Shimizu, K. Kawasaki, S. Minoshima, G. A. Evans, M. Athanasiou, R. Schultz, B. A. Roe, F. Chen, H. Pan, J. Ramser, H. Lehrach, R. Reinhardt, W. R. McCombie, M. de la Bastide, N. Dedhia, H. Blocker, K. Hornischer, G. Nordsiek, R. Agarwala, L. Aravind, J. A. Bailey, A. Bateman, S. Batzoglou, E. Birney, P. Bork, D. G. Brown, C. B. Burge, L. Cerutti, H. C. Chen, D. Church, M. Clamp, R. R. Copley, T. Doerks, S. R. Eddy, E. E. Eichler, T. S. Furey, J. Galagan, J. G. Gilbert, C. Harmon, Y. Hayashizaki, D. Haussler, H. Hermjakob, K. Hokamp, W. Jang, L. S. Johnson, T. A. Jones, S. Kasif, A. Kaspryzk, S. Kennedy, W. J. Kent, P. Kitts, E. V. Koonin, I. Korf, D. Kulp, D. Lancet, T. M. Lowe, A. McLysaght, T. Mikkelsen, J. V. Moran, N. Mulder, V. J. Pollara, C. P. Ponting, G. Schuler, J. Schultz, G. Slater, A. F. Smit, E. Stupka, J. Szustakowski, D. Thierry-Mieg, J. Thierry-Mieg, L. Wagner, J. Wallis, R. Wheeler, A. Williams, Y. I. Wolf, K. H. Wolfe, S. P. Yang, R. F. Yeh, F. Collins, M. S. Guyer, J. Peterson, A. Felsenfeld, K. A. Wetterstrand, A. Patrinos, M. J. Morgan, P. de Jong, J. J. Catanese, K. Osoegawa, H. Shizuya, S. Choi and Y. J. Chen: Initial sequencing and analysis of the human genome. Nature, 409 (6822), 860-921 (2001)) (Pubitemid 32165345)
3. R. H. Waterston, K. Lindblad-Toh, E. Birney, J. Rogers, J. F. Abril, P. Agarwal, R. Agarwala, R. Ainscough, M. Alexandersson, P. An, S. E. Antonarakis, J. Attwood, R. Baertsch, J. Bailey, K. Barlow, S. Beck, E. Berry, B. Birren, T. Bloom, P. Bork, M. Botcherby, N. Bray, M. R. Brent, D. G. Brown, S. D. Brown, C. Bult, J. Burton, J. Butler, R. D. Campbell, P. Carninci, S. Cawley, F. Chiaromonte, A. T. Chinwalla, D. M. Church, M. Clamp, C. Clee, F. S. Collins, L. L. Cook, R. R. Copley, A. Coulson, O. Couronne, J. Cuff, V. Curwen, T. Cutts, M. Daly, R. David, J. Davies, K. D. Delehaunty, J. Deri, E. T. Dermitzakis, C. Dewey, N. J. Dickens, M. Diekhans, S. Dodge, I. Dubchak, D. M. Dunn, S. R. Eddy, L. Elnitski, R. D. Emes, P. Eswara, E. Eyras, A. Felsenfeld, G. A. Fewell, P. Flicek, K. Foley, W. N. Frankel, L. A. Fulton, R. S. Fulton, T. S. Furey, D. Gage, R. A. Gibbs, G. Glusman, S. Gnerre, N. Goldman, L. Goodstadt, D. Grafham, T. A. Graves, E. D. Green, S. Gregory, R. Guigo, M. Guyer, R. C. Hardison, D. Haussler, Y. Hayashizaki, L. W. Hillier, A. Hinrichs, W. Hlavina, T. Holzer, F. Hsu, A. Hua, T. Hubbard, A. Hunt, I. Jackson, D. B. Jaffe, L. S. Johnson, M. Jones, T. A. Jones, A. Joy, M. Kamal, E. K. Karlsson, D. Karolchik, A. Kasprzyk, J. Kawai, E. Keibler, C. Kells, W. J. Kent, A. Kirby, D. L. Kolbe, I. Korf, R. S. Kucherlapati, E. J. Kulbokas, D. Kulp, T. Landers, J. P. Leger, S. Leonard, I. Letunic, R. Levine, J. Li, M. Li, C. Lloyd, S. Lucas, B. Ma, D. R. Maglott, E. R. Mardis, L. Matthews, E. Mauceli, J. H. Mayer, M. McCarthy, W. R. McCombie, S. McLaren, K. McLay, J. D. McPherson, J. Meldrim, B. Meredith, J. P. Mesirov, W. Miller, T. L. Miner, E. Mongin, K. T. Montgomery, M. Morgan, R. Mott, J. C. Mullikin, D. M. Muzny, W. E. Nash, J. O. Nelson, M. N. Nhan, R. Nicol, Z. Ning, C. Nusbaum, M. J. O'Connor, Y. Okazaki, K. Oliver, E. Overton-Larty, L. Pachter, G. Parra, K. H. Pepin, J. Peterson, P. Pevzner, R. Plumb, C. S. Pohl, A. Poliakov, T. C. Ponce, C. P. Ponting, S. Potter, M. Quail, A. Reymond, B. A. Roe, K. M. Roskin, E. M. Rubin, A. G. Rust, R. Santos, V. Sapojnikov, B. Schultz, J. Schultz, M. S. Schwartz, S. Schwartz, C. Scott, S. Seaman, S. Searle, T. Sharpe, A. Sheridan, R. Shownkeen, S. Sims, J. B. Singer, G. Slater, A. Smit, D. R. Smith, B. Spencer, A. Stabenau, N. Stange-Thomann, C. Sugnet, M. Suyama, G. Tesler, J. Thompson, D. Torrents, E. Trevaskis, J. Tromp, C. Ucla, A. Ureta-Vidal, J. P. Vinson, A. C. Von Niederhausern, C. M. Wade, M. Wall, R. J. Weber, R. B. Weiss, M. C. Wendl, A. P. West, K. Wetterstrand, R. Wheeler, S. Whelan, J. Wierzbowski, D. Willey, S. Williams, R. K. Wilson, E. Winter, K. C. Worley, D. Wyman, S. Yang, S. P. Yang, E. M. Zdobnov, M. C. Zody and E. S. Lander: Initial sequencing and comparative analysis of the mouse genome. Nature, 420 (6915), 520-62 (2002)) (Pubitemid 35477048)
4. A. F. Smit, G. Toth, A. D. Riggs and J. Jurka: Ancestral, mammalian-wide subfamilies of LINE-1 repetitive sequences. J Mol Biol, 246 (3), 401-417 (1995))
5. S. Boissinot and A. V. Furano: The recent evolution of human L1 retrotransposons. Cytogenet Genome Res, 110 (1-4), 402-6 (2005)) (Pubitemid 41159917)
6. S. Boissinot, P. Chevret and A. V. Furano: L1 (LINE-1) retrotransposon evolution and amplification in recent human history. Mol Biol Evol, 17 (6), 915-28 (2000)) (Pubitemid 30346551)
7. S. Boissinot, J. Davis, A. Entezam, D. Petrov and A. V. Furano: Fitness cost of LINE-1 (L1) activity in humans. Proc Natl Acad Sci U S A, 103 (25), 9590-4 (2006)) (Pubitemid 43955869)
8. A. V. Furano: The biological properties and evolutionary dynamics of mammalian LINE-1 retrotransposons. Prog Nucleic Acid Res Mol Biol, 64, 255-94 (2000))
9. R. Minakami, K. Kurose, K. Etoh, Y. Furuhata, M. Hattori and Y. Sakaki: Identification of an internal ciselement essential for the human L1 transcription and a nuclear factor (s) binding to the element. Nucleic Acids Res, 20 (12), 3139-45 (1992))
10. I. Nur, E. Pascale and A. V. Furano: The left end of rat L1 (L1Rn, long interspersed repeated) DNA which is a CpG island can function as a promoter. Nucleic Acids Res, 16 (19), 9233-51 (1988))
11. D. M. Severynse, C. A. Hutchison, 3rd and M. H. Edgell: Identification of transcriptional regulatory activity within the 5' A-type monomer sequence of the mouse LINE-1 retroposon. Mamm Genome, 2 (1), 41-50 (1992))
12. G. D. Swergold: Identification, characterization, and cell specificity of a human LINE-1 promoter. Mol Cell Biol, 10 (12), 6718-29 (1990)) (Pubitemid 120004617)
13. C. F. Voliva, C. L. Jahn, M. B. Comer, C. A. Hutchison, 3rd and M. H. Edgell: The L1Md long interspersed repeat family in the mouse: almost all examples are truncated at one end. Nucleic Acids Res, 11 (24), 8847-59 (1983))
14. G. Grimaldi, J. Skowronski and M. F. Singer: Defining the beginning and end of KpnI family segments. EMBO J, 3 (8), 1753-9 (1984))
15. J. V. Moran, S. E. Holmes, T. P. Naas, R. J. DeBerardinis, J. D. Boeke and H. H. Kazazian, Jr.: High frequency retrotransposition in cultured mammalian cells. Cell, 87 (5), 917-27 (1996)) (Pubitemid 26404290)
16. T. Penzkofer, T. Dandekar and T. Zemojtel: L1Base: from functional annotation to prediction of active LINE-1 elements. Nucleic Acids Res, 33 (Database issue), D498-500 (2005)) (Pubitemid 40207923)
17. H. Khan, A. Smit and S. Boissinot: Molecular evolution and tempo of amplification of human LINE-1 retrotransposons since the origin of primates. Genome Res, 16 (1), 78-87 (2006)) (Pubitemid 43048936)
18. K. Akagi, J. Li, R. M. Stephens, N. Volfovsky and D. E. Symer: Extensive variation between inbred mouse strains due to endogenous L1 retrotransposition. Genome Res, 18 (6), 869-80 (2008)) (Pubitemid 351793059)
19. B. Brouha, J. Schustak, R. M. Badge, S. Lutz-Prigge, A. H. Farley, J. V. Moran and H. H. Kazazian, Jr.: Hot L1s account for the bulk of retrotransposition in the human population. Proc Natl Acad Sci U S A, 100 (9), 5280-5 (2003))
20. J. L. Goodier, E. M. Ostertag, K. Du and H. H. Kazazian, Jr.: A novel active L1 retrotransposon subfamily in the mouse. Genome Res, 11 (10), 1677-85 (2001)) (Pubitemid 33040494)
21. C. Esnault, J. Maestre and T. Heidmann: Human LINE retrotransposons generate processed pseudogenes. Nat Genet, 24 (4), 363-7 (2000)) (Pubitemid 30187433)
22. W. Wei, N. Gilbert, S. L. Ooi, J. F. Lawler, E. M. Ostertag, H. H. Kazazian, J. D. Boeke and J. V. Moran: Human L1 retrotransposition: cis preference versus trans complementation. Mol Cell Biol, 21 (4), 1429-39 (2001)) (Pubitemid 32114989)
23. D. A. Kulpa and J. V. Moran: Cis-preferential LINE-1 reverse transcriptase activity in ribonucleoprotein particles. Nat Struct Mol Biol, 13 (7), 655-60 (2006)) (Pubitemid 44036477)
24. M. Dewannieux, C. Esnault and T. Heidmann: LINEmediated retrotransposition of marked Alu sequences. Nat Genet, 35 (1), 41-8 (2003)) (Pubitemid 37048594)
25. M. Dewannieux and T. Heidmann: L1-mediated retrotransposition of murine B1 and B2 SINEs recapitulated in cultured cells. J Mol Biol, 349 (2), 241-7 (2005)) (Pubitemid 40693746)
26. H. H. Kazazian, Jr.: Mobile elements: drivers of genome evolution. Science, 303 (5664), 1626-32 (2004)) (Pubitemid 38338313)
27. J. S. Han and J. D. Boeke: LINE-1 retrotransposons: modulators of quantity and quality of mammalian gene expression? Bioessays, 27 (8), 775-84 (2005)) (Pubitemid 41297400)
28. J. S. Han, S. T. Szak and J. D. Boeke: Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes. Nature, 429 (6989), 268-74 (2004)) (Pubitemid 38684807)
29. N. A. Wallace, V. P. Belancio and P. L. Deininger: L1 mobile element expression causes multiple types of toxicity. Gene, 419 (1-2), 75-81 (2008))
30. S. L. Gasior, T. P. Wakeman, B. Xu and P. L. Deininger: The human LINE-1 retrotransposon creates DNA double-strand breaks. J Mol Biol, 357 (5), 1383-93 (2006))
31. S. M. Belgnaoui, R. G. Gosden, O. J. Semmes and A. Haoudi: Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells. Cancer Cell Int, 6, 13 (2006))
32. A. Haoudi, O. J. Semmes, J. M. Mason and R. E. Cannon: Retrotransposition-Competent Human LINE-1 Induces Apoptosis in Cancer Cells With Intact p53. J Biomed Biotechnol, 2004 (4), 185-194 (2004)) (Pubitemid 40128954)
33. V. P. Belancio, D. J. Hedges and P. Deininger: Mammalian non-LTR retrotransposons: for better or worse, in sickness and in health. Genome Res, 18 (3), 343-58 (2008)) (Pubitemid 351347078)
34. J. M. Chen, P. D. Stenson, D. N. Cooper and C. Ferec: A systematic analysis of LINE-1 endonuclease-dependent retrotranspositional events causing human genetic disease. Hum Genet, 117 (5), 411-27 (2005)) (Pubitemid 41236363)
35. Y. Miki, I. Nishisho, A. Horii, Y. Miyoshi, J. Utsunomiya, K. W. Kinzler, B. Vogelstein and Y. Nakamura: Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. Cancer Res, 52 (3), 643-5 (1992))
36. B. Morse, P. G. Rotherg, V. J. South, J. M. Spandorfer and S. M. Astrin: Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma. Nature, 333 (6168), 87-90 (1988))
37. R. C. Iskow, M. T. McCabe, R. E. Mills, S. Torene, W. S. Pittard, A. F. Neuwald, E. G. Van Meir, P. M. Vertino and S. E. Devine: Natural mutagenesis of human genomes by endogenous retrotransposons. Cell, 141 (7), 1253-61 (2010))
38. V. Perepelitsa-Belancio and P. Deininger: RNA truncation by premature polyadenylation attenuates human mobile element activity. Nat Genet, 35 (4), 363-6 (2003)) (Pubitemid 37486920)
39. V. P. Belancio, D. J. Hedges and P. Deininger: LINE-1 RNA splicing and influences on mammalian gene expression. Nucleic Acids Res, 34 (5), 1512-21 (2006))
40. M. Speek: Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes. Mol Cell Biol, 21 (6), 1973-85 (2001)) (Pubitemid 32479621)
41. P. Nigumann, K. Redik, K. Matlik and M. Speek: Many human genes are transcribed from the antisense promoter of L1 retrotransposon. Genomics, 79 (5), 628-34 (2002)) (Pubitemid 34499478)
42. A. R. Florl, R. Lower, B. J. Schmitz-Drager and W. A. Schulz: DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas. Br J Cancer, 80 (9), 1312-21 (1999)) (Pubitemid 29308598)
43. D. M. Leibold, G. D. Swergold, M. F. Singer, R. E. Thayer, B. A. Dombroski and T. G. Fanning: Translation of LINE-1 DNA elements in vitro and in human cells. Proc Natl Acad Sci U S A, 87 (18), 6990-4 (1990))
44. J. Skowronski and M. F. Singer: Expression of a cytoplasmic LINE-1 transcript is regulated in a human teratocarcinoma cell line. Proc Natl Acad Sci U S A, 82 (18), 6050-4 (1985))
45. R. E. Thayer, M. F. Singer and T. G. Fanning: Undermethylation of specific LINE-1 sequences in human cells producing a LINE-1-encoded protein. Gene, 133 (2), 273-7 (1993))
46. L. B. Kole, S. R. Haynes and W. R. Jelinek: Discrete and heterogeneous high molecular weight RNAs complementary to a long dispersed repeat family (a possible transposon) of human DNA. J Mol Biol, 165 (2), 257-86 (1983)) (Pubitemid 13027653)
47. J. Skowronski, T. G. Fanning and M. F. Singer: Unitlength line-1 transcripts in human teratocarcinoma cells. Mol Cell Biol, 8 (4), 1385-97 (1988))
48. G. L. Bratthauer, R. D. Cardiff and T. G. Fanning: Expression of LINE-1 retrotransposons in human breast cancer. Cancer, 73 (9), 2333-6 (1994))
49. P. Nangia-Makker, R. Sarvis, D. W. Visscher, J. Bailey-Penrod, A. Raz and F. H. Sarkar: Galectin-3 and L1 retrotransposons in human breast carcinomas. Breast Cancer Res Treat, 49 (2), 171-83 (1998)) (Pubitemid 28279595)
50. V. P. Belancio, A. M. Roy-Engel, R. R. Pochampally and P. Deininger: Somatic expression of LINE-1 elements in human tissues. Nucleic Acids Res, 38 (12), 3909-22 (2010))
51. J. L. Garcia-Perez, M. C. Marchetto, A. R. Muotri, N. G. Coufal, F. H. Gage, K. S. O'Shea and J. V. Moran: LINE-1 retrotransposition in human embryonic stem cells. Hum Mol Genet, 16 (13), 1569-77 (2007)) (Pubitemid 47050670)
52. L. H. Looijenga and J. W. Oosterhuis: Pathobiology of testicular germ cell tumors: views and news. Anal Quant Cytol Histol, 24 (5), 263-79 (2002)) (Pubitemid 35191467)
53. J. W. Oosterhuis and L. H. Looijenga: Testicular germcell tumours in a broader perspective. Nat Rev Cancer, 5 (3), 210-22 (2005)) (Pubitemid 40314952)
54. G. L. Bratthauer and T. G. Fanning: Active LINE-1 retrotransposons in human testicular cancer. Oncogene, 7 (3), 507-10 (1992))
55. G. L. Bratthauer and T. G. Fanning: LINE-1 retrotransposon expression in pediatric germ cell tumors. Cancer, 71 (7), 2383-6 (1993))
56. Y. Su, S. Davies, M. Davis, H. Lu, R. Giller, M. Krailo, Q. Cai, L. Robison and X. O. Shu: Expression of LINE-1 p40 protein in pediatric malignant germ cell tumors and its association with clinicopathological parameters: a report from the Children's Oncology Group. Cancer Lett, 247 (2), 204-12 (2007)) (Pubitemid 46240607)
57. H. L. Asch, E. Eliacin, T. G. Fanning, J. L. Connolly, G. Bratthauer and B. B. Asch: Comparative expression of the LINE-1 p40 protein in human breast carcinomas and normal breast tissues. Oncol Res, 8 (6), 239-47 (1996)) (Pubitemid 26357607)
58. C. R. Harris, R. Normart, Q. Yang, E. Stevenson, B. G. Haffty, S. Ganesan, C. Cordon-Cardo, A. J. Levine and L. H. Tang: Association of Nuclear Localization of a Long Interspersed Nuclear Element-1 Protein in Breast Tumors with Poor Prognostic Outcomes. Genes Cancer, 1 (2), 115-124 (2010))
59. S. Ergun, C. Buschmann, J. Heukeshoven, K. Dammann, F. Schnieders, H. Lauke, F. Chalajour, N. Kilic, W. H. Stratling and G. G. Schumann: Cell typespecific expression of LINE-1 open reading frames 1 and 2 in fetal and adult human tissues. J Biol Chem, 279 (26), 27753-63 (2004))
60. D. Branciforte and S. L. Martin: Developmental and cell type specificity of LINE-1 expression in mouse testis: implications for transposition. Mol Cell Biol, 14 (4), 2584-92 (1994)) (Pubitemid 24108241)
61. S. A. Trelogan and S. L. Martin: Tightly regulated, developmentally specific expression of the first open reading frame from LINE-1 during mouse embryogenesis. Proc Natl Acad Sci U S A, 92 (5), 1520-4 (1995))
62. I. Georgiou, D. Noutsopoulos, E. Dimitriadou, G. Markopoulos, A. Apergi, L. Lazaros, T. Vaxevanoglou, K. Pantos, M. Syrrou and T. Tzavaras: Retrotransposon RNA expression and evidence for retrotransposition events in human oocytes. Hum Mol Genet, 18 (7), 1221-8 (2009))
63. A. R. Muotri, V. T. Chu, M. C. Marchetto, W. Deng, J. V. Moran and F. H. Gage: Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature, 435 (7044), 903-10 (2005)) (Pubitemid 40896309)
64. H. Shay, M. Gruenstein, H. E. Marx and L. Glazer: The development of lymphatic and myelogenous leukemia in Wistar rats following gastric instillation of methylcholanthrene. Cancer Res, 11 (1), 29-34 (1951))
65. W. C. Moloney, A. D. Dorr, G. Dowd and A. E. Boschetti: Myelogenous leukemia in the rat. Blood, 19, 45-59 (1962))
66. K. Servomaa and T. Rytomaa: Suicidal death of rat chloroleukaemia cells by activation of the long interspersed repetitive DNA element (L1Rn). Cell Tissue Kinet, 21 (1), 33-43 (1988)) (Pubitemid 18262406)
67. K. Servomaa and T. Rytomaa: UV light and ionizing radiations cause programmed death of rat chloroleukaemia cells by inducing retropositions of a mobile DNA element (L1Rn). Int J Radiat Biol, 57 (2), 331-43 (1990)) (Pubitemid 20088859)
68. A. Kirilyuk, G. V. Tolstonog, A. Damert, U. Held, S. Hahn, R. Lower, C. Buschmann, A. V. Horn, P. Traub and G. G. Schumann: Functional endogenous LINE-1 retrotransposons are expressed and mobilized in rat chloroleukemia cells. Nucleic Acids Res, 36 (2), 648-65 (2008)) (Pubitemid 351250455)
69. F. R. Witney and A. V. Furano: Highly repeated DNA families in the rat. J Biol Chem, 259 (16), 10481-92 (1984))
70. E. Lucchinetti, J. Feng, R. Silva, G. V. Tolstonog, M. C. Schaub, G. G. Schumann and M. Zaugg: Inhibition of LINE-1 expression in the heart decreases ischemic damage by activation of Akt/PKB signaling. Physiol Genomics, 25 (2), 314-24 (2006))
71. M. F. Singer: SINEs and LINEs: highly repeated short and long interspersed sequences in mammalian genomes. Cell, 28 (3), 433-4 (1982)) (Pubitemid 12111916)
72. J. P. Dudley: Discrete high molecular weight RNA transcribed from the long interspersed repetitive element L1Md. Nucleic Acids Res, 15 (6), 2581-92 (1987))
73. S. L. Martin: Ribonucleoprotein particles with LINE-1 RNA in mouse embryonal carcinoma cells. Mol Cell Biol, 11 (9), 4804-7 (1991))
74. S. A. Schichman, D. M. Severynse, M. H. Edgell and C. A. Hutchison, 3rd: Strand-specific LINE-1 transcription in mouse F9 cells originates from the youngest phylogenetic subgroup of LINE-1 elements. J Mol Biol, 224 (3), 559-74 (1992))
75. S. L. Martin and D. Branciforte: Synchronous expression of LINE-1 RNA and protein in mouse embryonal carcinoma cells. Mol Cell Biol, 13 (9), 5383-92 (1993)) (Pubitemid 23260642)
76. A. I. Packer, K. Manova and R. F. Bachvarova: A discrete LINE-1 transcript in mouse blastocysts. Dev Biol, 157 (1), 281-3 (1993)) (Pubitemid 23164977)
77. A. A. Aravin, G. W. van der Heijden, J. Castaneda, V. V. Vagin, G. J. Hannon and A. Bortvin: Cytoplasmic compartmentalization of the fetal piRNA pathway in mice. PLoS Genet, 5 (12), e1000764 (2009))
78. S. F. Soper, G. W. van der Heijden, T. C. Hardiman, M. Goodheart, S. L. Martin, P. de Boer and A. Bortvin: Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis. Dev Cell, 15 (2), 285-97 (2008))
79. J. A. Saxton and S. L. Martin: Recombination between subtypes creates a mosaic lineage of LINE-1 that is expressed and actively retrotransposing in the mouse genome. J Mol Biol, 280 (4), 611-22 (1998)) (Pubitemid 28336369)
80. K. G. Becker, G. D. Swergold, K. Ozato and R. E. Thayer: Binding of the ubiquitous nuclear transcription factor YY1 to a cis regulatory sequence in the human LINE-1 transposable element. Hum Mol Genet, 2 (10), 1697-702 (1993)) (Pubitemid 23358691)
81. S. L. Mathias and A. F. Scott: Promoter binding proteins of an active human L1 retrotransposon. Biochem Biophys Res Commun, 191 (2), 625-32 (1993)) (Pubitemid 23222681)
82. J. N. Athanikar, R. M. Badge and J. V. Moran: A YY1- binding site is required for accurate human LINE-1 transcription initiation. Nucleic Acids Res, 32 (13), 3846-55 (2004)) (Pubitemid 39199077)
83. N. Yang, L. Zhang, Y. Zhang and H. H. Kazazian, Jr.: An important role for RUNX3 in human L1 transcription and retrotransposition. Nucleic Acids Res, 31 (16), 4929-40 (2003)) (Pubitemid 37441858)
84. T. Tchenio, J. F. Casella and T. Heidmann: Members of the SRY family regulate the human LINE retrotransposons. Nucleic Acids Res, 28 (2), 411-5 (2000)) (Pubitemid 30057978)
85. C. R. Harris, A. Dewan, A. Zupnick, R. Normart, A. Gabriel, C. Prives, A. J. Levine and J. Hoh: p53 responsive elements in human retrotransposons. Oncogene, 28 (44), 3857-65 (2009))
86. T. Kuwabara, J. Hsieh, A. Muotri, G. Yeo, M. Warashina, D. C. Lie, L. Moore, K. Nakashima, M. Asashima and F. H. Gage: Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Nat Neurosci, 12 (9), 1097-105 (2009))
87. T. B. Miranda and P. A. Jones: DNA methylation: the nuts and bolts of repression. J Cell Physiol, 213 (2), 384-90 (2007)) (Pubitemid 47509717)
88. A. F. Scott, B. J. Schmeckpeper, M. Abdelrazik, C. T. Comey, B. O'Hara, J. P. Rossiter, T. Cooley, P. Heath, K. D. Smith and L. Margolet: Origin of the human L1 elements: proposed progenitor genes deduced from a consensus DNA sequence. Genomics, 1 (2), 113-25 (1987))
89. E. D'Ambrosio, S. D. Waitzkin, F. R. Witney, A. Salemme and A. V. Furano: Structure of the highly repeated, long interspersed DNA family (LINE or L1Rn) of the rat. Mol Cell Biol, 6 (2), 411-24 (1986)) (Pubitemid 16158115)
90. A. V. Furano, S. M. Robb and F. T. Robb: The structure of the regulatory region of the rat L1 (L1Rn, long interspersed repeated) DNA family of transposable elements. Nucleic Acids Res, 16 (19), 9215-31 (1988))
91. D. D. Loeb, R. W. Padgett, S. C. Hardies, W. R. Shehee, M. B. Comer, M. H. Edgell and C. A. Hutchison, 3rd: The sequence of a large L1Md element reveals a tandemly repeated 5' end and several features found in retrotransposons. Mol Cell Biol, 6 (1), 168-82 (1986)) (Pubitemid 16182096)
92. W. R. Shehee, S. F. Chao, D. D. Loeb, M. B. Comer, C. A. Hutchison, 3rd and M. H. Edgell: Determination of a functional ancestral sequence and definition of the 5' end of A-type mouse L1 elements. J Mol Biol, 196 (4), 757-67 (1987))
93. R. W. Padgett, C. A. Hutchison, 3rd and M. H. Edgell: The F-type 5' motif of mouse L1 elements: a major class of L1 termini similar to the A-type in organization but unrelated in sequence. Nucleic Acids Res, 16 (2), 739-49 (1988))
94. T. Tchenio, E. Segal-Bendirdjian and T. Heidmann: Generation of processed pseudogenes in murine cells. EMBO J, 12 (4), 1487-97 (1993)) (Pubitemid 23112802)
95. D. M. Woodcock, C. B. Lawler, M. E. Linsenmeyer, J. P. Doherty and W. D. Warren: Asymmetric methylation in the hypermethylated CpG promoter region of the human L1 retrotransposon. J Biol Chem, 272 (12), 7810-6 (1997))
96. G. Alves, A. Tatro and T. Fanning: Differential methylation of human LINE-1 retrotransposons in malignant cells. Gene, 176 (1-2), 39-44 (1996)) (Pubitemid 26375750)
97. K. Hata and Y. Sakaki: Identification of critical CpG sites for repression of L1 transcription by DNA methylation. Gene, 189 (2), 227-34 (1997)) (Pubitemid 27187196)
98. A. P. Bird and A. P. Wolffe: Methylation-induced repression - belts, braces, and chromatin. Cell, 99 (5), 451-4 (1999)) (Pubitemid 129746827)
99. F. Yu, N. Zingler, G. Schumann and W. H. Stratling: Methyl-CpG-binding protein 2 represses LINE-1 expression and retrotransposition but not Alu transcription. Nucleic Acids Res, 29 (21), 4493-501 (2001)) (Pubitemid 33064789)
100. A. R. Muotri, M. C. Marchetto, N. G. Coufal, R. Oefner, G. Yeo, K. Nakashima and F. H. Gage: L1 retrotransposition in neurons is modulated by MeCP2. Nature, 468 (7322), 443-6 (2010))
101. H. D. Morgan, F. Santos, K. Green, W. Dean and W. Reik: Epigenetic reprogramming in mammals. Hum Mol Genet, 14 Spec No 1, R47-58 (2005)) (Pubitemid 40542620)
102. V. Chapman, L. Forrester, J. Sanford, N. Hastie and J. Rossant: Cell lineage-specific undermethylation of mouse repetitive DNA. Nature, 307 (5948), 284-6 (1984)) (Pubitemid 14128975)
103. J. P. Sanford, H. J. Clark, V. M. Chapman and J. Rossant: Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse. Genes Dev, 1 (10), 1039-46 (1987))
104. J. Sanford, L. Forrester, V. Chapman, A. Chandley and N. Hastie: Methylation patterns of repetitive DNA sequences in germ cells of Mus musculus. Nucleic Acids Res, 12 (6), 2823-36 (1984))
105. M. Monk, M. Boubelik and S. Lehnert: Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development, 99 (3), 371-82 (1987)) (Pubitemid 17048855)
106. S. K. Howlett and W. Reik: Methylation levels of maternal and paternal genomes during preimplantation development. Development, 113 (1), 119-27 (1991))
107. N. Lane, W. Dean, S. Erhardt, P. Hajkova, A. Surani, J. Walter and W. Reik: Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse. Genesis, 35 (2), 88-93 (2003)) (Pubitemid 36330631)
108. P. Hajkova, S. Erhardt, N. Lane, T. Haaf, O. El-Maarri, W. Reik, J. Walter and M. A. Surani: Epigenetic reprogramming in mouse primordial germ cells. Mech Dev, 117 (1-2), 15-23 (2002)) (Pubitemid 36158711)
109. D. J. Lees-Murdock, M. De Felici and C. P. Walsh: Methylation dynamics of repetitive DNA elements in the mouse germ cell lineage. Genomics, 82 (2), 230-7 (2003)) (Pubitemid 36808623)
110. S. Kuramochi-Miyagawa, T. Watanabe, K. Gotoh, Y. Totoki, A. Toyoda, M. Ikawa, N. Asada, K. Kojima, Y. Yamaguchi, T. W. Ijiri, K. Hata, E. Li, Y. Matsuda, T. Kimura, M. Okabe, Y. Sakaki, H. Sasaki and T. Nakano: DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev, 22 (7), 908-17 (2008)) (Pubitemid 351482844)
111. Y. Kato, M. Kaneda, K. Hata, K. Kumaki, M. Hisano, Y. Kohara, M. Okano, E. Li, M. Nozaki and H. Sasaki: Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse. Hum Mol Genet, 16 (19), 2272-80 (2007)) (Pubitemid 47423893)
112. M. Reuter, S. Chuma, T. Tanaka, T. Franz, A. Stark and R. S. Pillai: Loss of the Mili-interacting Tudor domaincontaining protein-1 activates transposons and alters the Mili-associated small RNA profile. Nat Struct Mol Biol, 16 (6), 639-46 (2009))
113. D. Bourc'his and T. H. Bestor: Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature, 431 (7004), 96-9 (2004)) (Pubitemid 39215115)
114. A. R. Bellve, J. C. Cavicchia, C. F. Millette, D. A. O'Brien, Y. M. Bhatnagar and M. Dym: Spermatogenic cells of the prepuberal mouse. Isolation and morphological characterization. J Cell Biol, 74 (1), 68-85 (1977)) (Pubitemid 8141486)
115. B. R. Nebel, A. P. Amarose and E. M. Hacket: Calendar of gametogenic development in the prepuberal male mouse. Science, 134, 832-3 (1961))
116. H. Sasaki and Y. Matsui: Epigenetic events in mammalian germ-cell development: reprogramming and beyond. Nat Rev Genet, 9 (2), 129-40 (2008))
117. S. K. Ooi, A. H. O'Donnell and T. H. Bestor: Mammalian cytosine methylation at a glance. J Cell Sci, 122 (Pt 16), 2787-91 (2009))
118. T. Thomson and H. Lin: The biogenesis and function of PIWI proteins and piRNAs: progress and prospect. Annu Rev Cell Dev Biol, 25, 355-76 (2009))
119. A. A. Aravin, R. Sachidanandam, D. Bourc'his, C. Schaefer, D. Pezic, K. F. Toth, T. Bestor and G. J. Hannon: A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell, 31 (6), 785-99 (2008))
120. A. A. Aravin, R. Sachidanandam, A. Girard, K. Fejes-Toth and G. J. Hannon: Developmentally regulated piRNA clusters implicate MILI in transposon control. Science, 316 (5825), 744-7 (2007)) (Pubitemid 46717682)
121. M. A. Carmell, A. Girard, H. J. van de Kant, D. Bourc'his, T. H. Bestor, D. G. de Rooij and G. J. Hannon: MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev Cell, 12 (4), 503-14 (2007)) (Pubitemid 46523643)
122. M. Shoji, T. Tanaka, M. Hosokawa, M. Reuter, A. Stark, Y. Kato, G. Kondoh, K. Okawa, T. Chujo, T. Suzuki, K. Hata, S. L. Martin, T. Noce, S. Kuramochi-Miyagawa, T. Nakano, H. Sasaki, R. S. Pillai, N. Nakatsuji and S. Chuma: The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev Cell, 17 (6), 775-87 (2009))
123. L. Ma, G. M. Buchold, M. P. Greenbaum, A. Roy, K. H. Burns, H. Zhu, D. Y. Han, R. A. Harris, C. Coarfa, P. H. Gunaratne, W. Yan and M. M. Matzuk: GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet, 5 (9), e1000635 (2009))
124. T. Yoshimura, S. Toyoda, S. Kuramochi-Miyagawa, T. Miyazaki, S. Miyazaki, F. Tashiro, E. Yamato, T. Nakano and J. Miyazaki: Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC Zn-finger motif, is involved in spermatogenesis and retrotransposon suppression in murine testes. Dev Biol, 335 (1), 216-27 (2009))
125. K. Zheng, J. Xiol, M. Reuter, S. Eckardt, N. A. Leu, K. J. McLaughlin, A. Stark, R. Sachidanandam, R. S. Pillai and P. J. Wang: Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwiinteracting RNA (piRNA) pathway. Proc Natl Acad Sci U S A, 107 (26), 11841-6 (2010))
126. R. J. Frost, F. K. Hamra, J. A. Richardson, X. Qi, R. Bassel-Duby and E. N. Olson: MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs. Proc Natl Acad Sci U S A, 107 (26), 11847-52 (2010))
127. Y. L. Chiu and W. C. Greene: The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements. Annu Rev Immunol, 26, 317-53 (2008)) (Pubitemid 351600379)
128. H. P. Bogerd, H. L. Wiegand, A. E. Hulme, J. L. Garcia-Perez, K. S. O'Shea, J. V. Moran and B. R. Cullen: Cellular inhibitors of long interspersed element 1 and Alu retrotransposition. Proc Natl Acad Sci U S A, 103 (23), 8780-5 (2006)) (Pubitemid 43878096)
129. H. Chen, C. E. Lilley, Q. Yu, D. V. Lee, J. Chou, I. Narvaiza, N. R. Landau and M. D. Weitzman: APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons. Curr Biol, 16 (5), 480-5 (2006)) (Pubitemid 43343708)
130. M. Kinomoto, T. Kanno, M. Shimura, Y. Ishizaka, A. Kojima, T. Kurata, T. Sata and K. Tokunaga: All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition. Nucleic Acids Res, 35 (9), 2955-64 (2007)) (Pubitemid 47073634)
131. H. Muckenfuss, M. Hamdorf, U. Held, M. Perkovic, J. Lower, K. Cichutek, E. Flory, G. G. Schumann and C. Munk: APOBEC3 proteins inhibit human LINE-1 retrotransposition. J Biol Chem, 281 (31), 22161-72 (2006))
132. M. D. Stenglein and R. S. Harris: APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism. J Biol Chem, 281 (25), 16837-41 (2006))
133. A. M. Niewiadomska, C. Tian, L. Tan, T. Wang, P. T. Sarkis and X. F. Yu: Differential inhibition of long interspersed element 1 by APOBEC3 does not correlate with high-molecular-mass-complex formation or P-body association. J Virol, 81 (17), 9577-83 (2007)) (Pubitemid 47311504)
134. C. Esnault, O. Heidmann, F. Delebecque, M. Dewannieux, D. Ribet, A. J. Hance, T. Heidmann and O. Schwartz: APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses. Nature, 433 (7024), 430-3 (2005)) (Pubitemid 40203324)
135. D. A. MacDuff, Z. L. Demorest and R. S. Harris: AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity. Nucleic Acids Res, 37 (6), 1854-67 (2009))
136. T. Ikeda, K. H. Abd El Galil, K. Tokunaga, K. Maeda, T. Sata, N. Sakaguchi, T. Heidmann and A. Koito: Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons. Nucleic Acids Res (2011))
137. G. G. Schumann: APOBEC3 proteins: major players in intracellular defence against LINE-1-mediated retrotransposition. Biochem Soc Trans, 35 (Pt 3), 637-42 (2007)) (Pubitemid 46975093)
138. D. B. Stetson, J. S. Ko, T. Heidmann and R. Medzhitov: Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell, 134 (4), 587-98 (2008))
139. C. Popp, W. Dean, S. Feng, S. J. Cokus, S. Andrews, M. Pellegrini, S. E. Jacobsen and W. Reik: Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature, 463 (7284), 1101-5 (2010))
140. M. Ghildiyal and P. D. Zamore: Small silencing RNAs: an expanding universe. Nat Rev Genet, 10 (2), 94-108 (2009))
141. N. Yang and H. H. Kazazian, Jr.: L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells. Nat Struct Mol Biol, 13 (9), 763-71 (2006)) (Pubitemid 44338769)
142. H. S. Soifer and J. J. Rossi: Small interfering RNAs to the rescue: blocking L1 retrotransposition. Nat Struct Mol Biol, 13 (9), 758-9 (2006)) (Pubitemid 44338767)
143. C. Kanellopoulou, S. A. Muljo, A. L. Kung, S. Ganesan, R. Drapkin, T. Jenuwein, D. M. Livingston and K. Rajewsky: Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev, 19 (4), 489-501 (2005)) (Pubitemid 40256280)
144. K. Hayashi, S. M. Chuva de Sousa Lopes, M. Kaneda, F. Tang, P. Hajkova, K. Lao, D. O'Carroll, P. P. Das, A. Tarakhovsky, E. A. Miska and M. A. Surani: MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis. PLoS One, 3 (3), e1738 (2008)
145. S. L. Martin, D. Branciforte, D. Keller and D. L. Bain: Trimeric structure for an essential protein in L1 retrotransposition. Proc Natl Acad Sci U S A, 100 (24), 13815-20 (2003))
146. M. Xu, Y. You, P. Hunsicker, T. Hori, C. Small, M. D. Griswold and N. B. Hecht: Mice deficient for a small cluster of Piwi-interacting RNAs implicate Piwi-interacting RNAs in transposon control. Biol Reprod, 79 (1), 51-7 (2008)) (Pubitemid 351931041)
147. H. Hohjoh and M. F. Singer: Cytoplasmic ribonucleoprotein complexes containing human LINE-1 protein and RNA. EMBO J, 15 (3), 630-9 (1996)) (Pubitemid 26044576)
148. H. Hohjoh and M. F. Singer: Ribonuclease and high salt sensitivity of the ribonucleoprotein complex formed by the human LINE-1 retrotransposon. J Mol Biol, 271 (1), 7-12 (1997)) (Pubitemid 27338763)
149. J. L. Goodier, L. Zhang, M. R. Vetter and H. H. Kazazian, Jr.: LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex. Mol Cell Biol, 27 (18), 6469-83 (2007)) (Pubitemid 47435752)
150. J. L. Goodier, P. K. Mandal, L. Zhang and H. H. Kazazian, Jr.: Discrete subcellular partitioning of human retrotransposon RNAs despite a common mechanism of genome insertion. Hum Mol Genet, 19 (9), 1712-25 (2010))
151. A. J. Doucet, A. E. Hulme, E. Sahinovic, D. A. Kulpa, J. B. Moldovan, H. C. Kopera, J. N. Athanikar, M. Hasnaoui, A. Bucheton, J. V. Moran and N. Gilbert: Characterization of LINE-1 ribonucleoprotein particles. PLoS Genet, 6 (10), e1001150 (2010))
152. J. R. Buchan and R. Parker: Eukaryotic stress granules: the ins and outs of translation. Mol Cell, 36 (6), 932-41 (2009))
153. E. M. Ostertag, R. J. DeBerardinis, J. L. Goodier, Y. Zhang, N. Yang, G. L. Gerton and H. H. Kazazian, Jr.: A mouse model of human L1 retrotransposition. Nat Genet, 32 (4), 655-60 (2002)) (Pubitemid 35435180)
154. E. T. Prak, A. W. Dodson, E. A. Farkash and H. H. Kazazian, Jr.: Tracking an embryonic L1 retrotransposition event. Proc Natl Acad Sci U S A, 100 (4), 1832-7 (2003))
155. D. V. Babushok, E. M. Ostertag, C. E. Courtney, J. M. Choi and H. H. Kazazian, Jr.: L1 integration in a transgenic mouse model. Genome Res, 16 (2), 240-50 (2006)) (Pubitemid 43200273)
156. W. An, J. S. Han, C. M. Schrum, A. Maitra, F. Koentgen and J. D. Boeke: Conditional activation of a single-copy L1 transgene in mice by Cre. Genesis, 46 (7), 373-83 (2008))
157. W. An, J. S. Han, S. J. Wheelan, E. S. Davis, C. E. Coombes, P. Ye, C. Triplett and J. D. Boeke: Active retrotransposition by a synthetic L1 element in mice. Proc Natl Acad Sci U S A, 103 (49), 18662-7 (2006))
158. H. Kano, I. Godoy, C. Courtney, M. R. Vetter, G. L. Gerton, E. M. Ostertag and H. H. Kazazian, Jr.: L1 retrotransposition occurs mainly in embryogenesis and creates somatic mosaicism. Genes Dev, 23 (11), 1303-12 (2009))
159. A. R. Muotri, C. Zhao, M. C. Marchetto and F. H. Gage: Environmental influence on L1 retrotransposons in the adult hippocampus. Hippocampus, 19 (10), 1002-7 (2009))
160. J. M. Rosser and W. An: Repeat-induced gene silencing of L1 transgenes is correlated with differential promoter methylation. Gene, 456 (1-2), 15-23 (2010))
161. M. L. Kimberland, V. Divoky, J. Prchal, U. Schwahn, W. Berger and H. H. Kazazian, Jr.: Full-length human L1 insertions retain the capacity for high frequency retrotransposition in cultured cells. Hum Mol Genet, 8 (8), 1557-60 (1999)) (Pubitemid 29374091)
162. B. Brouha, C. Meischl, E. Ostertag, M. de Boer, Y. Zhang, H. Neijens, D. Roos and H. H. Kazazian, Jr.: Evidence consistent with human L1 retrotransposition in maternal meiosis I. Am J Hum Genet, 71 (2), 327-36 (2002)) (Pubitemid 34800249)
163. D. C. Lie, H. Song, S. A. Colamarino, G. L. Ming and F. H. Gage: Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu Rev Pharmacol Toxicol, 44, 399-421 (2004)) (Pubitemid 38263847)
164. J. A. van den Hurk, I. C. Meij, M. C. Seleme, H. Kano, K. Nikopoulos, L. H. Hoefsloot, E. A. Sistermans, I. J. de Wijs, A. Mukhopadhyay, A. S. Plomp, P. T. de Jong, H. H. Kazazian and F. P. Cremers: L1 retrotransposition can occur early in human embryonic development. Hum Mol Genet, 16 (13), 1587-92 (2007)) (Pubitemid 47050672)
165. K. Hayashi, S. M. de Sousa Lopes and M. A. Surani: Germ cell specification in mice. Science, 316 (5823), 394-6 (2007)) (Pubitemid 46651475)
166. B. Plusa, A. Piliszek, S. Frankenberg, J. Artus and A. K. Hadjantonakis: Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst. Development, 135 (18), 3081-91 (2008))
167. J. L. Garcia-Perez, M. Morell, J. O. Scheys, D. A. Kulpa, S. Morell, C. C. Carter, G. D. Hammer, K. L. Collins, K. S. O'Shea, P. Menendez and J. V. Moran: Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells. Nature, 466 (7307), 769-73 (2010))
168. N. G. Coufal, J. L. Garcia-Perez, G. E. Peng, G. W. Yeo, Y. Mu, M. T. Lovci, M. Morell, K. S. O'Shea, J. V. Moran and F. H. Gage: L1 retrotransposition in human neural progenitor cells. Nature, 460 (7259), 1127-31 (2009))
169. N. C. Lau, A. G. Seto, J. Kim, S. Kuramochi-Miyagawa, T. Nakano, D. P. Bartel and R. E. Kingston: Characterization of the piRNA complex from rat testes. Science, 313 (5785), 363-7 (2006)) (Pubitemid 44480963)
170. R. D. Palmiter and R. L. Brinster: Germ-line transformation of mice. Annu Rev Genet, 20, 465-99 (1986))
171. D. I. Martin and E. Whitelaw: The vagaries of variegating transgenes. Bioessays, 18 (11), 919-23 (1996)) (Pubitemid 26420249)
172. F. F. Assaad, K. L. Tucker and E. R. Signer: Epigenetic repeat-induced gene silencing (RIGS) in Arabidopsis. Plant Mol Biol, 22 (6), 1067-85 (1993))
173. D. Garrick, S. Fiering, D. I. Martin and E. Whitelaw: Repeat-induced gene silencing in mammals. Nat Genet, 18 (1), 56-9 (1998)) (Pubitemid 28027880)