Stimulated erythropoiesis with secondary iron loading leads to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression

British Journal of Haematology

Volumn 157, Issue 5, 2012, Pages 615-626

  Frazer, David M ^a   Wilkins, Sarah J ^a   Darshan, Deepak ^a   Badrick, Alison C ^a   McLaren, Gordon D ^b   Anderson, Gregory J ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

thalassaemia; BMP6; Iron; Phenylhydrazine; SMAD

Indexed keywords

BONE MORPHOGENETIC PROTEIN 6; HEPCIDIN; IRON; LIVER PROTEIN; MESSENGER RNA; PHENYLHYDRAZINE; PROTEIN HAMP; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA THALASSEMIA INTERMEDIA; CONTROLLED STUDY; ERYTHROPOIESIS; EXPERIMENTAL MODEL; FEMALE; IRON LIVER LEVEL; LIVER LEVEL; LOADING TEST; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THALASSEMIA INTERMEDIA;

ANEMIA, HEMOLYTIC; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BETA-THALASSEMIA; BONE MORPHOGENETIC PROTEIN 6; DISEASE MODELS, ANIMAL; ERYTHROPOIESIS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GROWTH DIFFERENTIATION FACTOR 15; HEMOLYSIS; IRON OVERLOAD; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHENYLHYDRAZINES; PHOSPHORYLATION; RECEPTORS, TRANSFERRIN; SIGNAL TRANSDUCTION; SMAD PROTEINS; SPLEEN; TRANSFERRIN;

EID: 84860842095     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2012.09104.x     Document Type: Article

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