Iron loading and overloading due to ineffective erythropoiesis

Advances in Hematology

Volumn 2010, Issue , 2010, Pages

  Miller, Jeffery L ^a   Tanno, Toshihiko ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; GROWTH DIFFERENTIATION FACTOR 15; HEPCIDIN;

ADULT; ANEMIA; BLOOD TRANSFUSION; CELL DIFFERENTIATION; CELL PROLIFERATION; ERYTHROID CELL; ERYTHROPOIESIS; HEMOGLOBIN SYNTHESIS; HUMAN; HYPOXIA; IRON ABSORPTION; IRON BLOOD LEVEL; IRON KINETICS; IRON METABOLISM; IRON OVERLOAD; IRON TRANSPORT; PRIORITY JOURNAL; REVIEW; TISSUE LEVEL;

EID: 77954611973     PISSN: 16879104     EISSN: 16879112     Source Type: Journal    
DOI: 10.1155/2010/358283     Document Type: Review

References (88)

1. Janssen M. C. H., Swinkels D. W., Hereditary haemochromatosis Best Practice and Research: Clinical Gastroenterology 2009 23 2 171 183
2. Andrews N. C., Forging a field: the golden age of iron biology Blood 2008 112 2 219 230
3. Lacombe C., Da Silva J.-L., Bruneval P., Erythropoietin: sites of synthesis and regulation of secretion American Journal of Kidney Diseases 1991 18 4, supplement 1 14 19
4. Semenza G. L., Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis Blood 2009 114 10 2015 2019
5. Miller J. L., Njoroge J. M., Gubin A. N., Rodgers G. P., Prospective identification of erythroid elements in cultured peripheral blood Experimental Hematology 1999 27 4 624 629
6. Hemmaplardh D., Morgan E. H., The role of endocytosis in transferrin uptake by reticulocytes and bone marrow cells British Journal of Haematology 1977 36 1 85 96 (Pubitemid 8201072)
7. Klausner R. D., Ashwell G., van Renswoude J., Harford J. B., Bridges K. R., Binding of apotransferrin to K562 cells: explanation of the transferrin cycle Proceedings of the National Academy of Sciences of the United States of America 1983 80 8 2263 2266
8. Grant B. D., Donaldson J. G., Pathways and mechanisms of endocytic recycling Nature Reviews Molecular Cell Biology 2009 10 9 597 608
9. Schranzhofer M., Schifrer M., Cabrera J. A., Remodeling the regulation of iron metabolism during erythroid differentiation to ensure efficient heme biosynthesis Blood 2006 107 10 4159 4167
10. Ahn J., Johnstone R. M., Origin of a soluble truncated transferrin receptor Blood 1993 81 9 2442 2451
11. Xenakis A., Marcu I., Radioisotope investigations in some hemolytic disorders of children Revue Roumaine de Medecine 1977 15 1 79 83
12. Ricketts C., Cavill I., Ferrokinetics: methods and interpretation Clinical Nuclear Medicine 1978 3 4 159 164
13. Huff R. L., Elmlinger P. J., Garcia J. F., Oda J. M., Cockrell M. C., Lawrence J. H., Ferrokinetics in normal persons and in patients having various erythropoietic disorders The Journal of Clinical Investigation 1951 30 12:2 1512 1526
14. Schrier S. L., Pathophysiology of thalassemia Current Opinion in Hematology 2002 9 2 123 126
15. Centis F., Tabellini L., Lucarelli G., The importance of erythroid expansion in determining the extent of apoptosis in erythroid precursors in patients with -thalassemia major Blood 2000 96 10 3624 3629
16. Sansone G., Masera G., Cantu-Rajnoldi A., Terzoli S., An unclassified case of congenital dyserythropoietic anaemia with a severe neonatal onset Acta Haematologica 1992 88 1 41 45
17. Ineffective erythropoiesis The Lancet 1973 1 7813 1164 1165
18. Di Matteo R., Liuzza F., Manicone P. F., Bone and maxillofacial abnormalities in thalassemia: a review of the literature Journal of Biological Regulators and Homeostatic Agents 2008 22 4 211 216
19. Aizawa S., Kohdera U., Hiramoto M., Ineffective erythropoiesis in the spleen of a patient with pyruvate kinase deficiency American Journal of Hematology 2003 74 1 68 72
20. Pippard M. J., Callender S. T., Warner G. T., Weatherall D. J., Iron absorption and loading in -thalassaemia intermedia The Lancet 1979 2 8147 819 821
21. Bowman W. D. Jr., Abnormal (ringed) sideroblasts in various hematologic and non-hematologic disorders Blood 1961 18 662 671
22. Merchant S. H., Gonchoroff N. J., Hutchison R. E., Apoptotic index by annexin V flow cytometry: adjunct to morphologic and cytogenetic diagnosis of myelodysplastic syndromes Cytometry Part B 2001 46 1 28 32
23. Camaschella C., Recent advances in the understanding of inherited sideroblastic anaemia British Journal of Haematology 2008 143 1 27 38
24. Fontenay M., Cathelin S., Amiot M., Gyan E., Solary E., Mitochondria in hematopoiesis and hematological diseases Oncogene 2006 25 34 4757 4767
25. Sheftel A. D., Richardson D. R., Prchal J., Ponka P., Mitochondrial iron metabolism and sideroblastic anemia Acta Haematologica 2009 122 2-3 120 133
26. Renella R., Wood W. G., The congenital dyserythropoietic anemias Hematology/Oncology Clinics of North America 2009 23 2 283 306
27. Schwarz K., Iolascon A., Verissimo F., Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II Nature Genetics 2009 41 8 936 940
28. Zanella A., Colombo M. B., Miniero R., Perroni L., Meloni T., Sirchia G., Erythrocyte pyruvate kinase deficiency: 11 new cases British Journal of Haematology 1988 69 3 399 404
29. Zanella A., Bianchi P., Fermo E., Pyruvate kinase deficiency Haematologica 2007 92 6 721 723
30. Finkenstedt A., Bianchi P., Theurl I., Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency British Journal of Haematology 2009 144 5 789 793
31. Iancu T. C., Iron overload Molecular Aspects of Medicine 1983 6 1 1 100
32. Wu C. J., Krishnamurti L., Kutok J. L., Evidence for ineffective erythropoiesis in severe sickle cell disease Blood 2005 106 10 3639 3645
33. Samson D., Halliday D., Chanarin I., Reversal of ineffective erythropoiesis in pernicious anaemia following vitamin B12 therapy British Journal of Haematology 1977 35 2 217 224
34. Koury M. J., Ponka P., New insights into erythropoiesis: the roles of folate, vitamin B 12, and iron Annual Review of Nutrition 2004 24 105 131
35. Smith D. W. E., The molecular biology of mammalian hemoglobin synthesis Annals of Clinical and Laboratory Science 1980 10 2 116 122
36. Goodnough L. T., Skikne B., Brugnara C., Erythropoietin, iron, and erythropoiesis Blood 2000 96 3 823 833
37. Park C. H., Valore E. V., Waring A. J., Ganz T., Hepcidin, a urinary antimicrobial peptide synthesized in the liver Journal of Biological Chemistry 2001 276 11 7806 7810
38. Nemeth E., Tuttle M. S., Powelson J., Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization Science 2004 306 5704 2090 2093
39. De Domenico I., Lo E., Ward D. M., Kaplan J., Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2 Proceedings of the National Academy of Sciences of the United States of America 2009 106 10 3800 3805
40. Grebenchtchikov N., Geurts-Moespot A. J., Kroot J. J. C., High-sensitive radioimmunoassay for human serum hepcidin British Journal of Haematology 2009 146 3 317 325
41. Kemna E. H. J. M., Kartikasari A. E. R., van Tits L. J. H., Pickkers P., Tjalsma H., Swinkels D. W., Regulation of hepcidin: insights from biochemical analyses on human serum samples Blood Cells, Molecules, and Diseases 2008 40 3 339 346
42. Theurl I., Aigner E., Theurl M., Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications Blood 2009 113 21 5277 5286
43. Auerbach M., Coyne D., Ballard H., Intravenous iron: from anathema to standard of care American Journal of Hematology 2008 83 7 580 588
44. Nicolas G., Chauvet C., Viatte L., The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation Journal of Clinical Investigation 2002 110 7 1037 1044
45. Muoz M., Villar I., Garca-Erce J. A., An update on iron physiology World Journal of Gastroenterology 2009 15 37 4617 4626
46. Finch C., Regulators of iron balance in humans Blood 1994 84 6 1697 1702
47. Bothwell T. H., Hurutado A. V., Donohue D. M., Finch C. A., Erythrokinetics. IV. The plasma iron turnover as a measure of erythropoiesis Blood 1957 12 5 409 427
48. Cazzola M., Huebers H. A., Sayers M. H., MacPhail A. P., Eng M., Finch C. A., Transferrin saturation, plasma iron turnover, and transferrin uptake in normal humans Blood 1985 66 4 935 939
49. Lin L., Valore E. V., Nemeth E., Goodnough J. B., Gabayan V., Ganz T., Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4 Blood 2007 110 6 2182 2189
50. Astaldi G., Burgio G. R., Priolisi A., Evaluation of plasma iron turnover in Cooley's anemia Annals of the New York Academy of Sciences 1969 165 1 111 125
51. Peyssonnaux C., Nizet V., Johnson R. S., Role of the hypoxia inducible factors in iron metabolism Cell Cycle 2008 7 1 28 32
52. Peyssonnaux C., Zinkernagel A. S., Schuepbach R. A., Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs) Journal of Clinical Investigation 2007 117 7 1926 1932
53. Braliou G. G., Verga Falzacappa M. V., Chachami G., Casanovas G., Muckenthaler M. U., Simos G., 2-oxoglutarate-dependent oxygenases control hepcidin gene expression Journal of Hepatology 2008 48 5 801 810
54. Babitt J. L., Huang F. W., Wrighting D. M., Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression Nature Genetics 2006 38 5 531 539
55. Kuninger D., Kuns-Hashimoto R., Kuzmickas R., Rotwein P., Complex biosynthesis of the muscle-enriched iron regulator RGMc Journal of Cell Science 2006 119 16 3273 3283
56. Lin L., Nemeth E., Goodnough J. B., Thapa D. R., Gabayan V., Ganz T., Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site Blood Cells, Molecules, and Diseases 2008 40 1 122 131
57. Silvestri L., Pagani A., Camaschella C., Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis Blood 2008 111 2 924 931
58. Lin L., Goldberg Y. P., Ganz T., Competitive regulation of hepcidin mRNAby soluble and cell-associated hemojuvelin Blood 2005 106 8 2884 2889
59. Babitt J. L., Huang F. W., Xia Y., Sidis Y., Andrews N. C., Lin H. Y., Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance Journal of Clinical Investigation 2007 117 7 1933 1939
60. Vuji Spasi M., Kiss J., Herrmann T., Hfe acts in hepatocytes to prevent hemochromatosis Cell Metabolism 2008 7 2 173 178
61. Kattamis A., Papassotiriou I., Palaiologou D., The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major Haematologica 2006 91 6 809 812
62. Pak M., Lopez M. A., Gabayan V., Ganz T., Rivera S., Suppression of hepcidin during anemia requires erythropoietic activity Blood 2006 108 12 3730 3735
63. Vokurka M., Krijt J., ulc K., Neas E., Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis Physiological Research 2006 55 6 667 674
64. Pinto J. P., Ribeiro S., Pontes H., Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBP Blood 2008 111 12 5727 5733
65. Weizer-Stern O., Adamsky K., Amariglio N., Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera British Journal of Haematology 2006 135 1 129 138
66. Wang R.-H., Li C., Xu X., A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression Cell Metabolism 2005 2 6 399 409
67. Tanno T., Bhanu N. V., Oneal P. A., High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin Nature Medicine 2007 13 9 1096 1101
68. Yang H., Filipovic Z., Brown D., Breit S. N., Vassilev L. T., Macrophage inhibitory cytokine-1: a novel biomarker for p53 pathway activation Molecular Cancer Therapeutics 2003 2 10 1023 1029
69. Tamary H., Shalev H., Perez-Avraham G., Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I Blood 2008 112 13 5241 5244
70. Ramirez J.-M., Schaad O., Durual S., Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts British Journal of Haematology 2009 144 2 251 262
71. Lakhal S., Talbot N. P., Crosby A., Regulation of growth differentiation factor 15 expression by intracellular iron Blood 2009 113 7 1555 1563
72. Mast A. E., Foster T. M., Pinder H. L., Behavioral, biochemical, and genetic analysis of iron metabolism in high-intensity blood donors Transfusion 2008 48 10 2197 2204
73. Kanda J., Mizumoto C., Kawabata H., Serum hepcidin level and erythropoietic activity after hematopoietic stem cell transplantation Haematologica 2008 93 10 1550 1554
74. Ashby D. R., Gale D. P., Busbridge M., Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin Haematologica 2010 95 3 505 508
75. Chang C., Holtzman D. A., Chau S., Twisted gastrulation can function as a BMP antagonist Nature 2001 410 6827 483 487
76. Ross J. J., Shimmi O., Vilmos P., Twisted is a conserved extracellular BMP antagonist Nature 2001 410 6827 479 483
77. Tanno T., Porayette P., Sripichai O., Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells Blood 2009 114 1 181 186
78. May C., Rivella S., Chadburn A., Sadelain M., Successful treatment of murine -thalassemia intermedia by transfer of the human -globin gene Blood 2002 99 6 1902 1908
79. Ginzburg Y. Z., Rybicki A. C., Suzuka S. M., Exogenous iron increases hemoglobin in -thalassemic mice Experimental Hematology 2009 37 2 172 183
80. R'zik S., Loo M., Beguin Y., Reticulocyte transferrin receptor (TfR) expression and contribution to soluble TfR levels Haematologica 2001 86 3 244 251
81. Weiss G., Houston T., Kastner S., Jhrer K., Grnewald K., Brock J. H., Regulation of cellular iron metabolism by erythropoietin: activation of iron-regulatory protein and upregulation of transferrin receptor expression in erythroid cells Blood 1997 89 2 680 687
82. Cazzola M., Beguin Y., Bergamaschi G., Soluble transferrin receptor as a potential determinant of iron loading in congenital anaemias due to ineffective erythropoiesis British Journal of Haematology 1999 106 3 752 755
83. Metzgeroth G., Rose P. L., Kuhn C., The soluble transferrin receptor in dysplastic erythropoiesis in myelodysplastic syndrome European Journal of Haematology 2007 79 1 8 16
84. Flanagan J. M., Peng H., Wang L., Soluble transferrin receptor-1 levels in mice do not affect iron absorption Acta Haematologica 2006 116 4 249 254
85. Cazzola M., Della Porta M. G., Malcovati L., Clinical relevance of anemia and transfusion iron overload in myelodysplastic syndromes Hematology 2008 166 175
86. Rivella S., Ineffective erythropoiesis and thalassemias Current Opinion in Hematology 2009 16 3 187 194
87. Solomon L. R., Hillman R. S., Finch C. A., Serum ferritin in refractory anemias Acta Haematologica 1981 66 1 1 5
88. Greenberg P. L., Young N. S., Gattermann N., Myelodysplastic syndromes Hematology 2002 136 161