Loss of bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy

Circulation Research

Volumn 103, Issue 12, 2008, Pages 1359-1362

  Mitchell Jordan, Scherise A ^a   Holopainen, Tanja ^c   Ren, Shuxun ^a   Wang, Sujing ^a   Warburton, Sarah ^a   Zhang, Michael J ^a   Alitalo, Kari ^c   Wang, Yibin ^a,b   Vondriska, Thomas M ^a,b  

^a BH 557A CHS   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BMX PROTEIN; PROTEIN; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; BMX PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA CONSTRICTION; ARTICLE; CELL LEVEL; CONTROLLED STUDY; HEART DEVELOPMENT; HEART EJECTION FRACTION; HEART HYPERTROPHY; HEART VENTRICLE HYPERTROPHY; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; BLOOD PRESSURE; CARDIOMEGALY; COMPARATIVE STUDY; GENETICS; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

ANIMALS; BLOOD PRESSURE; CARDIOMEGALY; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; PROTEIN-TYROSINE KINASES;

EID: 58149385416     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.186577     Document Type: Article

References (18)

1. Tamagnone L, Lahtinen I, Mustonen T, Virtaneva K, Francis F, Mus-catelli F, Alitalo R, Smith CI, Larsson C, Alitalo K. BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. Oncogene. 1994;9:3683-3688.
2. Qiu Y, Robinson D, Pretlow TG, Kung HJ. Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells. Proc Natl Acad Sci USA. 1998;95: 3644-3649.
3. Tsukada S, Saffran DC, Rawlings DJ, Parolini O, Allen RC, Klisak I, Sparkes RS, Kubagawa H, Mohandas T, Quan S, Belmont JW, Cooper MD, Conley ME, Witte ON. Deficient expression of a B-cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell. 1993;72: 279-290.
4. Vetrie D, Vorechovsky I, Sideras P, Holland J, Davies A, Flinter F, Hammarstrom L, Kinnon C, Levinsky R, Bobrow M, Smith CIE, Bentley DR. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature. 1993;361:226-233.
5. Rajantie I, Ekman N, Iljin K, Arighi E, Gunji Y, Kaukonen J, Palotie A, Dewerchin M, Carmeliet P, Alitalo K. Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium. Mol Cell Biol. 2001;21: 4647-4655.
6. He Y, Luo Y, Tang SB, Rajantie I, Salven P, Heil M, Zhang R, Luo DH, Li XH, Chi HB, Yu J, Carmeliet P, Schaper W, Sinusas AJ, Sessa WC, Alitalo K, Min W. Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. J Clin Invest. 2006;116:2344-2355.
7. Ekman N, Lymboussaki A, Vastrik I, Sarvas K, Kaipainen A, Alitalo K. Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries. Circulation. 1997;96:1729-1732.
8. Zhang J, Ping P, Wang GW, Lu M, Pantaleon D, Tang XL, Bolli R, Vondriska TM. Bmx, a member of the Tec family of nonreceptor tyrosine kinases, is a novel participant in pharmacological cardioprotection. Am J Physiol. 2004;287:H2364-H2366.
9. Mathur P, Kaga S, Zhan LJ, Das DK, Maulik N. Potential candidates for ischemic preconditioning-associated vascular growth pathways revealed by antibody array. Am J Physiol. 2005;288:H3006-H3010.
10. Willey CD, Palanisamy AP, Johnston RK, Mani SK, Shiraishi H, Tuxworth WJ, Zile MR, Balasubramanian S, Kuppuswamy D. STAT3 activation in pressure-overloaded feline myocardium: role for integrins and the tyrosine kinase BMX. Int J Biol Sci. 2008;4:184-199.
11. Saharinen P, Ekman N, Sarvas K, Parker P, Alitalo K, Silvennoinen O. The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase Cdelta. Blood. 1997;90: 4341-4353.
12. Chau CH, Clavijo CA, Deng HT, Zhang QZ, Kim KJ, Qiu Y, Le AD, Ann DK. Etk/Bmx mediates expression of stress-induced adaptive genes VEGF, PAI-1, and iNOS via multiple signaling cascades in different cell systems. Am J Physiol. 2005;289:C444-C454.
13. Takimoto E, Champion HC, Li M, Ren S, Rodriguez ER, Tavazzi B, Lazzarino G, Paolocci N, Gabrielson KL, Wang Y, Kass DA. Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load. J Clin Invest. 2005; 115:1221-1231.
14. Vargas L, Nore BF, Berglof A, Heinonen JE, Mattsson PT, Smith CI, Mohamed AJ. Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx. J Biol Chem. 2002;277:9351-9357.
15. Schwartzberg PL, Finkelstein LD, Readinger JA. TEC-family kinases: regulators of T-helper-cell differentiation. Nat Rev Immunol. 2005;5: 284-295.
16. Wu YM, Huang CL, Kung HJ, Huang CY. Proteolytic activation of ETK/Bmx tyrosine kinase by caspases. J Biol Chem. 2001;276: 17672-17678.
17. Shiojima I, Walsh K. Regulation of cardiac growth and coronary angio-genesis by the Akt/PKB signaling pathway. Genes Dev. 2006;20: 3347-3365.
18. Zhang R, Xu Y, Ekman N, Wu Z, Wu J, Alitalo K, Min W. Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phospha-tidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathway. J Biol Chem. 2003;278:51267-51276.