Expression of Etk/Bmx tyrosine kinase in the tumorigenicity of nasopharyngeal epithelium and its relation with EB virus infection and the apoptosis-related protein Bcl-2

Cancer Letters

Volumn 232, Issue 2, 2006, Pages 255-261

  Guo, Linlang ^a,b   Guo, Ying ^a   Xiao, Sha ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bcl 2; Epstein Barr virus; Etk Bmx; Immunohistochemistry; In situ hybridization; Nasopharyngeal carcinoma

Indexed keywords

LATENT MEMBRANE PROTEIN 1; PROTEIN BCL 2; PROTEIN BMX; PROTEIN ETK; PROTEIN TYROSINE KINASE; RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BASAL CELL; CARCINOGENICITY; CONTROLLED STUDY; DYSPLASIA; EPITHELIUM; EPSTEIN BARR VIRUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NASOPHARYNX; NASOPHARYNX CARCINOMA; PHARYNX DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHINOPHARYNGITIS; VIRUS INFECTION;

APOPTOSIS; EPSTEIN-BARR VIRUS INFECTIONS; HUMANS; NASOPHARYNGEAL NEOPLASMS; NASOPHARYNX; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, VIRAL; VIRAL MATRIX PROTEINS;

HUMAN HERPESVIRUS 4;

EID: 31644442039     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.02.028     Document Type: Article

References (24)

1. L. Tamagnone, I. Lahtinen, T. Mustonen, K. Virtaneva, F. Francis, and F. Muscatelli BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2 Oncogene 9 1994 3683 3688
2. C.I. Smith, T.C. Islam, P.T. Mattsson, A.J. Mohamed, B.F. Nore, and M. Vihinen The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species Bioessays 23 2001 436 446
3. Y. Qiu, and H.J. Kung Signaling network of the Btk family kinases Oncogene 19 2000 5651 5661
4. H. Mano Tec family of protein-tyrosine kinases: an overview of their structure and function Cytokine Growth Factor Rev. 10 1999 267 280
5. X. Wen, H.H. Lin, H.M. Shih, H.J. Kung, and D.K. Ann Kinase activation of the non-receptor tyrosine kinase Etk/Bmx alone is sufficient to transactivate STAT-mediated gene expression in salivary and lung epithelial cells J. Biol. Chem. 274 1999 38204 38210
6. D. Robinson, F. He, T. Pretlow, and H.J. Kung A tyrosine kinase profile of prostate carcinoma Proc. Natl Acad. Sci. USA 93 1996 5958 5962
7. L.F. Lee, J. Guan, Y. Qiu, and H.J. Kung Neuropeptide-induced androgen independence in prostate cancer cells: roles of nonreceptor tyrosine kinases Etk/Bmx, Src, and focal adhesion kinase Mol. Cell. Biol. 21 2001 8385 8397
8. Y. Qiu, D. Robinson, T.G. Pretlow, and H.J. Kung Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3′-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells Proc. Natl Acad. Sci. USA 95 1998 3644 3649
9. L.Y. Xue, Y. Qiu, J. He, H.J. Kung, and N.L. Oleinick Etk/Bmx, a PH-domain containing tyrosine kinase, protects prostate cancer cells from apoptosis induced by photodynamic therapy or thapsigargin Oncogene 18 1999 3391 3398
10. K.Y. Chen, L.M. Huang, H.J. Kung, D.K. Ann, and H.M. Shih The role of tyrosine kinase Etk/Bmx in EGF-induced apoptosis of MDA-MB-468 breast cancer cells Oncogene 23 2004 1854 1862
11. R. Bagheri-Yarmand, M. Mandal, A.H. Taludker, R.A. Wang, R.K. Vadlamudi, H.J. Kung, and R. Kumar Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells J. Biol. Chem. 276 2001 29403 29409
12. G. Klein The relationship of the virus to nasopharyngeal carcinoma M.A. Epstein B.G. Aching The Epstein-Barr Virus 1979 Spinger New York, NY 340 350
13. G. Niedoditek, M.L. Hansmann, H. Herbst, L.S. Young, D. Dienemann, and C.A. Hartmann Epstein-Barr virus and carcinoma: undifferentiated carcinomas but not squamous cell carcinomas of the nasopharynx are regularly associated with the virus J. Pathol. 165 1991 17 24
14. R. Pathmanathan, U. Prasad, R.H. Salder, K. Flynn, and N. Raab-Traub Preinvasive neoplasia of nasopharynx: a clonal proliferation of EBV-infected cells N. Engl. J. Med. 333 1995 695 698
15. I. Brooks, Q.Y. Yao, A.B. Rickinson, and L.S. Young Epstein-Barr virus latent gene transcription in nasopharyngeal carcinoma cells: coexpression of EBNA1,LMP1, and LMP2 transcripts J. Virol. 66 1992 2689 2697
16. T.C. Wu, R.B. Mann, J.I. Epstein, E. Macmahon, W.A. Lee, and P. Charache Abundant expression of EBER1 small nuclear RNA in nasopharyngeal carcinoma. A morphologically distinctive target for detection of Epstein-Barr virus in formalin-fixed paraffin-embedded carcinoma specimens Am. J. Pathol. 138 1991 1461 1469
17. G. Niedobitek Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma Mol. Pathol. 53 2000 248 254
18. R. Fahraeus, L. Rymo, J.S. Rhim, and G. Klein Morphological transformation of human keratinocytes expressing the LMP gene of Epstein-Barr viruses Nature (Lond.) 345 1990 447 449
19. J.J. Lu, J.Y. Chen, T.Y. Hsu, W.C. Yu, I.J. Su, and C.S. Yang Cooperative interaction between Bcl-2 and Epstein-Barr virus latent membrane protein 1 in the growth transformation of human epithelial cells J. Gen. Virol. 78 1997 2975 2985
20. C.W. Dawson, A.B. Rickinson, and L.S. Young Epstein-Barr virus latent membrane protein inhibits human epithelial cell differentiation Nature 344 1990 777 780
21. W. Shi, I. Pataki, C. MacMillan, M. Pintilie, D. Payne, and B. O'Sullivan Molecular pathology parameters in human nasopharyngeal carcinoma Cancer 94 2002 1997 2006
22. M.L. Gulley, M.P. Burton, D.C. Allred, J.M. Nicholls, M.B. Amin, J.Y. Ro, and B.G. Schneider Epstein-Barr virus infection is associated with p53 accumulation in nasopharyngeal carcinoma Hum. Pathol. 29 1998 252 259
23. Q.L. Lu, G. Elia, S. Lucas, and J.A. Thomas Bcl-2 proto-oncogene expression in Epstein-Barr virus associated nasopharyngeal carcinoma Int. J. Cancer 53 1993 29 35
24. S. Sarac, M.U. Akyol, B. Kanbur, A. Poyraz, G. Akyol, T. Yilmaz, and A. Sungur Bcl-2 and LMP1 expression in nasopharyngeal carcinomas Am. J. Otolaryngol. 22 2001 377 382