SCOPUS 정보 검색 플랫폼

Volumn 19, Issue 17, 2011, Pages 5117-5124

Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs

(8) Gu, Shuang Xi a He, Qiu Qin a Yang, Shi Qiong a Ma, Xiao Dong a Chen, Fen Er a Clercq, Erik De b Balzarini, Jan b Pannecouque, Christophe b

a FUDAN UNIVERSITY (China)

b REGA INSTITUTE FOR MEDICAL RESEARCH (Belgium)

Author keywords

CH(OH) DAPYs; Diarylpyrimidines; HIV 1 reverse transcriptase; NNRTIs

Indexed keywords

4 [[4 (HYDROXY(2 TOLYL)METHYL) 5 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 (HYDROXY(2 TOLYL)METHYL)PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 (HYDROXY(3 TOLYL)METHYL) 5 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 (HYDROXY(3 TOLYL)METHYL)PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 (HYDROXY(4 TOLYL)METHYL) 5 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 (HYDROXY(4 TOLYL)METHYL)PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 (HYDROXY(PHENYL)METHYL) 5 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(2 BROMOPHENYL)(HYDROXY)METHYL] 5 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(2 BROMOPHENYL)(HYDROXY)METHYL] 6 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(2 BROMOPHENYL)(HYDROXY)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(2 CHLOROPHENYL)(HYDROXY)METHYL] 5 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(2 CHLOROPHENYL)(HYDROXY)METHYL] 6 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(2 FLUOROPHENYL)(HYDROXY)METHYL] 6 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(2 FLUOROPHENYL)(HYDROXY)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(2,5 DIFLUOROPHENYL)(HYDROXY)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(2,5 DIMETHYLPHENYL)(HYDROXY)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(3 FLUOROPHENYL)(HYDROXY)METHYL] 5 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(3 FLUOROPHENYL)(HYDROXY)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(3,4 DICHLOROPHENYL)(HYDROXY)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(4 (TERT BUTYL)PHENYL)(HYDROXY)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(4 CHLOROPHENYL)(HYDROXY)METHYL] 5 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(4 FLUOROPHENYL)(HYDROXY)METHYL] 5 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(4 FLUOROPHENYL)(HYDROXY)METHYL] 6 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(4 FLUOROPHENYL)(HYDROXY)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [HYDROXY(4 METHOXYPHENYL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; DIARYLPYRIMIDINE DERIVATIVE; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IN VITRO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS MUTANT; WILD TYPE;

ANILINE COMPOUNDS; CELL LINE; CHLORINE; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MUTATION; PYRIMIDINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2;

EID: 84860390578 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2011.07.023 Document Type: Article

Times cited : (28)

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