Non-nucleoside HIV-1 reverse-transcriptase inhibitors. Part 10: Synthesis and anti-HIV activity of 5-alkyl-6-(1-naphthylmethyl)pyrimidin-4(3h)-ones with a mono- or disubstituted 2-amino function as novel 'dihydro-alkoxy-benzyl-oxopyrimidine' (DABO) analogues

Chemistry and Biodiversity

Volumn 5, Issue 1, 2008, Pages 168-176

  Wang, Yueping ^a   Chen, Fen Er ^a   Balzarini, Jan ^b   De Clercq, Erik ^b   Pannecouque, Christophe ^b  

^a FUDAN UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2 (BENZYLAMINO) 5 BUTYL 6 (NAPHTHALEN 1 YLMETHYL)PYRIMIDIN 4(3H)ONE; 2 (BENZYLAMINO) 5 ETHYL 6 (NAPHTHALEN 1 YLMETHYL)PYRIMIDIN 4(3H)ONE; 2 (BENZYLAMINO) 5 METHYL 6 (NAPHTHALEN 1 YLMETHYL)PYRIMIDIN 4(3H)ONE; 2 (BUTYLAMINO) 5 ETHYL 6 (NAPHTHALEN 1 YLMETHYL)PYRIMIDIN 4(3H)ONE; 2 (CYCLOHEXYLAMINO) 5 METHYL 6 (NAPHTHALEN 1 YLMETHYL)PYRIMIDIN 4(3H)ONE; 2 (DIBUTYLAMINO) 5 METHYL 6 (NAPHTHALEN 1 YLMETHYL)PYRIMIDIN 4(3H)ONE; 2 (DIETHYLAMINO) 5 (1 METHYLETHYL) 6 (NAPHTHALEN 1 YLMETHYL)PYRIMIDIN 4(3H)ONE; 2 (DIETHYLAMINO) 5 ETHYL 6 (NAPHTHALEN 1 YLMETHYL)PYRIMIDIN 4(3H)ONE; 2 (DIETHYLAMINO) 5 METHYL 6 (NAPHTHALEN 1 YLMETHYL)PYRIMIDIN 4(3H)ONE; 2 (DIETHYLAMINO) 6 (NAPHTHALEN 1 YLMETHYL)PYRIMIDIN 4(3H)ONE; 2 (DIMETHYLAMINO) 5 ETHYL 6 (NAPHTHALEN 1 YLMETHYL)PYRIMIDIN 4(3H)ONE; 2 [(4 CHLOROPHENYL)AMINO] 5 ETHYL 6 (NAPHTHALEN 1 YLMETHYL)PYRIMIDIN 4(3H)ONE; 2 AMINO 5 ETHYL 6 (NAPHTHALEN 1 YLMETHYL)PYRIMIDIN 4(3H)ONE; 5 BUTYL 2 (DIETHYLAMINO) 6 (NAPHTHALEN 1 YLMETHYL)PYRIMIDIN 4(3H)ONE; 5 ETHYL 2 [(4 FLUOROBENZYL)AMINO] 6 (NAPHTHALEN 1 YLMETHYL)PYRIMIDIN 4(3H)ONE; 5 METHYL 2 (1 METHYLETHYLAMINO) 6 (NAPHTHALEN 1 YLMETHYL)PYRIMIDIN 4(3H)ONE; 5 METHYL 6 (NAPHTHALEN 1 YLMETHYL) 2 (PROPYLAMINO)PYRIMIDIN 4(3H)ONE; 5 METHYL 6 (NAPHTHALEN 1 YLMETHYL) 2 (PYRROLIDIN 1 YL)PYRIMIDIN 4(3H)ONE; ALKYL GROUP; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DIDANOSINE; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IC 50; IN VITRO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION; WILD TYPE;

ANTI-HIV AGENTS; CELL LINE; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRIMIDINES; REVERSE TRANSCRIPTASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 38849173071     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.200890008     Document Type: Article

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