Non-nucleoside HIV-1 reverse transcriptase inhibitors, part 7. Synthesis, antiviral activity, and 3D-QSAR investigations of novel 6-(1-naphthoyl) HEPT analogues

Chemical and Pharmaceutical Bulletin

Volumn 54, Issue 9, 2006, Pages 1248-1253

  Ji, Lei ^a   Chen, Fen Er ^a   Feng, Xiao Qing ^a   De Clercq, Erik ^b   Balzarini, Jan ^b   Pannecouque, Christophe ^b  

^a FUDAN UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

3D QSAR; 6 (1 naphthoyl); Antiviral activity; HIV 1 reverse transcriptase inhibitor; Synthesis

Indexed keywords

1 [(2 HYDROXYETHOXY)METHYL] 6 (PHENYLTHIO)THYMINE; 5 ISOPROPYL 6 (1 NAPHTHOYL) 1 [(2E) 3 PHENYLALLYL] 2,4 PYRIMIDINEDIONE; DIDANOSINE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IC 50; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; BINDING SITES; CELL LINE; CELL PROLIFERATION; CHEMISTRY, PHYSICAL; DRUG DESIGN; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; HYDROGEN BONDING; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REVERSE TRANSCRIPTASE INHIBITORS; STEREOISOMERISM; THYMINE;

EID: 33748469514     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.54.1248     Document Type: Article

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