Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 7, 2010, Pages 2370-2374

  Feng, Xiao Qing ^a   Zeng, Zhao Sen ^a   Liang, Yong Hong ^a   Chen, Fen Er ^a   Pannecouque, Christophe ^b   Balzarini, Jan ^b   Clercq, Erik De ^b  

^a FUDAN UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

DAPYs; HIV; NNRTIs; SAR

Indexed keywords

4 (HYDROXYIMINO)ARYLMETHYLDIARYLPYRIMIDINE DERIVATIVE; 4 [4 [(HYDROXYIMINO)(3 METHOXYPHENYL)METHYL]PYRIMIDIN 2 YLAMINO]BENZONITRILE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 2; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; CELL LINE; CELL SURVIVAL; HIV-1; HIV-2; HUMANS; INDICATORS AND REAGENTS; PYRIMIDINES; REVERSE TRANSCRIPTASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2;

EID: 77950037962     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.007     Document Type: Article

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