Nonnucleoside HIV-1 reverse transcriptase inhibitors: Part I. Synthesis and structure-activity relationship of 1-alkoxymethyl-5-alkyl-6-naphthylmethyl uracils as HEPT analogues

Chemical and Pharmaceutical Bulletin

Volumn 51, Issue 7, 2003, Pages 779-789

  Meng, Ge ^a   Chen, Fen Er ^a   De Clercq, Erik ^b   Balzarini, Jan ^b   Pannecouque, Christophe ^b  

^a FUDAN UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

1 alkoxymethyl 5 alkyl 6 naphthylmethyl uracil; HIV 1 reverse transcriptase inhibitor; Structure activity relationship

Indexed keywords

1 (BENZYLOXY)METHYL] 5 ETHYL 6 (1 NAPHTHYLMETHYL)URACIL; 1 (BENZYLOXY)METHYL] 5 ETHYL 6 (2 NAPHTHYLMETHYL)URACIL; 1 (BENZYLOXY)METHYL] 5 ISOPROPYL 6 (1 NAPHTHYLMETHYL)URACIL; 1 (BENZYLOXY)METHYL] 5 METHYL 6 (1 NAPHTHYLMETHYL)URACIL; 1 (BENZYLOXY)METHYL] 5 METHYL 6 (2 NAPHTHYLMETHYL)URACIL; 1 (BENZYLOXY)METHYL] 5 N PROPYL 6 (1 NAPHTHYLMETHYL)URACIL; 1 (BENZYLOXY)METHYL] 5 N PROPYL 6 (2 NAPHTHYLMETHYL)URACIL; 1 ETHOXYMETHYL 5 ETHYL 6 (1 NAPHTHYLMETHYL)URACIL; 1 ETHOXYMETHYL 5 ETHYL 6 (2 NAPHTHYLMETHYL)URACIL; 1 ETHOXYMETHYL 5 ISOPROPYL 6 (1 NAPHTHYLMETHYL)URACIL; 1 ETHOXYMETHYL 5 METHYL 6 (1 NAPHTHYLMETHYL)URACIL; 1 ETHOXYMETHYL 5 METHYL 6 (2 NAPHTHYLMETHYL)URACIL; 1 ETHOXYMETHYL 5 N PROPYL 6 (1 NAPHTHYLMETHYL)URACIL; 1 METHOXYMETHYL 5 ETHYL 6 (1 NAPHTHYLMETHYL)URACIL; 1 METHOXYMETHYL 5 ETHYL 6 (2 NAPHTHYLMETHYL)URACIL; 1 METHOXYMETHYL 5 ISOPROPYL 6 (1 NAPHTHYLMETHYL)URACIL; 1 METHOXYMETHYL 5 METHYL 6 (1 NAPHTHYLMETHYL)URACIL; 1 METHOXYMETHYL 5 METHYL 6 (2 NAPHTHYLMETHYL)URACIL; 1 METHOXYMETHYL 5 N PROPYL 6 (1 NAPHTHYLMETHYL)URACIL; 1 METHOXYMETHYL 5 N PROPYL 6 (2 NAPHTHYLMETHYL)URACIL; 1 [(2 HYDROXYETHOXY)METHYL] 5 ETHYL 6 (1 NAPHTHYLMETHYL)URACIL; 1 [(2 HYDROXYETHOXY)METHYL] 5 ETHYL 6 (2 NAPHTHYLMETHYL)URACIL; 1 [(2 HYDROXYETHOXY)METHYL] 5 ISOPROPYL 6 (1 NAPHTHYLMETHYL)URACIL; 1 [(2 HYDROXYETHOXY)METHYL] 5 METHYL 6 (1 NAPHTHYLMETHYL)URACIL; 1 [(2 HYDROXYETHOXY)METHYL] 5 METHYL 6 (2 NAPHTHYLMETHYL)URACIL; 1 [(2 HYDROXYETHOXY)METHYL] 5 N PROPYL 6 (1 NAPHTHYLMETHYL)URACIL; 1 [(2 HYDROXYETHOXY)METHYL] 6 (PHENYLTHIO)THYMINE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; 1 ((2 HYDROXYETHOXY)METHYL) 6 (PHENYLTHIO)THYMINE; 1-((2-HYDROXYETHOXY)METHYL)-6-(PHENYLTHIO)THYMINE; DRUG DERIVATIVE; THYMINE; URACIL;

ANTIVIRAL ACTIVITY; ARTICLE; BIOASSAY; CALCULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; IN VITRO STUDY; MEDICAL RECORD; NONHUMAN; STRUCTURE ACTIVITY RELATION; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; METABOLISM; SYNTHESIS;

CELL LINE; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THYMINE; URACIL;

EID: 1542471588     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.51.779     Document Type: Article

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