Synthesis of novel diarylpyrimidine analogues of TMC278 and their antiviral activity against HIV-1 wild-type and mutant strains

European Journal of Medicinal Chemistry

Volumn 42, Issue 5, 2007, Pages 567-579

  Mordant, Céline ^a   Schmitt, Benoit ^a   Pasquier, Elisabeth ^a   Demestre, Christophe ^a   Queguiner, Laurence ^a   Masungi, Chantal ^b   Peeters, Anik ^b   Smeulders, Liesbeth ^b   Bettens, Eva ^b   Hertogs, Kurt ^b   Heeres, Jan ^c   Lewi, Paul ^c   Guillemont, Jerome ^a  

^a JOHNSON AND JOHNSON   (United States)

^b TIBOTEC BVBA   (Belgium)

^c Center for Molecular Design   (Belgium)

Author keywords

Diarylpyrimidine (DAPY); HIV 1; NNRTI

Indexed keywords

4 [4 [4 (2 CYANOCINYL) PHENYLAMINO] PYRIMIDIN 2 YLAMINO] BENZONITRILE; 4 [4 [4 (2 CYANOVINYL) 2 CHLORO 6 METHOXY PHENYLAMINO] PYRIMIDIN 2 YLAMINO] BENZONITRILE; 4 [4 [4 (2 CYANOVINYL) 2 CHLORO 6 METHYL PHENYLAMINO] PYRIMIDIN 2 YLAMINO] BENZONITRILE; 4 [4 [4 (2 CYANOVINYL) 2 ETHYL 6 METHYL PHENYLAMINO] PYRIMIDIN 2 YLAMINO] BENZONTRILE; 4 [4 [4 (2 CYANOVINYL) 2 ISOPROPYL 6 METHYL PHENYLAMINO] PYRIMIDIN 2 YLAMINO] BENZONITRILE; 4 [4 [4 (2 CYANOVINYL) 2 METHYL 6 METHOXY PHENYLAMINO] PYRIMIDIN 2 YLAMINO] BENZONITRILE; 4 [4 [4 (2 CYANOVINYL) 2 METHYL PHENYLAMINO] PYRIMIDIN 2 YLAMINO] BENZONITRILE; 4 [4 [4 (2 CYANOVINYL) 2,6 DIMETHYL PHENYLSULFANYL] PYRIMIDIN 2 YLAMINO] BENZONITRILE; 4 [4 [[4 (2 CYANOVINYL) 2 METHYL PHENYL] METHYLAMINO] PYRIMIDIN 2 YLAMINO] BENZONITRILE; DELAVIRDINE; DIARYLPYRIMIDINE DERIVATIVE; EFAVIRENZ; ETRAVIRINE; NEVIRAPINE; PYRIMIDINE DERIVATIVE; RILPIVIRINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; DRUG ABSORPTION; DRUG HALF LIFE; DRUG POTENCY; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; HECK REACTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MUTANT; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION; VIRUS STRAIN;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; FEMALE; HIV-1; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; NITRILES; PYRIMIDINES; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE INHIBITORS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 34248397581     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.11.014     Document Type: Article

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