Structural modifications of DAPY analogues with potent anti-HIV-1 activity

ChemMedChem

Volumn 4, Issue 2, 2009, Pages 219-224

  Feng, Xiao Qing ^a   Liang, Yong Hong ^a   Zeng, Zhao Sen ^a   Chen, Fen Er ^a   Balzarini, Jan ^b   Pannecouque, Christophe ^b   De Clercq, Erik ^b  

^a FUDAN UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antiviral agents; DAPYs; Inhibitors; NRTIs; Structure activity relationships

Indexed keywords

4 [4 (1 BROMONAPHTHALEN 2 YLOXY) 5 METHYLPYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (1 BROMONAPHTHALEN 2 YLOXY) 6 METHYLPYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (1 BROMONAPHTHALEN 2 YLOXY)PYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (1 CHLORONAPHTHALEN 2 YLOXY) 5 METHYLPYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (1 CHLORONAPHTHALEN 2 YLOXY) 6 METHYLPYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (1 CHLORONAPHTHALEN 2 YLOXY)PYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (1,6 DIBROMONAPHTHALEN 2 YLOXY) 5 METHYLPYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (1,6 DIBROMONAPHTHALEN 2 YLOXY) 6 METHYLPYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (1,6 DIBROMONNAPHTHALEN 2 YLOXY)PYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (4 BROMONAPHTHALEN 1 YLOXY) 5 METHYLPYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (4 BROMONAPHTHALEN 1 YLOXY) 6 METHYLPYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (4 BROMONAPHTHALEN 1 YLOXY)PYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (4 CHLORONAPHTHALEN 1 YLOXY) 5 METHYLPYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (4 CHLORONAPHTHALEN 1 YLOXY) 6 METHYLPYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (4 CHLORONAPHTHALENE 1 YLOXY)PYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (6 BROMONAPHTHALEN 2 YLOXY) 5 METHYLPYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (6 BROMONAPHTHALEN 2 YLOXY) 6 METHYLPYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (NAPHTHALEN 1 YLOXY)PYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (NAPHTHALEN 1 YLTHIO)PYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (NAPHTHALEN 2 YLOXY)PYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 (NAPHTHALEN 2 YLTHIO)PYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 METHYL 6 (NAPHTHALEN 1 YLOXY)PYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 METHYL 6 (NAPHTHALEN 2 YLOXY)PYRMIDIN 2 YLAMINO]BENZONITRILE; 4 [4 METHYL 6 (NAPHTHALEN 2 YLTHIO)PYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [5 BROMO 4 (NAPHTHALEN 2 YLTHIO)PYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [5 METHYL 4 (NAPHTHALEN 1 YLOXY)PYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [5 METHYL 4 (NAPHTHALEN 2 YLOXY)PYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 [5 METHYL 4 (NAPHTHALEN 2 YLTHIO)PYRIMIDIN 2 YLAMINO]BENZONITRILE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IN VITRO STUDY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VIRUS MUTANT; VIRUS STRAIN; WILD TYPE;

ANTI-HIV AGENTS; CELL LINE; DRUG EVALUATION, PRECLINICAL; HIV-1; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIMIDINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 60849096957     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800334     Document Type: Article

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