Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 18, 2009, Pages 5482-5485

  Tian, Xingtao ^a   Qin, Bingjie ^a   Lu, Hong ^b   Lai, Weihong ^d   Jiang, Shibo ^b   Lee, Kuo Hsiung ^c   Chen, Chin Ho ^d   Xie, Lan ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b NEW YORK BLOOD CENTER   (United States)

^c University of North Carolina   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Diarylpyridine derivatives; Drug resistance; HIV 1 NNRTIs

Indexed keywords

PYRIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; VIRUS STRAIN;

ANTI-HIV AGENTS; DRUG RESISTANCE, VIRAL; HIV INFECTIONS; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 68949110165     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.080     Document Type: Article

References (17)

1. De Corte B.L. J. Med. Chem. 48 (2005) 1689
2. Tantillo C. J. Mol. Biol. 243 (1994) 369
3. Pauwels R. Curr. Opin. Pharmacol. 4 (2004) 437
4. Andries K., Azijn H., Thielemans T., Ludovici D., Kukla M., Heeres J., Janssen P., De Corte B., Vingerhoets J., Pauwels R., and de Béthuneet M.P. Antimicrob. Agents Chemother. 48 (2004) 4680
5. Gruzdev, B.; Horban, A.; Boron-Kaczmarska A.; Gille, D.; Van't Klooster, G.; Pauwels, R. Abstr. 13, 8th Conference on Retroviruses and Opportunistic Infections, Chicago, IL, February 4-8, 2001.
6. De Clercq E. Int. J. Antimicrob. Agents 33 (2009) 307
7. Janssen P.A.J., Lewi P.J., Arnold E., Daeyaert F., de Jonge M., Heeres J., Koymans L., Vinkers M., Guillemont J., Pasquier E., Kukla M., Ludovici D., Andries K., de Bethune M.P., Pauwels R., Das K., Clark A.D., Frenkel Y.V., Hughes S.H., Medaer B., De Knaep F., Bohets H., De Clerck F., Lampo A., Williams P., and Stoffels P. J. Med. Chem. 48 (2005) 1901
8. Das K., Lewi P.J., Hughes S.H., and Arnold E. Prog. Biophys. Mol. Biol. 88 (2005) 209
9. Van Herrewege Y., Vanham G., Michiels J., Fransen K., Kestens L., Andries K., Janssen P., and Lewi P. Antimicrob. Agents Chemother. 48 (2004) 3684
10. Guillemont J., Pasquier E., Palandjian P., Vernier D., Gaurrand S., Lewi P.J., Heeres J., de Jonge M.R., Koymans L.M.H., Daeyaert F.F.D., Vinkers M.H., Arnold E., Das K., Pauwels R., Andries K., de Bethune M.P., Bettens E., Hertogs K., Wigerinck P., Timmerman P., and Janssen P.A.J. J. Med. Chem. 48 (2005) 2072
11. Rodriguez J.G., Tejedor J.L., La Parra T., and Diaz C. Tetrahedron 62 (2006) 3355
12. Redemann C.E., and Redemann C.T. Org. Synth. 29 (1949) 8
13. +).
14. Xie L., Guo H.F., Lu H., Zhuang X.M., Zhang A.M., Wu G., Ruan J.X., Zhou T., Yu D., Qian K., Lee K.H., and Jiang S. J. Med. Chem. 51 (2008) 7689
15. Larder B.A., Kellam P., and Kemp S.D. Nature 365 (1993) 451
16. Das K., Bauman J.D., Clark A.D., Frenkel Y.V., Lewi P.J., Shatkin A.J., Hughes S.H., and Arnold E. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 1466
17. Ludovici D.W., De Corte B.L., Kukla M.J., Ye H., Ho C.Y., Lichtenstein M.A., Kavash R.W., Andries K., de Bethune M.P., Azijn H., Pauwels R., Lewi P.J., Heeres J., Koymans L.M.H., de Jonge M.R., Van Aken K.J.A., Daeyaert F.F.D., Das K., Arnold E., and Janssen P.A.J. Bioorg. Med. Chem. Lett. 11 (2001) 2235