-
2
-
-
17444392120
-
Fibrinogen and fibrin
-
DOI 10.1016/S0065-3233(05)70008-5, Fibrous Proteins Coiled-Coils, Collagen and Elastomers
-
J.W. Weisel Fibrinogen and fibrin Adv. Protein Chem. 70 2005 247 299 (Pubitemid 40544785)
-
(2005)
Advances in Protein Chemistry
, vol.70
, pp. 247-299
-
-
Weisel, J.W.1
-
3
-
-
79952178145
-
Molecular mechanisms affecting fibrin structure and stability
-
S.T. Lord Molecular mechanisms affecting fibrin structure and stability Arterioscler. Thromb. Vasc. Biol. 31 2011 494 499
-
(2011)
Arterioscler. Thromb. Vasc. Biol.
, vol.31
, pp. 494-499
-
-
Lord, S.T.1
-
5
-
-
0141819138
-
The protein C pathway
-
C.T. Esmon The protein C pathway Chest 124 2003 26S 32S (Pubitemid 37128433)
-
(2003)
Chest
, vol.124
, Issue.3 SUPPL.
-
-
Esmon, C.T.1
-
6
-
-
28344436780
-
Protease-activated receptors in hemostasis, thrombosis and vascular biology
-
DOI 10.1111/j.1538-7836.2005.01377.x
-
S.R. Coughlin Protease-activated receptors in hemostasis, thrombosis and vascular biology J. Thromb. Haemost. 3 2005 1800 1814 (Pubitemid 41716567)
-
(2005)
Journal of Thrombosis and Haemostasis
, vol.3
, Issue.8
, pp. 1800-1814
-
-
Coughlin, S.R.1
-
7
-
-
0026476381
-
Thrombin is a Na(+)-activated enzyme
-
C.M. Wells, and E. Di Cera Thrombin is a Na(+)-activated enzyme Biochemistry 31 1992 11721 11730
-
(1992)
Biochemistry
, vol.31
, pp. 11721-11730
-
-
Wells, C.M.1
Di Cera, E.2
-
8
-
-
35648975465
-
+ binding to thrombin resolved by ultra-rapid kinetics
-
DOI 10.1016/j.bpc.2007.09.009, PII S0301462207002311
-
S. Gianni, Y. Ivarsson, A. Bah, L.A. Bush-Pelc, and E. Di Cera Mechanism of Na(+) binding to thrombin resolved by ultra-rapid kinetics Biophys. Chem. 131 2007 111 114 (Pubitemid 350030362)
-
(2007)
Biophysical Chemistry
, vol.131
, Issue.1-3
, pp. 111-114
-
-
Gianni, S.1
Ivarsson, Y.2
Bah, A.3
Bush-Pelc, L.A.4
Di Cera, E.5
-
9
-
-
0027050807
-
The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships
-
W. Bode, D. Turk, and A. Karshikov The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships Protein Sci. 1 1992 426 471 (Pubitemid 23016868)
-
(1992)
Protein Science
, vol.1
, Issue.4
, pp. 426-471
-
-
Bode, W.1
Turk, D.2
Karshikov, A.3
-
10
-
-
33646477150
-
The structure of thrombin: A janus-headed proteinase
-
W. Bode The structure of thrombin: a janus-headed proteinase Semin. Thromb. Hemost. 32 Suppl. 1 2006 16 31
-
(2006)
Semin. Thromb. Hemost.
, vol.32
, Issue.SUPPL. 1
, pp. 16-31
-
-
Bode, W.1
-
11
-
-
3843133006
-
+ binding to thrombin
-
DOI 10.1074/jbc.M401756200
-
+ binding to thrombin J. Biol. Chem. 279 2004 31842 31853 (Pubitemid 39037857)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.30
, pp. 31842-31853
-
-
Pineda, A.O.1
Carrell, C.J.2
Bush, L.A.3
Prasad, S.4
Caccia, S.5
Chen, Z.-W.6
Mathews, F.S.7
Di Cera, E.8
-
12
-
-
0034704118
-
Rational design of a potent anticoagulant thrombin
-
DOI 10.1074/jbc.C000751200
-
A.M. Cantwell, and E. Di Cera Rational design of a potent anticoagulant thrombin J. Biol. Chem. 275 2000 39827 39830 (Pubitemid 32064601)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.51
, pp. 39827-39830
-
-
Cantwell, A.M.1
Di Cera, E.2
-
13
-
-
0034636749
-
Mutation of W215 compromises thrombin cleavage of fibrinogen, but not of PAR-1 or protein C
-
DOI 10.1021/bi0006215
-
D. Arosio, Y.M. Ayala, and E. Di Cera Mutation of W215 compromises thrombin cleavage of fibrinogen, but not of PAR-1 or protein C Biochemistry 39 2000 8095 8101 (Pubitemid 30452385)
-
(2000)
Biochemistry
, vol.39
, Issue.27
, pp. 8095-8101
-
-
Arosio, D.1
Ayala, Y.M.2
Di Cera, E.3
-
14
-
-
0029017360
-
Functional mapping of the surface residues of human thrombin
-
M. Tsiang, A.K. Jain, K.E. Dunn, M.E. Rojas, L.L. Leung, and C.S. Gibbs Functional mapping of the surface residues of human thrombin J. Biol. Chem. 270 1995 16854 16863
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 16854-16863
-
-
Tsiang, M.1
Jain, A.K.2
Dunn, K.E.3
Rojas, M.E.4
Leung, L.L.5
Gibbs, C.S.6
-
15
-
-
12644264319
-
Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo
-
DOI 10.1021/bi9616108
-
M. Tsiang, L.R. Paborsky, W.X. Li, A.K. Jain, C.T. Mao, K.E. Dunn, D.W. Lee, S.Y. Matsumura, M.D. Matteucci, S.E. Coutre, L.L. Leung, and C.S. Gibbs Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo Biochemistry 35 1996 16449 16457 (Pubitemid 27020485)
-
(1996)
Biochemistry
, vol.35
, Issue.51
, pp. 16449-16457
-
-
Tsiang, M.1
Paborsky, L.R.2
Li, W.-X.3
Jain, A.K.4
Mao, C.T.5
Dunn, K.E.6
Lee, D.W.7
Matsumura, S.Y.8
Matteucci, M.D.9
Coutre, S.E.10
Leung, L.L.K.11
Gibbs, C.S.12
-
16
-
-
0030878076
-
Modulation of thrombin's procoagulant and anticoagulant properties
-
L.L. Leung, and C.S. Gibbs Modulation of thrombin's procoagulant and anticoagulant properties Thromb. Haemost. 78 1997 577 580 (Pubitemid 27289307)
-
(1997)
Thrombosis and Haemostasis
, vol.78
, Issue.1
, pp. 577-580
-
-
Leung, L.L.K.1
Gibbs, C.S.2
-
17
-
-
4544312894
-
The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket
-
DOI 10.1074/jbc.M407272200
-
A.O. Pineda, Z.W. Chen, S. Caccia, A.M. Cantwell, S.N. Savvides, G. Waksman, F.S. Mathews, and E. Di Cera The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket J. Biol. Chem. 279 2004 39824 39828 (Pubitemid 39258253)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.38
, pp. 39824-39828
-
-
Pineda, A.O.1
Chen, Z.-W.2
Caccia, S.3
Cantwell, A.M.4
Savvides, S.N.5
Waksman, G.6
Mathews, F.S.7
Di Cera, E.8
-
18
-
-
69949124134
-
Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A
-
P.S. Gandhi, M.J. Page, Z. Chen, L. Bush-Pelc, and E. Di Cera Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A J. Biol. Chem. 284 2009 24098 24105
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 24098-24105
-
-
Gandhi, P.S.1
Page, M.J.2
Chen, Z.3
Bush-Pelc, L.4
Di Cera, E.5
-
19
-
-
77956544191
-
Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states
-
P. Kamath, J.A. Huntington, and S. Krishnaswamy Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states J. Biol. Chem. 285 2010 28651 28658
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 28651-28658
-
-
Kamath, P.1
Huntington, J.A.2
Krishnaswamy, S.3
-
20
-
-
0034617203
-
Examining thrombin hydrolysis of the Factor XIII activation peptide segment leads to a proposal for explaining the cardioprotective effects observed with the Factor XIII V34L mutation
-
DOI 10.1074/jbc.M000209200
-
T.A. Trumbo, and M.C. Maurer Examining thrombin hydrolysis of the factor XIII activation peptide segment leads to a proposal for explaining the cardioprotective effects observed with the factor XIII V34L mutation J. Biol. Chem. 275 2000 20627 20631 (Pubitemid 30457648)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.27
, pp. 20627-20631
-
-
Trumbo, T.A.1
Maurer, M.C.2
-
21
-
-
0037176908
-
4 positions in factor XIII activation
-
DOI 10.1021/bi0157823
-
T.A. Trumbo, and M.C. Maurer Thrombin hydrolysis of V29F and V34L mutants of factor XIII (28-41) reveals roles of the P(9) and P(4) positions in factor XIII activation Biochemistry 41 2002 2859 2868 (Pubitemid 34168956)
-
(2002)
Biochemistry
, vol.41
, Issue.8
, pp. 2859-2868
-
-
Trumbo, T.A.1
Maurer, M.C.2
-
22
-
-
0035501805
-
Molecular mapping of thrombin-receptor interactions
-
DOI 10.1002/prot.1130
-
Y.M. Ayala, A.M. Cantwell, T. Rose, L.A. Bush, D. Arosio, and E. Di Cera Molecular mapping of thrombin-receptor interactions Proteins 45 2001 107 116 (Pubitemid 32896635)
-
(2001)
Proteins: Structure, Function and Genetics
, vol.45
, Issue.2
, pp. 107-116
-
-
Ayala, Y.M.1
Cantwell, A.M.2
Rose, T.3
Bush, L.A.4
Arosio, D.5
Cera, E.D.6
-
23
-
-
0014405092
-
On the active site of proteases. 3. Mapping the active site of papain; Specific peptide inhibitors of papain
-
I. Schechter, and A. Berger On the active site of proteases. 3. Mapping the active site of papain; specific peptide inhibitors of papain Biochem. Biophys. Res. Commun. 32 1968 898 902
-
(1968)
Biochem. Biophys. Res. Commun.
, vol.32
, pp. 898-902
-
-
Schechter, I.1
Berger, A.2
-
24
-
-
0022924075
-
Chemical basis of thrombin interactions with fibrinogen
-
H.A. Scheraga Chemical basis of thrombin interactions with fibrinogen Ann. N. Y. Acad. Sci. 485 1986 124 133 (Pubitemid 17022489)
-
(1986)
Annals of the New York Academy of Sciences
, vol.485
, pp. 124-133
-
-
Scheraga, H.A.1
-
26
-
-
33644604137
-
The association between factor XIII Val34Leu polymorphism and early myocardial infarction
-
V.S. Hancer, R. Diz-Kucukkaya, A.K. Bilge, B. Ozben, A. Oncul, G. Ergen, and M. Nalcaci The association between factor XIII Val34Leu polymorphism and early myocardial infarction Circ. J. 70 2006 239 242
-
(2006)
Circ. J.
, vol.70
, pp. 239-242
-
-
Hancer, V.S.1
Diz-Kucukkaya, R.2
Bilge, A.K.3
Ozben, B.4
Oncul, A.5
Ergen, G.6
Nalcaci, M.7
-
27
-
-
0036682920
-
Role of factor XIII in fibrin clot formation and effects of genetic polymorphisms
-
DOI 10.1182/blood.V100.3.743
-
R.A. Ariens, T.S. Lai, J.W. Weisel, C.S. Greenberg, and P.J. Grant Role of factor XIII in fibrin clot formation and effects of genetic polymorphisms Blood 100 2002 743 754 (Pubitemid 34832596)
-
(2002)
Blood
, vol.100
, Issue.3
, pp. 743-754
-
-
Ariens, R.A.S.1
Lai, T.-S.2
Weisel, J.W.3
Greenberg, C.S.4
Grant, P.J.5
-
28
-
-
0031963827
-
Association of a common polymorphism in the Factor XIII gene with myocardial infarction
-
H.P. Kohler, M.H. Stickland, N. Ossei-Gerning, A. Carter, H. Mikkola, and P.J. Grant Association of a common polymorphism in the factor XIII gene with myocardial infarction Thromb. Haemost. 79 1998 8 13 (Pubitemid 28037047)
-
(1998)
Thrombosis and Haemostasis
, vol.79
, Issue.1
, pp. 8-13
-
-
Kohler, H.P.1
Stickland, M.H.2
Ossei-Gerning, N.3
Carter, A.4
Mikkola, H.5
Grant, P.J.6
-
29
-
-
0032588857
-
Association of FXIII Va134Leu with decreased risk of myocardial infarction in finnish males
-
DOI 10.1016/S0021-9150(98)00241-X, PII S002191509800241X
-
U. Wartiovaara, M. Perola, H. Mikkola, K. Totterman, V. Savolainen, A. Penttila, P.J. Grant, M.J. Tikkanen, E. Vartiainen, P.J. Karhunen, L. Peltonen, and A. Palotie Association of FXIII Val34Leu with decreased risk of myocardial infarction in Finnish males Atherosclerosis 142 1999 295 300 (Pubitemid 29059487)
-
(1999)
Atherosclerosis
, vol.142
, Issue.2
, pp. 295-300
-
-
Wartiovaara, U.1
Perola, M.2
Mikkola, H.3
Totterman, K.4
Savolainen, V.5
Penttila, A.6
Grant, P.J.7
Tikkanen, M.J.8
Vartiainen, E.9
Karhunen, P.J.10
Peltonen, L.11
Palotie, A.12
-
30
-
-
0034254319
-
The factor XIII V34L polymorphism accelerates thrombin activation of factor XIII affects cross-linked fibrin structure
-
R.A. Ariens, H. Philippou, C. Nagaswami, J.W. Weisel, D.A. Lane, and P.J. Grant The factor XIII V34L polymorphism accelerates thrombin activation of factor XIII and affects cross-linked fibrin structure Blood 96 2000 988 995 (Pubitemid 30616865)
-
(2000)
Blood
, vol.96
, Issue.3
, pp. 988-995
-
-
Ariens, R.A.S.1
Philippou, H.2
Nagaswami, C.3
Weisel, J.W.4
Lane, D.A.5
Grant, P.J.6
-
31
-
-
0034307686
-
Val34Leu polymorphism of plasma factor XIII: Biochemistry and epidemiology in familial thrombophilia
-
I. Balogh, G. Szoke, L. Karpati, U. Wartiovaara, E. Katona, I. Komaromi, G. Haramura, G. Pfliegler, H. Mikkola, and L. Muszbek Val34Leu polymorphism of plasma factor XIII: biochemistry and epidemiology in familial thrombophilia Blood 96 2000 2479 2486
-
(2000)
Blood
, vol.96
, pp. 2479-2486
-
-
Balogh, I.1
Szoke, G.2
Karpati, L.3
Wartiovaara, U.4
Katona, E.5
Komaromi, I.6
Haramura, G.7
Pfliegler, G.8
Mikkola, H.9
Muszbek, L.10
-
32
-
-
0033787010
-
Effect of Val34Leu polymorphism on the activation of the coagulation factor XIII-A
-
U. Wartiovaara, H. Mikkola, G. Szoke, G. Haramura, L. Karpati, I. Balogh, R. Lassila, L. Muszbek, and A. Palotie Effect of Val34Leu polymorphism on the activation of the coagulation factor XIII-A Thromb. Haemost. 84 2000 595 600
-
(2000)
Thromb. Haemost.
, vol.84
, pp. 595-600
-
-
Wartiovaara, U.1
Mikkola, H.2
Szoke, G.3
Haramura, G.4
Karpati, L.5
Balogh, I.6
Lassila, R.7
Muszbek, L.8
Palotie, A.9
-
33
-
-
0242348804
-
Genetic regulation of fibrin structure and function: Complex gene-environment interactions may modulate vascular risk
-
DOI 10.1016/S0140-6736(03)13135-2
-
B.C. Lim, R.A. Ariens, A.M. Carter, J.W. Weisel, and P.J. Grant Genetic regulation of fibrin structure and function: complex gene-environment interactions may modulate vascular risk Lancet 361 2003 1424 1431 (Pubitemid 36515043)
-
(2003)
Lancet
, vol.361
, Issue.9367
, pp. 1424-1431
-
-
Lim, B.C.B.1
Ariens, R.A.S.2
Carter, A.M.3
Weisel, J.W.4
Grant, P.J.5
-
34
-
-
0037393655
-
V34I and V34A substitutions within the factor XIII activation peptide segment (28-41) affect interactions with the thrombin active site
-
T.A. Trumbo, and M.C. Maurer V34I and V34A substitutions within the factor XIII activation peptide segment (28-41) affect interactions with the thrombin active site Thromb. Haemost. 89 2003 647 653 (Pubitemid 36456961)
-
(2003)
Thrombosis and Haemostasis
, vol.89
, Issue.4
, pp. 647-653
-
-
Trumbo, T.A.1
Maurer, M.C.2
-
35
-
-
1842473356
-
Probing thrombin's ability to accommodate a V34F substitution within the factor XIII activation peptide segment (28-41)
-
DOI 10.1111/j.1399-3011.2004.00132.x
-
G. Isetti, and M.C. Maurer Probing thrombin's ability to accommodate a V34F substitution within the factor XIII activation peptide segment (28-41) J. Pept. Res. 63 2004 241 252 (Pubitemid 38496676)
-
(2004)
Journal of Peptide Research
, vol.63
, Issue.3
, pp. 241-252
-
-
Isetti, G.1
Maurer, M.C.2
-
36
-
-
1842531406
-
Thrombin Activity Is Unaltered by N-Terminal Truncation of Factor XIII Activation Peptides
-
DOI 10.1021/bi049796v
-
G. Isetti, and M.C. Maurer Thrombin activity is unaltered by N-terminal truncation of factor XIII activation peptides Biochemistry 43 2004 4150 4159 (Pubitemid 38445635)
-
(2004)
Biochemistry
, vol.43
, Issue.14
, pp. 4150-4159
-
-
Isetti, G.1
Maurer, M.C.2
-
37
-
-
33847685148
-
Employing mutants to study thrombin residues responsible for factor XIII activation peptide recognition: A kinetic study
-
DOI 10.1021/bi0622120
-
G. Isetti, and M.C. Maurer Employing mutants to study thrombin residues responsible for factor XIII activation peptide recognition: a kinetic study Biochemistry 46 2007 2444 2452 (Pubitemid 46362418)
-
(2007)
Biochemistry
, vol.46
, Issue.9
, pp. 2444-2452
-
-
Isetti, G.1
Maurer, M.C.2
-
38
-
-
0042858157
-
Roles of low specificity and cofactor interaction sites on thrombin during factor XIII activation
-
DOI 10.1074/jbc.M305364200
-
H. Philippou, J. Rance, T. Myles, S.W. Hall, R.A. Ariens, P.J. Grant, L. Leung, and D.A. Lane Roles of low specificity and cofactor interaction sites on thrombin during factor XIII activation. Competition for cofactor sites on thrombin determines its fate J. Biol. Chem. 278 2003 32020 32026 (Pubitemid 37048390)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.34
, pp. 32020-32026
-
-
Philippou, H.1
Rance, J.2
Myles, T.3
Hall, S.W.4
Ariens, R.A.5
Grant, P.J.6
Leung, L.7
Lane, D.A.8
-
39
-
-
0026459469
-
Solution structure of a platelet receptor peptide bound to bovine alpha-thrombin
-
F. Ni, D.R. Ripoll, P.D. Martin, and B.F. Edwards Solution structure of a platelet receptor peptide bound to bovine alpha-thrombin Biochemistry 31 1992 11551 11557
-
(1992)
Biochemistry
, vol.31
, pp. 11551-11557
-
-
Ni, F.1
Ripoll, D.R.2
Martin, P.D.3
Edwards, B.F.4
-
40
-
-
0028209977
-
Crystallographic structures of thrombin complexed with thrombin receptor peptides: Existence of expected and novel binding modes
-
I.I. Mathews, K.P. Padmanabhan, V. Ganesh, A. Tulinsky, M. Ishii, J. Chen, C.W. Turck, S.R. Coughlin, and J.W. Fenton II Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes Biochemistry 33 1994 3266 3279 (Pubitemid 24112639)
-
(1994)
Biochemistry
, vol.33
, Issue.11
, pp. 3266-3279
-
-
Mathews, I.I.1
Padmanabhan, K.P.2
Ganesh, V.3
Tulinsky, A.4
-
41
-
-
77952030606
-
Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1
-
P.S. Gandhi, Z. Chen, and E. Di Cera Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1 J. Biol. Chem. 285 2010 15393 15398
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 15393-15398
-
-
Gandhi, P.S.1
Chen, Z.2
Di Cera, E.3
-
42
-
-
57749176194
-
Modeling of factor XIII activation peptide (28-41) V34L mutant bound to thrombin
-
D.G. Nair, P.N. Sunilkumar, and C. Sadasivan Modeling of factor XIII activation peptide (28-41) V34L mutant bound to thrombin J. Biomol. Struct. Dyn. 26 2008 387 394
-
(2008)
J. Biomol. Struct. Dyn.
, vol.26
, pp. 387-394
-
-
Nair, D.G.1
Sunilkumar, P.N.2
Sadasivan, C.3
-
43
-
-
0037099530
-
Protease-activated receptor 4-like peptides bind to thrombin through an optimized interaction with the enzyme active site surface
-
DOI 10.1016/S0003-9861(02)00220-5, PII S0003986102002205
-
D.B. Cleary, T.A. Trumbo, and M.C. Maurer Protease-activated receptor 4-like peptides bind to thrombin through an optimized interaction with the enzyme active site surface Arch. Biochem. Biophys. 403 2002 179 188 (Pubitemid 34800200)
-
(2002)
Archives of Biochemistry and Biophysics
, vol.403
, Issue.2
, pp. 179-188
-
-
Cleary, D.B.1
Trumbo, T.A.2
Maurer, M.C.3
-
44
-
-
0344925961
-
Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage
-
DOI 10.1042/BJ20030954
-
S.L. Jacques, and A. Kuliopulos Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage Biochem. J. 376 2003 733 740 (Pubitemid 38058072)
-
(2003)
Biochemical Journal
, vol.376
, Issue.3
, pp. 733-740
-
-
Jacques, S.L.1
Kuliopulos, A.2
-
45
-
-
34547108343
-
Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site
-
DOI 10.1021/bi700597p
-
M.T. Nieman, and A.H. Schmaier Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site Biochemistry 46 2007 8603 8610 (Pubitemid 47106111)
-
(2007)
Biochemistry
, vol.46
, Issue.29
, pp. 8603-8610
-
-
Nieman, M.T.1
Schmaier, A.H.2
-
46
-
-
34547466613
-
Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4
-
DOI 10.1073/pnas.0704409104
-
A. Bah, Z. Chen, L.A. Bush-Pelc, F.S. Mathews, and E. Di Cera Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4 Proc. Natl. Acad. Sci. U.S.A. 104 2007 11603 11608 (Pubitemid 47175059)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.28
, pp. 11603-11608
-
-
Bah, A.1
Chen, Z.2
Bush-Pelc, L.A.3
Mathews, F.S.4
Di Cera, E.5
-
47
-
-
77953509941
-
Engineering thrombin for selective specificity toward protein C and PAR1
-
F. Marino, L.A. Pelc, A. Vogt, P.S. Gandhi, and E. Di Cera Engineering thrombin for selective specificity toward protein C and PAR1 J. Biol. Chem. 285 2010 19145 19152
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 19145-19152
-
-
Marino, F.1
Pelc, L.A.2
Vogt, A.3
Gandhi, P.S.4
Di Cera, E.5
-
48
-
-
0030877442
-
Selective loss of fibrinogen clotting in a loop-less thrombin
-
DOI 10.1074/jbc.272.32.19649
-
Q.D. Dang, M. Sabetta, and E. Di Cera Selective loss of fibrinogen clotting in a loop-less thrombin J. Biol. Chem. 272 1997 19649 19651 (Pubitemid 27340051)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.32
, pp. 19649-19651
-
-
Dang, Q.D.1
Sabetta, M.2
Di Cera, E.3
-
49
-
-
22844449689
-
Hirudin binding reveals key determinants of thrombin allostery
-
DOI 10.1074/jbc.M502678200
-
K.E. Mengwasser, L.A. Bush, P. Shih, A.M. Cantwell, and E. Di Cera Hirudin binding reveals key determinants of thrombin allostery J. Biol. Chem. 280 2005 26997 27003 (Pubitemid 41040736)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.29
, pp. 26997-27003
-
-
Mengwasser, K.E.1
Bush, L.A.2
Shih, P.3
Cantwell, A.M.4
Di Cera, E.5
-
50
-
-
14844331743
-
Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C
-
DOI 10.1074/jbc.M412869200
-
H. Xu, L.A. Bush, A.O. Pineda, S. Caccia, and E. Di Cera Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C J. Biol. Chem. 280 2005 7956 7961 (Pubitemid 40349693)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.9
, pp. 7956-7961
-
-
Xu, H.1
Bush, L.A.2
Pineda, A.O.3
Caccia, S.4
Di Cera, E.5
-
51
-
-
0034711216
-
Interaction of the factor XIII activation peptide with α-thrombin. Crystal structure of its enzyme-substrate analog complex
-
DOI 10.1074/jbc.M006076200
-
C. Sadasivan, and V.C. Yee Interaction of the factor XIII activation peptide with alpha-thrombin. Crystal structure of its enzyme-substrate analog complex J. Biol. Chem. 275 2000 36942 36948 (Pubitemid 32002108)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.47
, pp. 36942-36948
-
-
Sadasivan, C.1
Yee, V.C.2
-
52
-
-
0030900909
-
Role of Leu99 of thrombin in determining the P2 specificity of serpins
-
DOI 10.1021/bi962965u
-
A.R. Rezaie Role of Leu99 of thrombin in determining the P2 specificity of serpins Biochemistry 36 1997 7437 7446 (Pubitemid 27262367)
-
(1997)
Biochemistry
, vol.36
, Issue.24
, pp. 7437-7446
-
-
Rezaie, A.R.1
-
53
-
-
27144518463
-
Directing thrombin
-
DOI 10.1182/blood-2005-04-1710
-
D.A. Lane, H. Philippou, and J.A. Huntington Directing thrombin Blood 106 2005 2605 2612 (Pubitemid 41510730)
-
(2005)
Blood
, vol.106
, Issue.8
, pp. 2605-2612
-
-
Lane, D.A.1
Philippou, H.2
Huntington, J.A.3
-
54
-
-
0026657151
-
The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution
-
P.D. Martin, W. Robertson, D. Turk, R. Huber, W. Bode, and B.F. Edwards The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution J. Biol. Chem. 267 1992 7911 7920
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 7911-7920
-
-
Martin, P.D.1
Robertson, W.2
Turk, D.3
Huber, R.4
Bode, W.5
Edwards, B.F.6
-
55
-
-
0037008668
-
The thrombin mutant W215A/E217A shows safe and potent anticoagulant and antithrombotic effects in vivo
-
DOI 10.1074/jbc.C200237200
-
A. Gruber, A.M. Cantwell, E. Di Cera, and S.R. Hanson The thrombin mutant W215A/E217A shows safe and potent anticoagulant and antithrombotic effects in vivo J. Biol. Chem. 277 2002 27581 27584 (Pubitemid 34966698)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.31
, pp. 27581-27584
-
-
Gruber, A.1
Cantwell, A.M.2
Di Cera, E.3
Hansonr, S.R.4
-
56
-
-
33645566787
-
Limited generation of activated protein C during infusion of the protein C activator thrombin analog W215A/E217A in primates
-
A. Gruber, J.A. Fernandez, L. Bush, U. Marzec, J.H. Griffin, S.R. Hanson, and E. Di Cera Limited generation of activated protein C during infusion of the protein C activator thrombin analog W215A/E217A in primates J. Thromb. Haemost. 4 2006 392 397
-
(2006)
J. Thromb. Haemost.
, vol.4
, pp. 392-397
-
-
Gruber, A.1
Fernandez, J.A.2
Bush, L.3
Marzec, U.4
Griffin, J.H.5
Hanson, S.R.6
Di Cera, E.7
-
57
-
-
34247379463
-
Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates
-
DOI 10.1182/blood-2006-07-035147
-
A. Gruber, U.M. Marzec, L. Bush, E. Di Cera, J.A. Fernandez, M.A. Berny, E.I. Tucker, O.J. McCarty, J.H. Griffin, and S.R. Hanson Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates Blood 109 2007 3733 3740 (Pubitemid 46641722)
-
(2007)
Blood
, vol.109
, Issue.9
, pp. 3733-3740
-
-
Gruber, A.1
Marzec, U.M.2
Bush, L.3
Di Cera, E.4
Fernandez, J.A.5
Berny, M.A.6
Tucker, E.I.7
McCarty, O.J.T.8
Griffin, J.H.9
Hanson, S.R.10
-
58
-
-
33746017989
-
Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells
-
DOI 10.1074/jbc.M600506200
-
C. Feistritzer, R.A. Schuepbach, L.O. Mosnier, L.A. Bush, E. Di Cera, J.H. Griffin, and M. Riewald Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells J. Biol. Chem. 281 2006 20077 20084 (Pubitemid 44065782)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.29
, pp. 20077-20084
-
-
Feistritzer, C.1
Schuepbach, R.A.2
Mosnier, L.O.3
Bush, L.A.4
Di Cera, E.5
Griffin, J.H.6
Riewald, M.7
-
59
-
-
38549115307
-
Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist
-
DOI 10.1161/ATVBAHA.107.156273, PII 0004360520080200000020
-
M.A. Berny, T.C. White, E.I. Tucker, L.A. Bush-Pelc, E. Di Cera, A. Gruber, and O.J. McCarty Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist Arterioscler. Thromb. Vasc. Biol. 28 2008 329 334 (Pubitemid 351161207)
-
(2008)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.28
, Issue.2
, pp. 329-334
-
-
Berny, M.A.1
White, T.C.2
Tucker, E.I.3
Bush-Pelc, L.A.4
Di Cera, E.5
Gruber, A.6
McCarty, O.J.T.7
-
60
-
-
79959383009
-
The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A
-
M.J. Flick, A.K. Chauhan, M. Frederick, K.E. Talmage, K.W. Kombrinck, W. Miller, E.S. Mullins, J.S. Palumbo, X.Z. Zheng, N.L. Esmon, C.T. Esmon, S. Thornton, A. Becker, L.A. Pelc, E. Di Cera, D.D. Wagner, and J.L. Degen The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A Blood 117 2011 6326 6337
-
(2011)
Blood
, vol.117
, pp. 6326-6337
-
-
Flick, M.J.1
Chauhan, A.K.2
Frederick, M.3
Talmage, K.E.4
Kombrinck, K.W.5
Miller, W.6
Mullins, E.S.7
Palumbo, J.S.8
Zheng, X.Z.9
Esmon, N.L.10
Esmon, C.T.11
Thornton, S.12
Becker, A.13
Pelc, L.A.14
Di Cera, E.15
Wagner, D.D.16
Degen, J.L.17
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