Engineering thrombin for selective specificity toward protein C and PAR1

Journal of Biological Chemistry

Volumn 285, Issue 25, 2010, Pages 19145-19152

  Marino, Francesca ^a   Pelc, Leslie A ^a   Vogt, Austin ^a   Gandhi, Prafull S ^a   Di Cera, Enrico ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOLYSIS LOOP; CLINICAL APPLICATION; CONTEXT DEPENDENT; FUNCTIONAL RESPONSE; ORDERS OF MAGNITUDE; PHYSIOLOGICAL SUBSTRATE; PROTEASE ACTIVATED RECEPTORS; SATURATION MUTAGENESIS; SOLVENT ACCESSIBLE SURFACE AREAS; WILD TYPES;

ANTIGEN-ANTIBODY REACTIONS; BLOOD; ENZYMES; MUTAGENESIS; PHYSIOLOGICAL MODELS;

GLYCOPROTEINS;

ALANINE; FIBRINOGEN; PROTEIN C; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; AUTOLYSIS; CELL STRAIN BHK; CONTROLLED STUDY; ENZYME ENGINEERING; ENZYME SPECIFICITY; GENE DELETION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; PROTEIN PROTEIN INTERACTION; WILD TYPE;

ALANINE; BASE SEQUENCE; FIBRINOGEN; HUMANS; KINETICS; LIGANDS; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; PROTEIN BINDING; PROTEIN C; PROTEIN ENGINEERING; RECEPTOR, PAR-1; THROMBIN;

EID: 77953509941     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.119875     Document Type: Article

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