The thrombin mutant W215A/E217A shows safe and potent anticoagulant and antithrombotic effects in vivo

Journal of Biological Chemistry

Volumn 277, Issue 31, 2002, Pages 27581-27584

  Gruber, Andras ^a   Cantwell, Angelene M ^b   Di Cera, Enrico ^b   Hansonr, Stephen R ^a  

^a Emory University   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS; BIOLOGICAL ORGANS; BLOOD; PROTEINS;

THROMBOTIC DISORDERS;

BIOCHEMISTRY;

ACTIVATED PROTEIN C; ANTICOAGULANT PROTEIN; E 217A; FIBRINOGEN; PROTEIN C; THROMBIN DERIVATIVE; UNCLASSIFIED DRUG; W 215A;

ANIMAL MODEL; ARTICLE; BABOON; BLEEDING TIME; CONTROLLED STUDY; DRUG POTENCY; DRUG SAFETY; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE COUNT; THROMBOSIS;

AMINO ACID SUBSTITUTION; ANIMALS; ANTICOAGULANTS; ANTITHROMBINS; BLOOD PLATELETS; FIBRIN; MUTAGENESIS, SITE-DIRECTED; PAPIO; PROTEIN C; THROMBIN;

ANIMALIA; PAPIO HAMADRYAS;

EID: 0037008668     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C200237200     Document Type: Article

References (15)