Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1

Journal of Biological Chemistry

Volumn 285, Issue 20, 2010, Pages 15393-15398

  Gandhi, Prafull S ^a   Chen, Zhiwei ^a   Di Cera, Enrico ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BINDING MODES; BIOLOGICAL EFFECTS; DEGREE OF DISORDER; EXOSITES; EXTRACELLULAR; FAVORABLE INTERACTIONS; MOLECULAR MECHANISM; PHYSIOLOGICAL SUBSTRATE; PROTEASE ACTIVATED RECEPTORS; RESOLUTION STRUCTURE; STRUCTURAL INFORMATION; TETHERED LIGAND;

BINDING ENERGY; LIGANDS;

CRYSTAL STRUCTURE;

PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN;

ACIDITY; ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; EXTRACELLULAR SPACE; LIGAND BINDING; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN CONFORMATION; RECEPTOR, PAR-1; THROMBIN;

EID: 77952030606     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.115337     Document Type: Article

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