Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function

Journal of Pharmacology and Experimental Therapeutics

Volumn 337, Issue 2, 2011, Pages 557-566

  Moir, Lyn M ^a,b   Trian, Thomas ^a,b   Ge, Qi ^a,b   Shepherd, Peter R ^c   Burgess, Janette K ^a,b   Oliver, Brian G G ^b   Black, Judith L ^a,b  

^a WOOLCOCK INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

2 (6 AMINO 9 PURINYLMETHYL) 5 METHYL 3 (2 METHYLPHENYL) 3H QUINAZOLIN 4 ONE; 2 [(6 AMINO 9H PURIN 9 YL)METHYL] 5 METHYL 3 (2 METHYLPHENYL) 4 (3H) QUINAZOLINONE; 3 METHYL 2 (4 MORPHOLINYL) 9 [1 (PHENYLAMINO)ETHYL] 4H PYRIDO [1,2 A]PYRIMIDIN 4 ONE; 9 (1 ANILINOETHYL) 7 METHYL 2 MORPHOLINOPYRIDO[1,2 A]PYRIMIDIN 4 ONE; BOVINE SERUM ALBUMIN; DIMETHYL SULFOXIDE; FIBRONECTIN; INTERLEUKIN 6; ISOENZYME; N' [(6 BROMOIMIDAZO[1,2 A]PYRIDIN 3 YL)METHYLIDENE]N,2 DIMETHYL 5 NITROBENZENESULFONOHYDRAZIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE CATALYTIC SUBUNIT P100ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE CATALYTIC SUBUNIT P100BETA; PHOSPHATIDYLINOSITOL 3 KINASE CATALYTIC SUBUNIT P100DELTA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PIK 75; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADULT; AGED; AIRWAY REMODELING; ANIMAL TISSUE; ARTICLE; ASTHMA; BREATHING MUSCLE; CELL FUNCTION; CELL STIMULATION; CELL SURVIVAL; CELL TYPE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; FEMALE; HUMAN; HUMAN CELL; LUNG FIBROBLAST; MALE; MESENCHYME CELL; MOLECULAR PATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN SECRETION; SMOOTH MUSCLE FIBER;

ADENINE; BLOTTING, WESTERN; EXTRACELLULAR MATRIX; FIBROBLASTS; FIBRONECTINS; HUMANS; HYDRAZONES; INTERLEUKIN-6; ISOENZYMES; MESENCHYMAL STEM CELLS; MITOCHONDRIA; MORPHOLINES; MUSCLE, SMOOTH; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PYRIMIDINONES; QUINAZOLINES; RESPIRATORY SYSTEM; SUBSTRATE SPECIFICITY; SULFONAMIDES; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79955015620     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.173583     Document Type: Article

References (35)

1. Arcaro A and Wymann MP (1993) Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem J 296:297-301. (Pubitemid 23350826)
2. Bi L, Okabe I, Bernard DJ, and Nussbaum RL (2002) Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase. Mamm Genome 13:169-172. (Pubitemid 34185317)
3. Bi L, Okabe I, Bernard DJ, Wynshaw-Boris A, and Nussbaum RL (1999) Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110α subunit of phosphoinositide 3-kinase. J Biol Chem 274:10963-10968.
4. Burgess JK, Ge Q, Poniris MH, Boustany S, Twigg SM, Black JL, and Johnson PR (2006) Connective tissue growth factor and vascular endothelial growth factor from airway smooth muscle interact with the extracellular matrix. Am J Physiol Lung Cell Mol Physiol 290:L153-L161.
5. Burgess JK, Lee JH, Ge Q, Ramsay EE, Poniris MH, Parmentier J, Roth M, Johnson PR, Hunt NH, Black JL, et al. (2008) Dual ERK and phosphatidylinositol 3-kinase pathways control airway smooth muscle proliferation: Differences in asthma. J Cell Physiol 216:673-679.
6. Chan V, Burgess JK, Ratoff JC, O'Connor BJ, Greenough A, Lee TH, and Hirst SJ (2006) Extracellular matrix regulates enhanced eotaxin expression in asthmatic airway smooth muscle cells. Am J Respir Crit Care Med 174:379-385. (Pubitemid 44223117)
7. Chaussade C, Rewcastle GW, Kendall JD, Denny WA, Cho K, Grønning LM, Chong ML, Anagnostou SH, Jackson SP, Daniele N, et al. (2007) Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J 404:449-458. (Pubitemid 46953919)
8. Dagia NM, Agarwal G, Kamath DV, Chetrapal-Kunwar A, Gupte RD, Jadhav MG, Dadarkar SS, Trivedi J, Kulkarni-Almeida AA, Kharas F, et al. (2010) A preferential p110α/γ PI3K inhibitor attenuates experimental inflammation by suppressing the production of proinflammatory mediators in NF-ΚB dependent manner. Am J Physiol Cell Physiol 298:C929-C941.
9. Dai R, Chen R, and Li H (2009) Cross-talk between PI3K/Akt and MEK/ERK pathways mediates endoplasmic reticulum stress-induced cell cycle progression and cell death in human hepatocellular carcinoma cells. Int J Oncol 34:1749-1757.
10. Deng H, Hershenson MB, Lei J, Bitar KN, Fingar DC, Solway J, and Bentley JK (2010) p70 Ribosomal S6 kinase is required for airway smooth muscle cell size enlargement but not increased contractile protein expression. Am J Respir Cell Mol Biol 42:744-752.
11. Grey A, Chaussade C, Empson V, Lin JM, Watson M, O'Sullivan S, Rewcastle G, Naot D, Cornish J, and Shepherd P (2010) Evidence for a role for the p110-α isoform of PI3K in skeletal function. Biochem Biophys Res Commun 391:564-569.
12. Hirst SJ, Twort CH, and Lee TH (2000) Differential effects of extracellular matrix proteins on human airway smooth muscle cell proliferation and phenotype. Am J Respir Cell Mol Biol 23:335-344.
13. Ihle NT and Powis G (2010) The biological effects of isoform-specific PI3-kinase inhibition. Curr Opin Drug Discov Dev 13:41-49.
14. Johnson PR, Black JL, Carlin S, Ge Q, and Underwood PA (2000) The production of extracellular matrix proteins by human passively sensitized airway smoothmuscle cells in culture: The effect of beclomethasone. Am J Respir Crit Care Med 162:2145-2151. (Pubitemid 32051678)
15. Johnson PR, Burgess JK, Ge Q, Poniris M, Boustany S, Twigg SM, and Black JL (2006) Connective tissue growth factor induces extracellular matrix in asthmatic airway smooth muscle. Am J Respir Crit Care Med 173:32-41. (Pubitemid 43069786)
16. Johnson PR, Burgess JK, Underwood PA, Au W, Poniris MH, Tamm M, Ge Q, Roth M, and Black JL (2004) Extracellular matrix proteins modulate asthmatic airway smooth muscle cell proliferation via an autocrine mechanism. J Allergy Clin Immunol 113:690-696. (Pubitemid 38530425)
17. Johnson PR, Roth M, Tamm M, Hughes M, Ge Q, King G, Burgess JK, and Black JL (2001) Airway smooth muscle cell proliferation is increased in asthma. Am J Respir Crit Care Med 164:474-477. (Pubitemid 32778219)
18. Kim JE, Shepherd PR, and Chaussade C (2009) Investigating the role of class-IA PI 3-kinase isoforms in adipocyte differentiation. Biochem Biophys Res Commun 379:830-834.
19. Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, et al. (2006) A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling. Cell 125:733-747.
20. Krymskaya VP, Penn RB, Orsini MJ, Scott PH, Plevin RJ, Walker TR, Eszterhas AJ, Amrani Y, Chilvers ER, and Panettieri RA Jr (1999) Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol 277:L65-L78. (Pubitemid 29356752)
21. Lee KS, Park SJ, Kim SR, Min KH, Lee KY, Choe YH, Hong SH, Lee YR, Kim JS, Hong SJ, et al. (2008) Inhibition of VEGF blocks TGF-β1 production through a PI3K/Akt signalling pathway. Eur Respir J 31:523-531.
22. Moir LM, Burgess JK, and Black JL (2008) Transforming growth factor β1 increases fibronectin deposition through integrin receptor α5β1 on human airway smooth muscle. J Allergy Clin Immunol 121:1034-1039.e4.
23. Okkenhaug K, Bilancio A, Farjot G, Priddle H, Sancho S, Peskett E, Pearce W, Meek SE, Salpekar A, Waterfield MD, et al. (2002) Impaired B and T cell antigen receptor signaling in p110δ PI 3-kinase mutant mice. Science 297: 1031-1034. (Pubitemid 34856039)
24. Redington AE, Madden J, Frew AJ, Djukanovic R, Roche WR, Holgate ST, and Howarth PH (1997) Transforming growth factor-β1 in asthma. Measurement in bronchoalveolar lavage fluid. Am J Respir Crit Care Med 156:642-647. (Pubitemid 27352007)
25. Roche WR, Beasley R, Williams JH, and Holgate ST (1989) Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1:520-524. (Pubitemid 19075206)
26. Rückle T, Schwarz MK, and Rommel C (2006) PI3Kγ inhibition: Towards an 'aspirin of the 21st century'? Nat Rev Drug Discov 5:903-918.
27. Scott PH, Belham CM, al-Hafidh J, Chilvers ER, Peacock AJ, Gould GW, and Plevin R (1996) A regulatory role for cAMP in phosphatidylinositol 3-kinase/ p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growthfactor- stimulated bovine airway smooth-muscle cells. Biochem J 318:965-971. (Pubitemid 26320966)
28. Shepherd PR, Withers DJ, and Siddle K (1998) Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling. Biochem J 333:471-490. (Pubitemid 28398511)
29. Shin JH, Shim JW, Kim DS, and Shim JY (2009) TGF-β effects on airway smooth muscle cell proliferation, VEGF release and signal transduction pathways. Respirology 14:347-353.
30. Trian T, Benard G, Begueret H, Rossignol R, Girodet PO, Ghosh D, Ousova O, Vernejoux JM, Marthan R, Tunon-de-Lara JM, et al. (2007) Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma. J Exp Med 204:3173-3181.
31. Tups A, Anderson GM, Rizwan M, Augustine RA, Chaussade C, Shepherd PR, and Grattan DR (2010) Both p110α and p110β isoforms of phosphatidylinositol 3-OHkinase are required for insulin signalling in the hypothalamus. J Neuroendocrinol 22:534-542.
32. Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, and Waterfield MD (1997) p110δ, a novel phosphoinositide 3-kinase in leukocytes. Proc Natl Acad Sci USA 94:4330-4335. (Pubitemid 27194241)
33. Vignola AM, Chanez P, Chiappara G, Merendino A, Pace E, Rizzo A, la Rocca AM, Bellia V, Bonsignore G, and Bousquet J (1997) Transforming growth factor-β expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med 156:591-599. (Pubitemid 27352000)
34. Vlahos CJ, Matter WF, Hui KY, and Brown RF (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269:5241-5248.
35. Wong KK, Engelman JA, and Cantley LC (2010) Targeting the PI3K signaling pathway in cancer. Curr Opin Genet Dev 20:87-90.