SCOPUS 정보 검색 플랫폼

Molecular Informatics

Volumn 31, Issue 3-4, 2012, Pages 222-230

Molecular dynamics simulations of g protein-coupled receptors

(2) Bruno, Agostino a Costantino, Gabriele a

a UNIVERSITY OF PARMA (Italy)

Author keywords

Conformation landscape; Flexibility; GPCRs; Molecular dynamics simulations

Indexed keywords

BIOLOGICAL MEMBRANES; C (PROGRAMMING LANGUAGE); PROTEINS;

3 DIMENSIONAL STRUCTURE; CLASS A; CLASS A/B; CONFORMATION LANDSCAPE; DYNAMICS SIMULATION; FLEXIBILITY; G PROTEIN COUPLED RECEPTORS; HIGH RESOLUTION; MEMBRANE-BOUND RECEPTORS; MOLECULAR DYNAMIC SIMULATION;

MOLECULAR DYNAMICS;

DELTA OPIATE RECEPTOR; G PROTEIN COUPLED RECEPTOR; RHODOPSIN; TERNARY COMPLEX FACTOR;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BIOLOGICAL FUNCTIONS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DIMERIZATION; HUMAN; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; OLIGOMERIZATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 84859887931 PISSN: 18681743 EISSN: 18681751 Source Type: Journal
DOI: 10.1002/minf.201100138 Document Type: Article

Times cited : (16)

References (120)

1
- 79960176452
- M. Congreve, C. J. Langmead, J. S. Mason, F. H. Marshall, J. Med. Chem. 2011, 54, 4283-4311.
- (2011) J. Med. Chem. , vol.54 , pp. 4283-4311
- Congreve, M.¹ Langmead, C.J.² Mason, J.S.³ Marshall, F.H.⁴

2
- 42149181885
- M. C. Lagerstrom, H. B. Schioth, Nat. Rev. Drug. Discov. 2008, 7, 339-357.
- (2008) Nat. Rev. Drug. Discov. , vol.7 , pp. 339-357
- Lagerstrom, M.C.¹ Schioth, H.B.²

3
- 85165475503
- Iuphar Database G-Protein-Coupled Receptor List, http://www.iuphar-db. org/DATABASE/GPCRListForward.
- Iuphar Database G-Protein-Coupled Receptor List

4
- 33749521608
- K. Lundstrom, Curr. Protein Pept. Sci. 2006, 7, 465-470.
- (2006) Curr. Protein Pept. Sci. , vol.7 , pp. 465-470
- Lundstrom, K.¹

5
- 0034604451
- K. Palczewski, T. Kumasaka, T. Hori, C. A. Behnke, H. Motoshima, B. A. Fox, I. Le Trong, D. C. Teller, T. Okada, R. E. Stenkamp, M. Yamamoto, M. Miyano, Science 2000, 289, 739-745.
- (2000) Science , vol.289 , pp. 739-745
- Palczewski, K.¹ Kumasaka, T.² Hori, T.³ Behnke, C.A.⁴ Motoshima, H.⁵ Fox, B.A.⁶ Le Trong, I.⁷ Teller, D.C.⁸ Okada, T.⁹ Stenkamp, R.E.¹⁰ Yamamoto, M.¹¹ Miyano, M.¹²

6
- 52949102889
- P. Scheerer, J. H. Park, P. W. Hildebrand, Y. J. Kim, N. Krauss, H.-W. Choe, K. P. Hofmann, O. P. Ernst, Nature 2008, 455, 497-502.
- (2008) Nature , vol.455 , pp. 497-502
- Scheerer, P.¹ Park, J.H.² Hildebrand, P.W.³ Kim, Y.J.⁴ Krauss, N.⁵ Choe, H.-W.⁶ Hofmann, K.P.⁷ Ernst, O.P.⁸

7
- 47049130668
- J. H. Park, P. Scheerer, K. P. Hofmann, H.-W. Choe, O. P. Ernst, Nature 2008, 454, 183-187.
- (2008) Nature , vol.454 , pp. 183-187
- Park, J.H.¹ Scheerer, P.² Hofmann, K.P.³ Choe, H.-W.⁴ Ernst, O.P.⁵

8
- 80051658642
- S. G. F. Rasmussen, B. T. DeVree, Y. Zou, A. C. Kruse, K. Y. Chung, T. S. Kobilka, F. S. Thian, P. S. Chae, E. Pardon, D. Calinski, J. M. Mathiesen, S. T. A. Shah, J. A. Lyons, M. Caffrey, S. H. Gellman, J. Steyaert, G. Skiniotis, W. I. Weis, R. K. Sunahara, B. K. Kobilka, Nature 2011, 477, 549-555.
- (2011) Nature , vol.477 , pp. 549-555
- Rasmussen, S.G.F.¹ Devree, B.T.² Zou, Y.³ Kruse, A.C.⁴ Chung, K.Y.⁵ Kobilka, T.S.⁶ Thian, F.S.⁷ Chae, P.S.⁸ Pardon, E.⁹ Calinski, D.¹⁰ Mathiesen, J.M.¹¹ Shah, S.T.A.¹² Lyons, J.A.¹³ Caffrey, M.¹⁴ Gellman, S.H.¹⁵ Steyaert, J.¹⁶ Skiniotis, G.¹⁷ Weis, W.I.¹⁸ Sunahara, R.K.¹⁹ Kobilka, B.K.²⁰ more..

9
- 78651411166
- S. G. F. Rasmussen, H.-J. Choi, J. J. Fung, E. Pardon, P. Casarosa, P. S. Chae, B. T. DeVree, D. M. Rosenbaum, F. S. Thian, T. S. Kobilka, A. Schnapp, I. Konetzki, R. K. Sunahara, S. H. Gellman, A. Pautsch, J. Steyaert, W. I. Weis, B. K. Kobilka, Nature 2011, 469, 175-180.
- (2011) Nature , vol.469 , pp. 175-180
- Rasmussen, S.G.F.¹ Choi, H.-J.² Fung, J.J.³ Pardon, E.⁴ Casarosa, P.⁵ Chae, P.S.⁶ Devree, B.T.⁷ Rosenbaum, D.M.⁸ Thian, F.S.⁹ Kobilka, T.S.¹⁰ Schnapp, A.¹¹ Konetzki, I.¹² Sunahara, R.K.¹³ Gellman, S.H.¹⁴ Pautsch, A.¹⁵ Steyaert, J.¹⁶ Weis, W.I.¹⁷ Kobilka, B.K.¹⁸

10
- 78651399683
- D. M. Rosenbaum, C. Zhang, J. A. Lyons, R. Holl, D. Aragao, D. H. Arlow, S. G. F. Rasmussen, H.-J. Choi, B. T. DeVree, R. K. Sunahara, P. S. Chae, S. H. Gellman, R. O. Dror, D. E. Shaw, W. I. Weis, M. Caffrey, P. Gmeiner, B. K. Kobilka, Nature 2011, 469, 236-240.
- (2011) Nature , vol.469 , pp. 236-240
- Rosenbaum, D.M.¹ Zhang, C.² Lyons, J.A.³ Holl, R.⁴ Aragao, D.⁵ Arlow, D.H.⁶ Rasmussen, S.G.F.⁷ Choi, H.-J.⁸ Devree, B.T.⁹ Sunahara, R.K.¹⁰ Chae, P.S.¹¹ Gellman, S.H.¹² Dror, R.O.¹³ Shaw, D.E.¹⁴ Weis, W.I.¹⁵ Caffrey, M.¹⁶ Gmeiner, P.¹⁷ Kobilka, B.K.¹⁸

11
- 79954782236
- F. Xu, H. Wu, V. Katritch, G. W. Han, K. A. Jacobson, Z.-G. Gao, V. Cherezov, R. C. Stevens, Science 2011, 332, 322-327.
- (2011) Science , vol.332 , pp. 322-327
- Xu, F.¹ Wu, H.² Katritch, V.³ Han, G.W.⁴ Jacobson, K.A.⁵ Gao, Z.-G.⁶ Cherezov, V.⁷ Stevens, R.C.⁸

12
- 79956124396
- G. Lebon, K. Bennett, A. Jazayeri, C. G. Tate, J. Mol. Biol. 2011, 409, 298-310.
- (2011) J. Mol. Biol. , vol.409 , pp. 298-310
- Lebon, G.¹ Bennett, K.² Jazayeri, A.³ Tate, C.G.⁴

13
- 33746321096
- H. Nakamichi, T. Okada, Angew. Chem. Int. Ed. Engl. 2006, 45, 4270-4273.
- (2006) Angew. Chem. Int. Ed. Engl. , vol.45 , pp. 4270-4273
- Nakamichi, H.¹ Okada, T.²

14
- 33748079137
- H. Nakamichi, T. Okada, Proc. Natl. Acad. Sci. USA 2006, 103, 12729-12734.
- (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 12729-12734
- Nakamichi, H.¹ Okada, T.²

15
- 5044235587
- J. J. Ruprecht, T. Mielke, R. Vogel, C. Villa, G. F. X. Schertler, EMBO J. 2004, 23, 3609-3620.
- (2004) EMBO J. , vol.23 , pp. 3609-3620
- Ruprecht, J.J.¹ Mielke, T.² Vogel, R.³ Villa, C.⁴ Schertler, G.F.X.⁵

16
- 41149137801
- P. S.-H. Park, D. T. Lodowski, K. Palczewski, Annu. Rev. Pharmacol. Toxicol. 2008, 48, 107-141.
- (2008) Annu. Rev. Pharmacol. Toxicol. , vol.48 , pp. 107-141
- Park, P.S.-H.¹ Lodowski, D.T.² Palczewski, K.³

17
- 0037285444
- W. L. Hubbell, C. Altenbach, C. M. Hubbell, H. G. Khorana, Adv. Protein Chem. 2003, 63, 243-290.
- (2003) Adv. Protein Chem. , vol.63 , pp. 243-290
- Hubbell, W.L.¹ Altenbach, C.² Hubbell, C.M.³ Khorana, H.G.⁴

18
- 77951877209
- S. Ye, E. Zaitseva, G. Caltabiano, G. F. X. Schertler, T. P. Sakmar, X. Deupi, R. Vogel, Nature 2010, 464, 1386-1389.
- (2010) Nature , vol.464 , pp. 1386-1389
- Ye, S.¹ Zaitseva, E.² Caltabiano, G.³ Schertler, G.F.X.⁴ Sakmar, T.P.⁵ Deupi, X.⁶ Vogel, R.⁷

19
- 34447633368
- B. K. Kobilka, X. Deupi, Trends Pharmacol. Sci. 2007, 28, 397-406.
- (2007) Trends Pharmacol. Sci. , vol.28 , pp. 397-406
- Kobilka, B.K.¹ Deupi, X.²

20
- 77958039571
- X. Deupi, B. K. Kobilka, Physiology (Bethesda) 2010, 25, 293-303.
- (2010) Physiology (Bethesda) , vol.25 , pp. 293-303
- Deupi, X.¹ Kobilka, B.K.²

21
- 4644260473
- J. Bockaert, L. Fagni, A. Dumuis, P. Marin, Pharmacol. Ther. 2004, 103, 203-221.
- (2004) Pharmacol. Ther. , vol.103 , pp. 203-221
- Bockaert, J.¹ Fagni, L.² Dumuis, A.³ Marin, P.⁴

22
- 33646943202
- S. A. Adcock, J. A. McCammon, Chem. Rev. 2006, 106, 1589-1615.
- (2006) Chem. Rev. , vol.106 , pp. 1589-1615
- Adcock, S.A.¹ McCammon, J.A.²

23
- 64649101249
- J. L. Klepeis, K. Lindorff-Larsen, R. O. Dror, D. E. Shaw, Curr. Opin. Struct. Biol. 2009, 19, 120-127.
- (2009) Curr. Opin. Struct. Biol. , vol.19 , pp. 120-127
- Klepeis, J.L.¹ Lindorff-Larsen, K.² Dror, R.O.³ Shaw, D.E.⁴

24
- 77953080085
- R. O. Dror, M. O. Jensen, D. W. Borhani, D. E. Shaw, J. Gen. Physiol. 2010, 135, 555-562.
- (2010) J. Gen. Physiol. , vol.135 , pp. 555-562
- Dror, R.O.¹ Jensen, M.O.² Borhani, D.W.³ Shaw, D.E.⁴

25
- 0342929614
- G. M. Torrie, J. P. Valleau, J. Comput. Phys. 1977, 23, 187-199.
- (1977) J. Comput. Phys. , vol.23 , pp. 187-199
- Torrie, G.M.¹ Valleau, J.P.²

26
- 38349091489
- A. Barducci, G. Bussi, M. Parrinello, Phys. Rev. Lett. 2008, 100, 020603.
- (2008) Phys. Rev. Lett. , vol.100 , pp. 020603
- Barducci, A.¹ Bussi, G.² Parrinello, M.³

27
- 33847242278
- P. J. Bond, J. Holyoake, A. Ivetac, S. Khalid, M. S. P. Sansom, J. Struct. Biol. 2007, 157, 593-605.
- (2007) J. Struct. Biol. , vol.157 , pp. 593-605
- Bond, P.J.¹ Holyoake, J.² Ivetac, A.³ Khalid, S.⁴ Sansom, M.S.P.⁵

28
- 79955811328
- A. Grossfield, Biochim. Biophys. Acta 2011, 1808, 1868-1878.
- (2011) Biochim. Biophys. Acta , vol.1808 , pp. 1868-1878
- Grossfield, A.¹

29
- 80052077522
- J. M. Johnston, M. Filizola, Curr. Opin. Struct. Biol. 2011, 21, 552-558.
- (2011) Curr. Opin. Struct. Biol. , vol.21 , pp. 552-558
- Johnston, J.M.¹ Filizola, M.²

30
- 0027465713
- P. Cronet, C. Sander, G. Vriend, Protein Eng. 1993, 6, 59-64.
- (1993) Protein Eng. , vol.6 , pp. 59-64
- Cronet, P.¹ Sander, C.² Vriend, G.³

31
- 0025716272
- R. Henderson, G. F. Schertler, Philos. Trans. Roy. Soc. London, B, Biol. Sci. 1990, 326, 379-389.
- (1990) Philos. Trans. Roy. Soc. London, B, Biol. Sci. , vol.326 , pp. 379-389
- Henderson, R.¹ Schertler, G.F.²

32
- 0027193530
- E. W. Taylor, A. Agarwal, FEBS Lett. 1993, 325, 161-166.
- (1993) FEBS Lett. , vol.325 , pp. 161-166
- Taylor, E.W.¹ Agarwal, A.²

33
- 0026517309
- L. Pardo, J. A. Ballesteros, R. Osman, H. Weinstein, Proc. Natl. Acad. Sci. USA 1992, 89, 4009-4012.
- (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 4009-4012
- Pardo, L.¹ Ballesteros, J.A.² Osman, R.³ Weinstein, H.⁴

34
- 0345621656
- A. M. ter Laak, R. Kühne, Recept. Channels 1999, 6, 295-308.
- (1999) Recept. Channels , vol.6 , pp. 295-308
- Ter Laak, A.M.¹ Kühne, R.²

35
- 0028600609
- X. Luo, D. Zhang, H. Weinstein, Protein Eng. 1994, 7, 1441-1448.
- (1994) Protein Eng. , vol.7 , pp. 1441-1448
- Luo, X.¹ Zhang, D.² Weinstein, H.³

36
- 0028258544
- W. Humphrey, I. Logunov, K. Schulten, M. Sheves, Biochemistry 1994, 33, 3668-3678.
- (1994) Biochemistry , vol.33 , pp. 3668-3678
- Humphrey, W.¹ Logunov, I.² Schulten, K.³ Sheves, M.⁴

37
- 80052024187
- H. Jin, D. Jespersen, P. Mehrotra, R. Biswas, L. Huang, B. Chapman, Parallel Comput. 2011, 37, 562-575.
- (2011) Parallel Comput. , vol.37 , pp. 562-575
- Jin, H.¹ Jespersen, D.² Mehrotra, P.³ Biswas, R.⁴ Huang, L.⁵ Chapman, B.⁶

38
- 79951638366
- 69.
- K. Karimi, N. Dickson, F. Hamze, Int. J. High Perform. Comput. Appl. 2011, 25, 61 -69.
- (2011) Int. J. High Perform. Comput. Appl. , vol.25 , pp. 61
- Karimi, K.¹ Dickson, N.² Hamze, F.³

39
- 79251643750
- M. Papadrakakis, G. Stavroulakis, A. Karatarakis, Comput. Meth. Appl. Mech. Eng. 2011, 200, 1490-1508.
- (2011) Comput. Meth. Appl. Mech. Eng. , vol.200 , pp. 1490-1508
- Papadrakakis, M.¹ Stavroulakis, G.² Karatarakis, A.³

40
- 77956286977
- J. E. Stone, D. J. Hardy, I. S. Ufimtsev, K. Schulten, J. Mol. Graph. Model. 2010, 29, 116-125.
- (2010) J. Mol. Graph. Model. , vol.29 , pp. 116-125
- Stone, J.E.¹ Hardy, D.J.² Ufimtsev, I.S.³ Schulten, K.⁴

41
- 67650266997
- G. Khelashvili, A. Grossfield, S. E. Feller, M. C. Pitman, H. Weinstein, Proteins 2009, 76, 403-417.
- (2009) Proteins , vol.76 , pp. 403-417
- Khelashvili, G.¹ Grossfield, A.² Feller, S.E.³ Pitman, M.C.⁴ Weinstein, H.⁵

42
- 33748325882
- R. A. Copeland, D. L. Pompliano, T. D. Meek, Nat. Rev. Drug. Discov. 2006, 5, 730-739.
- (2006) Nat. Rev. Drug. Discov. , vol.5 , pp. 730-739
- Copeland, R.A.¹ Pompliano, D.L.² Meek, T.D.³

43
- 77955329488
- H. Lu, P. J. Tonge, Curr. Opin. Chem. Biol. 2010, 14, 467-474.
- (2010) Curr. Opin. Chem. Biol. , vol.14 , pp. 467-474
- Lu, H.¹ Tonge, P.J.²

44
- 34249290776
- A. Fernández, A. Sanguino, Z. Peng, A. Crespo, E. Ozturk, X. Zhang, S. Wang, W. Bornmann, G. Lopez-Berestein, Cancer Res. 2007, 67, 4028-4033.
- (2007) Cancer Res. , vol.67 , pp. 4028-4033
- Fernández, A.¹ Sanguino, A.² Peng, Z.³ Crespo, A.⁴ Ozturk, E.⁵ Zhang, X.⁶ Wang, S.⁷ Bornmann, W.⁸ Lopez-Berestein, G.⁹

45
- 44049103958
- P. J. Tummino, R. A. Copeland, Biochemistry 2008, 47, 5481-5492.
- (2008) Biochemistry , vol.47 , pp. 5481-5492
- Tummino, P.J.¹ Copeland, R.A.²

46
- 77952921531
- D. P. Hurst, A. Grossfield, D. L. Lynch, S. Feller, T. D. Romo, K. Gawrisch, M. C. Pitman, P. H. Reggio, J. Biol. Chem. 2010, 285, 17954-17964.
- (2010) J. Biol. Chem. , vol.285 , pp. 17954-17964
- Hurst, D.P.¹ Grossfield, A.² Lynch, D.L.³ Feller, S.⁴ Romo, T.D.⁵ Gawrisch, K.⁶ Pitman, M.C.⁷ Reggio, P.H.⁸

47
- 70350230389
- D. Provasi, A. Bortolato, M. Filizola, Biochemistry 2009, 48, 10020-10029.
- (2009) Biochemistry , vol.48 , pp. 10020-10029
- Provasi, D.¹ Bortolato, A.² Filizola, M.³

48
- 69749115865
- T. Wang, Y. Duan, J. Mol. Biol 2009, 392, 1102-1115.
- (2009) J. Mol. Biol , vol.392 , pp. 1102-1115
- Wang, T.¹ Duan, Y.²

49
- 80052001378
- R. O. Dror, A. C. Pan, D. H. Arlow, D. W. Borhani, P. Maragakis, Y. Shan, H. Xu, D. E. Shaw, Proc. Natl. Acad. Sci. USA 2011, 108, 13118-13123.
- (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 13118-13123
- Dror, R.O.¹ Pan, A.C.² Arlow, D.H.³ Borhani, D.W.⁴ Maragakis, P.⁵ Shan, Y.⁶ Xu, H.⁷ Shaw, D.E.⁸

50
- 78751498756
- T. Kenakin, J. Pharmacol. Exp. Ther. 2011, 336, 296-302.
- (2011) J. Pharmacol. Exp. Ther. , vol.336 , pp. 296-302
- Kenakin, T.¹

51
- 36348946976
- T. Kenakin, Mol. Pharmacol. 2007, 72, 1393-1401.
- (2007) Mol. Pharmacol. , vol.72 , pp. 1393-1401
- Kenakin, T.¹

52
- 0043235844
- T. Kenakin, Trends Pharmacol. Sci. 2003, 24, 346-354.
- (2003) Trends Pharmacol. Sci. , vol.24 , pp. 346-354
- Kenakin, T.¹

53
- 22944487986
- D. M. Perez, S. S. Karnik, Pharmacol. Rev. 2005, 57, 147-161.
- (2005) Pharmacol. Rev. , vol.57 , pp. 147-161
- Perez, D.M.¹ Karnik, S.S.²

54
- 78149496656
- N. Vaidehi, T. Kenakin, Curr. Opin. Pharmacol. 2010, 10, 775-781.
- (2010) Curr. Opin. Pharmacol. , vol.10 , pp. 775-781
- Vaidehi, N.¹ Kenakin, T.²

55
- 85165471234
- G. Lebon, T. Warne, P. C. Edwards, K. Bennett, C. J. Langmead, A. G. W. Leslie, C. G. Tate, Nature 2011.
- (2011) Nature
- Lebon, G.¹ Warne, T.² Edwards, P.C.³ Bennett, K.⁴ Langmead, C.J.⁵ Leslie, A.G.W.⁶ Tate, C.G.⁷

56
- 36448995359
- V. Cherezov, D. M. Rosenbaum, M. A. Hanson, S. G. F. Rasmussen, F. S. Thian, T. S. Kobilka, H.-J. Choi, P. Kuhn, W. I. Weis, B. K. Kobilka, R. C. Stevens, Science 2007, 318, 1258-1265.
- (2007) Science , vol.318 , pp. 1258-1265
- Cherezov, V.¹ Rosenbaum, D.M.² Hanson, M.A.³ Rasmussen, S.G.F.⁴ Thian, F.S.⁵ Kobilka, T.S.⁶ Choi, H.-J.⁷ Kuhn, P.⁸ Weis, W.I.⁹ Kobilka, B.K.¹⁰ Stevens, R.C.¹¹

57
- 36248970132
- S. G. F. Rasmussen, H.-J. Choi, D. M. Rosenbaum, T. S. Kobilka, F. S. Thian, P. C. Edwards, M. Burghammer, V. R. P. Ratnala, R. Sanishvili, R. F. Fischetti, G. F. X. Schertler, W. I. Weis, B. K. Kobilka, Nature 2007, 450, 383-387.
- (2007) Nature , vol.450 , pp. 383-387
- Rasmussen, S.G.F.¹ Choi, H.-J.² Rosenbaum, D.M.³ Kobilka, T.S.⁴ Thian, F.S.⁵ Edwards, P.C.⁶ Burghammer, M.⁷ Ratnala, V.R.P.⁸ Sanishvili, R.⁹ Fischetti, R.F.¹⁰ Schertler, G.F.X.¹¹ Weis, W.I.¹² Kobilka, B.K.¹³

58
- 56749103466
- V.-P. Jaakola, M. T. Griffith, M. A. Hanson, V. Cherezov, E. Y. T. Chien, J. R. Lane, A. P. Ijzerman, R. C. Stevens, Science 2008, 322, 1211-1217.
- (2008) Science , vol.322 , pp. 1211-1217
- Jaakola, V.-P.¹ Griffith, M.T.² Hanson, M.A.³ Cherezov, V.⁴ Chien, E.Y.T.⁵ Lane, J.R.⁶ Ijzerman, A.P.⁷ Stevens, R.C.⁸

59
- 78651405537
- T. Warne, R. Moukhametzianov, J. G. Baker, R. Nehmé, P. C. Edwards, A. G. W. Leslie, G. F. X. Schertler, C. G. Tate, Nature 2011, 469, 241-244.
- (2011) Nature , vol.469 , pp. 241-244
- Warne, T.¹ Moukhametzianov, R.² Baker, J.G.³ Nehmé, R.⁴ Edwards, P.C.⁵ Leslie, A.G.W.⁶ Schertler, G.F.X.⁷ Tate, C.G.⁸

60
- 77951244300
- V.-P. Jaakola, J. R. Lane, J. Y. Lin, V. Katritch, A. P. Ijzerman, R. C. Stevens, J. Biol. Chem. 2010, 285, 13032-13044.
- (2010) J. Biol. Chem. , vol.285 , pp. 13032-13044
- Jaakola, V.-P.¹ Lane, J.R.² Lin, J.Y.³ Katritch, V.⁴ Ijzerman, A.P.⁵ Stevens, R.C.⁶

61
- 79954425389
- B. K. Kobilka, Trends Pharmacol. Sci. 2011, 32, 213-218.
- (2011) Trends Pharmacol. Sci. , vol.32 , pp. 213-218
- Kobilka, B.K.¹

62
- 33144459843
- T. W. Schwartz, T. M. Frimurer, B. Holst, M. M. Rosenkilde, C. E. Elling, Annu. Rev. Pharmacol. Toxicol. 2006, 46, 481-519.
- (2006) Annu. Rev. Pharmacol. Toxicol. , vol.46 , pp. 481-519
- Schwartz, T.W.¹ Frimurer, T.M.² Holst, B.³ Rosenkilde, M.M.⁴ Elling, C.E.⁵

63
- 0035800850
- J. A. Ballesteros, A. D. Jensen, G. Liapakis, S. G. Rasmussen, L. Shi, U. Gether, J. A. Javitch, J. Biol. Chem. 2001, 276, 29171-29177.
- (2001) J. Biol. Chem. , vol.276 , pp. 29171-29177
- Ballesteros, J.A.¹ Jensen, A.D.² Liapakis, G.³ Rasmussen, S.G.⁴ Shi, L.⁵ Gether, U.⁶ Javitch, J.A.⁷

64
- 66249144426
- D. M. Rosenbaum, S. G. F. Rasmussen, B. K. Kobilka, Nature 2009, 459, 356-363.
- (2009) Nature , vol.459 , pp. 356-363
- Rosenbaum, D.M.¹ Rasmussen, S.G.F.² Kobilka, B.K.³

65
- 80052082999
- X. Deupi, J. Standfuss, Curr. Opin. Struct. Biol. 2011, 21, 541-551.
- (2011) Curr. Opin. Struct. Biol. , vol.21 , pp. 541-551
- Deupi, X.¹ Standfuss, J.²

66
- 79953242234
- J. Standfuss, P. C. Edwards, A. D'Antona, M. Fransen, G. Xie, D. D. Oprian, G. F. X. Schertler, Nature 2011, 471, 656-660.
- (2011) Nature , vol.471 , pp. 656-660
- Standfuss, J.¹ Edwards, P.C.² D'Antona, A.³ Fransen, M.⁴ Xie, G.⁵ Oprian, D.D.⁶ Schertler, G.F.X.⁷

67
- 63849294621
- R. O. Dror, D. H. Arlow, D. W. Borhani, M. O. Jensen, S. Piana, D. E. Shaw, Proc. Natl. Acad. Sci. USA 2009, 106, 4689-4694.
- (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 4689-4694
- Dror, R.O.¹ Arlow, D.H.² Borhani, D.W.³ Jensen, M.O.⁴ Piana, S.⁵ Shaw, D.E.⁶

68
- 85165495816
- D. E. Shaw Research, http://www.deshawresearch.com/.
- D. E. Shaw Research

69
- 0019137579
- A. De Lean, J. M. Stadel, R. J. Lefkowitz, J. Biol. Chem. 1980, 255, 7108-7117.
- (1980) J. Biol. Chem. , vol.255 , pp. 7108-7117
- Lean, A.D.¹ Stadel, J.M.² Lefkowitz, R.J.³

70
- 34548671028
- M. Y. Niv, L. Skrabanek, M. Filizola, H. Weinstein, J. Comput. Aided Mol. Des. 2006, 20, 437-448.
- (2006) J. Comput. Aided Mol. Des. , vol.20 , pp. 437-448
- Niv, M.Y.¹ Skrabanek, L.² Filizola, M.³ Weinstein, H.⁴

71
- 48749113684
- I. G. Tikhonova, R. B. Best, S. Engel, M. C. Gershengorn, G. Hummer, S. Costanzi, J. Am. Chem. Soc. 2008, 130, 10141-10149.
- (2008) J. Am. Chem. Soc. , vol.130 , pp. 10141-10149
- Tikhonova, I.G.¹ Best, R.B.² Engel, S.³ Gershengorn, M.C.⁴ Hummer, G.⁵ Costanzi, S.⁶

72
- 77956638608
- D. Provasi, M. Filizola, Biophys. J. 2010, 98, 2347-2355.
- (2010) Biophys. J. , vol.98 , pp. 2347-2355
- Provasi, D.¹ Filizola, M.²

73
- 0037015153
- U. F. Röhrig, L. Guidoni, U. Rothlisberger, Biochemistry 2002, 41, 10799-10809.
- (2002) Biochemistry , vol.41 , pp. 10799-10809
- Röhrig, U.F.¹ Guidoni, L.² Rothlisberger, U.³

74
- 0842344300
- P. R. Gouldson, N. J. Kidley, R. P. Bywater, G. Psaroudakis, H. D. Brooks, C. Diaz, D. Shire, C. A. Reynolds, Proteins 2004, 56, 67-84.
- (2004) Proteins , vol.56 , pp. 67-84
- Gouldson, P.R.¹ Kidley, N.J.² Bywater, R.P.³ Psaroudakis, G.⁴ Brooks, H.D.⁵ Diaz, C.⁶ Shire, D.⁷ Reynolds, C.A.⁸

75
- 77949321753
- V. Hornak, S. Ahuja, M. Eilers, J. A. Goncalves, M. Sheves, P. J. Reeves, S. O. Smith, J. Mol. Biol. 2010, 396, 510-527.
- (2010) J. Mol. Biol. , vol.396 , pp. 510-527
- Hornak, V.¹ Ahuja, S.² Eilers, M.³ Goncalves, J.A.⁴ Sheves, M.⁵ Reeves, P.J.⁶ Smith, S.O.⁷

76
- 41549137044
- F. Raimondi, M. Seeber, P. G. D. Benedetti, F. Fanelli, J. Am. Chem. Soc. 2008, 130, 4310-4325.
- (2008) J. Am. Chem. Soc. , vol.130 , pp. 4310-4325
- Raimondi, F.¹ Seeber, M.² Benedetti, P.G.D.³ Fanelli, F.⁴

77
- 77950857819
- N. G. Sgourakis, A. E. Garcia, J. Mol. Biol. 2010, 398, 161-173.
- (2010) J. Mol. Biol. , vol.398 , pp. 161-173
- Sgourakis, N.G.¹ Garcia, A.E.²

78
- 39149104024
- V. V. Gurevich, E. V. Gurevich, Trends Neurosci. 2008, 31, 74-81.
- (2008) Trends Neurosci. , vol.31 , pp. 74-81
- Gurevich, V.V.¹ Gurevich, E.V.²

79
- 72449150733
- L. M. Simpson, B. Taddese, I. D. Wall, C. A. Reynolds, Curr. Opin. Pharmacol. 2010, 10, 30-37.
- (2010) Curr. Opin. Pharmacol. , vol.10 , pp. 30-37
- Simpson, L.M.¹ Taddese, B.² Wall, I.D.³ Reynolds, C.A.⁴

80
- 71749103741
- A. Bortolato, J. C. Mobarec, D. Provasi, M. Filizola, Curr. Pharm. Des. 2009, 15, 4017-4025.
- (2009) Curr. Pharm. Des. , vol.15 , pp. 4017-4025
- Bortolato, A.¹ Mobarec, J.C.² Provasi, D.³ Filizola, M.⁴

81
- 3242773021
- S. Filipek, K. A. Krzysko, D. Fotiadis, Y. Liang, D. A. Saperstein, A. Engel, K. Palczewski, Photochem. Photobiol. Sci. 2004, 3, 628-638.
- (2004) Photochem. Photobiol. Sci. , vol.3 , pp. 628-638
- Filipek, S.¹ Krzysko, K.A.² Fotiadis, D.³ Liang, Y.⁴ Saperstein, D.A.⁵ Engel, A.⁶ Palczewski, K.⁷

82
- 0037426865
- D. Fotiadis, Y. Liang, S. Filipek, D. A. Saperstein, A. Engel, K. Palczewski, Nature 2003, 421, 127-128.
- (2003) Nature , vol.421 , pp. 127-128
- Fotiadis, D.¹ Liang, Y.² Filipek, S.³ Saperstein, D.A.⁴ Engel, A.⁵ Palczewski, K.⁶

83
- 33644781659
- P. Kota, P. J. Reeves, U. L. Rajbhandary, H. G. Khorana, Proc. Natl. Acad. Sci. USA 2006, 103, 3054-3059.
- (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 3054-3059
- Kota, P.¹ Reeves, P.J.² Rajbhandary, U.L.³ Khorana, H.G.⁴

84
- 34347370129
- M. Filizola, S. X. Wang, H. Weinstein, J. Comput. Aided Mol. Des. 2006, 20, 405-416.
- (2006) J. Comput. Aided Mol. Des. , vol.20 , pp. 405-416
- Filizola, M.¹ Wang, S.X.² Weinstein, H.³

85
- 67650089750
- A. Bruno, A. E. Guadix, G. Costantino, J. Chem. Inf. Model. 2009, 49, 1602-1616.
- (2009) J. Chem. Inf. Model. , vol.49 , pp. 1602-1616
- Bruno, A.¹ Guadix, A.E.² Costantino, G.³

86
- 40449139964
- J. Gonzalez-Maeso, R. L. Ang, T. Yuen, P. Chan, N. V. Weisstaub, J. F. Lopez-Gimenez, M. Zhou, Y. Okawa, L. F. Callado, G. Milligan, J. A. Gingrich, M. Filizola, J. J. Meana, S. C. Sealfon, Nature 2008, 452, 93-97.
- (2008) Nature , vol.452 , pp. 93-97
- Gonzalez-Maeso, J.¹ Ang, R.L.² Yuen, T.³ Chan, P.⁴ Weisstaub, N.V.⁵ Lopez-Gimenez, J.F.⁶ Zhou, M.⁷ Okawa, Y.⁸ Callado, L.F.⁹ Milligan, G.¹⁰ Gingrich, J.A.¹¹ Filizola, M.¹² Meana, J.J.¹³ Sealfon, S.C.¹⁴

87
- 77955262698
- D. Provasi, J. M. Johnston, M. Filizola, Biochemistry 2010, 49, 6771-6776.
- (2010) Biochemistry , vol.49 , pp. 6771-6776
- Provasi, D.¹ Johnston, J.M.² Filizola, M.³

88
- 79952393275
- J. M. Johnston, M. Aburi, D. Provasi, A. Bortolato, E. Urizar, N. A. Lambert, J. A. Javitch, M. Filizola, Biochemistry 2011, 50, 1682-1690.
- (2011) Biochemistry , vol.50 , pp. 1682-1690
- Johnston, J.M.¹ Aburi, M.² Provasi, D.³ Bortolato, A.⁴ Urizar, E.⁵ Lambert, N.A.⁶ Javitch, J.A.⁷ Filizola, M.⁸

89
- 78650147139
- N. J. Smith, G. Milligan, Pharmacol. Rev. 2010, 62, 701-725.
- (2010) Pharmacol. Rev. , vol.62 , pp. 701-725
- Smith, N.J.¹ Milligan, G.²

90
- 79955965790
- A. Bruno, C. Beato, G. Costantino, Future Med. Chem. 2011, 3, 665-681.
- (2011) Future Med. Chem. , vol.3 , pp. 665-681
- Bruno, A.¹ Beato, C.² Costantino, G.³

91
- 66849093630
- J. Brea, M. Castro, J. Giraldo, J. F. Lõpez-Giménez, J. F. Padín, F. Quintián, M. I. Cadavid, M. T. Vilarõ, G. Mengod, K. A. Berg, W. P. Clarke, J.-P. Vilardaga, G. Milligan, M. I. Loza, Mol. Pharmacol. 2009, 75, 1380-1391.
- (2009) Mol. Pharmacol. , vol.75 , pp. 1380-1391
- Brea, J.¹ Castro, M.² Giraldo, J.³ Lõpez-Giménez, J.F.⁴ Padín, J.F.⁵ Quintián, F.⁶ Cadavid, M.I.⁷ Vilarõ, M.T.⁸ Mengod, G.⁹ Berg, K.A.¹⁰ Clarke, W.P.¹¹ Vilardaga, J.-P.¹² Milligan, G.¹³ Loza, M.I.¹⁴

92
- 77953281763
- M. Neri, S. Vanni, I. Tavernelli, U. Rothlisberger, Biochemistry 2010, 49, 4827-4832.
- (2010) Biochemistry , vol.49 , pp. 4827-4832
- Neri, M.¹ Vanni, S.² Tavernelli, I.³ Rothlisberger, U.⁴

93
- 34548146523
- X. Periole, T. Huber, S.-J. Marrink, T. P. Sakmar, J. Am. Chem. Soc. 2007, 129, 10126-10132.
- (2007) J. Am. Chem. Soc. , vol.129 , pp. 10126-10132
- Periole, X.¹ Huber, T.² Marrink, S.-J.³ Sakmar, T.P.⁴

94
- 34447624153
- T. Kenakin, Trends Pharmacol. Sci. 2007, 28, 407-415.
- (2007) Trends Pharmacol. Sci. , vol.28 , pp. 407-415
- Kenakin, T.¹

95
- 4644260473
- J. Bockaert, L. Fagni, A. Dumuis, P. Marin, Pharmacol. Ther. 2004, 103, 203-221.
- (2004) Pharmacol. Ther. , vol.103 , pp. 203-221
- Bockaert, J.¹ Fagni, L.² Dumuis, A.³ Marin, P.⁴

96
- 70450263435
- S. L. Ritter, R. A. Hall, Nat. Rev. Mol. Cell Biol. 2009, 10, 819-830.
- (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 819-830
- Ritter, S.L.¹ Hall, R.A.²

97
- 67649306770
- B. Chini, M. Parenti, J. Mol. Endocrinol. 2009, 42, 371-379.
- (2009) J. Mol. Endocrinol. , vol.42 , pp. 371-379
- Chini, B.¹ Parenti, M.²

98
- 33947431049
- P. V. Escriba, P. B. Wedegaertner, F. M. Goni, O. Vöegler, Biochim. Biophys. Acta 2007, 1768, 836-852.
- (2007) Biochim. Biophys. Acta , vol.1768 , pp. 836-852
- Escriba, P.V.¹ Wedegaertner, P.B.² Goni, F.M.³ Vöegler, O.⁴

99
- 59149087657
- S. S. Ericksen, D. F. Cummings, H. Weinstein, J. A. Schetz, J. Pharmacol. Exp. Ther. 2009, 328, 40-54.
- (2009) J. Pharmacol. Exp. Ther. , vol.328 , pp. 40-54
- Ericksen, S.S.¹ Cummings, D.F.² Weinstein, H.³ Schetz, J.A.⁴

100
- 34548757535
- G. Milligan, M. Canals, J. D. Pediani, J. Ellis and J. F. Lopez-Gimenez, Ernst Schering Found. Symp. Proc. 2006, 2, 145-161.
- (2006) Ernst Schering Found. Symp. Proc. , vol.2 , pp. 145-161
- Milligan, G.¹ Canals, M.² Pediani, J.D.³ Ellis, J.⁴ Lopez-Gimenez, J.F.⁵

101
- 20344370764
- J. P. Changeux, S. J. Edelstein, Science 2005, 308, 1424-1428.
- (2005) Science , vol.308 , pp. 1424-1428
- Changeux, J.P.¹ Edelstein, S.J.²

102
- 78650301416
- N. J. Smith, K. A. Bennet, G. Milligan, Mol. Cell. Endocrinol. 2011, 331, 241-247.
- (2011) Mol. Cell. Endocrinol. , vol.331 , pp. 241-247
- Smith, N.J.¹ Bennet, K.A.² Milligan, G.³

103
- 79960070651
- T. Shimamura, M. Shiroishi, S. Weyand, H. Tsujimoto, G. Winter, V. Katritch, R. Abagyan, V. Cherezov, W. Liu, G. W. Han, T. Kobayashi, R. C. Stevens, S. Iwata, Nature 2011, 475, 65-70.
- (2011) Nature , vol.475 , pp. 65-70
- Shimamura, T.¹ Shiroishi, M.² Weyand, S.³ Tsujimoto, H.⁴ Winter, G.⁵ Katritch, V.⁶ Abagyan, R.⁷ Cherezov, V.⁸ Liu, W.⁹ Han, G.W.¹⁰ Kobayashi, T.¹¹ Stevens, R.C.¹² Iwata, S.¹³

104
- 78449305788
- E. Y. Chien, W. Liu, Q. Zhao, V. Katritch, G. W. Han, M. A. Hanson, L. Shi, A. H. Newman, J. A. Javitch, V. Cherezov, R. C. Stevens, Science 2010, 330, 1091-1095.
- (2010) Science , vol.330 , pp. 1091-1095
- Chien, E.Y.¹ Liu, W.² Zhao, Q.³ Katritch, V.⁴ Han, G.W.⁵ Hanson, M.A.⁶ Shi, L.⁷ Newman, A.H.⁸ Javitch, J.A.⁹ Cherezov, V.¹⁰ Stevens, R.C.¹¹

105
- 44649172481
- M. A. Hanson, V. Cherezov, M. T. Griffith, C. B. Roth, V. P. Jaakola, E. Y. Chien, J. Velasquez, P. Kuhn, R. C. Stevens, Structure 2008, 16, 897-905.
- (2008) Structure , vol.16 , pp. 897-905
- Hanson, M.A.¹ Cherezov, V.² Griffith, M.T.³ Roth, C.B.⁴ Jaakola, V.P.⁵ Chien, E.Y.⁶ Velasquez, J.⁷ Kuhn, P.⁸ Stevens, R.C.⁹

106
- 78049415021
- e.
- J. Selent, F. Sanz, M. Pastor, G. De Fabritiis, Plos Comput. Biol. 2010, 6, e 1000884.
- (2010) Plos Comput. Biol. , vol.6 , pp. 1000884
- Selent, J.¹ Sanz, F.² Pastor, M.³ Fabritiis, G.D.⁴

107
- 85165464569
- ACEMD, Multiscale Laboratory
- ACEMD, Multiscale Laboratory, http://multiscalelab.org/acemd.

108
- 69349100797
- M. Bonomi, D. Branduardi, G. Bussi, C. Camilloni, D D D. Provasi, P. Raiteri, D. Donadio, F. Marinelli, F. Pietrucci, R. A. Broglia, M. Parrinello, PLUMED: Comput. Phys. Commun. 2009, 180, 1961-1972.
- (2009) PLUMED: Comput. Phys. Commun. , vol.180 , pp. 1961-1972
- Bonomi, M.¹ Branduardi, D.² Bussi, G.³ Camilloni, C.⁴ Provasi, D.D.D.⁵ Raiteri, P.⁶ Donadio, D.⁷ Marinelli, F.⁸ Pietrucci, F.⁹ Broglia, R.A.¹⁰ Parrinello, M.¹¹

109
- 85165475709
- P. Bell, Chem. Rev. 2008, 108, 74-108.
- (2008) Chem. Rev. , vol.108 , pp. 74-108
- Bell, P.¹

110
- 66649096395
- T. E. Angel, M. R. Chance, K. Palczewski, Proc. Natl. Acad. Sci. USA 2009, 106, 8555-8560.
- (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 8555-8560
- Angel, T.E.¹ Chance, M.R.² Palczewski, K.³

111
- 70149112575
- T. E. Angel, S. Gupta, B. Jastrzebska, K. Palczewski, M. R. Chance, Proc. Natl. Acad. Sci. USA 2009, 106, 14367-14372.
- (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 14367-14372
- Angel, T.E.¹ Gupta, S.² Jastrzebska, B.³ Palczewski, K.⁴ Chance, M.R.⁵

112
- 79959564813
- G. Lebon, T. Warne, P. C. Edwards, C. J. Langmead, A. G. Leslie, C. G. Tate, Nature 2011, 474, 521-525.
- (2011) Nature , vol.474 , pp. 521-525
- Lebon, G.¹ Warne, T.² Edwards, P.C.³ Langmead, C.J.⁴ Leslie, A.G.⁵ Tate, C.G.⁶

113
- 80052082999
- X. Deupi, J. Standfuss, Curr. Opin. Struct. Biol. 2011, 21, 541-551.
- (2011) Curr. Opin. Struct. Biol. , vol.21 , pp. 541-551
- Deupi, X.¹ Standfuss, J.²

114
- 47049084133
- A. Grossfield, M. C. Pitman, S. E. Feller, O. Soubias, K. Gawrish, J. Mol. Biol. 2008, 381, 478-486.
- (2008) J. Mol. Biol. , vol.381 , pp. 478-486
- Grossfield, A.¹ Pitman, M.C.² Feller, S.E.³ Soubias, O.⁴ Gawrish, K.⁵

115
- 33847361456
- A. Grossfield, S. E. Feller, M. C. Pitman, Proteins 2007, 67, 31-40.
- (2007) Proteins , vol.67 , pp. 31-40
- Grossfield, A.¹ Feller, S.E.² Pitman, M.C.³

116
- 69349101503
- A. Grossfield, D. M. Zuckerman, Annu. Rep. Comput. Chem. 2009, 5, 23-48.
- (2009) Annu. Rep. Comput. Chem. , vol.5 , pp. 23-48
- Grossfield, A.¹ Zuckerman, D.M.²

117
- 78049502261
- V. Cherezov, E. Abola, R. C. Stevens, Methods Mol. Biol. 2010, 654, 141-168.
- (2010) Methods Mol. Biol. , vol.654 , pp. 141-168
- Cherezov, V.¹ Abola, E.² Stevens, R.C.³

118
- 80052083563
- J. Steyaert, B. K. Kobilka, Curr. Opin. Struct. Biol. 2011, 21, 567-572.
- (2011) Curr. Opin. Struct. Biol. , vol.21 , pp. 567-572
- Steyaert, J.¹ Kobilka, B.K.²

119
- 79953900818
- R. M. Bill, P. J. Henderson, S. Iwata, E. R. Kunji, H. Michel, R. Neutze, S. Newstead, B. Poolman, C. G. Tate, H. Vogel, Nat. Biotechnol. 2011, 29, 335-340.
- (2011) Nat. Biotechnol. , vol.29 , pp. 335-340
- Bill, R.M.¹ Henderson, P.J.² Iwata, S.³ Kunji, E.R.⁴ Michel, H.⁵ Neutze, R.⁶ Newstead, S.⁷ Poolman, B.⁸ Tate, C.G.⁹ Vogel, H.¹⁰

120
- 85165502321
- GPCRs Network
- GPCRs Network, GPCR Targets, http://gpcr.scripps.edu/gpcr-targets.htm.
- GPCR Targets

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.