Role of aggregation in rhodopsin signal transduction

Biochemistry

Volumn 49, Issue 23, 2010, Pages 4827-4832

  Neri, Marilisa ^a   Vanni, Stefano ^a   Tavernelli, Ivano ^a   Rothlisberger, Ursula ^a  

^a EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION EFFICIENCY; FUNCTIONAL UNITS; G PROTEIN ACTIVATION; G PROTEIN COUPLED RECEPTORS; LIGHT DETECTION; MOLECULAR DYNAMICS SIMULATIONS;

BACTERIOPHAGES; MOLECULAR DYNAMICS; OLIGOMERIZATION; OLIGOMERS; PHOTOEXCITATION; PROTEINS;

SIGNAL TRANSDUCTION;

G PROTEIN COUPLED RECEPTOR; MONOMER; RHODOPSIN;

ARTICLE; BINDING SITE; DIMERIZATION; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; OLIGOMERIZATION; PHOTOSTIMULATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN STRUCTURE, FUNCTION AND VARIABILITY; SIGNAL TRANSDUCTION;

ANIMALS; CATTLE; CELL MEMBRANE; CROSS-LINKING REAGENTS; DIMERIZATION; EVOLUTION, MOLECULAR; INTRACELLULAR SPACE; MICROSCOPY, ATOMIC FORCE; MOLECULAR DYNAMICS SIMULATION; MULTIGENE FAMILY; PROTEIN CONFORMATION; PROTEIN SUBUNITS; RECEPTOR CROSS-TALK; RECEPTORS, DOPAMINE D2; RHODOPSIN; SIGNAL TRANSDUCTION;

EID: 77953281763     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100478j     Document Type: Article

References (44)

1. Pierce, K. L., Premont, R. T., and Lefkowitz, R. J. (2002) Seven-transmembrane receptors Nat. Rev. Mol. Cell Biol. 3, 639-650
2. Palczewski, K., Kumasaka, T., Hori, T., Behke, A., Motoshima, H., Fox, B. A., Trong, I. L., Teller, D. C., Okada, T., Stenkamp, R. E., Yamamoto, M., and Miyano, M. (2000) Crystal structure of rhodopsin: A G protein-coupled receptor Science 289, 739-745
3. Schwartz, T. H., Frimurer, T. M., Holst, B., Rosenkilde, M. M., and Elling, C. E. (2006) Molecular mechanism of 7TM receptor activation - a global toggle switch model Annu. Rev. Pharmacol. Toxicol. 46, 481-519
4. Kukura, P., McCamant, D. W., Yoon, S., Wandschneider, D. B., and Mathies, R. A. (2005) Structural observation of the primary isomerization in vision with femtosecond-stimulated raman Science 310, 1006-1009
5. Nakamichi, H. and Okada, T. (2006) Crystallographic analysis of primary visual photochemistry Angew. Chem., Int. Ed. Engl. 45, 4270
6. Salom, D., Lodowski, D. T., Stenkamp, R. E., Golczak, I. L. T. M., Jastrzebska, B., Harris, T., Ballesteros, J. A., and Palczewski, K. (2006) Crystal structure of a photoactivated deprotonated intermediate of rhodopsin Proc. Natl. Acad. Sci. U.S.A. 103, 16123-16128
7. Rohrig, U. F., Guidoni, L., and Rothlisberger, U. (2002) Early steps of the intramolecular signal transduction in rhodopsin explored by molecular dynamics simulations Biochemistry 41, 10799-10809
8. Saam, J., Tajkhorshid, E., Hayashi, S., and Schulten, K. (2002) Molecular dynamics investigation of primary photoinduced events in the activation of rhodopsin Biophys. J. 83, 3097-3112
9. Rohrig, U. F., Guidoni, L., Laio, A., Frank, I., and Rothlisberger, U. (2004) A molecular spring for vision J. Am. Chem. Soc. 126, 15328-15329
10. Borhan, B., Souto, M. L., Imai, H., Shichida, Y., and Nakanishi, K. (2000) Movement of retinal along the visual transduction path Science 288, 2209-2212
11. Farrens, D. L., Altenbach, C., Yang, K., Hubbell, W., and Khorana, H. G. (1996) Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin Science 276, 768-770
12. Patel, A. B., Crocker, E., Eilers, M., Hirshfeld, A., Sheves, M., and Smith, S. O. (2004) Coupling of retinal isomerization to the activation of rhodopsin Proc. Natl. Acad. Sci. U.S.A. 101, 10048-10053
13. Altenbach, C., Kusnetzow, A. K., Ernst, O. P., Hofmann, K. P., and Hubbell, W. L. (2008) High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation Proc. Natl. Acad. Sci. U.S.A. 105, 7439-7444
14. Scheerer, P., Park, J. H., Hildebrand, P. W., Kim, Y. J., Kraub, N., Choe, H., Hofmann, K. P., and Ernst, O. P. (2008) Crystal structure of opsin in its G-protein-interacting conformation Nature 455, 497-502
15. Franke, R. R., Konig, B., Sakmar, T. P., Khorana, H. G., and Hofmann, K. P. (1990) Rhodopsin mutants that bind but fail to activate transducin Science 250, 123-125
16. Fritze, O., Filipek, S., Kuksa, V., Palczewski, K., Hofmann, K. P., and Ernst, O. P. (2003) Role of the conserved NPxxY(x)5,6f motif in the rhodopsin ground state and during activation Proc. Natl. Acad. Sci. U.S.A. 100, 2290-2295
17. Knierim, B., Hofmann, K. P., Ernst, O. P., and Hubbell, W. L. (2007) Sequence of late molecular events in the activation of rhodopsin Proc. Natl. Acad. Sci. U.S.A. 104, 20290-20295
18. Scheerer, P., Heck, M., Goede, A., Park, J. H., Choe, H., Ernst, O. P., Hofmann, K. P., and Hildebrand, P. W. (2009) Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface Proc. Natl. Acad. Sci. U.S.A. 106, 10660-10665
19. Liang, Y., Fotiadis, D., Filipek, S., Saperstein, D. A., Palczewski, K., and Engel, A. (2003) Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes J. Biol. Chem. 278, 21655-21662
20. Fotiadis, D., Liang, Y., Filipek, S., Saperstein, D. A., Palczewski, K., and Engel, A. (2003) Atomic-force microscopy: Rhodopsin dimers in native disc membranes Nature 421, 127-128
21. Waldhoer, M., Fong, J., Jones, R. M., Lunzer, M. M., Sharma, S. K., Kostenis, E., Portoghese, P. S., and Whistler, J. L. (2005) A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers Proc. Natl. Acad. Sci. U.S.A. 102, 9050-9055
22. Fotiadis, D., Jastrzebska, B., Philippsen, A., and Muller, D. J. (2006) Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors Curr. Opin. Struct. Biol. 16, 252-259
23. Palczewski, K. (2006) G protein-coupled receptor rhodopsin Annu. Rev. Biochem. 75, 74-7673
24. Kota, P., Reeves, P. J., Rajbhandary, U. L., and Khorana, H. G. (2006) Opsin is present as dimers in cos1 cells: Identification of amino acids at the dimeric interface Proc. Natl. Acad. Sci. U.S.A. 103, 3054-3059
25. Lohse, M. J. (2010) Dimerization in GPCR mobility and signaling Curr. Opin. Pharmacol. 10, 53-58
26. Simpson, L. M., Taddese, B., Wall, I. D., and Reynolds, C. A. (2010) Bioinformatics and molecular modelling approaches to gpcr oligomerization Curr. Opin. Pharmacol. 10, 30-37
27. Jastrzebska, B., Maeda, T., Zhu, L., Fotiadis, D., Filipek, S., Engel, A., Stenkamp, R. E., and Palczewski, K. (2004) Functional characterization of rhodopsin monomers and dimers in detergents J. Biol. Chem. 279, 54663-54675
28. Jastrzebska, B., Fotiadis, D., Jang, G., Stenkamp, R. E., Engel, A., and Palczewski, K. (2006) Functional and structural characterization of rhodopsin oligomers J. Biol. Chem. 281, 11917-11922
29. Whorton, M. R., Bokoch, M. P., Rasmussen, S. G., Huang, B., Zare, R. N., Kobilka, B., and Sunahara, R. K. (2007) A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein Proc. Natl. Acad. Sci. U.S.A. 104, 7682-7687
30. Milligan, G. (2006) G-protein-coupled receptor heterodimers: Pharmacology, function and relevance to drug discovery Drug Discov. Today 11, 541-549
31. Guo, W., Shi, L., Filizola, M., Weinstein, H., and Javitch, J. A. (2005) Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface determine activation Proc. Natl. Acad. Sci. U.S.A. 102, 17495-17500
32. Guo, W., Shi, L., and Javitch, J. A. (2003) The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer J. Biol. Chem. 278, 4385-4388
33. Berendsen, H. J. C., Postma, J. P. M., van Gunsteren, W. F., and Hermans, J. (1981) in Intermolecular Forces (Pullman, B., Ed.) pp 331-342, Reidel, Dordrecht.
34. Cornell, W. D., Cieplak, P., Bayly, C. I., Gould, I. R., Merz, K. M., Ferguson, D. M., Spellmeyer, D. C., Fox, T., Caldwell, J. W., and Kollman, P. A. (1995) A second generation force field for the simulation of proteins, nucleic acids, and organic molecules J. Am. Chem. Soc. 117, 5179-5191
35. Vanni, S., Neri, M., Tavernelli, I., and Rothlisberger, U. (2010) A conserved protonationinduced switch can trigger ionic-lock formation in adrenergic receptors J. Mol. Biol. 397, 1339-1349
36. Vanni, S., Neri, M., Tavernelli, I., and Rothlisberger, U. (2009) Observation of ionic lock formation in molecular dynamics simulations of wild-type beta 1 and beta 2 adrenergic receptors Biochemistry 48, 4789-4797
37. Van der Spoel, D., Lindahl, E., Hess, B., Groenhof, G., Mark, A. E., and Berendsen, H. J. C. (2005) Gromacs: Fast, flexible and free J. Comput. Chem. 26, 1701-1718
38. Essmann, U., Perera, L., Berkowitz, M. L., Darden, T., Lee, H., and Pedersen, L. G. (1995) A smooth particle mesh Ewald method J. Chem. Phys. 103, 8577-8593
39. Hess, B., Bekker, H., Berendsen, H. J. C., and Fraaije, J. G. E. M. (1997) Lincs: A linear constraint solver for molecular simulations J. Comput. Chem. 18, 1463-1472
40. Berendsen, H. J. C., Postma, J. P. M., van Gunsteren, W. F., DiNola, A., and Haak, J. R. (1984) Molecular dynamics with coupling to an external bath J. Chem. Phys. 81, 3684
41. Humphrey, W., Dalke, A., and Schulten, K. (1996) Vmd - visual molecular dynamics J. Mol. Graphics 14, 33
42. Furutani, Y., Kandori, H., and Shichida, Y. (2003) Structural changes of water molecules during the photoactivation processes in bovine rhodopsin Biochemistry 42, 9619-9625
43. Amadei, A., Linssen, A. B., and Berendsen, H. J. (1993) Essential dynamics of proteins Proteins 17, 412-425
44. Arnis, S. and Hofmann., k. P. (1993) Two different forms of metarhodopsin II: Schiff base deprotonation precedes proton uptake and signaling state Proc. Natl. Acad. Sci. U.S.A. 90, 7849-7853