-
1
-
-
0037246310
-
Systematic review of incidence studies of Parkinson's disease
-
DOI 10.1002/mds.10305
-
Twelves D., Perkins K. S. M., Counsell C., Systematic review of incidence studies of Parkinson's disease Movement Disorders 2003 18 1 19 31 (Pubitemid 36150204)
-
(2003)
Movement Disorders
, vol.18
, Issue.1
, pp. 19-31
-
-
Twelves, D.1
Perkins, K.S.M.2
Counsell, C.3
-
2
-
-
0035115941
-
Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease
-
Brown P., Oliviero A., Mazzone P., Insola A., Tonali P., Di Lazzaro V., Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease Journal of Neuroscience 2001 21 3 1033 1038 (Pubitemid 32163143)
-
(2001)
Journal of Neuroscience
, vol.21
, Issue.3
, pp. 1033-1038
-
-
Brown, P.1
Oliviero, A.2
Mazzone, P.3
Insola, A.4
Tonali, P.5
Di Lazzaro, V.6
-
3
-
-
0038389600
-
Pathophysiology of Parkinson's disease: The MPTP primate model of the human disorder
-
Wichmann T., DeLong M. R., Pathophysiology of Parkinson's disease: the MPTP primate model of the human disorder Annals of the New York Academy of Sciences 2003 991 199 213 (Pubitemid 36793815)
-
(2003)
Annals of the New York Academy of Sciences
, vol.991
, pp. 199-213
-
-
Wichmann, T.1
DeLong, M.R.2
-
4
-
-
0035241271
-
Dorsal subthalamotomy for Parkinson's disease
-
DOI 10.1002/1531-8257(200101)16:1<72::AID-MDS1019>3.0.CO;2-6
-
Alvarez L., Macias R., Guridi J., Lopez G., Alvarez E., Maragoto C., Teijeiro J., Torres A., Pavon N., Rodriguez-Oroz M. C., Ochoa L., Hetherington H., Juncos J., DeLong M. R., Obeso J. A., Dorsal subthalamotomy for Parkinson's disease Movement Disorders 2001 16 1 72 78 (Pubitemid 36041116)
-
(2001)
Movement Disorders
, vol.16
, Issue.1
, pp. 72-78
-
-
Alvarez, L.1
Macias, R.2
Guridi, J.3
Lopez, G.4
Alvarez, E.5
Maragoto, C.6
Teijeiro, J.7
Torres, A.8
Pavon, N.9
Rodriguez-Oroz, M.C.10
Ochoa, L.11
Hetherington, H.12
Juncos, J.13
DeLong, M.R.14
Obeso, J.A.15
-
5
-
-
0037809608
-
Treatment of advanced Parkinson's disease by subthalamotomy: One-year results
-
DOI 10.1002/mds.10393
-
Su P. C., Tseng H. M., Liu H. M., Yen R. F., Liou H. H., Treatment of advanced Parkinson's disease by subthalamotomy: one-year results Movement Disorders 2003 18 5 531 538 (Pubitemid 36656537)
-
(2003)
Movement Disorders
, vol.18
, Issue.5
, pp. 531-538
-
-
Su, P.C.1
Tseng, H.-M.2
Liu, H.-M.3
Yen, R.-F.4
Liou, H.-H.5
-
6
-
-
0030053751
-
Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders
-
Benabid A. L., Pollak P., Gao D., Hoffmann D., Limousin P., Gay E., Payen I., Benazzouz A., Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders Journal of Neurosurgery 1996 84 2 203 214 (Pubitemid 26039470)
-
(1996)
Journal of Neurosurgery
, vol.84
, Issue.2
, pp. 203-214
-
-
Benabid, A.L.1
Pollak, P.2
Gao, D.3
Hoffmann, D.4
Limousin, P.5
Gay, E.6
Payen, I.7
Benazzouz, A.8
-
7
-
-
0035960120
-
Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease
-
Obeso J. A., Olanow C. W., Rodriguez-Oroz M. C., Krack P., Kumar R., Lang A. E., Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease New England Journal of Medicine 2001 345 13 956 963
-
(2001)
New England Journal of Medicine
, vol.345
, Issue.13
, pp. 956-963
-
-
Obeso, J.A.1
Olanow, C.W.2
Rodriguez-Oroz, M.C.3
Krack, P.4
Kumar, R.5
Lang, A.E.6
-
8
-
-
0034778739
-
Lidocaine and muscimol microinjections in subthalamic nucleus reverse parkinsonian symptoms
-
Levy R., Lang A. E., Dostrovsky J. O., Pahapill P., Romas J., Saint-Cyr J., Hutchison W. D., Lozano A. M., Lidocaine and muscimol microinjections in subthalamic nucleus reverse parkinsonian symptoms Brain 2001 124 10 2105 2118 (Pubitemid 32945907)
-
(2001)
Brain
, vol.124
, Issue.10
, pp. 2105-2118
-
-
Levy, R.1
Lang, A.E.2
Dostrovsky, J.O.3
Pahapill, P.4
Romas, J.5
Saint-Cyr, J.6
Hutchison, W.D.7
Lozano, A.M.8
-
9
-
-
34248575534
-
Levodopa in the treatment of Parkinson's disease
-
Fahn S., Levodopa in the treatment of Parkinson's disease Journal of Neural Transmission 2006 71 1 15 (Pubitemid 351412101)
-
(2006)
Journal of Neural Transmission, Supplement
, Issue.71
, pp. 1-15
-
-
Fahn, S.1
-
10
-
-
0034684139
-
Pramipexole vs levodopa as initial treatment for Parkinson's disease: A randomised controlled trial
-
Parkinson Study Group
-
Parkinson Study Group, Pramipexole vs levodopa as initial treatment for Parkinson's disease: a randomised controlled trial Journal of the American Medical Association 2000 284 15 1931 1938
-
(2000)
Journal of the American Medical Association
, vol.284
, Issue.15
, pp. 1931-1938
-
-
-
11
-
-
0034721690
-
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
-
Kordower J. H., Emborg M. E., Bloch J., Ma S. Y., Chu Y., Leventhal L., McBride J., Chen E. Y., Palfi S., Roitberg B. Z., Brown W. D., Holden J. E., Pyzalski R., Taylor M. D., Carvey P., Ling Z., Trono D., Hantraye P., Deglon N., Aebischer P., Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease Science 2000 290 5492 767 773
-
(2000)
Science
, vol.290
, Issue.5492
, pp. 767-773
-
-
Kordower, J.H.1
Emborg, M.E.2
Bloch, J.3
Ma, S.Y.4
Chu, Y.5
Leventhal, L.6
McBride, J.7
Chen, E.Y.8
Palfi, S.9
Roitberg, B.Z.10
Brown, W.D.11
Holden, J.E.12
Pyzalski, R.13
Taylor, M.D.14
Carvey, P.15
Ling, Z.16
Trono, D.17
Hantraye, P.18
Deglon, N.19
Aebischer, P.20
more..
-
12
-
-
78349247631
-
Gene delivery of AAV2-neurturin for Parkinson's disease: A double-blind, randomised, controlled trial
-
Marks W. J. Jr. , Bartus R. T., Siffert J., Davis C. S., Lozano A., Boulis N., Vitek J., Stacy M., Turner D., Verhagen L., Bakay R., Watts R., Guthrie B., Jankovic J., Simpson R., Tagliati M., Alterman R., Stern M., Baltuch G., Starr P. A., Larson P. S., Ostrem J. L., Nutt J., Kieburtz K., Kordower J. H., Olanow C. W., Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial The Lancet Neurology 2010 9 12 1164 1172
-
(2010)
The Lancet Neurology
, vol.9
, Issue.12
, pp. 1164-1172
-
-
Marks Jr., W.J.1
Bartus, R.T.2
Siffert, J.3
Davis, C.S.4
Lozano, A.5
Boulis, N.6
Vitek, J.7
Stacy, M.8
Turner, D.9
Verhagen, L.10
Bakay, R.11
Watts, R.12
Guthrie, B.13
Jankovic, J.14
Simpson, R.15
Tagliati, M.16
Alterman, R.17
Stern, M.18
Baltuch, G.19
Starr, P.A.20
Larson, P.S.21
Ostrem, J.L.22
Nutt, J.23
Kieburtz, K.24
Kordower, J.H.25
Olanow, C.W.26
more..
-
13
-
-
44949222522
-
Results from a phase i safety trial of hAADC gene therapy for Parkinson disease
-
Eberling J. L., Jagust W. J., Christine C. W., Starr P., Larson P., Bankiewicz K. S., Aminoff M. J., Results from a phase I safety trial of hAADC gene therapy for Parkinson disease Neurology 2008 70 21 1980 1983
-
(2008)
Neurology
, vol.70
, Issue.21
, pp. 1980-1983
-
-
Eberling, J.L.1
Jagust, W.J.2
Christine, C.W.3
Starr, P.4
Larson, P.5
Bankiewicz, K.S.6
Aminoff, M.J.7
-
14
-
-
0036897235
-
Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease
-
Azzouz M., Martin-Rendon E., Barber R. D., Mitrophanous K. A., Carter E. E., Rohll J. B., Kingsman S. M., Kingsman A. J., Mazarakis N. D., Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease Journal of Neuroscience 2002 22 23 10302 10312 (Pubitemid 35416868)
-
(2002)
Journal of Neuroscience
, vol.22
, Issue.23
, pp. 10302-10312
-
-
Azzouz, M.1
Martin-Rendon, E.2
Barber, R.D.3
Mitrophanous, K.A.4
Carter, E.E.5
Rohll, J.B.6
Kingsman, S.M.7
Kingsman, A.J.8
Mazarakis, N.D.9
-
15
-
-
32544432029
-
Non-motor symptoms of Parkinson's disease: Diagnosis and management
-
DOI 10.1016/S1474-4422(06)70373-8, PII S1474442206703738
-
Chaudhuri K. R., Healy D. G., Schapira A. H. V., Non-motor symptoms of Parkinson's disease: diagnosis and management Lancet Neurology 2006 5 3 235 245 (Pubitemid 43238347)
-
(2006)
Lancet Neurology
, vol.5
, Issue.3
, pp. 235-245
-
-
Chaudhuri, K.R.1
Healy, D.G.2
Schapira, A.H.V.3
-
16
-
-
51449123001
-
Non-dopaminergic treatments in development for Parkinson's disease
-
Fox S. H., Brotchie J. M., Lang A. E., Non-dopaminergic treatments in development for Parkinson's disease The Lancet Neurology 2008 7 10 927 938
-
(2008)
The Lancet Neurology
, vol.7
, Issue.10
, pp. 927-938
-
-
Fox, S.H.1
Brotchie, J.M.2
Lang, A.E.3
-
17
-
-
70349501374
-
Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles
-
Huang R., Han L., Li J., Ren F., Ke W., Jiang C., Pei Y., Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles Journal of Gene Medicine 2009 11 9 754 763
-
(2009)
Journal of Gene Medicine
, vol.11
, Issue.9
, pp. 754-763
-
-
Huang, R.1
Han, L.2
Li, J.3
Ren, F.4
Ke, W.5
Jiang, C.6
Pei, Y.7
-
18
-
-
33751267286
-
Neurotensin polyplex as an efficient carrier for delivering the human GDNF gene into nigral dopamine neurons of hemiparkinsonian rats
-
DOI 10.1016/j.ymthe.2006.09.001, PII S1525001606016534
-
Gonzalez-Barrios J. A., Lindahl M., Bannon M. J., Anaya-Martnez V., Flores G., Navarro-Quiroga I., Trudeau L. E., Aceves J., Martinez-Arguelles D. B., Garcia-Villegas R., Jiménez I., Segovia J., Martinez-Fong D., Neurotensin polyplex as an efficient carrier for delivering the human GDNF gene into nigral dopamine neurons of hemiparkinsonian rats Molecular Therapy 2006 14 6 857 865 (Pubitemid 44793642)
-
(2006)
Molecular Therapy
, vol.14
, Issue.6
, pp. 857-865
-
-
Gonzalez-Barrios, J.A.1
Lindahl, M.2
Bannon, M.J.3
Anaya-Martinez, V.4
Flores, G.5
Navarro-Quiroga, I.6
Trudeau, L.E.7
Aceves, J.8
Martinez-Arguelles, D.B.9
Garcia-Villegas, R.10
Jimenez, I.11
Segovia, J.12
Martinez-Fong, D.13
-
19
-
-
40549111959
-
Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoter
-
DOI 10.1002/jgm.1152
-
Xia C. F., Boado R. J., Zhang Y., Chu C., Pardridge W. M., Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoter Journal of Gene Medicine 2008 10 3 306 315 (Pubitemid 351359643)
-
(2008)
Journal of Gene Medicine
, vol.10
, Issue.3
, pp. 306-315
-
-
Xia, C.-F.1
Boado, R.J.2
Zhang, Y.3
Chu, C.4
Pardridge, W.M.5
-
20
-
-
0020684648
-
Nucleotide sequence and organization of the adeno-associated virus 2 genome
-
Srivastava A., Lusby E. W., Berns K. I., Nucleotide sequence and organization of the adeno-associated virus 2 genome Journal of Virology 1983 45 2 555 564 (Pubitemid 13225420)
-
(1983)
Journal of Virology
, vol.45
, Issue.2
, pp. 555-564
-
-
Srivastava, A.1
Lusby, E.W.2
Berns, K.I.3
-
21
-
-
0037333815
-
Genetic fate of recombinant adeno-associated virus vector genomes in muscle
-
DOI 10.1128/JVI.77.6.3495-3504.2003
-
Schnepp B. C., Clark K. R., Klemanski D. L., Pacak C. A., Johnson P. R., Genetic fate of recombinant adeno-associated virus vector genomes in muscle Journal of Virology 2003 77 6 3495 3504 (Pubitemid 36297269)
-
(2003)
Journal of Virology
, vol.77
, Issue.6
, pp. 3495-3504
-
-
Schnepp, B.C.1
Clark, K.R.2
Klemanski, D.L.3
Pacak, C.A.4
Johnson, P.R.5
-
22
-
-
37549054118
-
Viral vectors for in vivo gene transfer in Parkinson's disease: Properties and clinical grade production
-
Mandel R. J., Burger C., Snyder R. O., Viral vectors for in vivo gene transfer in Parkinson's disease: properties and clinical grade production Experimental Neurology 2008 209 1 58 71
-
(2008)
Experimental Neurology
, vol.209
, Issue.1
, pp. 58-71
-
-
Mandel, R.J.1
Burger, C.2
Snyder, R.O.3
-
23
-
-
0026525713
-
Use of adeno-associated virus as a general transduction vector for mammalian cells
-
Muzyczka N., Use of adeno-associated virus as a general transduction vector for mammalian cells Current Topics in Microbiology and Immunology 1992 158 97 129
-
(1992)
Current Topics in Microbiology and Immunology
, vol.158
, pp. 97-129
-
-
Muzyczka, N.1
-
24
-
-
2642512201
-
Clades of adeno-associated viruses are widely disseminated in human tissues
-
DOI 10.1128/JVI.78.12.6381-6388.2004
-
Gao G., Vandenberghe L. H., Alvira M. R., Lu Y., Calcedo R., Zhou X., Wilson J. M., Clades of adeno-associated viruses are widely disseminated in human tissues Journal of Virology 2004 78 12 6381 6388 (Pubitemid 38715936)
-
(2004)
Journal of Virology
, vol.78
, Issue.12
, pp. 6381-6388
-
-
Gao, G.1
Vandenberghe, L.H.2
Alvira, M.R.3
Lu, Y.4
Calcedo, R.5
Zhou, X.6
Wilson, J.M.7
-
25
-
-
77950913649
-
Biodistribution and safety assessment of AAV2-GAD following intrasubthalamic injection in the rat
-
Fitzsimons H. L., Riban V., Bland R. J., Wendelken J. L., Sapan C. V., During M. J., Biodistribution and safety assessment of AAV2-GAD following intrasubthalamic injection in the rat Journal of Gene Medicine 2010 12 4 385 398
-
(2010)
Journal of Gene Medicine
, vol.12
, Issue.4
, pp. 385-398
-
-
Fitzsimons, H.L.1
Riban, V.2
Bland, R.J.3
Wendelken, J.L.4
Sapan, C.V.5
During, M.J.6
-
26
-
-
77649270699
-
Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primates
-
Dodiya H. B., Bjorklund T., Stansell J. III, Mandel R. J., Kirik D., Kordower J. H., Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primates Molecular Therapy 2010 18 3 579 587
-
(2010)
Molecular Therapy
, vol.18
, Issue.3
, pp. 579-587
-
-
Dodiya, H.B.1
Bjorklund, T.2
Stansell III, J.3
Mandel, R.J.4
Kirik, D.5
Kordower, J.H.6
-
27
-
-
74349129455
-
AAV9-mediated erythropoietin gene delivery into the brain protects nigral dopaminergic neurons in a rat model of Parkinson's disease
-
Xue Y. Q., Ma B. F., Zhao L. R., Tatom J. B., Li B., Jiang L. X., Klein R. L., Duan W. M., AAV9-mediated erythropoietin gene delivery into the brain protects nigral dopaminergic neurons in a rat model of Parkinson's disease Gene Therapy 2010 17 1 83 94
-
(2010)
Gene Therapy
, vol.17
, Issue.1
, pp. 83-94
-
-
Xue, Y.Q.1
Ma, B.F.2
Zhao, L.R.3
Tatom, J.B.4
Li, B.5
Jiang, L.X.6
Klein, R.L.7
Duan, W.M.8
-
28
-
-
2642537522
-
Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain
-
DOI 10.1128/JVI.78.12.6344-6359.2004
-
Peden C. S., Burger C., Muzyczka N., Mandel R. J., Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain Journal of Virology 2004 78 12 6344 6359 (Pubitemid 38715933)
-
(2004)
Journal of Virology
, vol.78
, Issue.12
, pp. 6344-6359
-
-
Peden, C.S.1
Burger, C.2
Muzyczka, N.3
Mandel, R.J.4
-
29
-
-
1642443395
-
Striatal delivery of rAAV-hAADC to rats with preexisting immunity to AAV
-
DOI 10.1016/j.ymthe.2003.12.005
-
Sanftner L. M., Suzuki B. M., Doroudchi M. M., Feng L., McClelland A., Forsayeth J. R., Cunningham J., Striatal delivery of rAAV-hAADC to rats with preexisting immunity to AAV Molecular Therapy 2004 9 3 403 409 (Pubitemid 38404529)
-
(2004)
Molecular Therapy
, vol.9
, Issue.3
, pp. 403-409
-
-
Sanftner, L.M.1
Suzuki, B.M.2
Doroudchi, M.M.3
Feng, L.4
McClelland, A.5
Forsayeth, J.R.6
Cunningham, J.7
-
30
-
-
3042856167
-
Input virion proteins: Cryptic targets of antivector immune responses in preimmunized subjects
-
DOI 10.1016/j.ymthe.2004.05.019, PII S1525001604001650
-
Lowenstein P. R., Input virion proteins: cryptic targets of antivector immune responses in preimmunized subjects Molecular Therapy 2004 9 6 771 774 (Pubitemid 38878123)
-
(2004)
Molecular Therapy
, vol.9
, Issue.6
, pp. 771-774
-
-
Lowenstein, P.R.1
-
31
-
-
0009963512
-
Safety of adeno-associated virus gene therapy vectors: A current evaluation
-
Monahan P. E., Jooss K., Sands M. S., Safety of adeno-associated virus gene therapy vectors: a current evaluation Expert Opinion on Drug Safety 2002 1 1 79 91
-
(2002)
Expert Opinion on Drug Safety
, vol.1
, Issue.1
, pp. 79-91
-
-
Monahan, P.E.1
Jooss, K.2
Sands, M.S.3
-
32
-
-
2142751261
-
Evaluation of risks related to the use of adeno-associated virus-based vectors
-
Tenenbaum L., Lehtonen E., Monahan P. E., Evaluation of risks related to the use of adeno-associated virus-based vectors Current Gene Therapy 2003 3 6 545 565
-
(2003)
Current Gene Therapy
, vol.3
, Issue.6
, pp. 545-565
-
-
Tenenbaum, L.1
Lehtonen, E.2
Monahan, P.E.3
-
33
-
-
0024311525
-
Helper-free stocks of recombinant adeno-associated viruses: Normal integration does not require viral gene expression
-
Samulski R. J., Chang L. S., Shenk T., Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression Journal of Virology 1989 63 9 3822 3828 (Pubitemid 19205454)
-
(1989)
Journal of Virology
, vol.63
, Issue.9
, pp. 3822-3828
-
-
Samulski, R.J.1
Chang, L.-S.2
Shenk, T.3
-
34
-
-
0034278156
-
Lentiviral vectors: Excellent tools for experimental gene transfer and promising candidates for gene therapy
-
Vigna E., Naldini L., Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy Journal of Gene Medicine 2000 2 5 308 316
-
(2000)
Journal of Gene Medicine
, vol.2
, Issue.5
, pp. 308-316
-
-
Vigna, E.1
Naldini, L.2
-
35
-
-
22244459917
-
Gene therapy: Twenty-first century medicine
-
DOI 10.1146/annurev.biochem.74.050304.091637
-
Verma I. M., Weitzman M. D., Gene therapy: twenty-first century medicine Annual Review of Biochemistry 2005 74 711 738 (Pubitemid 40995522)
-
(2005)
Annual Review of Biochemistry
, vol.74
, pp. 711-738
-
-
Verma, I.M.1
Weitzman, M.D.2
-
36
-
-
0029996147
-
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
-
Naldini L., Blmer U., Gallay P., Ory D., Mulligan R., Gage F. H., Verma I. M., Trono D., In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector Science 1996 272 5259 263 267 (Pubitemid 26119138)
-
(1996)
Science
, vol.272
, Issue.5259
, pp. 263-267
-
-
Naldini, L.1
Blomer, U.2
Gallay, P.3
Ory, D.4
Mulligan, R.5
Gage, F.H.6
Verma, I.M.7
Trono, D.8
-
37
-
-
34249067496
-
Efficient gene transduction of neurons by lentivirus with enhanced neuron-specific promoters
-
DOI 10.1038/sj.gt.3302924, PII 3302924
-
Hioki H., Kameda H., Nakamura H., Okunomiya T., Ohira K., Nakamura K., Kuroda M., Furuta T., Kaneko T., Efficient gene transduction of neurons by lentivirus with enhanced neuron-specific promoters Gene Therapy 2007 14 11 872 882 (Pubitemid 46780070)
-
(2007)
Gene Therapy
, vol.14
, Issue.11
, pp. 872-882
-
-
Hioki, H.1
Kameda, H.2
Nakamura, H.3
Okunomiya, T.4
Ohira, K.5
Nakamura, K.6
Kuroda, M.7
Furuta, T.8
Kaneko, T.9
-
38
-
-
32944473438
-
Lentiviral vectors for use in the central nervous system
-
DOI 10.1016/j.ymthe.2005.11.012, PII S1525001605017053
-
Jakobsson J., Lundberg C., Lentiviral vectors for use in the central nervous system Molecular Therapy 2006 13 3 484 493 (Pubitemid 43257616)
-
(2006)
Molecular Therapy
, vol.13
, Issue.3
, pp. 484-493
-
-
Jakobsson, J.1
Lundberg, C.2
-
39
-
-
0030819379
-
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
-
Zufferey R., Nagy D., Mandel R. J., Naldini L., Trono D., Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo Nature Biotechnology 1997 15 9 871 875
-
(1997)
Nature Biotechnology
, vol.15
, Issue.9
, pp. 871-875
-
-
Zufferey, R.1
Nagy, D.2
Mandel, R.J.3
Naldini, L.4
Trono, D.5
-
40
-
-
34447250322
-
Lentivirus-mediated gene expression
-
DOI 10.1385/1-59745-030-8:343, Cardiac Gene Expression: Methods and Protocols
-
Zhao J., Lever A. M. L., Lentivirus-mediated gene expression Methods in Molecular Biology 2007 366 343 355 (Pubitemid 350183486)
-
(2007)
Methods in Molecular Biology
, vol.366
, pp. 343-355
-
-
Zhao, J.1
Lever, A.M.L.2
-
41
-
-
0031019795
-
Dopaminergic neurons protected from degeneration by GDNF gene therapy
-
DOI 10.1126/science.275.5301.838
-
Choi-Lundberg D. L., Lin Q., Chang Y. N., Chiang Y. L., Hay C. M., Mohajeri H., Davidson B. L., Bohn M. C., Dopaminergic neurons protected from degeneration by GDNF gene therapy Science 1997 275 5301 838 841 (Pubitemid 27074886)
-
(1997)
Science
, vol.275
, Issue.5301
, pp. 838-841
-
-
Choi-Lundberg, D.L.1
Lin, Q.2
Chang, Y.-N.3
Chiang, Y.L.4
Hay, C.M.5
Mohajeri, H.6
Davidson, B.L.7
Bohn, M.C.8
-
43
-
-
0038128348
-
Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: Peculiarities, mechanisms, and consequences
-
DOI 10.1038/sj.gt.3302048
-
Lowenstein P. R., Castro M. G., Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: peculiarities, mechanisms, and consequences Gene Therapy 2003 10 11 946 954 (Pubitemid 36722429)
-
(2003)
Gene Therapy
, vol.10
, Issue.11 SPEC.
, pp. 946-954
-
-
Lowenstein, P.R.1
Castro, M.G.2
-
44
-
-
0031916435
-
Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity
-
DOI 10.1038/ng0298-180
-
Schiedner G., Morral N., Parks R. J., Wu Y., Koopmans S. C., Langston C., Graham F. L., Beaudet A. L., Kochanek S., Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity Nature Genetics 1998 18 2 180 183 (Pubitemid 28082470)
-
(1998)
Nature Genetics
, vol.18
, Issue.2
, pp. 180-183
-
-
Schiedner, G.1
Morral, N.2
Parks, R.J.3
Wu, Y.4
Koopmans, S.C.5
Langston, C.6
Graham, F.L.7
Beaudet, A.L.8
Kochanek, S.9
-
45
-
-
0036370360
-
High-capacity, helper-dependent, "gutless" adenoviral vectors for gene transfer into brain
-
DOI 10.1016/S0076-6879(02)46062-4, 17, Gene Therapy Methods
-
Lowenstein P. R., Thomas C. E., Umana P., Gerdes C. A., Verakis T., Boyer O., Tondeur S., Klatzmann D., Castro M. G., Lowenstein P. R., High-capacity, helper-dependent, gutless adenoviral vectors for gene transfer into brain Methods in Enzymology 2002 346, article no. 17 292 311 (Pubitemid 41103144)
-
(2002)
Methods in Enzymology
, vol.346
, pp. 292-311
-
-
Lowenstein, P.R.1
Thomas, C.E.2
Umana, P.3
Gerdes, C.A.4
Verakis, T.5
Boyer, O.6
Tondeur, S.7
Klatzmann, D.8
Castro, M.G.9
Lowenstein, P.R.10
-
46
-
-
11144248909
-
The innate immune response to adenovirus vectors
-
Muruve D. A., The innate immune response to adenovirus vectors Human Gene Therapy 2004 15 12 1157 1166 (Pubitemid 40052429)
-
(2004)
Human Gene Therapy
, vol.15
, Issue.12
, pp. 1157-1166
-
-
Muruve, D.A.1
-
47
-
-
3042704538
-
Development and optimization of an adenovirus production process
-
DOI 10.1002/jgm.503
-
Kamen A., Henry O., Development and optimization of an adenovirus production process Journal of Gene Medicine 2004 6 supplement 1 S184 S192 (Pubitemid 40228027)
-
(2004)
Journal of Gene Medicine
, vol.6
, Issue.SUPPL. 1
-
-
Kamen, A.1
Henry, O.2
-
49
-
-
0031048964
-
Engineering herpes simplex virus vectors for gene transfer to neurons
-
DOI 10.1038/nm0397-357
-
Fink D. J., Glorioso J. C., Engineering herpes simplex virus vectors for gene transfer to neurons Nature Medicine 1997 3 3 357 359 (Pubitemid 27112938)
-
(1997)
Nature Medicine
, vol.3
, Issue.3
, pp. 357-359
-
-
Fink, D.J.1
Glorioso, J.C.2
-
50
-
-
42549170505
-
Enhanced nigrostriatal neuron-specific, long-term expression by using neural-specific promoters in combination with targeted gene transfer by modified helper virus-free HSV-1 vector particles
-
ARTICLE 37
-
Cao H., Zhang G. R., Wang X., Kong L., Geller A. I., Enhanced nigrostriatal neuron-specific, long-term expression by using neural-specific promoters in combination with targeted gene transfer by modified helper virus-free HSV-1 vector particles BMC Neuroscience 2008 10 9, article 37
-
(2008)
BMC Neuroscience
, vol.10
, Issue.9
-
-
Cao, H.1
Zhang, G.R.2
Wang, X.3
Kong, L.4
Geller, A.I.5
-
51
-
-
33947314352
-
Glutamatergic or GABAergic neuron-specific, long-term expression in neocortical neurons from helper virus-free HSV-1 vectors containing the phosphate-activated glutaminase, vesicular glutamate transporter-1, or glutamic acid decarboxylase promoter
-
DOI 10.1016/j.brainres.2007.01.125, PII S0006899307001941
-
Rasmussen M., Kong L., Zhang G. R., Liu M., Wang X., Szabo G., Curthoys N. P., Geller A. I., Glutamatergic or GABAergic neuron-specific, long-term expression in neocortical neurons from helper virus-free HSV-1 vectors containing the phosphate-activated glutaminase, vesicular glutamate transporter-1, or glutamic acid decarboxylase promoter Brain Research 2007 1144 1 19 32 (Pubitemid 46440832)
-
(2007)
Brain Research
, vol.1144
, Issue.1
, pp. 19-32
-
-
Rasmussen, M.1
Kong, L.2
Zhang, G.-r.3
Liu, M.4
Wang, X.5
Szabo, G.6
Curthoys, N.P.7
Geller, A.I.8
-
52
-
-
0031947861
-
Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins
-
Samaniego L. A., Neiderhiser L., DeLuca N. A., Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins Journal of Virology 1998 72 4 3307 3320 (Pubitemid 28175576)
-
(1998)
Journal of Virology
, vol.72
, Issue.4
, pp. 3307-3320
-
-
Samaniego, L.A.1
Neiderhiser, L.2
DeLuca, N.A.3
-
54
-
-
84859776672
-
-
Oxford BioMedica, ProSavin. Oxford Biomedica
-
Oxford BioMedica, ProSavin. Oxford Biomedica, http://www.oxfordbiomedica. co.uk/page.asp?pageid=29
-
-
-
-
55
-
-
76949085430
-
Dopamine gene therapy for Parkinson's disease in a nonhuman primate without associated dyskinesia
-
Jarraya B., Boulet S., Ralph G. S., Jan C., Bonvento G., Azzouz M., Miskin J. E., Shin M., Delzescaux T., Drouot X., Hérard A. S., Day D. M., Brouillet E., Kingsman S. M., Hantraye P., Mitrophanous K. A., Mazarakis N. D., Palfi S., Dopamine gene therapy for Parkinson's disease in a nonhuman primate without associated dyskinesia Science Translational Medicine 2009 1 2 2ra4
-
(2009)
Science Translational Medicine
, vol.1
, Issue.2
-
-
Jarraya, B.1
Boulet, S.2
Ralph, G.S.3
Jan, C.4
Bonvento, G.5
Azzouz, M.6
Miskin, J.E.7
Shin, M.8
Delzescaux, T.9
Drouot, X.10
Hérard, A.S.11
Day, D.M.12
Brouillet, E.13
Kingsman, S.M.14
Hantraye, P.15
Mitrophanous, K.A.16
Mazarakis, N.D.17
Palfi, S.18
-
56
-
-
0025876757
-
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
-
Hyman C., Hofer M., Barde Y. A., Juhasz M., Yancopoulos G. D., Squinto S. P., Lindsay R. M., BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra Nature 1991 350 6315 230 232 (Pubitemid 21912205)
-
(1991)
Nature
, vol.350
, Issue.6315
, pp. 230-232
-
-
Hyman, C.1
Hofer, M.2
Barde, Y.-A.3
Juhasz, M.4
Yancopoulos, G.D.5
Squinto, S.P.6
Lindsay, R.M.7
-
57
-
-
0032704605
-
Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer
-
Klein R. L., Lewis M. H., Muzyczka N., Meyer E. M., Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer Brain Research 1999 847 2 314 320
-
(1999)
Brain Research
, vol.847
, Issue.2
, pp. 314-320
-
-
Klein, R.L.1
Lewis, M.H.2
Muzyczka, N.3
Meyer, E.M.4
-
58
-
-
0034672304
-
Towards a neuroprotective gene therapy for Parkinson's disease: Use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model
-
Bjrklund A., Kirik D., Rosenblad C., Georgievska B., Lundberg C., Mandel R. J., Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model Brain Research 2000 886 1-2 82 98
-
(2000)
Brain Research
, vol.886
, Issue.12
, pp. 82-98
-
-
Bjrklund, A.1
Kirik, D.2
Rosenblad, C.3
Georgievska, B.4
Lundberg, C.5
Mandel, R.J.6
-
59
-
-
41949110690
-
Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: An open-label, phase i trial
-
Marks W. J. Jr. , Ostrem J. L., Verhagen L., Starr P. A., Larson P. S., Bakay R. A., Taylor R., Cahn-Weiner D. A., Stoessl A. J., Olanow C. W., Bartus R. T., Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial The Lancet Neurology 2008 7 5 400 408
-
(2008)
The Lancet Neurology
, vol.7
, Issue.5
, pp. 400-408
-
-
Marks Jr., W.J.1
Ostrem, J.L.2
Verhagen, L.3
Starr, P.A.4
Larson, P.S.5
Bakay, R.A.6
Taylor, R.7
Cahn-Weiner, D.A.8
Stoessl, A.J.9
Olanow, C.W.10
Bartus, R.T.11
-
60
-
-
73449128979
-
Safety and tolerability of putaminal AADC gene therapy for Parkinson disease
-
Christine C. W., Starr P. A., Larson P. S., Eberling J. L., Jagust W. J., Hawkins R. A., Vanbrocklin H. F., Wright J. F., Bankiewicz K. S., Aminoff M. J., Safety and tolerability of putaminal AADC gene therapy for Parkinson disease Neurology 2009 73 20 1662 1669
-
(2009)
Neurology
, vol.73
, Issue.20
, pp. 1662-1669
-
-
Christine, C.W.1
Starr, P.A.2
Larson, P.S.3
Eberling, J.L.4
Jagust, W.J.5
Hawkins, R.A.6
Vanbrocklin, H.F.7
Wright, J.F.8
Bankiewicz, K.S.9
Aminoff, M.J.10
-
61
-
-
34250683023
-
Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: An open label, phase I trial
-
DOI 10.1016/S0140-6736(07)60982-9, PII S0140673607609829
-
Kaplitt M. G., Feigin A., Tang C., Fitzsimons H. L., Mattis P., Lawlor P. A., Bland R. J., Young D., Strybing K., Eidelberg D., During M. J., Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial The Lancet 2007 369 9579 2097 2105 (Pubitemid 46935946)
-
(2007)
Lancet
, vol.369
, Issue.9579
, pp. 2097-2105
-
-
Kaplitt, M.G.1
Feigin, A.2
Tang, C.3
Fitzsimons, H.L.4
Mattis, P.5
Lawlor, P.A.6
Bland, R.J.7
Young, D.8
Strybing, K.9
Eidelberg, D.10
During, M.J.11
-
62
-
-
79952740079
-
AAV2-GAD gene therapy for advanced Parkinson's disease: A double-blind, sham-surgery controlled, randomised trial
-
LeWitt P. A., Rezai A. R., Leehey M. A., Ojemann S. G., Flaherty A. W., Eskandar E. N., Kostyk S. K., Thomas K., Sarkar A., Siddiqui M. S., Tatter S. B., Schwalb J. M., Poston K. L., Henderson J. M., Kurlan R. M., Richard I. H., Van Meter L., Sapan C. V., During M. J., Kaplitt M. G., Feigin A., AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial The Lancet Neurology 2011 10 4 309 319
-
(2011)
The Lancet Neurology
, vol.10
, Issue.4
, pp. 309-319
-
-
Lewitt, P.A.1
Rezai, A.R.2
Leehey, M.A.3
Ojemann, S.G.4
Flaherty, A.W.5
Eskandar, E.N.6
Kostyk, S.K.7
Thomas, K.8
Sarkar, A.9
Siddiqui, M.S.10
Tatter, S.B.11
Schwalb, J.M.12
Poston, K.L.13
Henderson, J.M.14
Kurlan, R.M.15
Richard, I.H.16
Van Meter, L.17
Sapan, C.V.18
During, M.J.19
Kaplitt, M.G.20
Feigin, A.21
more..
-
63
-
-
84859770727
-
AMT obtains license to amgens GDNF gene to develop treatment for Parkinsons disease with AMTs proprietary gene therapy platform
-
Amsterdam Molecular Therapeutics September 2008
-
Amsterdam Molecular Therapeutics, AMT obtains license to amgens GDNF gene to develop treatment for Parkinsons disease with AMTs proprietary gene therapy platform. Amsterdam molecular therapeutics. September 2008, http://www. amtbiopharma.com/news/92/182/AMT-Obtains-License-to-Amgen-s-GDNF-Gene-to- Develop-Treatment-for-Parkinson-s-Disease-with-AMT-s-Proprietary-Gene-Therapy- Platform.html
-
Amsterdam Molecular Therapeutics
-
-
-
64
-
-
0033942230
-
Convection-enhanced delivery of AAV vector in Parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach
-
DOI 10.1006/exnr.2000.7408
-
Bankiewicz K. S., Eberling J. L., Kohutnicka M., Jagust W., Pivirotto P., Bringas J., Cunningham J., Budinger T. F., Harvey-White J., Convection-enhanced delivery of AAV vector in Parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach Experimental Neurology 2000 164 1 2 14 (Pubitemid 30490717)
-
(2000)
Experimental Neurology
, vol.164
, Issue.1
, pp. 2-14
-
-
Bankiewicz, K.S.1
Eberling, J.L.2
Kohutnicka, M.3
Jagust, W.4
Pivirotto, P.5
Bringas, J.6
Cunningham, J.7
Budinger, T.F.8
Harvey-White, J.9
-
65
-
-
68549125045
-
Aromatic l-amino acid decarboxylase-immunoreactive structures in human midbrain, pons, and medulla
-
Kitahama K., Ikemoto K., Jouvet A., Araneda S., Nagatsu I., Raynaud B., Nishimura A., Nishi K., Niwa S. I., Aromatic l-amino acid decarboxylase- immunoreactive structures in human midbrain, pons, and medulla Journal of Chemical Neuroanatomy 2009 38 2 130 140
-
(2009)
Journal of Chemical Neuroanatomy
, vol.38
, Issue.2
, pp. 130-140
-
-
Kitahama, K.1
Ikemoto, K.2
Jouvet, A.3
Araneda, S.4
Nagatsu, I.5
Raynaud, B.6
Nishimura, A.7
Nishi, K.8
Niwa, S.I.9
-
66
-
-
33748083041
-
Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC
-
DOI 10.1016/j.ymthe.2006.05.005, PII S1525001606001778
-
Bankiewicz K. S., Forsayeth J., Eberling J. L., Sanchez-Pernaute R., Pivirotto P., Bringas J., Herscovitch P., Carson R. E., Eckelman W., Reutter B., Cunningham J., Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC Molecular Therapy 2006 14 4 564 570 (Pubitemid 44296090)
-
(2006)
Molecular Therapy
, vol.14
, Issue.4
, pp. 564-570
-
-
Bankiewicz, K.S.1
Forsayeth, J.2
Eberling, J.L.3
Sanchez-Pernaute, R.4
Pivirotto, P.5
Bringas, J.6
Herscovitch, P.7
Carson, R.E.8
Eckelman, W.9
Reutter, B.10
Cunningham, J.11
-
67
-
-
77955175906
-
Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC
-
Hadaczek P., Eberling J. L., Pivirotto P., Bringas J., Forsayeth J., Bankiewicz K. S., Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC Molecular Therapy 2010 18 8 1458 1461
-
(2010)
Molecular Therapy
, vol.18
, Issue.8
, pp. 1458-1461
-
-
Hadaczek, P.1
Eberling, J.L.2
Pivirotto, P.3
Bringas, J.4
Forsayeth, J.5
Bankiewicz, K.S.6
-
68
-
-
0346097884
-
The subthalamic nucleus in the context of movement disorders
-
DOI 10.1093/brain/awh029
-
Hamani C., Saint-Cyr J. A., Fraser J., Kaplitt M., Lozano A. M., The subthalamic nucleus in the context of movement disorders Brain 2004 127 1 4 20 (Pubitemid 38055342)
-
(2004)
Brain
, vol.127
, Issue.1
, pp. 4-20
-
-
Hamani, C.1
Saint-Cyr, J.A.2
Fraser, J.3
Kaplitt, M.4
Lozano, A.M.5
-
69
-
-
0025169590
-
Reversal of experimental Parkinsonism by lesions of the subthalamic nucleus
-
Bergman H., Wichmann T., DeLong M. R., Reversal of experimental Parkinsonism by lesions of the subthalamic nucleus Science 1990 249 4975 1436 1438
-
(1990)
Science
, vol.249
, Issue.4975
, pp. 1436-1438
-
-
Bergman, H.1
Wichmann, T.2
Delong, M.R.3
-
70
-
-
0026577196
-
Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene
-
Bu D. F., Erlander M. G., Hitz B. C., Tillakaratne N. J. K., Kaufman D. L., Wagner-McPherson C. B., Evans G. A., Tobin A. J., Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene Proceedings of the National Academy of Sciences of the United States of America 1992 89 6 2115 2119
-
(1992)
Proceedings of the National Academy of Sciences of the United States of America
, vol.89
, Issue.6
, pp. 2115-2119
-
-
Bu, D.F.1
Erlander, M.G.2
Hitz, B.C.3
Tillakaratne, N.J.K.4
Kaufman, D.L.5
Wagner-Mcpherson, C.B.6
Evans, G.A.7
Tobin, A.J.8
-
71
-
-
0025738117
-
Two genes encode distinct glutamate decarboxylases
-
Erlander M. G., Tillakaratne N. J. K., Feldblum S., Patel N., Tobin A. J., Two genes encode distinct glutamate decarboxylases Neuron 1991 7 1 91 100
-
(1991)
Neuron
, vol.7
, Issue.1
, pp. 91-100
-
-
Erlander, M.G.1
Tillakaratne, N.J.K.2
Feldblum, S.3
Patel, N.4
Tobin, A.J.5
-
72
-
-
0027336431
-
67 mRNAs suggest that the two glutamate decarboxylases play distinctive functional roles
-
DOI 10.1002/jnr.490340612
-
Feldblum S., Erlander M. G., Tobin A. J., Different distributions of GAD65 and GAD67 mRNAs suggest that the two glutamate decarboxylases play distinctive functional roles Journal of Neuroscience Research 1993 34 6 689 706 (Pubitemid 23150329)
-
(1993)
Journal of Neuroscience Research
, vol.34
, Issue.6
, pp. 689-706
-
-
Feldblum, S.1
Erlander, M.G.2
Tobin, A.J.3
-
73
-
-
0033168914
-
Recombinant adeno-associated virus (AAV) drives constitutive production of glutamate decarboxylase in neural cell lines
-
DOI 10.1002/(SICI)1097-4547(19990701)57:1<137::AID-JNR15>3.0.CO;2-D
-
Mi J., Chatterjee S., Wong K. K., Forbes C., Lawless G., Tobin A. J., Recombinant adeno-associated virus (AAV) drives constitutive production of glutamate decarboxylase in neural cell lines Journal of Neuroscience Research 1999 57 1 137 148 (Pubitemid 29293588)
-
(1999)
Journal of Neuroscience Research
, vol.57
, Issue.1
, pp. 137-148
-
-
Mi, J.1
Chatterjee, S.2
Wong, K.K.3
Forbes, C.4
Lawless, G.5
Tobin, A.J.6
-
74
-
-
0037064165
-
Subthalamic GAD gene therapy in a Parkinson's disease rat model
-
DOI 10.1126/science.1074549
-
Luo J., Kaplitt M. G., Fitzsimons H. L., Zuzga D. S., Liu Y., Oshinsky M. L., During M. J., Subthalamic GAD gene therapy in a Parkinson's disease rat model Science 2002 298 5592 425 429 (Pubitemid 35176353)
-
(2002)
Science
, vol.298
, Issue.5592
, pp. 425-429
-
-
Luo, J.1
Kaplitt, M.G.2
Fitzsimons, H.L.3
Zuzga, D.S.4
Liu, Y.5
Oshinsky, M.L.6
During, M.J.7
-
75
-
-
23744497262
-
Enhanced expression of glutamate decarboxylase 65 improves symptoms of rat parkinsonian models
-
DOI 10.1038/sj.gt.3302520
-
Lee B., Lee H., Nam Y. R., Oh J. H., Cho Y. H., Chang J. W., Enhanced expression of glutamate decarboxylase 65 improves symptoms of rat parkinsonian models Gene Therapy 2005 12 15 1215 1222 (Pubitemid 41136316)
-
(2005)
Gene Therapy
, vol.12
, Issue.15
, pp. 1215-1222
-
-
Lee, B.1
Lee, H.2
Nam, Y.R.3
Oh, J.H.4
Cho, Y.H.5
Chang, J.W.6
-
76
-
-
33847198228
-
Subthalamic glutamic acid decarboxylase gene therapy: Changes in motor function and cortical metabolism
-
Emborg M. E., Carbon M., Holden J. E., During M. J., Ma Y., Tang C., Moirano J., Fitzsimons H., Roitberg B. Z., Tuccar E., Roberts A., Kaplitt M. G., Eidelberg D., Subthalamic glutamic acid decarboxylase gene therapy: changes in motor function and cortical metabolism Journal of Cerebral Blood Flow and Metabolism 2007 27 3 501 509
-
(2007)
Journal of Cerebral Blood Flow and Metabolism
, vol.27
, Issue.3
, pp. 501-509
-
-
Emborg, M.E.1
Carbon, M.2
Holden, J.E.3
During, M.J.4
Ma, Y.5
Tang, C.6
Moirano, J.7
Fitzsimons, H.8
Roitberg, B.Z.9
Tuccar, E.10
Roberts, A.11
Kaplitt, M.G.12
Eidelberg, D.13
-
77
-
-
0027285510
-
GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
-
Lin L. F. H., Doherty D. H., Lile J. D., Bektesh S., Collins F., GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons Science 1993 260 5111 1130 1132 (Pubitemid 23186789)
-
(1993)
Science
, vol.260
, Issue.5111
, pp. 1130-1132
-
-
Lin, L.-F.H.1
Doherty, D.H.2
Lile, J.D.3
Bektesh, S.4
Collins, F.5
-
78
-
-
0028834063
-
Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
-
Tomac A., Lindqvist E., Lin L. F. H., gren S. O., Young D., Hoffer B. J., Olson L., Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo Nature 1995 373 6512 335 339
-
(1995)
Nature
, vol.373
, Issue.6512
, pp. 335-339
-
-
Tomac, A.1
Lindqvist, E.2
Lin, L.F.H.3
Gren, S.O.4
Young, D.5
Hoffer, B.J.6
Olson, L.7
-
79
-
-
0038249170
-
Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
-
DOI 10.1038/nm850
-
Gill S. S., Patel N. K., Hotton G. R., O'Sullivan K., McCarter R., Bunnage M., Brooks D. J., Svendsen C. N., Heywood P., Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease Nature Medicine 2003 9 5 589 595 (Pubitemid 36597106)
-
(2003)
Nature Medicine
, vol.9
, Issue.5
, pp. 589-595
-
-
Gill, S.S.1
Patel, N.K.2
Hotton, G.R.3
O'Sullivan, K.4
McCarter, R.5
Bunnage, M.6
Brooks, D.J.7
Svendsen, C.N.8
Heywood, P.9
-
80
-
-
33644833272
-
Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease
-
DOI 10.1002/ana.20737
-
Lang A. E., Gill S., Patel N. K., Lozano A., Nutt J. G., Penn R., Brooks D. J., Hotton G., Moro E., Heywood P., Brodsky M. A., Burchiel K., Kelly P., Dalvi A., Scott B., Stacy M., Turner D., Wooten V. G. F., Elias W. J., Laws E. R., Dhawan V., Stoessl A. J., Matcham J., Coffey R. J., Traub M., Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease Annals of Neurology 2006 59 3 459 466 (Pubitemid 43358066)
-
(2006)
Annals of Neurology
, vol.59
, Issue.3
, pp. 459-466
-
-
Lang, A.E.1
Gill, S.2
Patel, N.K.3
Lozano, A.4
Nutt, J.G.5
Penn, R.6
Brooks, D.J.7
Hotton, G.8
Moro, E.9
Heywood, P.10
Brodsky, M.A.11
Burchiel, K.12
Kelly, P.13
Dalvi, A.14
Scott, B.15
Stacy, M.16
Turner, D.17
Wooten, V.G.F.18
Elias, W.J.19
Laws, E.R.20
Dhawan, V.21
Stoessl, A.J.22
Matcham, J.23
Coffey, R.J.24
Traub, M.25
more..
-
81
-
-
13144282676
-
Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: A two-year outcome study
-
DOI 10.1002/ana.20374
-
Patel N. K., Bunnage M., Plaha P., Svendsen C. N., Heywood P., Gill S. S., Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study Annals of Neurology 2005 57 2 298 302 (Pubitemid 40179870)
-
(2005)
Annals of Neurology
, vol.57
, Issue.2
, pp. 298-302
-
-
Patel, N.K.1
Bunnage, M.2
Plaha, P.3
Svendsen, C.N.4
Heywood, P.5
Gill, S.S.6
-
82
-
-
34047220707
-
Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: Response to 1 year of treatment and 1 year of withdrawal
-
Slevin J. T., Gash D. M., Smith C. D., Gerhardt G. A., Kryscio R., Chebrolu H., Walton A., Wagner R., Young A. B., Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal Journal of Neurosurgery 2007 106 4 614 620 (Pubitemid 46536457)
-
(2007)
Journal of Neurosurgery
, vol.106
, Issue.4
, pp. 614-620
-
-
Slevin, J.T.1
Gash, D.M.2
Smith, C.D.3
Gerhardt, G.A.4
Kryscio, R.5
Chebrolu, H.6
Walton, A.7
Wagner, R.8
Young, A.B.9
-
83
-
-
0029827559
-
Neurturin, a relative of glial-cell-line-derived neurotrophic factor
-
DOI 10.1038/384467a0
-
Kotzbauer P. T., Lampe P. A., Heuckeroth R. O., Golden J. P., Creedon D. J., Johnson E. M., Milbrandt J., Neurturin, a relative of glial-cell-line- derived neurotrophic factor Nature 1996 384 6608 467 470 (Pubitemid 26414664)
-
(1996)
Nature
, vol.384
, Issue.6608
, pp. 467-470
-
-
Kotzbauer, P.T.1
Lampe, P.A.2
Heuckeroth, R.O.3
Golden, J.P.4
Creedon, D.J.5
Johnson Jr., E.M.6
Milbrandt, J.7
-
84
-
-
0030917158
-
Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons
-
DOI 10.1073/pnas.94.13.7018
-
Creedon D. J., Tansey M. G., Baloh R. H., Osborne P. A., Lampe P. A., Fahrner T. J., Heuckeroth R. O., Milbrandt J., Johnson E. M., Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons Proceedings of the National Academy of Sciences of the United States of America 1997 94 13 7018 7023 (Pubitemid 27281983)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.13
, pp. 7018-7023
-
-
Creedon, D.J.1
Tansey, M.G.2
Baloh, R.H.3
Osborne, P.A.4
Lampe, P.A.5
Fahrner, T.J.6
Heuckeroth, R.O.7
Milbrandt, J.8
Johnson Jr., E.M.9
-
85
-
-
0032125462
-
Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons
-
Horger B. A., Nishimura M. C., Armanini M. P., Wang L. C., Poulsen K. T., Rosenblad C., Kirik D., Moffat B., Simmons L., Johnson E., Milbrandt J., Rosenthal A., Bjorklund A., Vandlen R. A., Hynes M. A., Phillips H. S., Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons Journal of Neuroscience 1998 18 13 4929 4937 (Pubitemid 28285401)
-
(1998)
Journal of Neuroscience
, vol.18
, Issue.13
, pp. 4929-4937
-
-
Horger, B.A.1
Nishimura, M.C.2
Armanini, M.P.3
Wang, L.-C.4
Poulsen, K.T.5
Rosenblad, C.6
Kirik, D.7
Moffat, B.8
Simmons, L.9
Johnson Jr., E.10
Milbrandt, J.11
Rosenthal, A.12
Bjorklund, A.13
Vandlen, R.A.14
Hynes, M.A.15
Phillips, H.S.16
-
86
-
-
33845993229
-
Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys
-
DOI 10.1002/ana.21032
-
Kordower J. H., Herzog C. D., Dass B., Bakay R. A. E., Stansell J., Gasmi M., Bartus R. T., Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys Annals of Neurology 2006 60 6 706 715 (Pubitemid 46048488)
-
(2006)
Annals of Neurology
, vol.60
, Issue.6
, pp. 706-715
-
-
Kordower, J.H.1
Herzog, C.D.2
Dass, B.3
Bakay, R.A.E.4
Stansell III, J.5
Gasmi, M.6
Bartus, R.T.7
-
87
-
-
54849391400
-
Transgene expression, bioactivity, and safety of CERE-120 (AAV2-Neurturin) following delivery to the monkey striatum
-
Herzog C. D., Dass B., Gasmi M., Bakay R., Stansell J. E., Tuszynski M., Bankiewicz K., Chen E. Y., Chu Y., Bishop K., Kordower J. H., Bartus R. T., Transgene expression, bioactivity, and safety of CERE-120 (AAV2-Neurturin) following delivery to the monkey striatum Molecular Therapy 2008 16 10 1737 1744
-
(2008)
Molecular Therapy
, vol.16
, Issue.10
, pp. 1737-1744
-
-
Herzog, C.D.1
Dass, B.2
Gasmi, M.3
Bakay, R.4
Stansell, J.E.5
Tuszynski, M.6
Bankiewicz, K.7
Chen, E.Y.8
Chu, Y.9
Bishop, K.10
Kordower, J.H.11
Bartus, R.T.12
-
88
-
-
67649839976
-
Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support CERE-120 for Parkinson's disease
-
Herzog C. D., Brown L., Gammon D., Kruegel B., Lin R., Wilson A., Bolton A., Printz M., Gasmi M., Bishop K. M., Kordower J. H., Bartus R. T., Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support CERE-120 for Parkinson's disease Neurosurgery 2009 64 4 602 612
-
(2009)
Neurosurgery
, vol.64
, Issue.4
, pp. 602-612
-
-
Herzog, C.D.1
Brown, L.2
Gammon, D.3
Kruegel, B.4
Lin, R.5
Wilson, A.6
Bolton, A.7
Printz, M.8
Gasmi, M.9
Bishop, K.M.10
Kordower, J.H.11
Bartus, R.T.12
-
89
-
-
85027957635
-
Of monkeys and men: Analysis of the phase 2 double-blind, sham-surgery controlled, randomized trial of AAV2-neurturin gene therapy for parkinson's disease
-
Huddleston D. E., Factor S. A., Of monkeys and men: analysis of the phase 2 double-blind, sham-surgery controlled, randomized trial of AAV2-neurturin gene therapy for parkinson's disease Current Neurology and Neuroscience Reports 2011 11 4 345 348
-
(2011)
Current Neurology and Neuroscience Reports
, vol.11
, Issue.4
, pp. 345-348
-
-
Huddleston, D.E.1
Factor, S.A.2
-
90
-
-
79951476995
-
Bioactivity of AAV2-neurturin gene therapy (CERE-120): Differences between Parkinson's disease and nonhuman primate brains
-
Bartus R. T., Herzog C. D., Chu Y., Wilson A., Brown L., Siffert J., Johnson E. M., Olanow C. W., Mufson E. J., Kordower J. H., Bioactivity of AAV2-neurturin gene therapy (CERE-120): differences between Parkinson's disease and nonhuman primate brains Movement Disorders 2011 26 1 27 36
-
(2011)
Movement Disorders
, vol.26
, Issue.1
, pp. 27-36
-
-
Bartus, R.T.1
Herzog, C.D.2
Chu, Y.3
Wilson, A.4
Brown, L.5
Siffert, J.6
Johnson, E.M.7
Olanow, C.W.8
Mufson, E.J.9
Kordower, J.H.10
-
92
-
-
14844303486
-
Parkin gene therapy for α-synucleinopathy: A rat model of Parkinson's disease
-
DOI 10.1089/hum.2005.16.262
-
Yamada M., Mizuno Y., Mochizuki H., Parkin gene therapy for -synucleinopathy: a rat model of Parkinson's disease Human Gene Therapy 2005 16 2 262 270 (Pubitemid 40344217)
-
(2005)
Human Gene Therapy
, vol.16
, Issue.2
, pp. 262-270
-
-
Yamada, M.1
Mizuno, Y.2
Mochizuki, H.3
-
93
-
-
10644281090
-
Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an α-synuclein rat model of Parkinson's disease
-
DOI 10.1073/pnas.0405313101
-
Lo Bianco C., Schneider B. L., Bauer M., Sajadi A., Brice A., Iwatsubo T., Aebischer P., Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an -synuclein rat model of Parkinson's disease Proceedings of the National Academy of Sciences of the United States of America 2004 101 50 17510 17515 (Pubitemid 39657434)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.50
, pp. 17510-17515
-
-
Lo Bianco, C.1
Schneider, B.L.2
Bauer, M.3
Sajadi, A.4
Brice, A.5
Iwatsubo, T.6
Aebischer, P.7
-
94
-
-
33845196246
-
Neuronal specificity of α-synuclein toxicity and effect of Parkin co-expression in primates
-
DOI 10.1016/j.neuroscience.2006.09.052, PII S0306452206013005
-
Yasuda T., Miyachi S., Kitagawa R., Wada K., Nihira T., Ren Y. R., Hirai Y., Ageyama N., Terao K., Shimada T., Takada M., Mizuno Y., Mochizuki H., Neuronal specificity of -synuclein toxicity and effect of Parkin co-expression in primates Neuroscience 2007 144 2 743 753 (Pubitemid 44855304)
-
(2007)
Neuroscience
, vol.144
, Issue.2
, pp. 743-753
-
-
Yasuda, T.1
Miyachi, S.2
Kitagawa, R.3
Wada, K.4
Nihira, T.5
Ren, Y.-R.6
Hirai, Y.7
Ageyama, N.8
Terao, K.9
Shimada, T.10
Takada, M.11
Mizuno, Y.12
Mochizuki, H.13
-
95
-
-
79961029955
-
Parkin-mediated protection of dopaminergic neurons in a chronic MPTP-minipump mouse model of parkinson disease
-
Yasuda T., Hayakawa H., Nihira T., Ren Y.-R., Nakata Y., Nagai M., Hattori N., Miyake K., Takada M., Shimada T., Mizuno Y., Mochizuki H., Parkin-mediated protection of dopaminergic neurons in a chronic MPTP-minipump mouse model of parkinson disease Journal of Neuropathology and Experimental Neurology 2011 70 8 686 697
-
(2011)
Journal of Neuropathology and Experimental Neurology
, vol.70
, Issue.8
, pp. 686-697
-
-
Yasuda, T.1
Hayakawa, H.2
Nihira, T.3
Ren, Y.-R.4
Nakata, Y.5
Nagai, M.6
Hattori, N.7
Miyake, K.8
Takada, M.9
Shimada, T.10
Mizuno, Y.11
Mochizuki, H.12
-
96
-
-
78649866553
-
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
-
Guzman J. N., Sanchez-Padilla J., Wokosin D., Kondapalli J., Ilijic E., Schumacker P. T., Surmeier D. J., Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1 Nature 2010 468 7324 696 700
-
(2010)
Nature
, vol.468
, Issue.7324
, pp. 696-700
-
-
Guzman, J.N.1
Sanchez-Padilla, J.2
Wokosin, D.3
Kondapalli, J.4
Ilijic, E.5
Schumacker, P.T.6
Surmeier, D.J.7
-
97
-
-
33947282153
-
DJ-1 and parkin modulate dopamine-dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in mice
-
DOI 10.1038/sj.mt.6300067, PII 6300067
-
Paterna J. C., Leng A., Weber E., Feldon J., Beler H., DJ-1 and parkin modulate dopamine-dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in mice Molecular Therapy 2007 15 4 698 704 (Pubitemid 46431989)
-
(2007)
Molecular Therapy
, vol.15
, Issue.4
, pp. 698-704
-
-
Paterna, J.-C.1
Leng, A.2
Weber, E.3
Feldon, J.4
Bueler, H.5
-
98
-
-
79959330427
-
Efficient Allele-specific targeting of LRRK2 R1441 mutations mediated by RNAi
-
ARTICLE E21352
-
de Yigo-Mojado L., Martn-Ruz I., Sutherland J. D., Efficient Allele-specific targeting of LRRK2 R1441 mutations mediated by RNAi PLoS ONE 2011 6 6, article e21352
-
(2011)
PLoS ONE
, vol.6
, Issue.6
-
-
De Yigo-Mojado, L.1
Martn-Ruz, I.2
Sutherland, J.D.3
-
99
-
-
37549042441
-
Design of clinical trials of gene therapy in Parkinson disease
-
Lewis T. B., Standaert D. G., Design of clinical trials of gene therapy in Parkinson disease Experimental Neurology 2008 209 1 41 47
-
(2008)
Experimental Neurology
, vol.209
, Issue.1
, pp. 41-47
-
-
Lewis, T.B.1
Standaert, D.G.2
-
100
-
-
77950838482
-
CERE-110, an adeno-associated virus-based gene delivery vector expressing human nerve growth factor for the treatment of Alzheimer's disease
-
Mandel R. J., CERE-110, an adeno-associated virus-based gene delivery vector expressing human nerve growth factor for the treatment of Alzheimer's disease Current Opinion in Molecular Therapeutics 2010 12 2 240 247
-
(2010)
Current Opinion in Molecular Therapeutics
, vol.12
, Issue.2
, pp. 240-247
-
-
Mandel, R.J.1
-
101
-
-
33744825168
-
Immune responses to AAV in a phase I study for Canavan disease
-
DOI 10.1002/jgm.885
-
McPhee S. W. J., Janson C. G., Li C., Samulski R. J., Camp A. S., Francis J., Shera D., Lioutermann L., Feely M., Freese A., Leone P., Immune responses to AAV in a phase I study for Canavan disease Journal of Gene Medicine 2006 8 5 577 588 (Pubitemid 43827251)
-
(2006)
Journal of Gene Medicine
, vol.8
, Issue.5
, pp. 577-588
-
-
McPhee, S.W.J.1
Janson, C.G.2
Li, C.3
Samulski, R.J.4
Camp, A.S.5
Francis, J.6
Shera, D.7
Lioutermann, L.8
Feely, M.9
Freese, A.10
Leone, P.11
-
102
-
-
37549036323
-
Regulatable promoters and gene therapy for Parkinson's disease: Is the only thing to fear, fear itself?
-
Kordower J. H., Olanow C. W., Regulatable promoters and gene therapy for Parkinson's disease: is the only thing to fear, fear itself? Experimental Neurology 2008 209 1 34 40
-
(2008)
Experimental Neurology
, vol.209
, Issue.1
, pp. 34-40
-
-
Kordower, J.H.1
Olanow, C.W.2
-
103
-
-
0034328925
-
Gene therapy: Trials and tribulations
-
Somia N., Verma I. M., Gene therapy: trials and tribulations Nature Reviews Genetics 2000 1 2 91 99
-
(2000)
Nature Reviews Genetics
, vol.1
, Issue.2
, pp. 91-99
-
-
Somia, N.1
Verma, I.M.2
-
104
-
-
44049094771
-
Clinical gene therapy using recombinant adeno-associated virus vectors
-
DOI 10.1038/gt.2008.68, PII GT200868, Special Issue: AAV Vectors for Clinical GeneTherapy
-
Mueller C., Flotte T. R., Clinical gene therapy using recombinant adeno-associated virus vectors Gene Therapy 2008 15 11 858 863 (Pubitemid 351712619)
-
(2008)
Gene Therapy
, vol.15
, Issue.11
, pp. 858-863
-
-
Mueller, C.1
Flotte, T.R.2
|