Recombinant adeno-associated virus (AAV) drives constitutive production of glutamate decarboxylase in neural cell lines

Journal of Neuroscience Research

Volumn 57, Issue 1, 1999, Pages 137-148

  Mi, Jie ^a   Chatterjee, Saswati ^b   Wong, Kamehameha K ^b   Forbes, Chelsea ^a   Lawless, George ^a   Tobin, Allan J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Epilepsy; GABA; Gene delivery; Neural cell lines; Neurodegenerative diseases

Indexed keywords

4 AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; DEGENERATIVE DISEASE; ENZYME SYNTHESIS; EPILEPSY; GABAERGIC TRANSMISSION; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; VIRUS RECOMBINANT;

ANIMALS; ASTROCYTES; CELL DIVISION; CELL LINE; DEPENDOVIRUS; GLUTAMATE DECARBOXYLASE; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MICE; NEURONS; OLIGODENDROGLIA; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSDUCTION, GENETIC;

EID: 0033168914     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19990701)57:1<137::AID-JNR15>3.0.CO;2-D     Document Type: Article

References (47)

1. Abu-Hasan NS, Sutcliffe RG. 1985. Placental alkaline phosphatase integrates via its carboxy-terminus into the microvillous membrane: its allotypes differ in conformation. Placenta 6:391-404.
2. Alexander IE, Russell DW, Miller AD. 1994. DNA-damaging reagents greatly increase the transduction of nondividing cells by adeno-associated virus vectors. J Virol 68:8282-8287.
3. Berns KI. 1990. Parvovirus replication. Microbiol Rev 54:316-329.
4. Bongarzone ER, Foster LM, Byravan S, Verity AN, Landry CF, Schonmann V, Amur-Umarjee S, Campagnoni AT. 1996. Conditionally immortalized neural cell lines: potential models for the study of neural cell function. Methods: A Comp to Method in Enzymol 10:489-500.
5. Bu DF, Erlander MG, Hitz BC, Tillakaratne NJK, Kaufman DL, Wagner-McPherson CB, Evans GA, Tobin AJ. 1992. Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene. Proc Natl Acad Sci USA 89:2115-2119.
6. Chatterjee S, Lu D, Podsakoff G, Wong KK. 1995. Strategies for efficient gene transfer into hematopoietic cells: the use of adeno-associated virus vectors in gene therapy. Ann NY Acad Sci 770:79-90.
7. Chesselet MF, Delfs JM. 1996. Basal ganglia and movement disorders: an update. TINS 19(10):417-422.
8. Chomczymski P, Sacchi N. 1987. Single-step method of RNA isolation by acid-guanidinium thiocynate-phenol-chloroform extraction. Anal Biochem 162:156-159.
9. Denner LA, Wu JY. 1985. Two forms of rat brain glutamate decarboxylase differ in their dependence on free pyridoxyl phosphate. J Neurochem 44:957-965.
10. Erlander MG, Tillakaratne NJK, Feldbium S, Patel N.Tobin AJ. 1991. Two genes encode distinct glutamate decarboxylases. Neuron 7:91-100.
11. Esclapez M, Tillakaratne NJK, Kaufman DL, Tobin AJ. 1994. Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms. J Neurosci 14(3):1834-1855.
12. Ferrari FK, Samulski T, Shenk T, Samulski RJ. 1996. Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors. J Virol 70(5):3227-3234.
13. Fields-Berry SC, Halliday AL, Cepco CL. 1992. A recombinant retrovirus encoding alkaline phosphatase confirms clonal boundary assignment in lineage analysis of murine retina. Proc Natl Acad Sci USA 89:693-697.
14. Fisher KJ, Gao G-P, Weitzman MD, DeMatteo R, Burda JF, Wilson JM. 1996. Transduction with recombinant adeno-associated virus for gene therapy is limited by leading strand synthesis. J Virol 70(1):520-532.
15. Fisher-Adams G, Wong KK Jr, Podsakoff G, Forman SJ, Chatterjee S. 1996. Integration of adeno-associated virus vectors in CD34+ human hematopoietic progenitor cells after transduction. Blood 88(2):492-504.
16. Flotte TR, Afione SA, Solow R, Drumm ML, Markakis D, Guggino WB, Zeitlin PL, Carter BJ. 1993. Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoter. J Biol Chem 268:3781-3790.
17. Flotte TR, Afione SA, Zeitlin PL. 1994. Adeno-associated virus vector gene expression occurs in nondividing cells in the absence of vector DNA integration. Am J Respir Cell Mol Biol 11:517-521.
18. Foster LM, Phan T, Verity AN, Bredesen D, Campagnoni AT. 1993. Generation and analysis of normal and shieverer temperature-sensitive immortalized cell lines exhibiting phenotypic characteristics of oligodendrocytes at several stages of differentiation. Dev Neurosci 15:100-109.
19. Gale K. 1989. GABA in epilepsy: the pharmacologic basis. Epilepsia 30(suppl):S1-S11.
20. Giordano M, Takashima H, Herranz A, Poltorak M, Geller HM, Marone M, Freed W. 1993. Immortalized GABAergic cell lines derived from rat striatum using a temperature-sensitive allele of the SV40 large T antigen. Exp Neurol 124:395-400.
21. Halbert CL, Alexander IE, Wolgamot GM, Miller AD. 1995. Adeno-associated virus vectors transduce primary cells much less efficiently than that immortalized cells. J Virol 69:1473-1479.
22. Hoggan MD, Blacklow NR, Rowe WP. 1966. Studies of small DNA viruses found in adenovirus preparations: physical, biological and immunological characteristics. Proc Natl Acad Sci USA 55:1467.
23. Houser CR. 1991. GABA neurons in seizure disorders: a review of immunocytochemical studies. Neurochem Res 16(3):295-308.
24. Kaplitt MG, Leone R, Samulski RJ, Xiao X, Pfaff DW, O'Malley KL, During MJ. 1994. Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nature Genet 8:148-154.
25. Kaufman DL, Houser CR, Tobin AJ. 1991. Two forms of the g-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J Neurochem 56(2):720-723.
26. Kobayashi Y, Kaufman DL, Tobin AJ. 1987. Glutamic acid decarboxylase cDNA: nucleotide sequence encoding an enzymatically active fusion protein. J Neurosci 7:2768-2772.
27. Krieger NR, Heller JS. 1984. Localization of GAD within laminae of rat olfactory tubercle. J Neurochem 33:299-309.
28. Lebkowski JS, McNally MM, Okarma TB, Lerch LB. 1988. Adeno-associated virus: a vector system for efficient introduction and integration of DNA into a variety of mammalian cell types. Mol Cell Biol 8:3988-3996.
29. Mandel RJ, Rendahl KG, Spratt SK, Snyder RO, Cohen LK, Leff SE. 1998. Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease. J Neurosci 18(11):4272-4284.
30. McLaughlin SK, Collis P, Hermonat PL, Muzyczka N. 1988. Adeno-associated general transduction vectors: analysis of proviral structures. J Virol 62:1963-1973.
31. Meldrum BS. 1989. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br J Clin Pharmac 27:3S-11S.
32. Mizukami H, Young NS, Brown KE. 1996. Adeno-associated virus type 2 binds to a 150-kilodalton cell membrane glycoprotein. Virol 217:124-130.
33. Neve RL, Geller AI. 1996. A defective herpes simplex virus vector system for gene delivery into the brain: comparison with alternative gene delivery systems and usefulness for gene therapy. Clin Neurosci 3:262-267.
34. Nudel U, Zakut R, Shani M, Neuman S, Levy Z, Yaffe D. 1983. The nucleotide sequence of the rat cytoplasmic b-actin gene. Nucleic Acids Res 11:1759-1771.
35. Olsen RW. 1991. Antiepileptic actions of benzodiazapines. In: Pain-gold C, editors. Drugs for the control of epilepsy: actions on neuronal networks involved in seizure disorders. Miami: CRS Press.
36. Podsakoff G, Wong KK, Chatterjee S. 1994. Efficient gene transfer into non-dividing cells by adeno-associated virus-based vectors. J Virol 68(9):5656-5666.
37. Prince DA, Connors BW. 1986. Mechanisms of interictal epileptogenesis. Adv Neurol 44:275-318.
38. Russell DW, Miller AD, Alexander IE. 1994. Adeno-associated virus vectors preferentially transduce cells in S phase. Proc Natl Acad Sci USA 91:8915-8919.
39. 67) and increases the expression of an astroglial marker (GFAP) in C6 cells. J Neurochem 63:1218-1225.
40. Shaughnessy E, Lu D, Chatterjee S, Wong KK. 1996. Parvoviral vectors for the gene therapy of cancer. Semin Oncol 23:159-171.
41. Shelling AN, Smith MG. 1994. Targeted integration of transfected and infected adeno-associated virus vectors containing the neomycin resistance gene. Gene Ther 1:165-169.
42. Tenenbaum L, Darling JL, Hooghe-Peters E. 1994. Adeno-associated virus (AAV) as a vector for gene transfer into glial cells of the human central nervous system. Gene Ther 1 (suppl 1):S80.
43. Whittemore SR, White LA. 1993. Target regulation of neuronal differentiation in a temperature-sensitive cell line derived from medullary raphe. Brain Res 615:27-40.
44. Wu P, Phillips MI, Bui J, Terwilliger EF. 1998. Adeno-associated virus vector-mediated transgene integration into neurons and other nondividing cell targets. J Virol 72(7):5919-26.
45. Xie WQ, Rothblum LI. 1992. Rapid, small scale RNA isolation from tissue and cultured cells. Biotechniques 11:324-327.
46. Yakinoglu AO, Heilbronn R, Burkle A, Schlehofer JR, zur Hausen H. 1988. DNA amplification of adeno-associated virus as a response to cellular genotoxic stress. Cancer Res 48(11):3123-3129.
47. Yang Y, Nunes FA, Berencsi K, Furth EE, Gonczol E, Wilson JM. 1994. Cellular immunity to viral antigens limits El-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 91:4407-4411.