-
1
-
-
2542596183
-
Parkinson's disease
-
Samii A, Nutt JG, Ransom BR. Parkinson's disease. Lancet 363(9423), 1783-1793 (2004).
-
(2004)
Lancet
, vol.363
, Issue.9423
, pp. 1783-1793
-
-
Samii, A.1
Nutt, J.G.2
Ransom, B.R.3
-
3
-
-
0028060492
-
Increased risk of Parkinson's disease in parents and siblings of patients
-
Payami H, Larsen K, Bernard S, Nutt J. Increased risk of Parkinson's disease in parents and siblings of patients. Ann. Neurol. 36(4), 659-661 (1994).
-
(1994)
Ann. Neurol
, vol.36
, Issue.4
, pp. 659-661
-
-
Payami, H.1
Larsen, K.2
Bernard, S.3
Nutt, J.4
-
4
-
-
0034049691
-
Familial aggregation of Parkinson's disease in a Finnish population
-
Autere JM, Moilanen JS, Myllyla VV, Majamaa K. Familial aggregation of Parkinson's disease in a Finnish population. J. Neurol. Neurosurg. Psychiatry 69(1), 107-109 (2000).
-
(2000)
J. Neurol. Neurosurg. Psychiatry
, vol.69
, Issue.1
, pp. 107-109
-
-
Autere, J.M.1
Moilanen, J.S.2
Myllyla, V.V.3
Majamaa, K.4
-
5
-
-
0034649710
-
Familial aggregation of Parkinson's disease in Iceland
-
Sveinbjornsdottir S, Hicks AA, Jonsson T et al. Familial aggregation of Parkinson's disease in Iceland. N. Engl. J. Med. 343(24), 1765-1770 (2000).
-
(2000)
N. Engl. J. Med
, vol.343
, Issue.24
, pp. 1765-1770
-
-
Sveinbjornsdottir, S.1
Hicks, A.A.2
Jonsson, T.3
-
6
-
-
0033768752
-
Parkinson's disease and environmental factors. Matched case-control study in the Limousin region, France
-
Preux PM, Condet A, Anglade C et al. Parkinson's disease and environmental factors. Matched case-control study in the Limousin region, France. Neuroepidemiology 19(6), 333-337 (2000).
-
(2000)
Neuroepidemiology
, vol.19
, Issue.6
, pp. 333-337
-
-
Preux, P.M.1
Condet, A.2
Anglade, C.3
-
7
-
-
4844223492
-
Familial aggregation of Parkinson's disease: The Mayo Clinic family study
-
Rocca WA, McDonnell SK, Strain KJ et al. Familial aggregation of Parkinson's disease: the Mayo Clinic family study. Ann. Neurol. 56(4), 495-502 (2004).
-
(2004)
Ann. Neurol
, vol.56
, Issue.4
, pp. 495-502
-
-
Rocca, W.A.1
McDonnell, S.K.2
Strain, K.J.3
-
8
-
-
0038727850
-
Parkinson's disease and related α-synucleinopathies are brain amyloidoses
-
Trojanowski JQ, Lee VM. Parkinson's disease and related α-synucleinopathies are brain amyloidoses. Ann. NY Acad. Sci. 991, 107-110 (2003).
-
(2003)
Ann. NY Acad. Sci
, vol.991
, pp. 107-110
-
-
Trojanowski, J.Q.1
Lee, V.M.2
-
9
-
-
2442668926
-
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
-
Valente EM, Abou-Sleiman PM, Caputo V et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 304(5674), 1158-1160 (2004).
-
(2004)
Science
, vol.304
, Issue.5674
, pp. 1158-1160
-
-
Valente, E.M.1
Abou-Sleiman, P.M.2
Caputo, V.3
-
10
-
-
0030744876
-
Mutation in the α-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos MH, Lavedan C, Leroy E et al. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276(5321), 2045-2047 (1997).
-
(1997)
Science
, vol.276
, Issue.5321
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
-
11
-
-
0032499264
-
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
-
Kitada T, Asakawa S, Hattori N et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392(6676), 605-608 (1998).
-
(1998)
Nature
, vol.392
, Issue.6676
, pp. 605-608
-
-
Kitada, T.1
Asakawa, S.2
Hattori, N.3
-
12
-
-
0037428241
-
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
-
Bonifati V, Rizzu P, van Baren MJ et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299(5604), 256-259 (2003).
-
(2003)
Science
, vol.299
, Issue.5604
, pp. 256-259
-
-
Bonifati, V.1
Rizzu, P.2
van Baren, M.J.3
-
13
-
-
8844266996
-
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
-
Paisan-Ruiz C, Jain S, Evans EW et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 44(4), 595-600 (2004).
-
(2004)
Neuron
, vol.44
, Issue.4
, pp. 595-600
-
-
Paisan-Ruiz, C.1
Jain, S.2
Evans, E.W.3
-
14
-
-
8844233579
-
Mutations in LRRK2 cause autosomaldominant parkinsonism with pleomorphic pathology
-
Zimprich A, Biskup S, Leitner P et al. Mutations in LRRK2 cause autosomaldominant parkinsonism with pleomorphic pathology. Neuron 44(4), 601-607 (2004).
-
(2004)
Neuron
, vol.44
, Issue.4
, pp. 601-607
-
-
Zimprich, A.1
Biskup, S.2
Leitner, P.3
-
15
-
-
0037226797
-
Mutation in NR4A2 associated with familial Parkinson disease
-
Le WD, Xu P, Jankovic J et al. Mutation in NR4A2 associated with familial Parkinson disease. Nat. Genet. 33(1), 85-89 (2003).
-
(2003)
Nat. Genet
, vol.33
, Issue.1
, pp. 85-89
-
-
WD, L.1
Xu, P.2
Jankovic, J.3
-
16
-
-
12444281013
-
Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease
-
Marx FP, Holzmann C, Strauss KM et al. Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease. Hum. Mol. Genet. 12(11), 1223-1231 (2003).
-
(2003)
Hum. Mol. Genet
, vol.12
, Issue.11
, pp. 1223-1231
-
-
Marx, F.P.1
Holzmann, C.2
Strauss, K.M.3
-
17
-
-
0037334423
-
Familial and sporadic Parkinson's disease usually display the same clinical features
-
Carr J, de la Fuente-Fernandez R, Schulzer M et al. Familial and sporadic Parkinson's disease usually display the same clinical features. Parkinsonism Relat. Disord. 9(4), 201-204 (2003).
-
(2003)
Parkinsonism Relat. Disord
, vol.9
, Issue.4
, pp. 201-204
-
-
Carr, J.1
de la Fuente-Fernandez, R.2
Schulzer, M.3
-
18
-
-
0029806563
-
Clinical genetic analysis of Parkinson's disease in the Contursi kindred
-
Golbe LI, Di Iorio G, Sanges G et al. Clinical genetic analysis of Parkinson's disease in the Contursi kindred. Ann. Neurol. 40(5), 767-775 (1996).
-
(1996)
Ann. Neurol
, vol.40
, Issue.5
, pp. 767-775
-
-
Golbe, L.I.1
Di Iorio, G.2
Sanges, G.3
-
19
-
-
0035031258
-
Clinical phenotype in patients with α-synuclein Parkinson's disease living in Greece in comparison with patients with sporadic Parkinson's disease
-
Papapetropoulos S, Paschalis C, Athanassiadou A et al. Clinical phenotype in patients with α-synuclein Parkinson's disease living in Greece in comparison with patients with sporadic Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 70(5), 662-665 (2001).
-
(2001)
J. Neurol. Neurosurg. Psychiatry
, vol.70
, Issue.5
, pp. 662-665
-
-
Papapetropoulos, S.1
Paschalis, C.2
Athanassiadou, A.3
-
20
-
-
0031990490
-
Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease
-
Kruger R, Kuhn W, Muller T et al. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat. Genet. 18(2), 106-108 (1998).
-
(1998)
Nat. Genet
, vol.18
, Issue.2
, pp. 106-108
-
-
Kruger, R.1
Kuhn, W.2
Muller, T.3
-
21
-
-
10744230149
-
The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia
-
Zarranz JJ, Alegre J, Gomez-Esteban JC et al. The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol. 55(2), 164-173 (2004).
-
(2004)
Ann. Neurol
, vol.55
, Issue.2
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gomez-Esteban, J.C.3
-
22
-
-
15444338952
-
The α-synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: A study of 230 European cases. European Consortium on Genetic Susceptibility in Parkinson's Disease
-
Vaughan J, Durr A, Tassin J et al. The α-synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: a study of 230 European cases. European Consortium on Genetic Susceptibility in Parkinson's Disease. Ann. Neurol. 44(2), 270-273 (1998).
-
(1998)
Ann. Neurol
, vol.44
, Issue.2
, pp. 270-273
-
-
Vaughan, J.1
Durr, A.2
Tassin, J.3
-
23
-
-
0035880458
-
α-synuclein gene haplotypes are associated with Parkinson's disease
-
Farrer M, Maraganore DM, Lockhart P et al. α-synuclein gene haplotypes are associated with Parkinson's disease. Hum. Mol. Genet. 10(17), 1847-1851 (2001).
-
(2001)
Hum. Mol. Genet
, vol.10
, Issue.17
, pp. 1847-1851
-
-
Farrer, M.1
Maraganore, D.M.2
Lockhart, P.3
-
24
-
-
4844222408
-
α-synuclein promoter confers susceptibility to Parkinson's disease
-
Pals P, Lincoln S, Manning J et al. α-synuclein promoter confers susceptibility to Parkinson's disease. Ann. Neurol. 56(4), 591-595 (2004).
-
(2004)
Ann. Neurol
, vol.56
, Issue.4
, pp. 591-595
-
-
Pals, P.1
Lincoln, S.2
Manning, J.3
-
25
-
-
4644290985
-
α-synuclein locus duplication as a cause of familial Parkinson's disease
-
Chartier-Harlin MC, Kachergus J, Roumier C et al. α-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 364(9440), 1167-1169 (2004).
-
(2004)
Lancet
, vol.364
, Issue.9440
, pp. 1167-1169
-
-
Chartier-Harlin, M.C.1
Kachergus, J.2
Roumier, C.3
-
26
-
-
4644236043
-
Causal relation between α-synuclein gene duplication and familial Parkinson's disease
-
Ibanez P, Bonnet AM, Debarges B et al. Causal relation between α-synuclein gene duplication and familial Parkinson's disease. Lancet 364(9440), 1169-1171 (2004).
-
(2004)
Lancet
, vol.364
, Issue.9440
, pp. 1169-1171
-
-
Ibanez, P.1
Bonnet, A.M.2
Debarges, B.3
-
27
-
-
15144345616
-
Hereditary form of parkinsonism - dementia
-
Muenter MD, Forno LS, Hornykiewicz O et al. Hereditary form of parkinsonism - dementia. Ann. Neurol. 43(6), 768-781 (1998).
-
(1998)
Ann. Neurol
, vol.43
, Issue.6
, pp. 768-781
-
-
Muenter, M.D.1
Forno, L.S.2
Hornykiewicz, O.3
-
28
-
-
9144266292
-
α-synuclein haplotypes implicated in risk of Parkinson's disease
-
Tan EK, Chai A, Teo YY et al. α-synuclein haplotypes implicated in risk of Parkinson's disease. Neurology 62(1), 128-131 (2004).
-
(2004)
Neurology
, vol.62
, Issue.1
, pp. 128-131
-
-
Tan, E.K.1
Chai, A.2
Teo, Y.Y.3
-
29
-
-
0242300619
-
α-synuclein locus triplication causes Parkinson's disease
-
Singleton AB, Farrer M, Johnson J et al. α-synuclein locus triplication causes Parkinson's disease. Science 302(5646), 841 (2003).
-
(2003)
Science
, vol.302
, Issue.5646
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
-
30
-
-
10744227740
-
Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications
-
Farrer M, Kachergus J, Forno L et al. Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications. Ann. Neurol. 55(2), 174-179 (2004).
-
(2004)
Ann. Neurol
, vol.55
, Issue.2
, pp. 174-179
-
-
Farrer, M.1
Kachergus, J.2
Forno, L.3
-
31
-
-
33746869343
-
Collaborative analysis of α-synuclein gene promoter variability and Parkinson disease
-
Maraganore DM, de Andrade M, Elbaz A et al. Collaborative analysis of α-synuclein gene promoter variability and Parkinson disease. JAMA 296(6), 661-670 (2006).
-
(2006)
JAMA
, vol.296
, Issue.6
, pp. 661-670
-
-
Maraganore, D.M.1
de Andrade, M.2
Elbaz, A.3
-
33
-
-
0034531475
-
The α-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy
-
Spillantini MG, Goedert M. The α-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Ann. NY Acad. Sci. 920, 16-27 (2000).
-
(2000)
Ann. NY Acad. Sci
, vol.920
, pp. 16-27
-
-
Spillantini, M.G.1
Goedert, M.2
-
34
-
-
33749240943
-
Mechanisms of Parkinson's disease linked to pathological α-synuclein: New targets for drug discovery
-
Lee VM, Trojanowski JQ. Mechanisms of Parkinson's disease linked to pathological α-synuclein: new targets for drug discovery. Neuron 52(1), 33-38 (2006).
-
(2006)
Neuron
, vol.52
, Issue.1
, pp. 33-38
-
-
Lee, V.M.1
Trojanowski, J.Q.2
-
35
-
-
2542461043
-
α-synuclein has a high affinity for packing defects in a bilayer membrane: A thermodynamics study
-
Nuscher B, Kamp F, Mehnert T et al. α-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study. J. Biol. Chem. 279(21), 21966-21975 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, Issue.21
, pp. 21966-21975
-
-
Nuscher, B.1
Kamp, F.2
Mehnert, T.3
-
36
-
-
27544507306
-
α-synuclein cooperates with CSPα in preventing neurodegeneration
-
Chandra S, Gallardo G, Fernandez-Chacon R, Schluter OM, Sudhof TC. α-synuclein cooperates with CSPα in preventing neurodegeneration. Cell 123(3), 383-396 (2005).
-
(2005)
Cell
, vol.123
, Issue.3
, pp. 383-396
-
-
Chandra, S.1
Gallardo, G.2
Fernandez-Chacon, R.3
Schluter, O.M.4
Sudhof, T.C.5
-
37
-
-
24044516868
-
α-synuclein alters proteasome function, protein synthesis, and stationary phase viability
-
Chen Q, Thorpe J, Keller JN. α-synuclein alters proteasome function, protein synthesis, and stationary phase viability. J. Biol. Chem. 280(34), 30009-30017 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, Issue.34
, pp. 30009-30017
-
-
Chen, Q.1
Thorpe, J.2
Keller, J.N.3
-
38
-
-
0031951197
-
A susceptibility locus for Parkinson's disease maps to chromosome 2p13
-
Gasser T, Muller-Myhsok B, Wszolek ZK et al. A susceptibility locus for Parkinson's disease maps to chromosome 2p13. Nat. Genet. 18(3), 262-265 (1998).
-
(1998)
Nat. Genet
, vol.18
, Issue.3
, pp. 262-265
-
-
Gasser, T.1
Muller-Myhsok, B.2
Wszolek, Z.K.3
-
39
-
-
2342611060
-
Genes influencing Parkinson disease onset: Replication of PARK3 and identification of novel loci
-
Pankratz N, Uniacke SK, Halter CA et al. Genes influencing Parkinson disease onset: replication of PARK3 and identification of novel loci. Neurology 62(9), 1616-1618 (2004).
-
(2004)
Neurology
, vol.62
, Issue.9
, pp. 1616-1618
-
-
Pankratz, N.1
Uniacke, S.K.2
Halter, C.A.3
-
40
-
-
0035949797
-
Genome-wide scan for Parkinson's disease: The GenePD Study
-
DeStefano AL, Golbe LI, Mark MH et al. Genome-wide scan for Parkinson's disease: the GenePD Study. Neurology 57(6), 1124-1126 (2001).
-
(2001)
Neurology
, vol.57
, Issue.6
, pp. 1124-1126
-
-
DeStefano, A.L.1
Golbe, L.I.2
Mark, M.H.3
-
41
-
-
19944410482
-
Genome-wide scan linkage analysis for Parkinson's disease: The European genetic study of Parkinson's disease
-
Martinez M, Brice A, Vaughan JR et al. Genome-wide scan linkage analysis for Parkinson's disease: the European genetic study of Parkinson's disease. J. Med. Genet. 41(12), 900-907 (2004).
-
(2004)
J. Med. Genet
, vol.41
, Issue.12
, pp. 900-907
-
-
Martinez, M.1
Brice, A.2
Vaughan, J.R.3
-
42
-
-
0034814928
-
Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes
-
West AB, Zimprich A, Lockhart PJ et al. Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes. Eur. J. Hum. Genet. 9(9), 659-666 (2001).
-
(2001)
Eur. J. Hum. Genet
, vol.9
, Issue.9
, pp. 659-666
-
-
West, A.B.1
Zimprich, A.2
Lockhart, P.J.3
-
43
-
-
33745875353
-
The sepiapterin reductase gene region reveals association in the PARK3 locus: Analysis of familial and sporadic Parkinson's disease in European populations
-
Sharma M, Mueller JC, Zimprich A et al. The sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson's disease in European populations. J. Med. Genet. 43(7), 557-562 (2006).
-
(2006)
J. Med. Genet
, vol.43
, Issue.7
, pp. 557-562
-
-
Sharma, M.1
Mueller, J.C.2
Zimprich, A.3
-
44
-
-
0032190090
-
The ubiquitin pathway in Parkinson's disease
-
Leroy E, Boyer R, Auburger G et al. The ubiquitin pathway in Parkinson's disease. Nature 395(6701), 451-452 (1998).
-
(1998)
Nature
, vol.395
, Issue.6701
, pp. 451-452
-
-
Leroy, E.1
Boyer, R.2
Auburger, G.3
-
45
-
-
0033544368
-
Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease
-
Maraganore DM, Farrer MJ, Hardy JA et al. Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease. Neurology 53(8), 1858-1860 (1999).
-
(1999)
Neurology
, vol.53
, Issue.8
, pp. 1858-1860
-
-
Maraganore, D.M.1
Farrer, M.J.2
Hardy, J.A.3
-
46
-
-
12144289221
-
UCHL1 is a Parkinson's disease susceptibility gene
-
Maraganore DM, Lesnick TG, Elbaz A et al. UCHL1 is a Parkinson's disease susceptibility gene. Ann. Neurol. 55(4), 512-521 (2004).
-
(2004)
Ann. Neurol
, vol.55
, Issue.4
, pp. 512-521
-
-
Maraganore, D.M.1
Lesnick, T.G.2
Elbaz, A.3
-
47
-
-
34249845272
-
Reversible monoubiquitination regulates the Parkinson's disease-associated ubiquitin hydrolase UCH-L1
-
Meray RK, Lansbury PT Jr. Reversible monoubiquitination regulates the Parkinson's disease-associated ubiquitin hydrolase UCH-L1. J. Biol. Chem. 282(14), 10567-10575 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, Issue.14
, pp. 10567-10575
-
-
Meray, R.K.1
Lansbury Jr., P.T.2
-
48
-
-
9144261126
-
The PARK8 locus in autosomal dominant parkinsonism: Confirmation of linkage and further delineation of the disease-containing interval
-
Zimprich A, Muller-Myhsok B, Farrer M et al. The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval. Am. J. Hum. Genet. 74(1), 11-19 (2004).
-
(2004)
Am. J. Hum. Genet
, vol.74
, Issue.1
, pp. 11-19
-
-
Zimprich, A.1
Muller-Myhsok, B.2
Farrer, M.3
-
49
-
-
0030875612
-
Autosomal dominant familial Parkinson disease: Older onset of age, and good response to levodopa therapy
-
Hasegawa K, Kowa H. Autosomal dominant familial Parkinson disease: older onset of age, and good response to levodopa therapy. Eur. Neurol. 38(Suppl. 1), 39-43 (1997).
-
(1997)
Eur. Neurol
, vol.38
, Issue.SUPPL. 1
, pp. 39-43
-
-
Hasegawa, K.1
Kowa, H.2
-
50
-
-
2342605968
-
Autosomal dominant parkinsonism associated with variable synuclein and tau pathology
-
Wszolek ZK, Pfeiffer RF, Tsuboi Y et al. Autosomal dominant parkinsonism associated with variable synuclein and tau pathology. Neurology 62(9), 1619-1622 (2004).
-
(2004)
Neurology
, vol.62
, Issue.9
, pp. 1619-1622
-
-
Wszolek, Z.K.1
Pfeiffer, R.F.2
Tsuboi, Y.3
-
51
-
-
28544441181
-
Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: Clinical, pathological, olfactory and functional imaging and genetic data
-
Khan NL, Jain S, Lynch JM et al. Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data. Brain 128(Pt 12), 2786-2796 (2005).
-
(2005)
Brain
, vol.128
, Issue.PART 12
, pp. 2786-2796
-
-
Khan, N.L.1
Jain, S.2
Lynch, J.M.3
-
52
-
-
33645139675
-
Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease
-
Di Fonzo A, Tassorelli C, De Mari M et al. Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease. Eur. J. Hum. Genet. 14(3), 322-331 (2006).
-
(2006)
Eur. J. Hum. Genet
, vol.14
, Issue.3
, pp. 322-331
-
-
Di Fonzo, A.1
Tassorelli, C.2
De Mari, M.3
-
53
-
-
20144387207
-
Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: Evidence of a common founder across European populations
-
Kachergus J, Mata IF, Hulihan M et al. Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations. Am. J. Hum. Genet. 76(4), 672-680 (2005).
-
(2005)
Am. J. Hum. Genet
, vol.76
, Issue.4
, pp. 672-680
-
-
Kachergus, J.1
Mata, I.F.2
Hulihan, M.3
-
54
-
-
19944432606
-
Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease
-
Nichols WC, Pankratz N, Hernandez D et al. Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease. Lancet 365(9457), 410-412 (2005).
-
(2005)
Lancet
, vol.365
, Issue.9457
, pp. 410-412
-
-
Nichols, W.C.1
Pankratz, N.2
Hernandez, D.3
-
55
-
-
28544446980
-
G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort
-
Bras JM, Guerreiro RJ, Ribeiro MH et al. G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort. Mov. Disord. 20(12), 1653-1655 (2005).
-
(2005)
Mov. Disord
, vol.20
, Issue.12
, pp. 1653-1655
-
-
Bras, J.M.1
Guerreiro, R.J.2
Ribeiro, M.H.3
-
56
-
-
33646887782
-
Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia
-
Saunders-Pullman R, Lipton RB, Senthil G et al. Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia. Neurosci. Lett. 402(1-2), 92-96 (2006).
-
(2006)
Neurosci. Lett
, vol.402
, Issue.1-2
, pp. 92-96
-
-
Saunders-Pullman, R.1
Lipton, R.B.2
Senthil, G.3
-
57
-
-
27644455523
-
G2019S LRRK2 mutation in French and North African families with Parkinson's disease
-
Lesage S, Ibanez P, Lohmann E et al. G2019S LRRK2 mutation in French and North African families with Parkinson's disease. Ann. Neurol. 58(5), 784-787 (2005).
-
(2005)
Ann. Neurol
, vol.58
, Issue.5
, pp. 784-787
-
-
Lesage, S.1
Ibanez, P.2
Lohmann, E.3
-
58
-
-
26444613397
-
Escaping Parkinson's disease: A neurologically healthy octogenarian with the LRRK2 G2019S mutation
-
Kay DM, Kramer P, Higgins D, Zabetian CP, Payami H. Escaping Parkinson's disease: a neurologically healthy octogenarian with the LRRK2 G2019S mutation. Mov. Disord. 20(8), 1077-1078 (2005).
-
(2005)
Mov. Disord
, vol.20
, Issue.8
, pp. 1077-1078
-
-
Kay, D.M.1
Kramer, P.2
Higgins, D.3
Zabetian, C.P.4
Payami, H.5
-
59
-
-
33846463019
-
Mutations in LRRK2 other than G2019S are rare in a north American-based sample of familial Parkinson's disease
-
Pankratz N, Pauciulo MW, Elsaesser VE et al. Mutations in LRRK2 other than G2019S are rare in a north American-based sample of familial Parkinson's disease. Mov. Disord. 21(12), 2257-2260 (2006).
-
(2006)
Mov. Disord
, vol.21
, Issue.12
, pp. 2257-2260
-
-
Pankratz, N.1
Pauciulo, M.W.2
Elsaesser, V.E.3
-
60
-
-
33847226901
-
Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population
-
Funayama M, Li Y, Tomiyama H et al. Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population. Neuroreport 18(3), 273-275 (2007).
-
(2007)
Neuroreport
, vol.18
, Issue.3
, pp. 273-275
-
-
Funayama, M.1
Li, Y.2
Tomiyama, H.3
-
61
-
-
33846587090
-
A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan
-
Fung HC, Chen CM, Hardy J, Singleton AB, Wu YR. A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan. BMC Neurol. 6, 47 (2006).
-
(2006)
BMC Neurol
, vol.6
, pp. 47
-
-
Fung, H.C.1
Chen, C.M.2
Hardy, J.3
Singleton, A.B.4
Wu, Y.R.5
-
62
-
-
33751256567
-
The familial parkinsonism gene LRRK2 regulates neurite process morphology
-
Macleod D, Dowman J, Hammond R et al. The familial parkinsonism gene LRRK2 regulates neurite process morphology. Neuron 52(4), 587-593 (2006).
-
(2006)
Neuron
, vol.52
, Issue.4
, pp. 587-593
-
-
Macleod, D.1
Dowman, J.2
Hammond, R.3
-
63
-
-
0345701479
-
Significant linkage of Parkinson disease to chromosome 2q36-37
-
Pankratz N, Nichols WC, Uniacke SK et al. Significant linkage of Parkinson disease to chromosome 2q36-37. Am. J. Hum. Genet. 72(4), 1053-1057 (2003).
-
(2003)
Am. J. Hum. Genet
, vol.72
, Issue.4
, pp. 1053-1057
-
-
Pankratz, N.1
Nichols, W.C.2
Uniacke, S.K.3
-
64
-
-
13544253718
-
PARK11 is not linked with Parkinson's disease in European families
-
Prestel J, Sharma M, Leitner P et al. PARK11 is not linked with Parkinson's disease in European families. Eur. J. Hum. Genet. 13(2), 193-197 (2005).
-
(2005)
Eur. J. Hum. Genet
, vol.13
, Issue.2
, pp. 193-197
-
-
Prestel, J.1
Sharma, M.2
Leitner, P.3
-
65
-
-
33749667345
-
Genome-wide genotyping in Parkinson's disease and neurologically normal controls: First stage analysis and public release of data
-
Fung HC, Scholz S, Matarin M et al. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. Lancet Neurol. 5(11), 911-916 (2006).
-
(2006)
Lancet Neurol
, vol.5
, Issue.11
, pp. 911-916
-
-
Fung, H.C.1
Scholz, S.2
Matarin, M.3
-
66
-
-
33749667971
-
Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: A large-scale international study
-
Elbaz A, Nelson LM, Payami H et al. Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study. Lancet Neurol. 5(11), 917-923 (2006).
-
(2006)
Lancet Neurol
, vol.5
, Issue.11
, pp. 917-923
-
-
Elbaz, A.1
Nelson, L.M.2
Payami, H.3
-
67
-
-
0037648357
-
Parkin mutations are frequent in patients with isolated early-onset parkinsonism
-
Periquet M, Latouche M, Lohmann E et al. Parkin mutations are frequent in patients with isolated early-onset parkinsonism. Brain 126(Pt 6), 1271-1278 (2003).
-
(2003)
Brain
, vol.126
, Issue.PART 6
, pp. 1271-1278
-
-
Periquet, M.1
Latouche, M.2
Lohmann, E.3
-
68
-
-
0042415580
-
How much phenotypic variation can be attributed to parkin genotype?
-
Lohmann E, Periquet M, Bonifati V et al. How much phenotypic variation can be attributed to parkin genotype? Ann. Neurol. 54(2), 176-185 (2003).
-
(2003)
Ann. Neurol
, vol.54
, Issue.2
, pp. 176-185
-
-
Lohmann, E.1
Periquet, M.2
Bonifati, V.3
-
69
-
-
0038662544
-
Parkin disease: A phenotypic study of a large case series
-
Khan NL, Graham E, Critchley P et al. Parkin disease: a phenotypic study of a large case series. Brain 126(Pt 6), 1279-1292 (2003).
-
(2003)
Brain
, vol.126
, Issue.PART 6
, pp. 1279-1292
-
-
Khan, N.L.1
Graham, E.2
Critchley, P.3
-
70
-
-
0033849550
-
Autosomal recessive early-onset parkinsonism with diurnal fluctuation: Clinicopathologic characteristics and molecular genetic identification
-
Yamamura Y, Hattori N, Matsumine H, Kuzuhara S, Mizuno Y. Autosomal recessive early-onset parkinsonism with diurnal fluctuation: clinicopathologic characteristics and molecular genetic identification. Brain Dev. 22(Suppl. 1) S87-S91 (2000).
-
(2000)
Brain Dev
, vol.22
, Issue.SUPPL. 1
-
-
Yamamura, Y.1
Hattori, N.2
Matsumine, H.3
Kuzuhara, S.4
Mizuno, Y.5
-
71
-
-
0034848395
-
Lewy bodies and parkinsonism in families with parkin mutations
-
Farrer M, Chan P, Chen R et al. Lewy bodies and parkinsonism in families with parkin mutations. Ann. Neurol. 50(3), 293-300 (2001).
-
(2001)
Ann. Neurol
, vol.50
, Issue.3
, pp. 293-300
-
-
Farrer, M.1
Chan, P.2
Chen, R.3
-
72
-
-
0031721141
-
Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q
-
Mori H, Kondo T, Yokochi M et al. Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q. Neurology 51(3), 890-892 (1998).
-
(1998)
Neurology
, vol.51
, Issue.3
, pp. 890-892
-
-
Mori, H.1
Kondo, T.2
Yokochi, M.3
-
73
-
-
0342368772
-
Association between early-onset Parkinson's disease and mutations in the parkin gene
-
Lucking CB, Durr A, Bonifati V et al. Association between early-onset Parkinson's disease and mutations in the parkin gene. N. Engl. J. Med. 342(21), 1560-1567 (2000).
-
(2000)
N. Engl. J. Med
, vol.342
, Issue.21
, pp. 1560-1567
-
-
Lucking, C.B.1
Durr, A.2
Bonifati, V.3
-
74
-
-
12244262766
-
Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease
-
Foroud T, Uniacke SK, Liu L et al. Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease. Neurology 60(5), 796-801 (2003).
-
(2003)
Neurology
, vol.60
, Issue.5
, pp. 796-801
-
-
Foroud, T.1
Uniacke, S.K.2
Liu, L.3
-
75
-
-
0035421416
-
The importance of gene dosage studies: Mutational analysis of the parkin gene in early-onset parkinsonism
-
Hedrich K, Kann M, Lanthaler AJ et al. The importance of gene dosage studies: mutational analysis of the parkin gene in early-onset parkinsonism. Hum. Mol. Genet. 10(16), 1649-1656 (2001).
-
(2001)
Hum. Mol. Genet
, vol.10
, Issue.16
, pp. 1649-1656
-
-
Hedrich, K.1
Kann, M.2
Lanthaler, A.J.3
-
76
-
-
7244261867
-
Distribution, type, and origin of Parkin mutations: Review and case studies
-
Hedrich K, Eskelson C, Wilmot B et al. Distribution, type, and origin of Parkin mutations: review and case studies. Mov. Disord. 19(10), 1146-1157 (2004).
-
(2004)
Mov. Disord
, vol.19
, Issue.10
, pp. 1146-1157
-
-
Hedrich, K.1
Eskelson, C.2
Wilmot, B.3
-
77
-
-
0033933048
-
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
-
Shimura H, Hattori N, Kubo S et al. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat. Genet. 25(3), 302-305 (2000).
-
(2000)
Nat. Genet
, vol.25
, Issue.3
, pp. 302-305
-
-
Shimura, H.1
Hattori, N.2
Kubo, S.3
-
78
-
-
0038771960
-
A potential proteasome-interacting motif within the ubiquitin-like domain of parkin and other proteins
-
Upadhya SC, Hegde AN. A potential proteasome-interacting motif within the ubiquitin-like domain of parkin and other proteins. Trends Biochem. Sci. 28(6), 280-283 (2003).
-
(2003)
Trends Biochem. Sci
, vol.28
, Issue.6
, pp. 280-283
-
-
Upadhya, S.C.1
Hegde, A.N.2
-
79
-
-
33751267701
-
Parkin: A multifaceted ubiquitin ligase
-
Moore DJ. Parkin: a multifaceted ubiquitin ligase. Biochem. Soc. Trans. 34(Pt 5), 749-753 (2006).
-
(2006)
Biochem. Soc. Trans
, vol.34
, Issue.PART 5
, pp. 749-753
-
-
Moore, D.J.1
-
80
-
-
0037468831
-
Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila
-
Yang Y, Nishimura I, Imai Y, Takahashi R, Lu B. Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila. Neuron 37(6), 911-924 (2003).
-
(2003)
Neuron
, vol.37
, Issue.6
, pp. 911-924
-
-
Yang, Y.1
Nishimura, I.2
Imai, Y.3
Takahashi, R.4
Lu, B.5
-
81
-
-
29444437871
-
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
-
Smith WW, Pei Z, Jiang H et al. Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Proc. Natl Acad. Sci. USA 102(51), 18676-18681 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, Issue.51
, pp. 18676-18681
-
-
Smith, W.W.1
Pei, Z.2
Jiang, H.3
-
82
-
-
12344251678
-
Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress
-
Moore DJ, Zhang L, Troncoso J et al. Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress. Hum. Mol. Genet. 14(1), 71-84 (2005).
-
(2005)
Hum. Mol. Genet
, vol.14
, Issue.1
, pp. 71-84
-
-
Moore, D.J.1
Zhang, L.2
Troncoso, J.3
-
83
-
-
0035068574
-
Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36
-
Valente EM, Bentivoglio AR, Dixon PH et al. Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36. Am. J. Hum. Genet. 68(4), 895-900 (2001).
-
(2001)
Am. J. Hum. Genet
, vol.68
, Issue.4
, pp. 895-900
-
-
Valente, E.M.1
Bentivoglio, A.R.2
Dixon, P.H.3
-
84
-
-
0036136951
-
PARK6-linked parkinsonism occurs in several European families
-
Valente EM, Brancati F, Ferraris A et al. PARK6-linked parkinsonism occurs in several European families. Ann. Neurol. 51(1), 14-18 (2002).
-
(2002)
Ann. Neurol
, vol.51
, Issue.1
, pp. 14-18
-
-
Valente, E.M.1
Brancati, F.2
Ferraris, A.3
-
85
-
-
4444274910
-
PINK1 mutations are associated with sporadic early-onset parkinsonism
-
Valente EM, Salvi S, Ialongo T et al. PINK1 mutations are associated with sporadic early-onset parkinsonism. Ann. Neurol. 56(3), 336-341 (2004).
-
(2004)
Ann. Neurol
, vol.56
, Issue.3
, pp. 336-341
-
-
Valente, E.M.1
Salvi, S.2
Ialongo, T.3
-
86
-
-
4444269012
-
Homozygous PINK1 C-terminus mutation causing early-onset parkinsonism
-
Rohe CF, Montagna P, Breedveld G et al. Homozygous PINK1 C-terminus mutation causing early-onset parkinsonism. Ann. Neurol. 56(3), 427-431 (2004).
-
(2004)
Ann. Neurol
, vol.56
, Issue.3
, pp. 427-431
-
-
Rohe, C.F.1
Montagna, P.2
Breedveld, G.3
-
87
-
-
4444237208
-
Novel PINK1 mutations in early-onset parkinsonism
-
Hatano Y, Li Y, Sato K et al. Novel PINK1 mutations in early-onset parkinsonism. Ann. Neurol. 56(3), 424-427 (2004).
-
(2004)
Ann. Neurol
, vol.56
, Issue.3
, pp. 424-427
-
-
Hatano, Y.1
Li, Y.2
Sato, K.3
-
88
-
-
5644254800
-
PINK1 (PARK6) associated Parkinson disease in Ireland
-
Healy DG, Abou-Sleiman PM, Gibson JM et al. PINK1 (PARK6) associated Parkinson disease in Ireland. Neurology 63(8), 1486-1488 (2004).
-
(2004)
Neurology
, vol.63
, Issue.8
, pp. 1486-1488
-
-
Healy, D.G.1
Abou-Sleiman, P.M.2
Gibson, J.M.3
-
89
-
-
33745099053
-
Clinical spectrum of homozygous and heterozygous PINK1 mutations in a large German family with Parkinson disease: Role of a single hit?
-
Hedrich K, Hagenah J, Djarmati A et al. Clinical spectrum of homozygous and heterozygous PINK1 mutations in a large German family with Parkinson disease: role of a single hit? Arch. Neurol. 63(6), 833-838 (2006).
-
(2006)
Arch. Neurol
, vol.63
, Issue.6
, pp. 833-838
-
-
Hedrich, K.1
Hagenah, J.2
Djarmati, A.3
-
90
-
-
33750598457
-
A heterozygous effect for PINK1 mutations in Parkinson's disease?
-
Abou-Sleiman PM, Muqit MM, McDonald NQ et al. A heterozygous effect for PINK1 mutations in Parkinson's disease? Ann. Neurol. 60(4), 414-419 (2006).
-
(2006)
Ann. Neurol
, vol.60
, Issue.4
, pp. 414-419
-
-
Abou-Sleiman, P.M.1
Muqit, M.M.2
McDonald, N.Q.3
-
91
-
-
33846029821
-
PINK1 mutation heterozygosity and the risk of Parkinson's disease
-
Toft M, Myhre R, Pielsticker L et al. PINK1 mutation heterozygosity and the risk of Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 78(1), 82-84 (2007).
-
(2007)
J. Neurol. Neurosurg. Psychiatry
, vol.78
, Issue.1
, pp. 82-84
-
-
Toft, M.1
Myhre, R.2
Pielsticker, L.3
-
92
-
-
0036895554
-
Clinical and subclinical dopaminergic dysfunction in PARK6-linked parkinsonism: An 18F-dopa PET study
-
Khan NL, Valente EM, Bentivoglio AR et al. Clinical and subclinical dopaminergic dysfunction in PARK6-linked parkinsonism: an 18F-dopa PET study. Ann. Neurol. 52(6), 849-853 (2002).
-
(2002)
Ann. Neurol
, vol.52
, Issue.6
, pp. 849-853
-
-
Khan, N.L.1
Valente, E.M.2
Bentivoglio, A.R.3
-
93
-
-
33244482539
-
Mutational analysis of the PINK1 gene in early-onset parkinsonism in Europe and North Africa
-
Ibanez P, Lesage S, Lohmann E et al. Mutational analysis of the PINK1 gene in early-onset parkinsonism in Europe and North Africa. Brain 129(Pt 3), 686-694 (2006).
-
(2006)
Brain
, vol.129
, Issue.PART 3
, pp. 686-694
-
-
Ibanez, P.1
Lesage, S.2
Lohmann, E.3
-
94
-
-
7044236967
-
PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations
-
Hatano Y, Sato K, Elibol B et al. PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations. Neurology 63(8), 1482-1485 (2004).
-
(2004)
Neurology
, vol.63
, Issue.8
, pp. 1482-1485
-
-
Hatano, Y.1
Sato, K.2
Elibol, B.3
-
95
-
-
33745087689
-
PINK1 protein in normal human brain and Parkinson's disease
-
Gandhi S, Muqit MM, Stanyer L et al. PINK1 protein in normal human brain and Parkinson's disease. Brain 129(Pt 7), 1720-1731 (2006).
-
(2006)
Brain
, vol.129
, Issue.PART 7
, pp. 1720-1731
-
-
Gandhi, S.1
Muqit, M.M.2
Stanyer, L.3
-
96
-
-
33745589773
-
Drosophila PINK1 is required for mitochondrial function and interacts genetically with parkin
-
Clark IE, Dodson MW, Jiang C et al. Drosophila PINK1 is required for mitochondrial function and interacts genetically with parkin. Nature 441(7097), 1162-1166 (2006).
-
(2006)
Nature
, vol.441
, Issue.7097
, pp. 1162-1166
-
-
Clark, I.E.1
Dodson, M.W.2
Jiang, C.3
-
97
-
-
33746080412
-
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila PINK1 is rescued by Parkin
-
Yang Y, Gehrke S, Imai Y et al. Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila PINK1 is rescued by Parkin. Proc. Natl Acad. Sci. USA 103(28), 10793-10798 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, Issue.28
, pp. 10793-10798
-
-
Yang, Y.1
Gehrke, S.2
Imai, Y.3
-
98
-
-
33745602748
-
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
-
Park J, Lee SB, Lee S et al. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441(7097), 1157-1161 (2006).
-
(2006)
Nature
, vol.441
, Issue.7097
, pp. 1157-1161
-
-
Park, J.1
Lee, S.B.2
Lee, S.3
-
99
-
-
0043204995
-
Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation
-
Hague S, Rogaeva E, Hernandez D et al. Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation. Ann. Neurol. 54(2), 271-274 (2003).
-
(2003)
Ann. Neurol
, vol.54
, Issue.2
, pp. 271-274
-
-
Hague, S.1
Rogaeva, E.2
Hernandez, D.3
-
100
-
-
0042232353
-
The role of pathogenic DJ-1 mutations in Parkinson's disease
-
Abou-Sleiman PM, Healy DG, Quinn N, Lees AJ, Wood NW. The role of pathogenic DJ-1 mutations in Parkinson's disease. Ann. Neurol. 54(3), 283-286 (2003).
-
(2003)
Ann. Neurol
, vol.54
, Issue.3
, pp. 283-286
-
-
Abou-Sleiman, P.M.1
Healy, D.G.2
Quinn, N.3
Lees, A.J.4
Wood, N.W.5
-
101
-
-
10744226640
-
DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in earlyonset Parkinson disease
-
Hedrich K, Djarmati A, Schafer N et al. DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in earlyonset Parkinson disease. Neurology 62(3), 389-394 (2004).
-
(2004)
Neurology
, vol.62
, Issue.3
, pp. 389-394
-
-
Hedrich, K.1
Djarmati, A.2
Schafer, N.3
-
102
-
-
10744232719
-
Clinical features and neuroimaging of PARK7-linked parkinsonism
-
Dekker M, Bonifati V, van Swieten J et al. Clinical features and neuroimaging of PARK7-linked parkinsonism. Mov. Disord. 18(7), 751-757 (2003).
-
(2003)
Mov. Disord
, vol.18
, Issue.7
, pp. 751-757
-
-
Dekker, M.1
Bonifati, V.2
van Swieten, J.3
-
103
-
-
33750598175
-
Role of DJ-1 in Parkinson's disease
-
Lev N, Roncevich D, Ickowicz D, Melamed E, Offen D. Role of DJ-1 in Parkinson's disease. J. Mol. Neurosci. 29(3), 215-225 (2006).
-
(2006)
J. Mol. Neurosci
, vol.29
, Issue.3
, pp. 215-225
-
-
Lev, N.1
Roncevich, D.2
Ickowicz, D.3
Melamed, E.4
Offen, D.5
-
104
-
-
2942684871
-
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
-
Canet-Aviles RM, Wilson MA, Miller DW et al. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc. Natl Acad. Sci. USA 101(24), 9103-9108 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, Issue.24
, pp. 9103-9108
-
-
Canet-Aviles, R.M.1
Wilson, M.A.2
Miller, D.W.3
-
105
-
-
20144389422
-
-
Kim RH, Smith PD, Aleyasin H et al. Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc. Natl Acad. Sci. USA 102(14), 5215-5220 (2005).
-
Kim RH, Smith PD, Aleyasin H et al. Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc. Natl Acad. Sci. USA 102(14), 5215-5220 (2005).
-
-
-
-
106
-
-
0028298816
-
Pallido-pyramidal degeneration, supranuclear upgaze paresis and dementia: Kufor-Rakeb syndrome
-
Najim al-Din AS, Wriekat A, Mubaidin A, Dasouki M, Hiari M. Pallido-pyramidal degeneration, supranuclear upgaze paresis and dementia: Kufor-Rakeb syndrome. Acta Neurol. Scand. 89(5), 347-352 (1994).
-
(1994)
Acta Neurol. Scand
, vol.89
, Issue.5
, pp. 347-352
-
-
Najim al-Din, A.S.1
Wriekat, A.2
Mubaidin, A.3
Dasouki, M.4
Hiari, M.5
-
107
-
-
0034796326
-
Kufor-Rakeb syndrome, pallido-pyramidal degeneration with supranuclear upgaze paresis and dementia, maps to 1p36
-
Hampshire DJ, Roberts E, Crow Y et al. Kufor-Rakeb syndrome, pallido-pyramidal degeneration with supranuclear upgaze paresis and dementia, maps to 1p36. J. Med. Genet. 38(10), 680-682 (2001).
-
(2001)
J. Med. Genet
, vol.38
, Issue.10
, pp. 680-682
-
-
Hampshire, D.J.1
Roberts, E.2
Crow, Y.3
-
108
-
-
27844571985
-
Kufor Rakeb disease: Autosomal recessive, levodopa-responsive parkinsonism with pyramidal degeneration, supranuclear gaze palsy, and dementia
-
Williams DR, Hadeed A, al-Din AS, Wreikat AL, Lees AJ. Kufor Rakeb disease: autosomal recessive, levodopa-responsive parkinsonism with pyramidal degeneration, supranuclear gaze palsy, and dementia. Mov. Disord. 20(10), 1264-1271 (2005).
-
(2005)
Mov. Disord
, vol.20
, Issue.10
, pp. 1264-1271
-
-
Williams, D.R.1
Hadeed, A.2
al-Din, A.S.3
Wreikat, A.L.4
Lees, A.J.5
-
109
-
-
33749133430
-
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
-
Ramirez A, Heimbach A, Grundemann J et al. Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase. Nat. Genet. 38(10), 1184-1191 (2006).
-
(2006)
Nat. Genet
, vol.38
, Issue.10
, pp. 1184-1191
-
-
Ramirez, A.1
Heimbach, A.2
Grundemann, J.3
-
110
-
-
0036830525
-
A susceptibility gene for late-onset idiopathic Parkinson's disease
-
Hicks AA, Petursson H, Jonsson T et al. A susceptibility gene for late-onset idiopathic Parkinson's disease. Ann. Neurol. 52(5), 549-555 (2002).
-
(2002)
Ann. Neurol
, vol.52
, Issue.5
, pp. 549-555
-
-
Hicks, A.A.1
Petursson, H.2
Jonsson, T.3
-
111
-
-
18344393780
-
Age at onset in two common neurodegenerative diseases is genetically controlled
-
Li YJ, Scott WK, Hedges DJ et al. Age at onset in two common neurodegenerative diseases is genetically controlled. Am. J. Hum. Genet. 70(4), 985-993 (2002).
-
(2002)
Am. J. Hum. Genet
, vol.70
, Issue.4
, pp. 985-993
-
-
Li, Y.J.1
Scott, W.K.2
Hedges, D.J.3
-
112
-
-
22544472702
-
Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease
-
Oliveira SA, Li YJ, Noureddine MA et al. Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease. Am. J. Hum. Genet. 77(2), 252-264 (2005).
-
(2005)
Am. J. Hum. Genet
, vol.77
, Issue.2
, pp. 252-264
-
-
Oliveira, S.A.1
Li, Y.J.2
Noureddine, M.A.3
-
113
-
-
18444364221
-
Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations
-
Pankratz N, Nichols WC, Uniacke SK et al. Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations. Am. J. Hum. Genet. 71(1), 124-135 (2002).
-
(2002)
Am. J. Hum. Genet
, vol.71
, Issue.1
, pp. 124-135
-
-
Pankratz, N.1
Nichols, W.C.2
Uniacke, S.K.3
-
114
-
-
25444498785
-
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
-
Strauss KM, Martins LM, Plun-Favreau H et al. Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease. Hum. Mol. Genet. 14(15), 2099-2111 (2005).
-
(2005)
Hum. Mol. Genet
, vol.14
, Issue.15
, pp. 2099-2111
-
-
Strauss, K.M.1
Martins, L.M.2
Plun-Favreau, H.3
-
115
-
-
0033837202
-
Variability and validity of polymorphism association studies in Parkinson's disease
-
Tan EK, Khajavi M, Thornby JI et al. Variability and validity of polymorphism association studies in Parkinson's disease. Neurology 55(4), 533-538 (2000).
-
(2000)
Neurology
, vol.55
, Issue.4
, pp. 533-538
-
-
Tan, E.K.1
Khajavi, M.2
Thornby, J.I.3
-
116
-
-
27844547616
-
The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease
-
Jankovic J, Chen S, Le WD. The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Prog. Neurobiol. 77(1-2), 128-138 (2005).
-
(2005)
Prog. Neurobiol
, vol.77
, Issue.1-2
, pp. 128-138
-
-
Jankovic, J.1
Chen, S.2
Le, W.D.3
-
117
-
-
3843050571
-
Evaluation of the role of Nurr1 in a large sample of familial Parkinson's disease
-
Nichols WC, Uniacke SK, Pankratz N et al. Evaluation of the role of Nurr1 in a large sample of familial Parkinson's disease. Mov. Disord. 19(6), 649-655 (2004).
-
(2004)
Mov. Disord
, vol.19
, Issue.6
, pp. 649-655
-
-
Nichols, W.C.1
Uniacke, S.K.2
Pankratz, N.3
-
118
-
-
33845205797
-
NR4A2 genetic variation in sporadic Parkinson's disease: A genewide approach
-
Healy DG, Abou-Sleiman PM, Ahmadi KR et al. NR4A2 genetic variation in sporadic Parkinson's disease: a genewide approach. Mov. Disord. 21(11), 1960-1963 (2006).
-
(2006)
Mov. Disord
, vol.21
, Issue.11
, pp. 1960-1963
-
-
Healy, D.G.1
Abou-Sleiman, P.M.2
Ahmadi, K.R.3
-
119
-
-
0032952414
-
Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions
-
Engelender S, Kaminsky Z, Guo X et al. Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions. Nat. Genet. 22(1), 110-114 (1999).
-
(1999)
Nat. Genet
, vol.22
, Issue.1
, pp. 110-114
-
-
Engelender, S.1
Kaminsky, Z.2
Guo, X.3
-
120
-
-
34249803290
-
The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein - implications for Parkinson's disease
-
Marx FP, Soehn AS, Berg D et al. The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein - implications for Parkinson's disease. FASEB J. 21(8), 1759-1767 (2007).
-
(2007)
FASEB J
, vol.21
, Issue.8
, pp. 1759-1767
-
-
Marx, F.P.1
Soehn, A.S.2
Berg, D.3
-
121
-
-
20044388324
-
Interaction of α-synuclein and tau genotypes in Parkinson's disease
-
Mamah CE, Lesnick TG, Lincoln SJ et al. Interaction of α-synuclein and tau genotypes in Parkinson's disease. Ann. Neurol. 57(3), 439-443 (2005).
-
(2005)
Ann. Neurol
, vol.57
, Issue.3
, pp. 439-443
-
-
Mamah, C.E.1
Lesnick, T.G.2
Lincoln, S.J.3
-
122
-
-
3042797560
-
Tau gene and Parkinson's disease: A case-control study and meta-analysis
-
Healy DG, Abou-Sleiman PM, Lees AJ et al. Tau gene and Parkinson's disease: a case-control study and meta-analysis. J. Neurol. Neurosurg. Psychiatry 75(7), 962-965 (2004).
-
(2004)
J. Neurol. Neurosurg. Psychiatry
, vol.75
, Issue.7
, pp. 962-965
-
-
Healy, D.G.1
Abou-Sleiman, P.M.2
Lees, A.J.3
-
123
-
-
17144379764
-
The tau gene haplotype h1 confers a susceptibility to Parkinson's disease
-
Zhang J, Song Y, Chen H, Fan D. The tau gene haplotype h1 confers a susceptibility to Parkinson's disease. Eur. Neurol. 53(1), 15-21 (2005).
-
(2005)
Eur. Neurol
, vol.53
, Issue.1
, pp. 15-21
-
-
Zhang, J.1
Song, Y.2
Chen, H.3
Fan, D.4
-
124
-
-
0032849237
-
Cellular co-localization of phosphorylated tau- and NACP/α-synuclein-epitopes in lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies
-
Arima K, Hirai S, Sunohara N et al. Cellular co-localization of phosphorylated tau- and NACP/α-synuclein-epitopes in lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies. Brain Res. 843(1-2), 53-61 (1999).
-
(1999)
Brain Res
, vol.843
, Issue.1-2
, pp. 53-61
-
-
Arima, K.1
Hirai, S.2
Sunohara, N.3
-
125
-
-
0037383761
-
Colocalization of tau and α-synuclein epitopes in Lewy bodies
-
Ishizawa T, Mattila P, Davies P, Wang D, Dickson DW. Colocalization of tau and α-synuclein epitopes in Lewy bodies. J. Neuropathol. Exp. Neurol. 62(4), 389-397 (2003).
-
(2003)
J. Neuropathol. Exp. Neurol
, vol.62
, Issue.4
, pp. 389-397
-
-
Ishizawa, T.1
Mattila, P.2
Davies, P.3
Wang, D.4
Dickson, D.W.5
-
126
-
-
1442304904
-
Tau haplotypes regulate transcription and are associated with Parkinson's disease
-
Kwok JB, Teber ET, Loy C et al. Tau haplotypes regulate transcription and are associated with Parkinson's disease. Ann. Neurol. 55(3), 329-334 (2004).
-
(2004)
Ann. Neurol
, vol.55
, Issue.3
, pp. 329-334
-
-
Kwok, J.B.1
Teber, E.T.2
Loy, C.3
-
128
-
-
7444237665
-
Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews
-
Aharon-Peretz J, Rosenbaum H, Gershoni-Baruch R. Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews. N. Engl. J. Med. 351(19), 1972-1977 (2004).
-
(2004)
N. Engl. J. Med
, vol.351
, Issue.19
, pp. 1972-1977
-
-
Aharon-Peretz, J.1
Rosenbaum, H.2
Gershoni-Baruch, R.3
-
130
-
-
34250352065
-
Construction and validation of a Parkinson's disease mutation genotyping array for the Parkin gene
-
Clark LN, Haamer E, Mejia-Santana H et al. Construction and validation of a Parkinson's disease mutation genotyping array for the Parkin gene. Mov. Disord. 22(7), 932-937 (2007).
-
(2007)
Mov. Disord
, vol.22
, Issue.7
, pp. 932-937
-
-
Clark, L.N.1
Haamer, E.2
Mejia-Santana, H.3
-
131
-
-
33749170166
-
Cytosolic catechols inhibit α-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates
-
Mazzulli JR, Mishizen AJ, Giasson BI et al. Cytosolic catechols inhibit α-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates. J. Neurosci. 26(39), 10068-10078 (2006).
-
(2006)
J. Neurosci
, vol.26
, Issue.39
, pp. 10068-10078
-
-
Mazzulli, J.R.1
Mishizen, A.J.2
Giasson, B.I.3
-
132
-
-
27844472158
-
A-synuclein aggregation in neurodegenerative diseases and its inhibition as a potential therapeutic strategy
-
Paleologou KE, Irvine GB, El-Agnaf OM. A-synuclein aggregation in neurodegenerative diseases and its inhibition as a potential therapeutic strategy. Biochem. Soc. Trans. 33(Pt 5), 1106-1110 (2005).
-
(2005)
Biochem. Soc. Trans
, vol.33
, Issue.PART 5
, pp. 1106-1110
-
-
Paleologou, K.E.1
Irvine, G.B.2
El-Agnaf, O.M.3
-
133
-
-
34147130637
-
Isolation of a human single chain antibody fragment against oligomeric α-synuclein that inhibits aggregation and prevents α-synuclein-induced toxicity
-
Emadi S, Barkhordarian H, Wang MS, Schulz P, Sierks MR. Isolation of a human single chain antibody fragment against oligomeric α-synuclein that inhibits aggregation and prevents α-synuclein-induced toxicity. J. Mol. Biol. 368(4), 1132-1144 (2007).
-
(2007)
J. Mol. Biol
, vol.368
, Issue.4
, pp. 1132-1144
-
-
Emadi, S.1
Barkhordarian, H.2
Wang, M.S.3
Schulz, P.4
Sierks, M.R.5
-
134
-
-
33749654232
-
Parkinson's disease genetics: A complex disease comes to the clinic
-
Perez-Tur J. Parkinson's disease genetics: a complex disease comes to the clinic. Lancet Neurol. 5(11), 896-897 (2006).
-
(2006)
Lancet Neurol
, vol.5
, Issue.11
, pp. 896-897
-
-
Perez-Tur, J.1
-
135
-
-
34250380097
-
-
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-
-
-
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