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Volumn 10, Issue 11 SPEC., 2003, Pages 946-954

Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: Peculiarities, mechanisms, and consequences

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; INTERLEUKIN 1; INTERLEUKIN 6; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; VIRUS PROTEIN; CYTOKINE; VIRUS ANTIGEN; VIRUS ENVELOPE PROTEIN;

EID: 0038128348     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302048     Document Type: Review
Times cited : (79)

References (73)
  • 1
    • 0035135747 scopus 로고    scopus 로고
    • Viral vectors for gene therapy: The art of turning infectious agents into vehicles of therapeutics
    • Kay MA, Glorioso JC, Naldini L. Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nat Med 2001; 7: 33-40.
    • (2001) Nat. Med. , vol.7 , pp. 33-40
    • Kay, M.A.1    Glorioso, J.C.2    Naldini, L.3
  • 2
    • 0036705491 scopus 로고    scopus 로고
    • Progress and challenges in viral vector-mediated gene transfer to the brain
    • Lowenstein PR, Castro MG. Progress and challenges in viral vector-mediated gene transfer to the brain. Curr Opin Mol Ther 2002; 4: 359-371.
    • (2002) Curr. Opin. Mol. Ther. , vol.4 , pp. 359-371
    • Lowenstein, P.R.1    Castro, M.G.2
  • 3
    • 0037066502 scopus 로고    scopus 로고
    • Decoding the patterns of self and nonself by the innate immune system
    • Medzhitov R, Janeway Jr CA. Decoding the patterns of self and nonself by the innate immune system. Science 2002; 296: 298-300.
    • (2002) Science , vol.296 , pp. 298-300
    • Medzhitov, R.1    Janeway C.A., Jr.2
  • 4
    • 0033062377 scopus 로고    scopus 로고
    • Mechanisms of exogenous antigen presentation by MHC class I molecules in vitro and in vivo: Implications for generating CD8+ T cell responses to infectious agents, tumors, transplants, and vaccines
    • Yewdell JW, Norbury CC, Bennink JR. Mechanisms of exogenous antigen presentation by MHC class I molecules in vitro and in vivo: implications for generating CD8+ T cell responses to infectious agents, tumors, transplants, and vaccines. Adv Immunol 1999; 73: 1-77.
    • (1999) Adv. Immunol. , vol.73 , pp. 1-77
    • Yewdell, J.W.1    Norbury, C.C.2    Bennink, J.R.3
  • 5
    • 0037271850 scopus 로고    scopus 로고
    • Viral mimicry of cytokines, chemokines and their receptors
    • Alcami A. Viral mimicry of cytokines, chemokines and their receptors. Nat Rev Immunol 2003; 3: 36-50.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 36-50
    • Alcami, A.1
  • 6
    • 0033831421 scopus 로고    scopus 로고
    • Viral mechanisms of immune evasion
    • Alcami A, Koszinowski UH. Viral mechanisms of immune evasion. Immunol Today 2000; 21: 447-455.
    • (2000) Immunol. Today , vol.21 , pp. 447-455
    • Alcami, A.1    Koszinowski, U.H.2
  • 7
    • 0036852231 scopus 로고    scopus 로고
    • Viral interference with antigen presentation
    • Yewdell JW, Hill AB. Viral interference with antigen presentation. Nat Immunol 2002; 3: 1019-1025.
    • (2002) Nat. Immunol. , vol.3 , pp. 1019-1025
    • Yewdell, J.W.1    Hill, A.B.2
  • 8
    • 0034080319 scopus 로고    scopus 로고
    • Viral subversion of the immune system
    • Tortorella D et al. Viral subversion of the immune system. Annu Rev Immunol 2000; 18: 861-926.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 861-926
    • Tortorella, D.1
  • 9
    • 0036631249 scopus 로고    scopus 로고
    • Travels along the viral-immunobiology highway
    • Oldstone MB. Travels along the viral-immunobiology highway. Immunol Rev 2002; 185: 54-68.
    • (2002) Immunol. Rev. , vol.185 , pp. 54-68
    • Oldstone, M.B.1
  • 10
    • 0036668253 scopus 로고    scopus 로고
    • On differences between immunity and immunological memory
    • Zinkernagel RM. On differences between immunity and immunological memory. Curr Opin Immunol 2002; 14: 523-536.
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 523-536
    • Zinkernagel, R.M.1
  • 11
    • 0036630737 scopus 로고    scopus 로고
    • Uncertainties - Discrepancies in immunology
    • Zinkernagel RM. Uncertainties - discrepancies in immunology. Immunol Rev 2002; 185: 103-125.
    • (2002) Immunol. Rev. , vol.185 , pp. 103-125
    • Zinkernagel, R.M.1
  • 12
    • 0036152214 scopus 로고    scopus 로고
    • Immunology of viral-vector-mediated gene transfer into the brain: An evolutionary and developmental perspective
    • Lowenstein PR. Immunology of viral-vector-mediated gene transfer into the brain: an evolutionary and developmental perspective. Trends Immunol 2002; 23: 23-30.
    • (2002) Trends Immunol. , vol.23 , pp. 23-30
    • Lowenstein, P.R.1
  • 13
    • 0345294457 scopus 로고    scopus 로고
    • A revised view of the central nervous system microenvironment and major histocompatibility complex class II antigen presentation
    • Perry VH. A revised view of the central nervous system microenvironment and major histocompatibility complex class II antigen presentation. J Neuroimmunol 1998; 90: 113-21.
    • (1998) J. Neuroimmunol. , vol.90 , pp. 113-121
    • Perry, V.H.1
  • 14
    • 0002802349 scopus 로고
    • On the transplantation of the rat sarcoma in adult heterogenous animals
    • Shirai Y. On the transplantation of the rat sarcoma in adult heterogenous animals. Jpn Med World 1921; 1: 14-15.
    • (1921) Jpn. Med. World , vol.1 , pp. 14-15
    • Shirai, Y.1
  • 15
    • 0001481758 scopus 로고
    • Conditions determining the transplantability of tissues in the brain
    • Murphy JBS, E. Conditions determining the transplantability of tissues in the brain. J Exp Med 1923; 38: 183-97.
    • (1923) J. Exp. Med. , vol.38 , pp. 183-197
    • Murphy, J.B.S.1    Murphy, E.2
  • 16
    • 78651010946 scopus 로고
    • Immunity to homologous grafted skin. III. The fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye
    • Medawar PB. Immunity to homologous grafted skin. III. The fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. Br J Exp Pathol 1948; 29: 58-69.
    • (1948) Br. J. Exp. Pathol. , vol.29 , pp. 58-69
    • Medawar, P.B.1
  • 17
    • 0029062270 scopus 로고
    • Adenovirus gene transfer causes inflammation in the brain
    • Byrnes AP, Rusby JE, Wood MJ, Charlton HM. Adenovirus gene transfer causes inflammation in the brain. Neuroscience 1995; 66: 1015-1024.
    • (1995) Neuroscience , vol.66 , pp. 1015-1024
    • Byrnes, A.P.1    Rusby, J.E.2    Wood, M.J.3    Charlton, H.M.4
  • 18
    • 0030296554 scopus 로고    scopus 로고
    • Immune responses to adenovirus vectors in the nervous system
    • Wood MJ et al. Immune responses to adenovirus vectors in the nervous system. Trends Neurosci 1996; 19: 497-501.
    • (1996) Trends Neurosci. , vol.19 , pp. 497-501
    • Wood, M.J.1
  • 19
    • 0029876694 scopus 로고    scopus 로고
    • Immunological instability of persistent adenovirus vectors in the brain: Peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination
    • Byrnes AP, MacLaren RE, Charlton HM. Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination. J Neurosci 1996; 16: 3045-3055.
    • (1996) J. Neurosci. , vol.16 , pp. 3045-3055
    • Byrnes, A.P.1    MacLaren, R.E.2    Charlton, H.M.3
  • 20
    • 0033557657 scopus 로고    scopus 로고
    • Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain
    • Cartmell T et al. Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain. J Neurosci 1999; 19: 1517-1523.
    • (1999) J. Neurosci. , vol.19 , pp. 1517-1523
    • Cartmell, T.1
  • 21
    • 0029760296 scopus 로고    scopus 로고
    • Role of T cells in inflammation caused by adenovirus vectors in the brain
    • Byrnes AP, Wood MJ, Charlton HM. Role of T cells in inflammation caused by adenovirus vectors in the brain. Gene Therapy 1996; 3: 644-651.
    • (1996) Gene Therapy , vol.3 , pp. 644-651
    • Byrnes, A.P.1    Wood, M.J.2    Charlton, H.M.3
  • 22
    • 0032853699 scopus 로고    scopus 로고
    • Immune responses to adenovirus and adeno-associated virus in humans
    • Chirmule N et al. Immune responses to adenovirus and adeno-associated virus in humans. Gene Therapy 1999; 6: 1574-1583.
    • (1999) Gene Therapy , vol.6 , pp. 1574-1583
    • Chirmule, N.1
  • 23
    • 0036145350 scopus 로고    scopus 로고
    • A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency
    • Raper SE et al. A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency. Hum Gene Ther 2002; 13: 163-175.
    • (2002) Hum. Gene Ther. , vol.13 , pp. 163-175
    • Raper, S.E.1
  • 24
    • 0031060168 scopus 로고    scopus 로고
    • Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression
    • Bruder JT, Kovesdi I. Adenovirus infection stimulates the Raf/ MAPK signaling pathway and induces interleukin-8 expression. J Virol 1997; 71: 398-404.
    • (1997) J. Virol. , vol.71 , pp. 398-404
    • Bruder, J.T.1    Kovesdi, I.2
  • 25
    • 0033999338 scopus 로고    scopus 로고
    • Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB
    • Borgland SL et al. Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB. J Virol 2000; 74: 3941-3947.
    • (2000) J. Virol. , vol.74 , pp. 3941-3947
    • Borgland, S.L.1
  • 26
    • 0036202249 scopus 로고    scopus 로고
    • Adenovirus vector-induced inflammation: Capsid-dependent induction of the C-C chemokine RANTES requires NF-kappa B
    • Bowen GP et al. Adenovirus vector-induced inflammation: capsid-dependent induction of the C-C chemokine RANTES requires NF-kappa B. Hum Gene Ther 2002; 13: 367-379.
    • (2002) Hum. Gene. Ther. , vol.13 , pp. 367-379
    • Bowen, G.P.1
  • 27
    • 0033541522 scopus 로고    scopus 로고
    • Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo
    • Muruve DA, Barnes MJ, Stillman IE, Libermann TA. Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo. Hum Gene Ther 1999; 10: 965-976.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 965-976
    • Muruve, D.A.1    Barnes, M.J.2    Stillman, I.E.3    Libermann, T.A.4
  • 28
    • 0036145860 scopus 로고    scopus 로고
    • Activation of p38 and ERK signaling during adenovirus vector cell entry lead to expression of the C-X-C chemokine IP-10
    • Tibbles LA et al. Activation of p38 and ERK signaling during adenovirus vector cell entry lead to expression of the C-X-C chemokine IP-10. J Virol 2002; 76: 1559-1568.
    • (2002) J. Virol. , vol.76 , pp. 1559-1568
    • Tibbles, L.A.1
  • 29
    • 0034986065 scopus 로고    scopus 로고
    • Acute direct adenoviral vector cytotoxicity and chronic but not acute inflammatory responses correlate with decreased vector-mediated transgene expression in the brain
    • Thomas CE et al. Acute direct adenoviral vector cytotoxicity and chronic but not acute inflammatory responses correlate with decreased vector-mediated transgene expression in the brain. Mol Ther 2001; 3: 36-46.
    • (2001) Mol. Ther. , vol.3 , pp. 36-46
    • Thomas, C.E.1
  • 30
    • 0036118869 scopus 로고    scopus 로고
    • Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types
    • Thomas CE et al. Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types. J Virol 2002; 76: 3452-60.
    • (2002) J. Virol. , vol.76 , pp. 3452-3460
    • Thomas, C.E.1
  • 31
    • 0034691208 scopus 로고    scopus 로고
    • Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: Toward realistic long-term neurological gene therapy for chronic diseases
    • Thomas CE et al. Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for chronic diseases. Proc Natl Acad Sci USA 2000; 97: 7482-7478.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7479-7482
    • Thomas, C.E.1
  • 32
    • 0034926344 scopus 로고    scopus 로고
    • Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors
    • Thomas CE et al. Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors. Hum Gene Ther 2001; 12: 839-846.
    • (2001) Hum. Gene Ther. , vol.12 , pp. 839-846
    • Thomas, C.E.1
  • 33
    • 0033977310 scopus 로고    scopus 로고
    • Humoral immune responses to adenovirus vectors in the brain
    • Kajiwara K et al. Humoral immune responses to adenovirus vectors in the brain. J Neuroimmunol 2000; 103: 8-15.
    • (2000) J. Neuroimmunol. , vol.103 , pp. 8-15
    • Kajiwara, K.1
  • 34
    • 0001909288 scopus 로고    scopus 로고
    • Gene transfer into rat brain using adenoviral vectors
    • Gerfen JN, McKay R, Rogawski MA, Sibley DR, Skolnick P. (eds) John Wiley and Sons: New York, NY
    • Thomas CE et al. Gene transfer into rat brain using adenoviral vectors. In: Gerfen JN, McKay R, Rogawski MA, Sibley DR, Skolnick P. (eds) Current Protocols in Neuroscience, John Wiley and Sons: New York, NY; 2000, pp 4.23.1-4.40.
    • (2000) Current Protocols in Neuroscience
    • Thomas, C.E.1
  • 35
    • 13044300857 scopus 로고    scopus 로고
    • Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae
    • Roelvink PW et al. Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae. Science 1999; 286: 1568-1571.
    • (1999) Science , vol.286 , pp. 1568-1571
    • Roelvink, P.W.1
  • 36
    • 0033954001 scopus 로고    scopus 로고
    • Targeting adenovirus
    • Wickham TJ. Targeting adenovirus. Gene Ther 2000; 7: 110-114.
    • (2000) Gene Ther. , vol.7 , pp. 110-114
    • Wickham, T.J.1
  • 37
    • 0034991967 scopus 로고    scopus 로고
    • Classification of demyelinating diseases at the interface between etiology and pathogenesis
    • Lassmann H. Classification of demyelinating diseases at the interface between etiology and pathogenesis. Curr Opin Neurol 2001; 14: 253-258.
    • (2001) Curr. Opin. Neurol. , vol.14 , pp. 253-258
    • Lassmann, H.1
  • 38
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • Lucchinetti C et al. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 2000; 47: 707-717.
    • (2000) Ann. Neurol. , vol.47 , pp. 707-717
    • Lucchinetti, C.1
  • 39
    • 0037371088 scopus 로고    scopus 로고
    • Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies
    • Coesmans M et al. Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies. Ann Neurol 2003; 53: 325-336.
    • (2003) Ann. Neurol. , vol.53 , pp. 325-336
    • Coesmans, M.1
  • 40
    • 0034447657 scopus 로고    scopus 로고
    • Neuroimmunology of multiple sclerosis and experimental allergic encephalomyelitis
    • vii-viii
    • Stuerzebecher S, Martin R. Neuroimmunology of multiple sclerosis and experimental allergic encephalomyelitis. Neuroimaging Clin N Am 2000; 10: 649-68,vii-viii.
    • (2000) Neuroimaging Clin. N. Am. , vol.10 , pp. 649-668
    • Stuerzebecher, S.1    Martin, R.2
  • 41
    • 0030038208 scopus 로고    scopus 로고
    • A comparison of leucocyte responses to heat-killed bacillus Calmette-Guerin in different CNS compartments
    • Matyszak MK, Perry VH. A comparison of leucocyte responses to heat-killed bacillus Calmette-Guerin in different CNS compartments. Neuropathol Appl Neurobiol 1996; 22: 44-53.
    • (1996) Neuropathol. Appl. Neurobiol. , vol.22 , pp. 44-53
    • Matyszak, M.K.1    Perry, V.H.2
  • 42
    • 0031987334 scopus 로고    scopus 로고
    • Bacillus Calmette-Guerin sequestered in the brain parenchyma escapes immune recognition
    • Matyszak MK, Perry VH. Bacillus Calmette-Guerin sequestered in the brain parenchyma escapes immune recognition. J Neuroimmunol 1998; 82: 73-80.
    • (1998) J. Neuroimmunol. , vol.82 , pp. 73-80
    • Matyszak, M.K.1    Perry, V.H.2
  • 43
    • 0036298188 scopus 로고    scopus 로고
    • Uncoupling of virus-induced inflammation and anti-viral immunity in the brain parenchyma
    • Stevenson PG, Austyn JM, Hawke S. Uncoupling of virus-induced inflammation and anti-viral immunity in the brain parenchyma. J Gen Virol 2002; 83: 1735-1743.
    • (2002) J. Gen. Virol. , vol.83 , pp. 1735-1743
    • Stevenson, P.G.1    Austyn, J.M.2    Hawke, S.3
  • 44
    • 0031471822 scopus 로고    scopus 로고
    • Recruitment, activation and proliferation of CD8+ memory T cells in an immunoprivileged site
    • Stevenson PG, Bangham CR, Hawke S. Recruitment, activation and proliferation of CD8+ memory T cells in an immunoprivileged site. Eur J Immunol 1997; 27: 3259-3268.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 3259-3268
    • Stevenson, P.G.1    Bangham, C.R.2    Hawke, S.3
  • 45
    • 0031571231 scopus 로고    scopus 로고
    • Virus dissemination through the brain parenchyma without immunologic control
    • Stevenson PG, Freeman S, Bangham CR, Hawke S. Virus dissemination through the brain parenchyma without immunologic control. J Immunol 1997; 159: 1876-1884.
    • (1997) J. Immunol. , vol.159 , pp. 1876-1884
    • Stevenson, P.G.1    Freeman, S.2    Bangham, C.R.3    Hawke, S.4
  • 46
    • 0031060468 scopus 로고    scopus 로고
    • The immunogenicity of intracerebral virus infection depends on anatomical site
    • Stevenson PG, Hawke S, Sloan DJ, Bangham CR. The immunogenicity of intracerebral virus infection depends on anatomical site. J Virol 1997; 71: 145-151.
    • (1997) J. Virol. , vol.71 , pp. 145-151
    • Stevenson, P.G.1    Hawke, S.2    Sloan, D.J.3    Bangham, C.R.4
  • 47
    • 0035170589 scopus 로고    scopus 로고
    • T-cell- and macrophage-mediated axon damage in the absence of a CNS-specific immune response: Involvement of metalloproteinases
    • Newman TA et al. T-cell- and macrophage-mediated axon damage in the absence of a CNS-specific immune response: involvement of metalloproteinases. Brain 2001; 124: 2203-2214.
    • (2001) Brain , vol.124 , pp. 2203-2214
    • Newman, T.A.1
  • 48
    • 0032752574 scopus 로고    scopus 로고
    • Role of the cervical lymphatics in the Th2-type hierarchy of CNS immune regulation
    • Harling-Berg CJ, Park TJ, Knopf PM. Role of the cervical lymphatics in the Th2-type hierarchy of CNS immune regulation. J Neuroimmunol 1999; 101: 111-127.
    • (1999) J. Neuroimmunol. , vol.101 , pp. 111-127
    • Harling-Berg, C.J.1    Park, T.J.2    Knopf, P.M.3
  • 49
    • 0026444002 scopus 로고
    • Afferent and efferent arms of the humoral immune response to CSF-administered albumins in a rat model with normal bloodbrain barrier permeability
    • Cserr HF et al. Afferent and efferent arms of the humoral immune response to CSF-administered albumins in a rat model with normal bloodbrain barrier permeability. J Neuroimmunol 1992; 41: 195-202.
    • (1992) J. Neuroimmunol. , vol.41 , pp. 195-202
    • Cserr, H.F.1
  • 50
    • 0032964119 scopus 로고    scopus 로고
    • Disproportionate recruitment of CD8+ T cells into the central nervous system by professional antigen-presenting cells
    • Carson MJ, Reilly CR, Sutcliffe JG, Lo D. Disproportionate recruitment of CD8+ T cells into the central nervous system by professional antigen-presenting cells. Am J Pathol 1999; 154: 481-494.
    • (1999) Am. J. Pathol. , vol.154 , pp. 481-494
    • Carson, M.J.1    Reilly, C.R.2    Sutcliffe, J.G.3    Lo, D.4
  • 51
    • 0032797304 scopus 로고    scopus 로고
    • Antigen presentation function of brain-derived dendriform cells depends on astrocyte help
    • Fischer HG, Bielinsky AK. Antigen presentation function of brain-derived dendriform cells depends on astrocyte help. Int Immunol 1999; 11: 1265-1274.
    • (1999) Int. Immunol. , vol.11 , pp. 1265-1274
    • Fischer, H.G.1    Bielinsky, A.K.2
  • 52
    • 0034193965 scopus 로고    scopus 로고
    • Phenotype and functions of brain dendritic cells emerging during chronic infection of mice with Toxoplasma gondii
    • Fischer HG, Bonifas U, Reichmann G. Phenotype and functions of brain dendritic cells emerging during chronic infection of mice with Toxoplasma gondii. J Immunol 2000; 164: 4826-4834.
    • (2000) J. Immunol. , vol.164 , pp. 4826-4834
    • Fischer, H.G.1    Bonifas, U.2    Reichmann, G.3
  • 53
    • 0035865406 scopus 로고    scopus 로고
    • Brain dendritic cells and macrophages/microglia in central nervous system inflammation
    • Fischer HG, Reichmann G. Brain dendritic cells and macrophages/microglia in central nervous system inflammation. J Immunol 2001; 166: 2717-2726.
    • (2001) J. Immunol. , vol.166 , pp. 2717-2726
    • Fischer, H.G.1    Reichmann, G.2
  • 54
    • 0024467217 scopus 로고
    • Microglial cells in human brain have phenotypic characteristics related to possible function as dendritic antigen presenting cells
    • Lowe J et al. Microglial cells in human brain have phenotypic characteristics related to possible function as dendritic antigen presenting cells. J Pathol 1989; 159: 143-149.
    • (1989) J. Pathol. , vol.159 , pp. 143-149
    • Lowe, J.1
  • 55
    • 0030593433 scopus 로고    scopus 로고
    • The Potential role of dendritic cells in immune-mediated inflammatory diseases in the central nervous system
    • Matyszak MK, Perry VH. The Potential role of dendritic cells in immune-mediated inflammatory diseases in the central nervous system. Neuroscience 1996; 74: 599-608.
    • (1996) Neuroscience , vol.74 , pp. 599-608
    • Matyszak, M.K.1    Perry, V.H.2
  • 56
    • 0033594227 scopus 로고    scopus 로고
    • Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations
    • McMenamin PG. Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations. J Comp Neurol 1999; 405: 553-562.
    • (1999) J. Comp. Neurol. , vol.405 , pp. 553-562
    • McMenamin, P.G.1
  • 57
    • 0035933106 scopus 로고    scopus 로고
    • Developmental plasticity of CNS microglia
    • Santambrogio L et al. Developmental plasticity of CNS microglia. Proc Natl Acad Sci USA 2001; 98: 6295-6300.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6295-6300
    • Santambrogio, L.1
  • 58
    • 0033636254 scopus 로고    scopus 로고
    • Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis
    • Serafini B, Columba-Cabezas S, Di Rosa F, Aloisi F. Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis. Am J Pathol 2000; 157: 1991-2002.
    • (2000) Am. J. Pathol. , vol.157 , pp. 1991-2002
    • Serafini, B.1    Columba-Cabezas, S.2    Di Rosa, F.3    Aloisi, F.4
  • 59
    • 0036481263 scopus 로고    scopus 로고
    • Epitope spreading in immune-mediated diseases: Implications for immunotherapy
    • Vanderlugt CL, Miller SD. Epitope spreading in immune-mediated diseases: implications for immunotherapy. Nat Rev Immunol 2002; 2: 85-95.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 85-95
    • Vanderlugt, C.L.1    Miller, S.D.2
  • 60
    • 0036271301 scopus 로고    scopus 로고
    • Theiler's virus-mediated autoimmunity: Local presentation of CNS antigens and epitope spreading
    • Tompkins SM, Fuller KG, Miller SD. Theiler's virus-mediated autoimmunity: local presentation of CNS antigens and epitope spreading. Ann N Y Acad Sci 2002; 958: 26-38.
    • (2002) Ann. N. Y. Acad. Sci. , vol.958 , pp. 26-38
    • Tompkins, S.M.1    Fuller, K.G.2    Miller, S.D.3
  • 61
    • 0019415855 scopus 로고
    • Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain
    • Hart DN, Fabre JW. Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain. J Exp Med 1981; 154: 347-361.
    • (1981) J. Exp. Med. , vol.154 , pp. 347-361
    • Hart, D.N.1    Fabre, J.W.2
  • 62
    • 0032037595 scopus 로고    scopus 로고
    • A gamma34.5 mutant of herpes simplex 1 causes severe inflammation in the brain
    • McMenamin MM et al. A gamma34.5 mutant of herpes simplex 1 causes severe inflammation in the brain. Neuroscience 1998; 83: 1225-1237.
    • (1998) Neuroscience , vol.83 , pp. 1225-1237
    • McMenamin, M.M.1
  • 63
    • 0027496645 scopus 로고
    • Stepwise dismantling of adenovirus 2 during entry into cells
    • Greber UF, Willetts M, Webster P, Helenius A. Stepwise dismantling of adenovirus 2 during entry into cells. Cell 1993; 75: 477-486.
    • (1993) Cell , vol.75 , pp. 477-486
    • Greber, U.F.1    Willetts, M.2    Webster, P.3    Helenius, A.4
  • 64
    • 14344276590 scopus 로고    scopus 로고
    • An improved helper-dependent adenoviral vector allows persistent gene expression after intramuscular delivery and overcomes preexisting immunity to adenovirus
    • Maione D et al. An improved helper-dependent adenoviral vector allows persistent gene expression after intramuscular delivery and overcomes preexisting immunity to adenovirus. Proc Natl Acad Sci USA 2001; 98: 5986-5991.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 5986-5991
    • Maione, D.1
  • 65
    • 0033865751 scopus 로고    scopus 로고
    • Immune response to recombinant adenovirus in humans: Capsid components from viral input are targets for vector-specific cytotoxic T lymphocytes
    • Molinier-Frenkel V et al. Immune response to recombinant adenovirus in humans: capsid components from viral input are targets for vector-specific cytotoxic T lymphocytes. J Virol 2000; 74: 7678-7682.
    • (2000) J. Virol. , vol.74 , pp. 7678-7682
    • Molinier-Frenkel, V.1
  • 66
    • 0029793811 scopus 로고    scopus 로고
    • Adenovirus-pulsed dendritic cells stimulate human virus-specific T-cell responses in vitro
    • Smith CA, Woodruff LS, Kitchingman GR, Rooney CM. Adenovirus-pulsed dendritic cells stimulate human virus-specific T-cell responses in vitro. J Virol 1996; 70: 6733-6740.
    • (1996) J. Virol. , vol.70 , pp. 6733-6740
    • Smith, C.A.1    Woodruff, L.S.2    Kitchingman, G.R.3    Rooney, C.M.4
  • 67
    • 0032530110 scopus 로고    scopus 로고
    • Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: Implications for gene therapy
    • Kafri T et al. Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: implications for gene therapy. Proc Natl Acad Sci USA 1998; 95: 11377-11382.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 11377-11382
    • Kafri, T.1
  • 68
    • 0028484704 scopus 로고
    • MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses
    • Yang Y, Ertl HC, Wilson JM. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1994; 1: 433-442.
    • (1994) Immunity , vol.1 , pp. 433-442
    • Yang, Y.1    Ertl, H.C.2    Wilson, J.M.3
  • 69
    • 9244220682 scopus 로고    scopus 로고
    • Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo
    • Yang Y et al. Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo. Gene Therapy 1996; 3: 137-144.
    • (1996) Gene Therapy , vol.3 , pp. 137-144
    • Yang, Y.1
  • 70
    • 0028328261 scopus 로고
    • Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy
    • Yang Y et al. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 1994; 91: 4407-4411.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4407-4411
    • Yang, Y.1
  • 71
    • 0029028989 scopus 로고
    • Clearance of adenovirus-infected hepatocytes by MHC class I-restricted CD4+ CTLs in vivo
    • Yang Y, Wilson JM. Clearance of adenovirus-infected hepatocytes by MHC class I-restricted CD4+ CTLs in vivo. J Immunol 1995; 155: 2564-2570.
    • (1995) J. Immunol. , vol.155 , pp. 2564-2570
    • Yang, Y.1    Wilson, J.M.2
  • 72
    • 0030910842 scopus 로고    scopus 로고
    • Adenovirus vector-infected cells can escape adenovirus antigen-specific cytotoxic T-lymphocyte killing in vivo
    • Wadsworth SC, Zhou H, Smith AE, Kaplan JM. Adenovirus vector-infected cells can escape adenovirus antigen-specific cytotoxic T-lymphocyte killing in vivo. J Virol 1997; 71: 5189-5196.
    • (1997) J. Virol. , vol.71 , pp. 5189-5196
    • Wadsworth, S.C.1    Zhou, H.2    Smith, A.E.3    Kaplan, J.M.4
  • 73
    • 0035062597 scopus 로고    scopus 로고
    • Non-cytolytic control of viral infections by the innate and adaptive immune response
    • Guidotti LG, Chisari FV. Non-cytolytic control of viral infections by the innate and adaptive immune response. Annu Rev Immunol 2001; 19: 65-91.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 65-91
    • Guidotti, L.G.1    Chisari, F.V.2


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