Enhanced expression of glutamate decarboxylase 65 improves symptoms of rat parkinsonian models

Gene Therapy

Volumn 12, Issue 15, 2005, Pages 1215-1222

  Lee, B ^a   Lee, H ^b   Nam, Y R ^b   Oh, J H ^a   Cho, Y H ^a   Chang, J W ^a  

^a Yonsei University College of Medicine   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

Author keywords

6 hydroxydopamine; GAD65; Parkinson's disease; Subthalamic nucleus

Indexed keywords

4 AMINOBUTYRIC ACID; ADENOVIRUS VECTOR; GLUTAMATE DECARBOXYLASE 65; OXIDOPAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; ELECTROPHYSIOLOGY; GENE EXPRESSION REGULATION; GENE TRANSFER; IN VITRO STUDY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; SUBTHALAMIC NUCLEUS; SYMPTOMATOLOGY; SYNAPTIC INHIBITION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ADENOVIRIDAE; ANIMALS; BEHAVIOR, ANIMAL; CELLS, CULTURED; CYTOMEGALOVIRUS; ELECTROCARDIOGRAPHY; GENE EXPRESSION; GENE THERAPY; GLUTAMATE DECARBOXYLASE; HUMANS; MALE; MODELS, ANIMAL; PARKINSON DISEASE; PROMOTER REGIONS (GENETICS); RATS; RATS, SPRAGUE-DAWLEY; SUBTHALAMIC NUCLEUS; TRANSDUCTION, GENETIC; TRANSFECTION; TREATMENT OUTCOME;

ADENO-ASSOCIATED VIRUS 2; CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; PARKINSONIA;

EID: 23744497262     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302520     Document Type: Article

References (29)

1. Obeso JA, Rodriguez-Oroz MC, Lanciego JL, Rodriguez Diaz M. How does Parkinson's disease begin? The role of compensatory mechanisms. Trends Neurosci 2004; 27: 125-127.
2. Obeso JA et al. Pathophysiology of the basal ganglia in Parkinson's disease. Trends Neurosci 2000; 23: S8-S19.
3. Luo J et al. Subthalamic GAD gene therapy in a Parkinson's disease rat model. Science 2002; 298: 425-429.
4. McCown TJ et al. Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector. Brain Res 1996; 713: 99-107.
5. Kaplitt MG et al. Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nat Genet 1994; 8: 148-154.
6. Wu P, Phillips MI, Bui J, Terwilliger EF. Adeno-associated virus vector-mediated transgene integration into neurons and other nondividing cell targets. J Virol 1998; 72: 5919-5926.
7. Bartlett JS, Samulski RJ, McCown TJ. Selective and rapid uptake of adeno-associated virus type 2 in brain. Hum Gene Ther 1998; 9: 1181-1186.
8. Tenenbaum L et al. Recombinant AAV-mediated gene delivery to the central nervous system. J Gene Med 2004; 6 (Suppl 1): S212-S222.
9. Xiao X, Li J, McCown TJ, Samulski RJ. Gene transfer by adeno-associated virus vectors into the central nervous system. Exp Neurol 1997; 144: 113-124.
10. Hermens WT et al. Purification of recombinant adeno-associated virus by iodixanol gradient ultracentrifugation allows rapid and reproducible preparation of vector stocks for gene transfer in the nervous system. Hum Gene Ther 1999; 10: 1885-1891.
11. Chang JW, Wachtel SR, Young D, Kang UJ. Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson's disease: studies on medial forebrain bundle and striatal lesions. Neuroscience 1999; 88: 617-628.
12. Chang JW et al. Effect of subthalamic lesion with kainic acid on the neuronal activities of the basal ganglia of rat parkinsonian models with 6-hydroxydopamine. Acta Neurochir Suppl 2003; 87: 163-168.
13. During MJ et al. Development and optimization of adeno-associated virus vector transfer into the central nervous system. Methods Mol Med 2003; 76: 221-236.
14. During MJ, Kaplitt MG, Stern MB, Eidelberg D. Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation. Hum Gene Ther 2001; 12: 1589-1591.
15. Mi J et al. Recombinant adeno-associated virus (AAV) drives constitutive production of glutamate decarboxylase in neural cell lines. J Neurosci Res 1999; 57: 137-148.
16. Erlander MG et al. Two genes encode distinct glutamate decarboxylases. Neuron 1991; 7: 91-100.
17. Monahan PE, Samulski RJ. AAV vectors: is clinical success on the horizon? Gene Therapy 2000; 7: 24-30.
18. Lo WD et al. Adeno-associated virus-mediated gene transfer to the brain: duration and modulation of expression. Hum Gene Ther 1999; 10: 201-213.
19. Mastakov MY et al. Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brain. J Virol 2002; 76: 8446-8454.
20. Fitzsimons HL, Bland RJ, During MJ. Promoters and regulatory elements that improve adeno-associated virus transgene expression in the brain. Methods 2002; 28: 227-236.
21. Jang HS et al. A novel ex vivo angiogenesis assay based on electroporation-mediated delivery of naked plasmid DNA to skeletal muscle. Mol Ther 2004; 9: 464-474.
22. Kim DK, Byun J. The pJDK vector contains the human cytomegalovirus enhancer/promoter-driven expression cassette within the inverted terminal repeats of AAV-2. Patent Pending in Korea, 2002, 10-2002-0008232.
23. Albin RL, Young AB, Penney JB. The functional anatomy of basal ganglia disorders. Trends Neurosci 1989; 12: 366-375.
24. Delfs JM, Ciaramitaro VM, Parry TJ, Chesselet MF. Subthalamic nucleus lesions: widespread effects on changes in gene expression induced by nigrostriatal dopamine depletion in rats. J Neurosci 1995; 15: 6562-6575.
25. Jeon MF et al. Effect of ipsilateral subthalamic nucleus lesioning in a rat parkinsonian model: study of behavior correlated with neuronal activity in the pedunculopontine nucleus. J Neurosurg 2003; 99: 762-767.
26. Byun J et al. Efficient expression of the vascular endothelial growth factor gene in vitro and in vivo, using an adeno-associated virus vector. J Mol Cell Cardiol 2001; 33: 295-305.
27. Song JJ et al. Enhancement of gene transfer efficiency into human cancer cells by modification of retroviral vectors and addition of chemicals. Oncol Rep 2000; 7: 119-124.
28. Haberman RA, Kroner-Lux GSR. Adeno-associated viral vectors. In: Current Protocols in Human Genetics. John Wiley & Sons Inc, 1999, pp 91-97.
29. Chang JW et al. Microelectrode recording-guided deep brain stimulation in patients with movement disorders (the first trial in Korea). In: Kultas-Ilinsky K, Ilinsky IA (eds). Kluwer Academic: New York, 1999.